Xp22.13CNV Type: Deletion
Largest CNV size: 9661 bp
Statistics Box:
Number of Reports: 8
Number of Reports: 8
Summary Information
Summary statement in development
Additional Locus Information
References
Major Reports
Title
Author, Year
Report Class
CNV Type
An evidence-based approach to establish the functional and clinical significance of copy number variants in intellectual and developmental disabili...
Duplication
Application of array comparative genomic hybridization in 102 patients with epilepsy and additional neurodevelopmental disorders.
Deletion
Neurodevelopmental and neurobehavioral characteristics in males and females with CDKL5 duplications.
Duplication
Array-CGH Analysis in a Cohort of Phenotypically Well-Characterized Individuals with Essential Autism Spectrum Disorders.
Duplication
Minor Reports
Title
Author, Year
Report Class
CNV Type
Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism.
Deletion
Infantile spasms are associated with abnormal copy number variations.
Deletion
Diagnostic yield of array comparative genomic hybridization in adults with autism spectrum disorders.
Duplication
Cases
Cohort ID
Author, Year
Descripton
Cohort Size
Diagnosis
Age
Gender
CNV Size
Deletion
Duplication
Total CNV's
bartnik_12_EP_discovery_cases
102 patients with idiopathic generalized epilepsy (IGE) or epilepsy with other neurodevelopmental disorders
102
Primary diagnosis of epilepsy. 50 cases with isolated epilepsy, 52 cases with epilepsy accompanied by DD/ID, dysmorphism, autism, or other neurological signs.
NA
NA
10000
2
0
2
kaminsky_11_DD/ID/ASD_discovery_cases
Cases from the International Standards for Cytogenomic Arrays (ISCA) consortium
15749
Unexplained developmental delay, intellectual disability, dysmorphic features, multiple congenital anomalies, autism spectrum disorders, or clinical features suggestive of a chromosomal syndrome
NA
NA
195159
0
1
1
napoli_17_ASD_discovery_cases
Children recruited between June 2009 and December 2014 at the Child Neuopsychiatry Unit of Bambino Gesu Children's Hospital, IRCCS, Rome, Italy
133
Inclusion criteria included a clinical diagnosis of pervasive developmental disorders (PDD) and of ASD, according to DSM-IV-TR and DSM-5 criteria, respectively, and fewer than six dysmorphic features (children with six or more minor anomalies and/or systemic congenital malformations, such as congenital heart defects, were excluded). Cognitive or developmental level was assessed by the brief intelligence quotient (IQ) from Leiter-R or by the general quotient (GQ) from Griffiths Mental Development Scales Extended Revised for age 2-8, GMDS-ER 2-8 (mean IQ, 73.7 24.3). The calibrated severity score (CSS) index was also calculated to quantify autism symptoms independently (median score of 7, r
Mean, 6.7 3.0 years
84.96% Male
46000
0
1
1
sanchis_juan_23_ASD/DD/ID_discovery_cases
Individuals affected with a neurodevelopmental disorder (NDD) from the National Institute for Health and Care Research (NIHR) BioResource project.
489
73% (357/489) of the participants in this study had autism spectrum disorder (ASD), developmental delay (DD), intellectual disability (ID), a movement disorder or dystonia, and/or seizures.
NA
NA
7847
1
0
1
sanders_11_ASD_discovery_cases
Autistic probands from the Simons Simplex Collection (SSC). 872 probands in quartet families, 272 probands in trios.
1124
ASD diagnosis: 89.5% autism; 8.5% PDD-NOS, 2% Asperger syndrome. Mean full-scale IQ 85.1 1.5 (mean verbal IQ, 81.9 1.7; mean non-verbal IQ, 88.4 1.4)
Mean, 9.1 yrs.
86.1% Male
9661
1
0
1
stobbe_13_ASD_discovery_cases
Adult ASD cases referred for genetic evaluation of autism from July 2009 through April 2012
36
Diagnosis of ASD confirmed in 34 of 36 patients; diagnosis of ASD based on DSM-IV criteria and confirmed by chart review by neurologist specializing in autism.
Range, 18-45 yrs. (mean 25.3 yrs.)
