The Protein Interaction (PIN) module of AutDB serves as a comprehensive, up-to-date reference for all known direct protein interactions of genes associated with autism spectrum disorders (ASD). It is integrated with other modules of AutDB (Human Gene, Animal Model, Copy Number Variant, Gene Scoring).
The first set of ASD candidate genes curated in the PIN module belong to the Rare and Syndromic genetic categories (see definitions of genetic categories below). The next set of genes to be curated will be those in the Association category, followed by genes in the Functional category. Our researchers continuously update interactomes as new scientific literature is published.
Our PIN database is envisioned to have immediate application for network biology analysis of molecular pathways involved in ASD pathogenesis.
Rare: rare single gene variants, disruptions/mutations, and submicroscopic deletions/duplications directly linked to ASD
Syndromic: genes implicated in syndromes in which a significant subpopulation develops autistic symptoms (examples: Angelman Syndrome, Fragile X Syndrome)
Association: small risk-conferring candidate genes with common polymorphisms identified from genetic association studies in idiopathic ASD
Functional: functional candidates not yet experimentally linked with ASD