FABP5
Homo sapiens
Gene Name: fatty acid binding protein 5 (psoriasis-associated)
Aliases: EFABP; E-FABP; PAFABP; PA-FABP; FABP5
Chromosome No: 8
Chromosome Band: 8q21.13
Genetic Category: Rare Single Gene variant, Genetic Association-Functional-Rare single gene variant
Aliases: EFABP; E-FABP; PAFABP; PA-FABP; FABP5
Chromosome No: 8
Chromosome Band: 8q21.13
Genetic Category: Rare Single Gene variant, Genetic Association-Functional-Rare single gene variant
Summary Statistics:
ASD Reports: 8
Recent Reports: 2
Annotated variants: 5
Associated CNVs: 7
Evidence score: 2
ASD Reports: 8
Recent Reports: 2
Annotated variants: 5
Associated CNVs: 7
Evidence score: 2
| Associated Disorders: |
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Relevance to Autism
Some rare and some common variants in the FABP5 gene were found in autistic patients. However, none were found to have significant genetic association with autism (Maekawa et al., 2010).
Molecular Function
The encoded protein binds long-chain fatty acids and other hydrophobic ligands
External Links
References
Type
Title
Type of Disorder
Associated Disorders
Author, Year
Primary
Polymorphism screening of brain-expressed FABP7, 5 and 3 genes and association studies in autism and schizophrenia in Japanese subjects.
ASD
SCZ
Support
Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies.
ASD
SCZ
Support
Inherited and De Novo Genetic Risk for Autism Impacts Shared Networks.
ASD
Highly Cited
Molecular cloning and expression of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regu...
Highly Cited
The mammalian fatty acid-binding protein multigene family: molecular and genetic insights into function.
Recent Recommendation
Expression of fatty acid-binding proteins in adult hippocampal neurogenic niche of postischemic monkeys.
Recent Recommendation
Identification of intracellular carriers for the endocannabinoid anandamide.
