Summary Statistics:
Gene Score: 3
Relevance to Autism
Several studies have found genetic association and rare variants in the DISC1 gene that are associated with autism. Positive associations have been found in the Chinese Han population and in the Finnish population (for both autism and Asperger syndrome; Kilpinen et al., 2008). In addition, genetic association between DISC1 and a psychosis phenotype was found in a Finnish sample, and association with schizophrenia and bipolar disorder was found in some European cohorts.
Molecular Function
This gene encodes a protein with multiple coiled coil motifs and is involved in neurite outgrowth and cortical development through its interaction with other proteins.
References
Primary
Association of DISC1 with autism and Asperger syndrome.
ASD
Asperger syndrome
Positive Association
708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits.
MDD
SCZ, BPD
Positive Association
Evidence for association between Disrupted-in-Schizophrenia 1 (DISC1) gene polymorphisms and autism in Chinese Han population: a family-based assoc...
ASD
Support
A 1q42 deletion involving DISC1, DISC2, and TSNAX in an autism spectrum disorder.
ASD
Support
Integrating de novo and inherited variants in 42
ASD
Support
The contribution of de novo coding mutations to autism spectrum disorder
ASD
Support
Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders.
ASD, SCZ
Support
Refinement and discovery of new hotspots of copy-number variation associated with autism spectrum disorder.
ASD
Support
De novo mutations revealed by whole-exome sequencing are strongly associated with autism.
ASD
Support
DISC1 duplication in two brothers with autism and mild mental retardation.
ASD
MR
Highly Cited
DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling.
Highly Cited
DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of ...
Recent Recommendation
DISC1 causes associative memory and neurodevelopmental defects in fruit flies.
Recent Recommendation
Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus.
Recent Recommendation
DISC1 (disrupted-in-schizophrenia-1) regulates differentiation of oligodendrocytes.
Recent Recommendation
Behavioral phenotypes of Disc1 missense mutations in mice.
Recent Recommendation
Missense mutation in DISC1 C-terminal coiled-coil has GSK3 signaling and sex-dependent behavioral effects in mice.
Recent Recommendation
Association studies and gene expression analyses of the DISC1-interacting molecules, pericentrin 2 (PCNT2) and DISC1-binding zinc finger protein (D...
Recent Recommendation
mTOR Inhibition ameliorates cognitive and affective deficits caused by Disc1 knockdown in adult-born dentate granule neurons.
Recent Recommendation
Early postnatal GABAA receptor modulation reverses deficits in neuronal maturation in a conditional neurodevelopmental mouse model of DISC1.
Recent Recommendation
Association of variants in DISC1 with psychosis-related traits in a large population cohort.
Recent Recommendation
Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophrenia.
Recent Recommendation
DISC1-dependent Regulation of Mitochondrial Dynamics Controls the Morphogenesis of Complex Neuronal Dendrites.
Recent Recommendation
Replication study of candidate genes for cognitive abilities: the Lothian Birth Cohort 1936.
Recent Recommendation
DISC1-dependent switch from progenitor proliferation to migration in the developing cortex.
Recent Recommendation
The cortical thickness phenotype of individuals with DISC1 translocation resembles schizophrenia.
Recent Recommendation
Nuclear DISC1 regulates CRE-mediated gene transcription and sleep homeostasis in the fruit fly.
Recent Recommendation
DISC1 regulates lactate metabolism in astrocytes: implications for psychiatric disorders.
Recent Recommendation
Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits.
Recent Recommendation
Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate.
Recent Recommendation
DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder.
SCZ, BPD
Recent Recommendation
Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids.
Recent Recommendation
Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1.
Recent Recommendation
Disrupted-in-schizophrenia 1 regulates transport of ITPR1 mRNA for synaptic plasticity.
Recent Recommendation
Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain.
GEN065R001
copy_number_gain
Familial
Paternal
Multiplex
GEN065R002
copy_number_loss
Familial
Maternal
Simplex
GEN065R003
missense_variant
c.1819C>T
p.Leu607Phe
Familial
Paternal
Simplex
GEN065R004
missense_variant
c.1981G>A
p.Glu661Lys
Familial
Paternal
Simplex
GEN065R005
missense_variant
c.112C>T
p.Arg38Trp
De novo
Simplex
GEN065R006
copy_number_loss
Familial
Paternal
Simplex
GEN065R007
copy_number_loss
Familial
Maternal
Simplex
GEN065R008
missense_variant
c.109C>T
p.Arg37Trp
Familial
Maternal
Multiplex
GEN065R009
missense_variant
c.248C>T
p.Ala83Val
Unknown
Unknown
GEN065R010
missense_variant
c.479G>T
p.Trp160Leu
Unknown
Unknown
GEN065R011
missense_variant
c.698G>A
p.Arg233Lys
Familial
Maternal
Simplex
GEN065R012
missense_variant
c.1253G>A
p.Arg418His
Unknown
Unknown
GEN065R013
synonymous_variant
c.348G>A
p.Ala116=
Familial (1 case), Unknown (1 case)
Paternal (1 case)
Multi-generational (1 case), unknown (1 case)
GEN065R014
synonymous_variant
c.816G>A
p.Arg272=
Familial
Paternal
Multiplex
GEN065R015
frameshift_variant
c.2220del
p.Asp740GlufsTer7
Unknown
Unknown
GEN065R016
missense_variant
c.1880C>G
p.Ala627Gly
De novo
Simplex
GEN065R017
missense_variant
c.991A>G
p.Arg331Gly
De novo
GEN065R018
splice_site_variant
c.2241+68T>G
De novo
GEN065R019
frameshift_variant
c.2358_2359+2del
