Interactions
Interactomes for ASD candidate genes within the PIN module contain the following six types of direct protein interactions, as defined in the following table:
| Interaction |
Definition |
| Protein Binding |
two proteins bind together; includes homodimerization |
| Promoter Binding |
one protein binds to the promoter of another protein; can be either direction |
| RNA Binding |
one protein binds to the RNA of another protein; can be either direction |
| Protein Modification |
one protein performs a post-translational modification on another protein (examples: phosphorylation, glycosylation, nitrosylation, oxidation, hydroxylation ubiquitination, etc.); can be either direction
|
| Direct Regulation |
one protein directly impacts the activity of another protein (examples: GTP hydrolysis; RNA splicing); can be either direction
|
| Autoregulation |
a protein regulates its own activity, typically by autophosphorylation
|