77.78% Male
288000
0
1
1
szafranski_14_ASD/ADHD/DD/ID/OCD_discovery_cases
Patients screened by chromosomal microrarray analysis (CMA) for Xp22.13 duplications involving the CDKL5 gene
27000
Cases with Xp22.13/CDKL5 duplications diagnosed with one or more of the following: ASD, ADHD, developmental delay (DD), intellectual disability (ID), OCD, sensory integration disorder
N/A
N/A
935000
0
7
7
tiwari_12_EP_discovery_cases
Patients with infantile spasms assessed at Wayne State University (Detroit, MI, USA)
13
Epilepsy (infantile spasms). Additional phenotypic features: developmental delay, autistic features, hypotonia/ataxia, and dysmorphic features.
NA
38.46% Male
16827376
1
0
1
Controls
Cohort ID
Author, Year
Descripton
Cohort Size
Diagnosis
Age
Gender
CNV Size
Deletion
Duplication
Total CNV's
engchuan_15_ASD_discovery_controls
Platform-matched controls from three large studies: SAGE (Study of Addiction Genetics and Environment), Ontario Colorectal Cancer study, and HABC (Health Aging and Body Composition)
2342
Controls; subjects had no previous psychiatric history
N/A
46.67% Male
206070
0
1
1
kaminsky_11_DD/ID/ASD_discovery_controls
Controls from the International Standards for Cytogenomic Arrays (ISCA) consortium
10118
Controls
NA
NA
NA
NA
NA
NA
sanders_11_ASD_discovery_controls
Matched siblings of autistic probands from the Simons Simplex Collection (SSC).
872
Controls
Mean, 10.0 yrs.
143319
5
0
5
Cases
Cohort ID
Geographical Ancestry
Discovery Method
Platform
Algorithm
Software
Validation Method
bartnik_12_EP_discovery_cases
Poland
aCGH
Custom Agilent 180K V8.0 and V8.1 microarrays designed by Medical Genetics Laboratories at Baylor College of Medicine
BCM web-based software, IMiD-web2py
MLPA, PCR
kaminsky_11_DD/ID/ASD_discovery_cases
NA
aCGH
Agilent 44K, Agilent 105K
Feature Extraction, DNA Analytics
FISH, qPCR, MLPA, aCGH, standard G-banded chromosome analysis
napoli_17_ASD_discovery_cases
Italy
aCGH
Agilent Human Genome 4x180K
ADM-2
Feature Extraction v.10.5, Agilent Genomic Workbench Lite Edition v.7.4
RT-PCR
sanchis_juan_23_ASD/DD/ID_discovery_cases
United Kingdom
Short-read WGS
Illumina HiSeq 2500/Illumina HiSeq X
Canvas v.1.1.0.5, Manta v.0.23.15
None
sanders_11_ASD_discovery_cases
White non-Hispanic, 74.5%; mixed, 9.3%, Asian, 4.3%, White Hispanic, 4.0%, African-American, 3.8%; other, 4.2&
Solid phase hybridization
Illumina 1M v1, Illumina 1M v3
PennCNV, QuantiSNP, GNOSIS
stobbe_13_ASD_discovery_cases
N/A
aCGH
NimbleGen CGX-3v1.0
ADM-1
NimbleScan 2.5, DNA Analytics 4.0
None
szafranski_14_ASD/ADHD/DD/ID/OCD_discovery_cases
N/A
aCGH
V8.0 OLIGO, V8.1.1 OLIGO, V8.2 OLIGO HR+SNP, V8.3 OLIGO HR+SNP, 180K, V9.1.1 OLIGO HR+SNP, 400K (Medical Genetics Laboratories at Baylor College of Medicine/Agilent)
FISH
tiwari_12_EP_discovery_cases
NA
Solid phase hybridization
Illumina 610Quad
SVS
Illumina BeadStudio, SVS
None
Controls
Cohort ID
Geographical Ancestry
Discovery Method
Platform
Algorithm
Software
Validation Method
engchuan_15_ASD_discovery_controls
Caucasian
Solid phase hybridization
Illumina 1M
None
kaminsky_11_DD/ID/ASD_discovery_controls
NA
aCGH
Agilent 44K, Agilent 105K
Feature Extraction, DNA Analytics
sanders_11_ASD_discovery_controls
Solid phase hybridization
Illumina 1M v1 or Illumina 1M v3
PennCNV, QuantiSNP, GNOSIS
Cases
Patient ID
Author, Year
Age
Gender
Primary Diagnosis
Clinical Profile
Cognitive Profile
CNV Start
CNV End
CNV Size
Genome Build
Type Method
Validation
bartnik_12_EP_discovery_cases-case1
NA
F
Epilepsy and intellectual disability
Age of onset of epilepsy: 2 months. Seizure types/epilepsy syndrome: Refractory epilepsy with different types of seizures (generalized tonic-clonic seizures, tonic, myoclonic). Rett-like syndrome. Angelman-like phenotype. Microcephaly. Parental phenotype: normal.