Familial
Maternal
Multiplex
GEN065R020
frameshift_variant
c.2358_2359+2del
Familial
Paternal
Multiplex
GEN065R021
frameshift_variant
c.2358_2359+2del
Familial
Maternal
Multiplex
GEN065C001
intron_variant
rs1322784
c.1635-2053G>A;c.1731-2053G>A;c.1269-2053G>A;c.1634+22119G>A;c.584+22119G>A
Finnish
Discovery
GEN065C002
intron_variant, microsatellite
Finnish
Discovery
GEN065C003
missense_variant, 3_prime_UTR_variant
rs821616
c.2110A>T;c.2206A>T;c.1744A>T;c.2049A>T;c.*83A>T
p.Ser704Cys;p.Ser736Cys;p.Ser582Cys;p.Arg683Ser
Finnish
Discovery
GEN065C004
intron_variant
rs4366301
c.68-23286G>C;c.67+43606G>C
C/G
Chinese Han
Discovery
GEN065C005
intron_variant
rs11585959
c.1047+3167T>C;c.68-51954T>C
C/T
Chinese Han
Discovery
GEN065C006
intron_variant
rs6668845
c.1981+54284A>G;c.2077+54284A>G;c.1615+54284A>G;c.1635-86027A>G
Chinese Han
Discovery
GEN065C007
intron_variant
rs821577
c.1982-27517T>G;c.2078-27517T>G;c.1616-27517T>G;c.1982-77474T>G;c.1635-27517T>G
N/A
Finnish
Discovery
GEN065C008
intron_variant
rs11122381
c.1982-467A>G;c.2078-467A>G;c.1616-467A>G;c.1982-50424A>G;c.1635-467A>G
Finnish
Discovery
GEN065C009
intron_variant
rs821592
c.1982-315G>A;c.2078-315G>A;c.1616-315G>A;c.1982-50272G>A;c.1635-315G>A
N/A
Finnish
Discovery
GEN065C010
intron_variant
rs1538979
c.1269-6018C>T;c.1365-6018C>T;c.1268+11046C>T;c.219-6018C>T
T/C
Finnish
Discovery
GEN065C011
intron_variant
rs821577
c.1982-27517T>G;c.2078-27517T>G;c.1616-27517T>G;c.1982-77474T>G;c.1635-27517T>G
G/T
London
Discovery
GEN065C012
missense_variant
rs6675281
c.1819C>T;c.1915C>T;c.1453C>T;c.1716C>T;c.1634+47285C>T;c.*5C>T
p.Leu607Phe
Edinburgh
Replication
GEN065C013
intron_variant
rs1322784
c.1635-2053G>A;c.1731-2053G>A;c.1269-2053G>A;c.1634+22119G>A;c.584+22119G>A
Finnish
Replication
GEN065C014
intron_variant
rs1322784
c.1635-2053G>A;c.1731-2053G>A;c.1269-2053G>A;c.1634+22119G>A;c.584+22119G>A
London
Replication
GEN065C015
intron_variant
rs16856199
c.2242-8069T>A;c.2404-8069T>A;c.1942-8069T>A;c.2308-8069T>A
Scotland: 192 cases with recurrent major depressive disorder (rMDD), 889 controls
Discovery
1
Deletion-Duplication
20
Summary Statistics:
Model Summary
Model provides insight into how DISC1 variation contributes to schizophrenia susceptibility in humans and have implications for modeling psychiatric diseases in mice.
References
Primary
Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice.
Additional
Behavioral phenotypes of Disc1 missense mutations in mice.
Additional
Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans.
Additional
Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia.
Additional
Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice.
Additional
A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition.
Additional
Repetitive and compulsive-like behaviors lead to cognitive dysfunction in Disc12-3/2-3 mice.
Model Type:
Genetic
Model Genotype:
Homozygous
Mutation:
25 bp deletion induces a frameshift in the reading frame leading to 13 novel amino acids leading to premature stop codon in exon 7 of the Disc1 gene.
Allele Type: Targeted (Knock Out)
Strain of Origin: Not Specified
Genetic Background: C57BL/6J
ES Cell Line: Not Specified
Mutant ES Cell Line: Not Specified
Model Source: Not Specified
Model Type:
Genetic
Model Genotype:
Heterozygous
Mutation:
25 bp deletion induces a frameshift in the reading frame leading to 13 novel amino acids leading to premature stop codon in exon 7 of the Disc1 gene.
Allele Type: Targeted (Knock Out)
Strain of Origin: Not Specified
Genetic Background: C57BL/6J
ES Cell Line: Not Specified
Mutant ES Cell Line: Not Specified
Model Source: Not Specified
Model Type:
Genetic
Model Genotype:
Homozygous
Mutation:
127A-T transversion in exon 2 of Disc1 gene resulting in amino acid exchange Q31L caused by 1686 ENU mutagenesis.
Allele Type: Spontaenous Mutation (Transversion)
Strain of Origin: C57BL/6JJcI
Genetic Background: Not Specified
ES Cell Line: Not Specified
Mutant ES Cell Line: Not Specified
Model Source: Not Specified
Model Type:
Genetic
Model Genotype:
Heterozygous
Mutation:
127A-T transversion in exon 2 of Disc1 gene resulting in amino acid exchange Q31L caused by 1686 ENU mutagenesis.
Allele Type: Spontaenous Mutation (Transversion)
Strain of Origin: C57BL/6JJcI
Genetic Background: Not Specified
ES Cell Line: Not Specified
Mutant ES Cell Line: Not Specified
Model Source: Not Specified
Model Type:
Genetic
Model Genotype:
Homozygous
Mutation:
334T-C transition in exon 2 of Disc1 gene resulting in amino acid exchange L100P caused by 1686 ENU mutagenesis.
Allele Type: Spontaenous Mutation (Transition)
Strain of Origin: C57BL/6JJcI
Genetic Background: Not Specified
ES Cell Line: Not Specified
Mutant ES Cell Line: Not Specified
Model Source: Not Specified
Model Type:
Genetic
Model Genotype:
Heterozygous
Mutation:
334T-C transition in exon 2 of Disc1 gene resulting in amino acid exchange L100P caused by 1686 ENU mutagenesis.
Allele Type: Spontaenous Mutation (Transition)
Strain of Origin: C57BL/6JJcI
Genetic Background: Not Specified
ES Cell Line: Not Specified
Mutant ES Cell Line: Not Specified
Model Source: Not Specified
Model Type:
Genetic
Model Genotype:
Homozygous
Mutation:
Insertion of C-terminal truncated dominant negative (DN) Disc1 under control of promoter for CaMKII.
Allele Type: Targeted (Knock In)
Strain of Origin: Not Specified
Genetic Background: C57BL/6
ES Cell Line: Not Specified
Mutant ES Cell Line: Not Specified
Model Source: Not Specified
Model Type:
Genetic
Model Genotype:
Homozygous
Mutation:
Tet-off mediated inducible expression of mutant human DISC1 gene in forebrain areas under control of the tetracycline-response element (TRE).
Allele Type: Targeted (Knock In)
Strain of Origin: Not Specified
Genetic Background: B6;SJL-Tg(TRE-cmv-Hdisc1) x B6; CBA-Tg(Camk2a-tTA_1Mmay/j
ES Cell Line: B6;SJL
Mutant ES Cell Line: Not Specified
Model Source: Not Specified
Model Type:
Genetic
Model Genotype:
Homozygous
Mutation:
Inducible Disc1-cc transgene spanning residues 671-852 of Disc1 gene expressed under the control of the -calmodulin kinase II promoter using tamoxifen either at postnatal day (PD) 7 or adulthood.
Allele Type: Targeted (Knock In)
Strain of Origin: C57BL/6
Genetic Background: Not Specified
ES Cell Line: Not Specified
Mutant ES Cell Line: Not Specified
Model Source: Not Specified
Model Type:
Genetic
Model Genotype:
Heterozygous
Mutation:
Truncation of Disc1 transcript due to two termination codons in exons 7 and 8 and a premature polyadenylation site in intron 8.
Allele Type: Targeted (Knock Out)
Strain of Origin: 129S6/SvEvTac
Genetic Background: Not Specified
ES Cell Line: Not Specified
Mutant ES Cell Line: Not Specified
Model Source: Not Specified
Model Type:
Genetic
Model Genotype:
Homozygous
Mutation:
Truncation of Disc1 transcript due to two termination codons in exons 7 and 8 and a premature polyadenylation site in intron 8.
Allele Type: Targeted (Knock Out)
Strain of Origin: Not Specified
Genetic Background: Not Specified
ES Cell Line: Not Specified
Mutant ES Cell Line: Not Specified
Model Source: Not Specified
Model Type:
Genetic
Model Genotype:
Homozygous
Mutation:
Mice lacking exons 2 and 3 of Disc1. Exons 2 and 3 were deleted and replaced with the targeted insertion of a stop codon and floxed neo cassette. .
Allele Type: knockout
Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1
Genetic Background: C57BL/6J
ES Cell Line: Not Specified
Mutant ES Cell Line: TT2 (ES Cell)
Model Source: Not Specified
Decreased
View More
Description: Exp Paradigm:
Delayed non-match to place test
6-8 weeks
Protein expression level evidence1
Decreased
View More
Description: Exp Paradigm:
Western blot
Unreported
General locomotor activity1 No change
Open field test
6-8 weeks
No change
Histology
Unreported
No change
Prepulse inhibition
6-8 weeks
Not Reported:
Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Maternal behavior, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Social behavior
Decreased
View More
Description: Exp Paradigm:
Delayed non-match to place test
6-8 weeks
General locomotor activity1 No change
Open field test
6-8 weeks
No change
Prepulse inhibition
6-8 weeks
Not Reported:
Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Maternal behavior, Molecular profile, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Social behavior
General locomotor activity1
Decreased
View More
Description: Exp Paradigm:
Open field test
12-16 weeks
Decreased
View More
Description: Exp Paradigm:
Magnetic resonance imaging (mri)
12-16 weeks
Increased
View More
Description: Exp Paradigm:
Prepulse inhibition
12-16 weeks
Decreased
View More
Description: Exp Paradigm:
Prepulse inhibition
12-16 weeks
Decreased
View More
Description: Exp Paradigm:
Sucrose preference test
12-16 weeks
Startle response: acoustic stimulus1
Decreased
View More
Description: Exp Paradigm:
Acoustic startle reflex test
12-16 weeks
Decreased
View More
Description: Exp Paradigm:
Three-chamber social approach test
12-16 weeks
Increased
View More
Description: Exp Paradigm:
Forced swim test
12-16 weeks
Decreased
View More
Description: Exp Paradigm:
Forced swim test
12-16 weeks
Decreased
View More
Description: Exp Paradigm:
T-maze test
12-16 weeks
Cued or contextual fear conditioning: latent inhibition1
Decreased
View More
Description: Exp Paradigm:
Fear conditioning test
12-16 weeks
Decreased
View More
Description: Exp Paradigm:
Enzyme assay
12-16 weeks
No change
Elevated plus maze test
12-16 weeks
Cued or contextual fear conditioning: latent inhibition1 No change
Fear conditioning test
12-16 weeks
Spatial reference memory1 No change
Morris water maze test
12-16 weeks
Protein expression level evidence1 No change
Western blot
12-16 weeks
Protein expression: in situ protein expression1 No change
Western blot
12-16 weeks
Protein expression: in situ protein expression1 No change
Western blot
12-16 weeks
General locomotor activity1 No change
Open field test
12-16 weeks
No change
Buried food test
12-16 weeks
No change
Prepulse inhibition
12-16 weeks
No change
Prepulse inhibition
12-16 weeks
Not Reported:
Circadian sleep/wake cycle, Communications, Developmental profile, Immune response, Maternal behavior, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure
General locomotor activity1
Decreased
View More
Description: Exp Paradigm:
Open field test
12-16 weeks
Decreased
View More
Description: Exp Paradigm:
Prepulse inhibition
12-16 weeks
Decreased
View More
Description: Exp Paradigm:
Sucrose preference test
12-16 weeks
Startle response: acoustic stimulus1
Decreased
View More
Description: Exp Paradigm:
Acoustic startle reflex test
12-16 weeks
No change
Elevated plus maze test
12-16 weeks
Cued or contextual fear conditioning: latent inhibition1 No change
Fear conditioning test
12-16 weeks
General locomotor activity1 No change
Open field test
12-16 weeks
No change
Buried food test
12-16 weeks
No change
Prepulse inhibition
12-16 weeks
No change