Profound intellectual disability
18564194
18564780
587
GRCh38
Deletion
Yes
bartnik_12_EP_discovery_cases-case2
NA
F
Epilepsy and autism
Age of onset of epilepsy: 5 months. Seizure types/epilepsy syndrome: Refractory epilepsy with different types of seizures (focal, tonic). Rett-like syndrome. Parental phenotype: normal.
Profound intellectual disability
18614205
18624968
10764
GRCh38
Deletion
Yes
kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00002520
NA
NA
Developmental delay/intellectual disability/ASD
Clinical profile NA
Cognitive profile NA
18643580
18838741
195162
GRCh38
Duplication
Yes
napoli_17_ASD_discovery_cases-case2
N/A
M
ASD
Case diagnosed with ASD according to DSM-5 criteria. Congenital anomalies: none. Dysmorphic features: fewer than six. Karyotype: 46,XY
18130317
18176037
45721
GRCh38
Duplication
Yes
sanchis_juan_23_ASD/DD/ID_discovery_cases-caseW000357
NA
M
Developmental delay and seizures
Patient was of European ancestry and presented with seizures and developmental delay.
18622629
18630475
7847
GRCh38
Deletion
No
sanders_11_ASD_discovery_cases-11375.p1
6.2
M
Autism
NA
Full-scale IQ, 108; non-verbal IQ, 115; verbal IQ, 93
18041971
18051632
9662
GRCh38
Deletion
No
stobbe_13_ASD_discovery_cases-case6
26 yrs.
M
Autism and epilepsy
Family history: paternal grandmother with epilepsy. Karyotype: not performed. Fragile X testing: normal.
17933995
18222045
288051
GRCh38
Duplication
No
szafranski_14_ASD/ADHD/DD/ID/OCD_discovery_cases-case1
13 yrs.
M
ADHD, OCD, DD
Birth/neonatal history: former 28-week preemie. Language and communication evaluation: verbal language delay. Behavioral/psychiatric evaluation: autistic behavior, attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), anxiety, history of behavioral problems. Additional medical history: hypertension treated with lisinopril. Growth parameters: short stature (takes growth hormones); head circumference of 55 cm (50th %ile). Family history: mother reported to have problems with reading and mathematics while at school and head circumference of 57 cm.
Developmental delay, dyslexia
18203417
19138033
934617
GRCh38
Duplication
Yes
szafranski_14_ASD/ADHD/DD/ID/OCD_discovery_cases-case2
6 yrs.
F
Developmental delay
Language and communication evaluation: language delay. Behavioral/psychiatric evaluation: numerous behavioral problems including sadness, irritability, inability to get along with others, and taking things that did not belong to her. Sleep disturbances: jerks/twitches, snoring/breathing problems. Growth parameters: obesity; height and weight both >95th %ile at age of 4.5 years; macrocephaly. Family history: father unavailable for clinical evaluation.
Developmental delay; done poorly in learning colors, numbers, and words
18203417
19138033
934617
GRCh38
Duplication
Yes
szafranski_14_ASD/ADHD/DD/ID/OCD_discovery_cases-case3
9 yrs.