Three-chamber social approach test
12-16 weeks
Not Reported:
Circadian sleep/wake cycle, Communications, Developmental profile, Immune response, Maternal behavior, Molecular profile, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure
General locomotor activity1
Decreased
View More
Description: Exp Paradigm:
Open field test
12-16 weeks
General locomotor activity1
Increased
View More
Description: Exp Paradigm:
Open field test
12-16 weeks
Decreased
View More
Description: Exp Paradigm:
Magnetic resonance imaging (mri)
12-16 weeks
Decreased
View More
Description: Exp Paradigm:
Sucrose preference test
12-16 weeks
Decreased
View More
Description: Exp Paradigm:
Prepulse inhibition
12-16 weeks
Startle response: acoustic stimulus1
Decreased
View More
Description: Exp Paradigm:
Acoustic startle reflex test
12-16 weeks
Increased
View More
Description: Exp Paradigm:
Prepulse inhibition
12-16 weeks
Increased
View More
Description: Exp Paradigm:
Prepulse inhibition
12-16 weeks
Increased
View More
Description: Exp Paradigm:
Forced swim test
12-16 weeks
Decreased
View More
Description: Exp Paradigm:
Forced swim test
12-16 weeks
Decreased
View More
Description: Exp Paradigm:
T-maze test
12-16 weeks
Cued or contextual fear conditioning: latent inhibition1
Increased
View More
Description: Exp Paradigm:
Fear conditioning test
12-16 weeks
Cued or contextual fear conditioning: latent inhibition1
Decreased
View More
Description: Exp Paradigm:
Fear conditioning test
12-16 weeks
No change
Elevated plus maze test
12-16 weeks
Spatial reference memory1 No change
Morris water maze test
12-16 weeks
No change
Enzyme assay
12-16 weeks
Protein expression level evidence1 No change
Western blot
12-16 weeks
Protein expression: in situ protein expression1 No change
Western blot
12-16 weeks
Protein expression: in situ protein expression1 No change
Western blot
12-16 weeks
No change
Auditory brainstem response test
12-16 weeks
No change
Buried food test
12-16 weeks
No change
Prepulse inhibition
12-16 weeks
No change
Three-chamber social approach test
12-16 weeks
Not Reported:
Circadian sleep/wake cycle, Communications, Developmental profile, Immune response, Maternal behavior, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure
General locomotor activity1
Decreased
View More
Description: Exp Paradigm:
Open field test
12-16 weeks
Decreased
View More
Description: Exp Paradigm:
Sucrose preference test
12-16 weeks
Increased
View More
Description: Exp Paradigm:
Prepulse inhibition
12-16 weeks
Increased
View More
Description: Exp Paradigm:
Prepulse inhibition
12-16 weeks
Decreased
View More
Description: Exp Paradigm:
Prepulse inhibition
12-16 weeks
Cued or contextual fear conditioning: latent inhibition1
Decreased
View More
Description: Exp Paradigm:
Fear conditioning test
12-16 weeks
No change
Elevated plus maze test
12-16 weeks
Cued or contextual fear conditioning: latent inhibition1 No change
Fear conditioning test
12-16 weeks
General locomotor activity1 No change
Open field test
12-16 weeks
No change
Buried food test
12-16 weeks
No change
Prepulse inhibition
12-16 weeks
No change
Three-chamber social approach test
12-16 weeks
Not Reported:
Circadian sleep/wake cycle, Communications, Developmental profile, Immune response, Maternal behavior, Molecular profile, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure
General locomotor activity1
Increased
View More
Description: Exp Paradigm:
Open field test
3-8 months
Abnormal
View More
Description: Exp Paradigm:
Magnetic resonance imaging (mri)
6 weeks
Increased
View More
Description: Exp Paradigm:
Magnetic resonance imaging (mri)
6 weeks
Size of cerebral ventricles: lateral ventricle1
Abnormal
View More
Description: Exp Paradigm:
Magnetic resonance imaging (mri)
6 weeks
Decreased
View More
Description: Exp Paradigm:
Buried food test
3-8 months
Increased
View More
Description: Exp Paradigm:
Forced swim test
3-8 months
Decreased
View More
Description: Exp Paradigm:
Immunohistochemistry
3 months
Protein expression level evidence1
Decreased
View More
Description: Exp Paradigm:
Immunohistochemistry
3 months
No change
Elevated plus maze test
3-8 months
No change
Open field test
3-8 months
Spatial reference memory1 No change
Morris water maze test
3-8 months
No change
Y-maze test
3-8 months
Protein expression level evidence1 No change
Immunohistochemistry
3 months
Protein expression level evidence1 No change
Immunohistochemistry
3 months
Motor coordination and balance1 No change
Accelerating rotarod test
3-8 months
No change
Magnetic resonance imaging (mri)
6, 13 weeks
No change
Prepulse inhibition
3-8 months
No change
Reciprocal social interaction test
3-8 months
Not Reported:
Circadian sleep/wake cycle, Communications, Developmental profile, Immune response, Maternal behavior, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure
General locomotor activity1
Increased
View More
Description: Exp Paradigm:
Open field test
4-9 months
Decreased
View More
Description: Exp Paradigm:
Immunohistochemistry
Unreported
Increased
View More
Description: Exp Paradigm:
Magnetic resonance imaging (mri)
9 months
Increased
View More
Description: Exp Paradigm:
Resident-intruder test
4-9 months
Spatial reference memory1
Decreased
View More
Description: Exp Paradigm:
Morris water maze test
4-9 months
Protein expression level evidence1
Decreased
View More
Description: Exp Paradigm:
Western blot
P7
Protein expression level evidence1
Decreased
View More
Description: Exp Paradigm:
Western blot
P7
Protein expression level evidence1
Decreased
View More
Description: Exp Paradigm:
Western blot
P7
No change
General observations
Unreported
No change
General observations
Unreported
No change
Elevated plus maze test
4-9 months
No change
Morris water maze test
4-9 months
Spatial reference memory1 No change
Morris water maze test
4-9 months
Protein expression level evidence1 No change
Western blot
P21, 9 months
Protein expression level evidence1 No change
Western blot
P7
Protein expression level evidence1 No change
Western blot
P7
General locomotor activity1 No change
Open field test
4-9 months
No change
Histology
P7, p21, p80
No change
Buried food test
4-9 months
No change
Prepulse inhibition
4-9 months
No change
Reciprocal social interaction test
4-9 months
Not Reported:
Circadian sleep/wake cycle, Communications, Immune response, Maternal behavior, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure
Dendritic architecture: spine density1
Decreased
View More
Description: Exp Paradigm:
Sholl analysis
3-4 months
Decreased
View More
Description: Exp Paradigm:
Field potential recordings
3-4 months
Decreased
View More
Description: Exp Paradigm:
Three-chamber social approach test
3-12 months
Increased
View More
Description: Exp Paradigm:
Forced swim test
3-12 months
Decreased
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Description: Exp Paradigm:
Delayed non-match to place test
3-12 months
No change
General observations
3-12 months
No change
Elevated plus maze test
3-12 months
No change
Forced swim test
3-12 months
No change
Delayed non-match to place test
3-12 months
General locomotor activity1 No change
Open field test
3-12 months
Presynaptic function: paired-pulse facilitation1 No change
Paired-pulse ratio
3-4 months
No change
Long term potentiation (ltp)
3-4 months
No change
Three-chamber social approach test
3-12 months
Not Reported:
Circadian sleep/wake cycle, Communications, Immune response, Maternal behavior, Molecular profile, Physiological parameters, Repetitive behavior, Seizure, Sensory
Decreased
View More
Description: Exp Paradigm:
Delayed non-match to place test
2-5 months
Not Reported:
Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Maternal behavior, Molecular profile, Motor phenotype, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior
Neuronal differentiation1
Decreased
View More
Description: Exp Paradigm:
NA
2-5 months
Decreased
View More
Description: Exp Paradigm:
Immunohistochemistry
2-5 months
Dendritic architecture: spine density1
Decreased
View More
Description: Exp Paradigm:
Immunohistochemistry
2-3 months
Dendritic architecture: dendritic tree complexity1
Decreased
View More
Description: Exp Paradigm:
Immunohistochemistry
2-3 months
Decreased
View More
Description: Exp Paradigm:
Histology
2-5 months
Decreased
View More
Description: Exp Paradigm:
Field potential recordings
7-9 weeks
Decreased
View More
Description: Exp Paradigm:
Delayed non-match to place test
2-5 months
Cued or contextual fear conditioning: memory of cue1 No change
Fear conditioning test
2-5 months
Object recognition memory1 No change
Novel object recognition test
2-5 months
Spatial reference memory1 No change
Morris water maze test
2-5 months
No change
Radial maze test
2-5 months
No change
Immunohistochemistry
2-5 months
No change
Immunohistochemistry
2-3 months
No change
Immunohistochemistry
2-3 months
No change
Histology
2-5 months
No change
Histology
2-5 months
No change
Histology
2-5 months
No change
Field potential recordings
7-9 weeks
No change
Field potential recordings
7-9 weeks
Not Reported:
Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Maternal behavior, Molecular profile, Motor phenotype, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior
Increased
View More
Description: Exp Paradigm:
Immunohistochemistry
Adult
Increased
View More
Description: Exp Paradigm:
Marble-burying test
Adult
Increased
View More
Description: Exp Paradigm:
Operant conditioning paradigm
Adult
Increased
View More
Description: Exp Paradigm:
Nest building assay
Adult
Reward reinforced choice behavior1
Decreased
View More
Description: Exp Paradigm:
Operant conditioning paradigm
Adult
No change
Operant conditioning paradigm
Adult
Not Reported:
Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Maternal behavior, Molecular profile, Motor phenotype, Neuroanatomy / ultrastructure / cytoarchitecture, Physiological parameters, Seizure, Sensory
Summary Statistics:
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Interactor Symbol
Interactor Name
Interactor Organism
Entrez ID
Uniprot ID
Interaction Type
Evidence
Reference
ACTG1
actin, gamma 1
71
P63261
Y2H
Camargo LM , et al. 2006
ACTN1
actinin, alpha 1
87
P12814
Y2H
Millar JK , et al. 2003
ACTN2
actinin, alpha 2
88
P35609
Y2H; Beta-galactosidase filter assay; IP/WB
Morris JA , et al. 2003
AGTPBP1
ATP/GTP binding protein 1
23287
Q9UPW5
Y2H
Camargo LM , et al. 2006
AKAP9
A kinase (PRKA) anchor protein (yotiao) 9
10142
Q99996
Y2H
Millar JK , et al. 2003
ANKHD1
ankyrin repeat and KH domain containing 1
54882
Q8IWZ3