M
ASD, ADHD, ID
Case diagnosed with Asperger syndrome, ADHD, and sensory integration disorder (based on DSM-IV criteria). Birth/neonatal history: born at 36 weeks with umbilical cord wrapped around his neck; experienced difficulty breathing and low Apgar scores. Developmental milestones: developmental regression around age of 1 year (had a few words and stopped speaking); gross motor delay consistent with sitting at 8 months and walking at 15 months. Language and communication evaluation: speech impairment; echolalia. Motor and musculoskeletal evaluation: trouble with fine motor skills, specifically with handwriting and using utensils to eat. Behavioral/psychiatric evaluation: presents with obsessive-compulsive and autistic behaviors; often flaps his hands; favors routines, patterns, lining things up, and does not like transitions; very argumentative, manifests oppositional behaviors, often gets aggressive with hitting other children and banging his own head; licks things, is sensitive to certain textures of foods, highly resistant to pain. EEG: normal. Brain imaging: normal head MRI. Dysmorphic features: mildly deeply placed eyes, mild frontal prominence, thin upper lips. Growth parameters: case is normocephalic. Family history: consistent for bipolar disorder in two maternal uncles, ADHD and learning disabilities in his brother and sister, depression in his maternal grandfather, and learning disabilities in his mother and maternal grandmother.
Mild intellectual disability
18349432
19138033
788602
GRCh38
Duplication
No
szafranski_14_ASD/ADHD/DD/ID/OCD_discovery_cases-case4
14 yrs.
M
Developmental delay
Case met clinical diagnosis for Marfan syndrome at age of 13 years (tall stature, malar hypoplasia, pectus carinatum and excavatum, slight scoliosis, arachnodactyly, bilateral thumb and signs, hind foot deformities, and dilated aorta); parents have refused further genetic testing to confirm this diagnosis. Developmental milestones: walked at 18 months; first words at 2 years of age. Motor and musculoskeletal evaluation: problems with gross motor activity, difficulty writing for school work activities; mixed pectus deformity that does not require surgery, pes planus, hyperextensibility. Behavioral/psychiatric evaluation: seems to be always fatigues and is sometimes easily distracted; no diagnosis of ADHD has been made. Additional medical history: enlarged aorta; history of neuroblastoma of right adrenal gland. Dysmorphic features: facial asymmetry. Growth parameters: tall stature and macrocephaly; height >97th %ile, weight 90th-97th %ile, head circumference >2 SD (OFC 56 cm).
Slightly delayed development; consistently performed at or above grade level (homeschooled), but had issues with becoming confused while performing multiple step tasks.
18318580
18858168
539589
GRCh38
Duplication
Yes
szafranski_14_ASD/ADHD/DD/ID/OCD_discovery_cases-case5
6 yrs.
M
ASD, sensory integration disorder
Diagnosis of Asperger syndrome and sensory integration disorder (based on DSM-IV criteria). Developmental milestones: normal gross motor milestones, but exhibits fine motor delay consistent with poor pencil grasp and difficulty with handwriting; mild speech delay and communication impairment. Language and communication evaluation: currently has large vocabulary with echolalia. Behavioral/psychiatric evaluation: hyperactivity, problems with social skills; pushes older children and bites his mother and father; hand flapping and stereotypic movements, as well as rocking body movements; sensitive to smells and textures of clothing; likes routines and is obsessed with doors; likes deep pressure and has sensory integration problems; on ADHD medications (Intuniv). Growth parameters: macrocephaly (54.5 cm, >95th %ile for age). Family history: adopted at age of 2 weeks; mother suspected to be on cocaine, marijuana, and antidepressants.
18441952
19083674
641723
GRCh38
Duplication
No
szafranski_14_ASD/ADHD/DD/ID/OCD_discovery_cases-case6
8 yrs.
F
ASD, ID
Diagnosis of autism, intellectual disability, and speech impairment (based on DSM-IV criteria). Birth/neonatal history: born by C-section secondary to breech presentation; mother had contractions at 6 months that resolved on their own. Developmental milestones: delayed head control, started to walk around 16 months of age. Language and communication evaluation: speech impairment, unable to speak in full sentences, vocabulary of about 30-40 words, has a lot of nonsensical words. Motor and musculoskeletal evaluation: fine motor delay consistent with handwriting difficulties. Behavioral/psychiatric evaluation: poor eye contact (possibly attributed to eye problems), poor social skills that have subsequently improved, does not like to share, hand flapping, inappropriate laughing, hyperactivity, autistic traits, likes to line things up and spin in circles, texture preference to foods consistent with sensory integration problems, likes routines and has repetitive behaviors. Brain imaging: brain MRI is significant for right tonsillar ectopia. Additional medical history: surgery for exotropia. Growth parameters: normocephalic. Family history: mother is reportedly healthy; family history is significant for a maternal cousin with probable intellectual disability.