Y2H; Beta-galactosidase filter assay; IP/WB
Morris JA , et al. 2003
APLP1
amyloid beta (A4) precursor-like protein 1
333
P51693
Y2H
Millar JK , et al. 2003
APP
amyloid beta (A4) precursor protein
351
P05067
IP/WB
Young-Pearse TL , et al. 2010
ARHGEF11
Rho guanine nucleotide exchange factor (GEF) 11
9826
O15085
Y2H
Millar JK , et al. 2003
ARIH2
ariadne homolog 2 (Drosophila)
10425
O95376
Y2H
Camargo LM , et al. 2006
ASB3
ankyrin repeat and SOCS box containing 3
51130
Q9Y575
IP; LC-MS/MS
Huttlin EL , et al. 2015
ATF4
activating transcription factor 4 (tax-responsive enhancer element B67)
468
P18848
Y2H; Beta-galactosidase filter assay; M2H; Luciferase reporter assay
Morris JA , et al. 2003
ATF5
activating transcription factor 5
22809
Q9Y2D1
Y2H; Beta-galactosidase filter assay; IP/WB; M2H; Luciferase reporter assay
Morris JA , et al. 2003
ATF7IP
activating transcription factor 7 interacting protein
55729
Q6VMQ6
Y2H; Beta-galactosidase filter assay
Morris JA , et al. 2003
BBS1
Bardet-Biedl syndrome 1
582
Q8NFJ9
IP/WB
Kamiya A , et al. 2008
BBS2
Bardet-Biedl syndrome 2
583
Q9BXC9
IP/WB
Kamiya A , et al. 2008
BBS4
Bardet-Biedl syndrome 4
585
Q96RK4
IP/WB
Kamiya A , et al. 2008
BBS5
Bardet-Biedl syndrome 5
129880
Q8N3I7
IP/WB
Kamiya A , et al. 2008
BBS7
Bardet-Biedl syndrome 7
55212
Q8IWZ6
IP/WB
Kamiya A , et al. 2008
BICD1
bicaudal D homolog 1 (Drosophila)
636
Q96G01
Y2H
Camargo LM , et al. 2006
BZRAP1
benzodiazapine receptor (peripheral) associated protein 1
9256
O95153
Y2H
Corominas R , et al. 2014
C14ORF135
chromosome 14 open reading frame 135
64430
Q63HM2
Y2H
Camargo LM , et al. 2006
C14ORF166
chromosome 14 open reading frame 166
51637
Q9Y224
Y2H
Camargo LM , et al. 2006
C17ORF59
chromosome 17 open reading frame 59
NM_017622
Q96GS4
IP; LC-MS/MS
Huttlin EL , et al. 2015
Cacna2d1
calcium channel, voltage-dependent, alpha2/delta subunit 1
12293
O08532
RNA immunoprecipitation (RIP)/qRT-PCR
Tsuboi D , et al. 2015
CCDC136
coiled-coil domain containing 136
64753
Q96JN2
Y2H
Camargo LM , et al. 2006
CCDC141
coiled-coil domain containing 141
285025
Q6ZP82
Y2H; Beta-galactosidase filter assay
Morris JA , et al. 2003
CCDC24
coiled-coil domain containing 24
149473
Q8N4L8
Y2H
Camargo LM , et al. 2006
CCDC88A
coiled-coil domain containing 88A
55704
Q3V6T2
Y2H
Camargo LM , et al. 2006
CDC16
cell division cycle 16
8881
Q13042
IP; LC-MS/MS
Huttlin EL , et al. 2015
CDC5L
CDC5 cell division cycle 5-like (S. pombe)
988
Q99459
Y2H
Camargo LM , et al. 2006
CDK5RAP3
CDK5 regulatory subunit associated protein 3
80279
Q96JB5
Y2H
Camargo LM , et al. 2006
CELA1
Chymotrypsin-like elastase family member 1
1990
Q9UNI1
IP; LC-MS/MS
Huttlin EL , et al. 2015
CEP170
centrosomal protein 170kDa
9859
Q5SW79
Y2H
Camargo LM , et al. 2006
CEP290
centrosomal protein 290kDa
80184
O15078
Y2H
Millar JK , et al. 2003
CEP57L1
centrosomal protein 57kDa-like 1
285753
Q8IYX8
Y2H
Camargo LM , et al. 2006
CEP63
centrosomal protein 63kDa
80254
Q96MT8
Y2H; Beta-galactosidase filter assay; IP/WB
Morris JA , et al. 2003
CHCHD6
coiled-coil-helix-coiled-coil-helix domain containing 6
84303
Q9BRQ6
S-tag pull-down assay; IP/WB
An J , et al. 2012
CIT
citron (rho-interacting, serine/threonine kinase 21)
11113
O14578
Y2H
Ozeki Y , et al. 2002
CLU
clusterin
1191
P10909
Y2H
Camargo LM , et al. 2006
COL6A2
collagen, type VI, alpha 2
1292
P12110
Y2H; Beta-galactosidase filter assay
Morris JA , et al. 2003
CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
51340
Q9BZJ0
Y2H
Camargo LM , et al. 2006
CRYBA4
Beta-crystallin A4
1413
P53673
IP; LC-MS/MS
Huttlin EL , et al. 2015
DAB1
disabled homolog 1 (Drosophila)
1600
O75553
IP/WB
Young-Pearse TL , et al. 2010
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
55861
Q9BQY9
Y2H; in vitro binding assay; IP/WB; Co-localization
Lee SA , et al. 2015
DCTN1
dynactin 1
1639
Q14203
Y2H
Camargo LM , et al. 2006
DCTN2
dynactin 2 (p50)
10540
Q13561
Y2H
Camargo LM , et al. 2006
DLG4
DLG4discs, large homolog 4 (Drosophila)
1742
P78352
IP/WB
Seshadri S , et al. 2015
DMD
dystrophin
1756
P11532
Y2H
Camargo LM , et al. 2006
DNAJC7
DnaJ (Hsp40) homolog, subfamily C, member 7
7266
Q99615
Y2H
Camargo LM , et al. 2006
DPYSL2
dihydropyrimidinase-like 2
1808
Q16555
Y2H
Camargo LM , et al. 2006
DPYSL3
dihydropyrimidinase-like 3
1809
Q14195
Y2H
Camargo LM , et al. 2006
DST
dystonin
667
Q03001
Y2H
Camargo LM , et al. 2006
DTNBP1
dystrobrevin binding protein 1
84062
Q96EV8
Size-exclusion chromatography (SEC)
Ottis P , et al. 2011
DYNC1H1
dynein, cytoplasmic 1, heavy chain 1
1778
Q14204
Y2H
Camargo LM , et al. 2006
DYNC1I1
dynein, cytoplasmic 1, intermediate chain 1
1780
A4D1I7
IP; LC-MS/MS
Huttlin EL , et al. 2015
Dysb
Dysbindin ortholog
40052
Q9VVT5
Proximity ligation assay
Furukubo-Tokunaga K , et al. 2016
EEF2
eukaryotic translation elongation factor 2
1938
P13639
Y2H
Camargo LM , et al. 2006
EIF3H
eukaryotic translation initiation factor 3, subunit H
8667
O15372
Y2H; Beta-galactosidase filter assay; IP/WB
Morris JA , et al. 2003
EPB49
erythrocyte membrane protein band 4.9 (dematin)
2039
Q08495
Y2H
Millar JK , et al. 2003
EXOC1
exocyst complex component 1
55763
Q9NV70
Y2H
Camargo LM , et al. 2006
EXOC7
exocyst complex component 7
23265
Q9UPT5
Y2H
Camargo LM , et al. 2006
FBXO41
F-box protein 41
150726
Q8TF61