Intellectual disability; memory problems and some cognitive deficits
18441952
19083674
641723
GRCh38
Duplication
No
szafranski_14_ASD/ADHD/DD/ID/OCD_discovery_cases-case7
8 yrs.
F
ASD, ID
Case diagnosed with autistic spectrum disorder (ASD). Birth/neonatal history: 36-week uneventful pregnancy and labor, which was induced due to high blood pressure; birth weight of 6 lbs 11 oz; did not latch on and had a poor suck, but did gain weight with bottle feedings; feedings improved at 6 months of age. Developmental milestones: sitting at 1 year, walking at 2.5 years, talking at 2.5 years; no regression. Language and communication evaluation: speech therapy started at age of 3 years; low-pitched hoarse voice. Motor and musculoskeletal evaluation: poor muscle tone; index and fifth fingers with short tapering distal phalanges and mildly hypoplastic creases; neck with full range of motion. Behavioral/psychiatric evaluation: occasional defiance and aggression, which tended to occur when there were sudden changes to routine; strong need to maintain her order and routine; very frustrated and acts out when routine is changed; very rapid mood swings; engages in repetitive activities (stacking cups, flipping through pages of a book); finger-sucking and -chewing behaviors resulting in calluses, ear-picking behaviors resulting in bleeding; increased pain tolerance. Epilepsy/seizures: may have had a seizure with fever at age of 3.5 years (EEG was normal); no epileptic encephalopathy. Additional medical history: wears glasses for astigmatism. Dysmorphic features: brachycephaly, wide flattened face, mild frontal bossing, deeply set eyes, prominent ears with mild cupping, thin upper and out-pouched lower lip with inverted V shape to lips, accessory nipple bilaterally, cafe-au-lait spots, hypopigmented spots near each scapula. Growth parameters: weight of 33.5 kg (90th-95th %ile), height of 119.8 cm (10th %ile), BMI of 23.34 (>97th %ile), and OFC of 52.4 cm (normal). Family history: carrier mother is healthy; brother and maternal first cousin with schizophrenia and bipolar disorder; 4-generation pedigree otherwise unremarkable.
Intellectual disability; functioning at about a 5.5 year levels with performance gaps; no learning plateau.
18441951
19076859
634909
GRCh38
Duplication
No
tiwari_12_EP_discovery_cases-patient2
2 yrs.
F
Epilepsy
Age of onset of seizures: 1 months. EEG: multifocal spike and wave activity (at 2 years of age). Brain imaging: normal MRI/MRS; focal cortical hypometabolism on PET. Clinical characteristics and comorbidities: developmental delay, flattened nose and upturned nostrils, 2 hypopigmented spots..
Developmental delay
1844373
1867174
22801
Unknown
Deletion
No
Controls
Patient ID
Author, Year
Age
Gender
Primary Diagnosis
Clinical Profile
Cognitive Profile
CNV Start
CNV End
CNV Size
Genome Build
Type Method
Validation
engchuan_15_ASD_discovery_controls-controlHABC_902647_902647
N/A
N/A
Control
No previous psychiatric history
18646752
18852824
206073
GRCh38
Duplication
No
sanders_11_ASD_discovery_controls-11088.s1
14.5
F
Control (matched sibling)
NA
NA
18472697
18483808
11112
GRCh38
Deletion
No
sanders_11_ASD_discovery_controls-11839.s1
4