Y2H
Camargo LM , et al. 2006
FEZ1
fasciculation and elongation protein zeta 1 (zygin I)
9638
Q99689
Y2H; IP/WB
Miyoshi K , et al. 2003
FMR1
fragile X mental retardation 1
2332
G8JLE9
PAR-CLIP
Ascano M Jr , et al. 2012
FRYL
FRY-like
285527
O94915
Y2H
Camargo LM , et al. 2006
GNB1
guanine nucleotide binding protein (G protein), beta polypeptide 1
2782
P62873
Y2H
Camargo LM , et al. 2006
GNPTAB
N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
79158
Q3T906
Y2H
Camargo LM , et al. 2006
GOLGA2
golgin A2
2801
Q08379
Y2H
Millar JK , et al. 2003
GPRASP2
G protein-coupled receptor associated sorting protein 2
114928
Q96D09
Y2H
Camargo LM , et al. 2006
GRIPAP1
GRIP1 associated protein 1
56850
Q4V328
Y2H
Millar JK , et al. 2003
HERC2P2
hect domain and RLD 2 pseudogene 2
400322
N/A
Y2H
Camargo LM , et al. 2006
IMMT
inner membrane protein, mitochondrial
10989
Q16891
Y2H
Millar JK , et al. 2003
Itpr1
inositol 1,4,5-trisphosphate receptor 1
16438
P11881
in vitro binding assay; EMSA; RNA immunoprecipitation (RIP)/qRT-PCR; Co-localization
Tsuboi D , et al. 2015
ITSN1
intersectin 1 (SH3 domain protein)
6453
Q15811
Y2H; Beta-galactosidase filter assay
Morris JA , et al. 2003
KALRN
kalirin, RhoGEF kinase
8997
O60229
Y2H
Millar JK , et al. 2003
Kalrn
kalirin, RhoGEF kinase
545156
A2CG49
RNA immunoprecipitation (RIP)/qRT-PCR
Tsuboi D , et al. 2015
KATNAL1
katanin p60 subunit A-like 1
84056
Q9BW62
Y2H
Millar JK , et al. 2003
KCNQ5
potassium voltage-gated channel, KQT-like subfamily, member 5
56479
Q9NR82
Y2H
Ozeki Y , et al. 2002
KIAA1377
KIAA1377
57562
Q9P2H0
Y2H; Beta-galactosidase filter assay
Morris JA , et al. 2003
KIF3A
kinesin family member 3A
11127
Q9Y496
Y2H
Camargo LM , et al. 2006
KIF3C
kinesin family member 3C
3797
O14782
Y2H
Camargo LM , et al. 2006
Kif5a
kinesin family member 5A
314906
Q6QLM7
IP; LC-MS/MS; IP/WB
Tsuboi D , et al. 2015
KIFAP3
kinesin-associated protein 3
22920
Q92845
Y2H
Camargo LM , et al. 2006
MACF1
microtubule-actin crosslinking factor 1
23499
Q9UPN3
Y2H
Camargo LM , et al. 2006
MAP1A
microtubule-associated protein 1A
4130
P78559
Y2H; Beta-galactosidase filter assay; IP/WB
Morris JA , et al. 2003
MATR3
matrin 3
9782
P43243
Y2H
Camargo LM , et al. 2006
MEMO1
mediator of cell motility 1
51072
Q9Y316
Y2H
Camargo LM , et al. 2006
Mfn1
mitofusin 1
67414
Q811U4
IP/WB; Co-localization
Norkett R , et al. 2015
Mfn2
mitofusin 2
170731
Q80U63
IP/WB; Co-localization
Norkett R , et al. 2015
MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
4248
Q09327
Y2H
Millar JK , et al. 2003
MKKS
McKusick-Kaufman syndrome
8195
Q9NPJ1
IP/WB
Kamiya A , et al. 2008
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
23209
Q15049
Y2H
Millar JK , et al. 2003
MPPED1
metallophosphoesterase domain containing 1
758
O15442
Y2H
Camargo LM , et al. 2006
MVP
major vault protein
9961
Q14764
Y2H
Corominas R , et al. 2014
MYF6
myogenic factor 6 (herculin)
4618
P23409
IP; LC-MS/MS
Huttlin EL , et al. 2015
MYH7
myosin, heavy chain 7, cardiac muscle, beta
4625
P12883
Y2H; Beta-galactosidase filter assay
Morris JA , et al. 2003
MYT1L
myelin transcription factor 1-like
23040
Q9UL68
Y2H
Camargo LM , et al. 2006
NDE1
nudE nuclear distribution E homolog 1 (A. nidulans)
54820
Q9NXR1
Y2H
Millar JK , et al. 2003
NDE1
nudE nuclear distribution E homolog 1 (A. nidulans)
54820
Q9NXR1
Y2H
Corominas R , et al. 2014
NDEL1
nudE nuclear distribution E homolog (A. nidulans)-like 1
81565
Q9GZM8
Y2H; in vitro binding assay; IP/WB
Ozeki Y , et al. 2002
NDEL1
nudE nuclear distribution E homolog (A. nidulans)-like 1
81565
Q9GZM8
Y2H
Lee SA , et al. 2015
NDEL1
nudE nuclear distribution E homolog (A. nidulans)-like 1
81565
Q9GZM8
IP; LC-MS/MS
Huttlin EL , et al. 2015
NUP160
nucleoporin 160kDa
23279
Q12769
Y2H
Camargo LM , et al. 2006
OLFM1
olfactomedin 1
10439
Q99784
Y2H
Camargo LM , et al. 2006
P4HA2
Prolyl 4-hydroxylase subunit alpha-2
8974
O15460-2
IP; LC-MS/MS
Huttlin EL , et al. 2015
P4HA3
prolyl 4-hydroxylase, alpha polypeptide III
283208
Q7Z4N8
IP; LC-MS/MS
Huttlin EL , et al. 2015
PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
5048
P43034
Y2H
Camargo LM , et al. 2006
PCM1
pericentriolar material 1
5108
Q15154
IP/WB
Kamiya A , et al. 2008
PCNT
pericentrin
5116
O95613
Y2H; IP/WB
Miyoshi K , et al. 2004
PDE4B
phosphodiesterase 4B, cAMP-specific
5142
Q07343
Y2H
Camargo LM , et al. 2006
PGK1
phosphoglycerate kinase 1
5230
P00558
Y2H
Camargo LM , et al. 2006
PPFIA4
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
8497
O75335
Y2H
Millar JK , et al. 2003
PPM1E
protein phosphatase, Mg2+/Mn2+ dependent, 1E
22843
Q8WY54
Y2H
Camargo LM , et al. 2006
PPP4R1
protein phosphatase 4, regulatory subunit 1
9989
Q8TF05
Y2H
Camargo LM , et al. 2006
PPP5C
protein phosphatase 5, catalytic subunit
5536
P53041
Y2H
Camargo LM , et al. 2006
RABGAP1
RAB GTPase activating protein 1
23637
Q9Y3P9
Y2H
Camargo LM , et al. 2006
RAD21
RAD21 homolog (S. pombe)
5885
O60216
Y2H
Camargo LM , et al. 2006
RANBP9
RAN binding protein 9
10048
Q96S59
Y2H; Beta-galactosidase filter assay; IP/WB
Morris JA , et al. 2003
RASSF7
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
8045
Q02833
Y2H; Beta-galactosidase filter assay
Morris JA , et al. 2003
RHOT1
ras homolog family member T1
55288
Q8IXI2
IP/WB; Proximity ligation assay; Co-localization