F
Control (matched sibling)
NA
NA
19102450
19108678
6229
GRCh38
Deletion
No
sanders_11_ASD_discovery_controls-12238.s1
11
F
Control (matched sibling)
NA
NA
17176928
17303986
127059
GRCh38
Deletion
No
sanders_11_ASD_discovery_controls-12497.s1
10.8
F
Control (matched sibling)
NA
NA
17226199
17369518
143320
GRCh38
Deletion
No
sanders_11_ASD_discovery_controls-12832.s1
4.5
F
Control (matched sibling)
NA
NA
19102450
19108678
6229
GRCh38
Deletion
No
Cases
Patient ID
Validation Description
Primary Disorder Inheritence
Inheritence
Family Profile
Disease Segregation
Gene Content
Altered Gene Expression
bartnik_12_EP_discovery_cases-case1
MLPA
De novo
CDKL5
bartnik_12_EP_discovery_cases-case2
MLPA and PCR
De novo
CDKL5
kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00002520
FISH, qPCR, MLPA, aCGH, or standard G-banded chromosome analysis
Unknown
Unknown
Unknown
PPEF1-AS1,RS1,CDKL5,PPEF1
napoli_17_ASD_discovery_cases-case2
RT-PCR
Unknown
BEND2
sanchis_juan_23_ASD/DD/ID_discovery_cases-caseW000357
Unknown
Simplex
CDKL5
sanders_11_ASD_discovery_cases-11375.p1
Maternal
Simplex (quad-proband matched)
Segregated
LINC01456
stobbe_13_ASD_discovery_cases-case6
Unknown
Unknown (possible simplex)
Unknown
LINC01456,BEND2
szafranski_14_ASD/ADHD/DD/ID/OCD_discovery_cases-case1
FISH
Possible maternal
Maternal
Possible multi-generational
Possibly segregated
TMSB10P2,GJA6P,PPEF1-AS1,HAUS1P2,RN7SL48P,RS1,PHKA2-AS1,PHKA2,BEND2,SCML2,CDKL5,PPEF1,ADGRG2
szafranski_14_ASD/ADHD/DD/ID/OCD_discovery_cases-case2
FISH
Paternal
Unknown
Unknown
TMSB10P2,GJA6P,PPEF1-AS1,HAUS1P2,RN7SL48P,RS1,PHKA2-AS1,PHKA2,BEND2,SCML2,CDKL5,PPEF1,ADGRG2
szafranski_14_ASD/ADHD/DD/ID/OCD_discovery_cases-case3
Maternal
Multi-generational
Unknown
GJA6P,PPEF1-AS1,HAUS1P2,RN7SL48P,RS1,PHKA2-AS1,PHKA2,SCML2,CDKL5,PPEF1,ADGRG2
szafranski_14_ASD/ADHD/DD/ID/OCD_discovery_cases-case4
FISH
Unknown
Unknown
Unknown
TMSB10P2,GJA6P,PPEF1-AS1,RS1,SCML2,CDKL5,PPEF1
szafranski_14_ASD/ADHD/DD/ID/OCD_discovery_cases-case5
Unknown
Unknown
Unknown
GJA6P,PPEF1-AS1,HAUS1P2,RN7SL48P,RS1,PHKA2-AS1,PHKA2,CDKL5,PPEF1,ADGRG2
szafranski_14_ASD/ADHD/DD/ID/OCD_discovery_cases-case6
Maternal
Extended multiplex (maternal cousin with probable intellectual disability)
Unknown
GJA6P,PPEF1-AS1,HAUS1P2,RN7SL48P,RS1,PHKA2-AS1,PHKA2,CDKL5,PPEF1,ADGRG2
szafranski_14_ASD/ADHD/DD/ID/OCD_discovery_cases-case7
Maternal
Multiplex
Unknown
GJA6P,PPEF1-AS1,HAUS1P2,RN7SL48P,RS1,PHKA2-AS1,PHKA2,CDKL5,PPEF1,ADGRG2
tiwari_12_EP_discovery_cases-patient2
Maternal
Unknown
Unknown
0 genes
Controls
Patient ID
Validation Description
Primary Disorder Inheritence
Inheritence
Family Profile
Disease Segregation
Gene Content
Altered Gene Expression
engchuan_15_ASD_discovery_controls-controlHABC_902647_902647
Unknown
PPEF1-AS1,RS1,CDKL5,PPEF1
sanders_11_ASD_discovery_controls-11088.s1
Paternal
Simplex (quad)
NA
CDKL5
sanders_11_ASD_discovery_controls-11839.s1
Paternal
Simplex (quad)
NA
ADGRG2
sanders_11_ASD_discovery_controls-12238.s1
Unknown
Simplex (quad)
NA
CBX1P4
sanders_11_ASD_discovery_controls-12497.s1
Unknown
Simplex (quad)
NA
CBX1P4
sanders_11_ASD_discovery_controls-12832.s1
Both parents
Simplex (quad)
NA
ADGRG2
No Animal Model Data Available