Norkett R , et al. 2015
RHOT2
ras homolog family member T2
89941
Q8IXI1
IP/WB
Norkett R , et al. 2015
RIBC1
RIB43A-like with coiled-coils protein 1
158787
Q8N443
IP; LC-MS/MS
Huttlin EL , et al. 2015
ROGDI
rogdi homolog (Drosophila)
79641
Q9GZN7
Y2H
Camargo LM , et al. 2006
SCOC
short coiled-coil protein
60592
Q9UIL1
Y2H
Millar JK , et al. 2003
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
9467
O60239
Y2H
Camargo LM , et al. 2006
SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
6502
B4DJT4
IP; LC-MS/MS
Huttlin EL , et al. 2015
SMARCE1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
6605
Q969G3
Y2H
Millar JK , et al. 2003
SMC2
structural maintenance of chromosomes 2
10592
O95347
Y2H
Camargo LM , et al. 2006
SNX6
sorting nexin 6
58533
Q9UNH7
Y2H
Camargo LM , et al. 2006
SPARCL1
SPARC-like 1 (hevin)
8404
Q14515
Y2H
Camargo LM , et al. 2006
SPTAN1
spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
6709
Q13813
Y2H
Millar JK , et al. 2003
SPTBN1
spectrin, beta, non-erythrocytic 1
6711
Q01082
Y2H
Camargo LM , et al. 2006
SPTBN4
spectrin, beta, non-erythrocytic 4
57731
Q9H254
Y2H
Ozeki Y , et al. 2002
SRGAP2
SLIT-ROBO Rho GTPase activating protein 2
23380
O75044
Y2H
Camargo LM , et al. 2006
STX11
syntaxin 11
8676
O75558
IP; LC-MS/MS
Huttlin EL , et al. 2015
STX18
syntaxin 18
53407
Q9P2W9
Y2H
Camargo LM , et al. 2006
Syncrip
synaptotagmin binding, cytoplasmic RNA interacting protein
363113
Q7TP47
IP; LC-MS/MS; IP/WB
Tsuboi D , et al. 2015
SYNE1
spectrin repeat containing, nuclear envelope 1
23345
Q8NF91
Y2H; Beta-galactosidase filter assay; IP/WB
Morris JA , et al. 2003
TCL1B
T-cell leukemia/lymphoma protein 1B
9623
O95988
IP; LC-MS/MS
Huttlin EL , et al. 2015
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
23371
Q63HR2
Y2H
Millar JK , et al. 2003
TFIP11
tuftelin interacting protein 11
24144
Q9UBB9
Y2H
Camargo LM , et al. 2006
TIAM2
T-cell lymphoma invasion and metastasis 2
26230
Q8IVF5
Y2H
Camargo LM , et al. 2006
TNIK
TRAF2 and NCK interacting kinase
23043
Q9UKE5
Y2H
Camargo LM , et al. 2006
TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
8658
O95271
Y2H
Camargo LM , et al. 2006
TRAF3IP1
TNF receptor-associated factor 3 interacting protein 1
26146
Q8TDR0
Y2H; Beta-galactosidase filter assay; IP/WB
Morris JA , et al. 2003
TRAK1
trafficking protein, kinesin binding 1
22906
Q9UPV9
IP/WB
Norkett R , et al. 2015
TRAK2
trafficking protein, kinesin binding 2
66008
O60296
IP/WB; Co-localization
Norkett R , et al. 2015
TRIO
triple functional domain (PTPRF interacting)
7204
O75962
Y2H
Camargo LM , et al. 2006
TTC8
tetratricopeptide repeat domain 8
123016
Q8TAM2
IP/WB
Kamiya A , et al. 2008
TUBB
tubulin, beta
203068
P07437
Y2H
Camargo LM , et al. 2006
TUBB2A
tubulin, beta 2A class IIa
7280
Q13885
Y2H
Camargo LM , et al. 2006
UTRN
utrophin
7402
P46939
Y2H
Camargo LM , et al. 2006
XPNPEP1
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
7511
Q9NQW7
Y2H
Camargo LM , et al. 2006
XRN2
5'-3' exoribonuclease 2
22803
Q9H0D6
Y2H
Camargo LM , et al. 2006
YWHAE
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
7531
P62258
Y2H
Camargo LM , et al. 2006
YWHAG
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
7532
P61981
Y2H
Ozeki Y , et al. 2002
YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
10971
P27348
Y2H
Camargo LM , et al. 2006
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
7534
P63104
Y2H
Camargo LM , et al. 2006
Zfp385a
zinc finger protein 385A
685474
A0A0G2KB91
in vitro binding assay; IP; LC-MS/MS; IP/WB; Co-localization
Tsuboi D , et al. 2015
ZNF197
zinc finger protein 197
10168
O14709
Y2H
Camargo LM , et al. 2006
ZNF365
zinc finger protein 365
22891
Q70YC5
Y2H
Camargo LM , et al. 2006
DIXDC1
DIX domain containing 1
330938
Q80Y83
IP/WB
Singh KK , et al. 2010
GSK3B
glycogen synthase kinase 3 beta
56637
Q9WV60
IP/WB; in vitro binding assay; in vitro kinase assay
Mao Y , et al. 2009
Rassf7
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
66985
Q9DD19
in vitro binding assay; IP/WB; Co-localization
Wang S , et al. 2016
ARFGEF2
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
296380
Q7TSU1
Affinity chromatography; MS
Taya S , et al. 2007
DISC1
disrupted in schizophrenia 1
307940
Q810H6
IP/WB; GST
Kamiya A , et al. 2005
DLG4
discs, large homolog 4 (Drosophila)
29495
P31016
IP/WB
Hayashi-Takagi A , et al. 2010
DYNC1I1
dynein cytoplasmic 1 intermediate chain 1
29564
Q63100
IP/WB
Taya S , et al. 2007
GNB2L1
guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1
83427
P63245
Affinity chromatography; MS
Taya S , et al. 2007
Grb2
growth factor receptor bound protein 2
81504
P62994
Affinity chromatography; MS; GST; IP/WB
Shinoda T , et al. 2007
KIF5A
kinesin family member 5A
314906
Q6QLM7
Affinity chromatography; MS; GST; IP/WB
Taya S , et al. 2007
KIF5B
kinesin family member 5B
117550
Q2PQA9
Affinity chromatography; MS; IP/WB
Taya S , et al. 2007
KIF5C
kinesin family member 5C
311024
P56536
GST
Taya S , et al. 2007
KLC1
kinesin light chain 1
171041
P37285
IP/WB
Taya S , et al. 2007
KLC2
kinesin light chain 2
309159
B2GV74
IP/WB
Taya S , et al. 2007
PACS1
phosphofurin acidic cluster sorting protein 1
171444
O88588
Affinity chromatography; MS
Taya S , et al. 2007
TUBG1
tubulin, gamma 1
252921
P83888
IP/WB
Kamiya A , et al. 2005
