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6p25.3-p25.1CNV Type: Deletion


Largest CNV size: 6610000 bp

Statistics Box:
Number of Reports: 4



Summary Information

Deletions in this region were identified in two patients, one male and one female, with developmental delay and a diagnosis of Axenfeld-Rieger anomaly. One of these patients displayed autistic behaviors.

Additional Locus Information

Genome browsers

USCS Symbol             NCBI Symbol

Decipher

            Decipher Symbol

References

Major Reports

Title
Author, Year
Report Class
CNV Type
An evidence-based approach to establish the functional and clinical significance of copy number variants in intellectual and developmental disabili...
Deletion-Duplication
Phenotypic heterogeneity of genomic disorders and rare copy-number variants.
Deletion-Duplication
Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder
Duplication

Minor Reports

Title
Author, Year
Report Class
CNV Type
Axenfeld-Rieger anomaly and Axenfeld-Rieger syndrome: clinical, molecular-cytogenetic, and DNA array analyses of three patients with chromosomal de...
Deletion

Cases

Cohort ID
Author, Year
Descripton
Cohort Size
Diagnosis
Age
Gender
CNV Size
Deletion
Duplication
Total CNV's
 girirajan_12_ASD/DD/ID_discovery_cases
 Samples from affected children submitted to Signature Genomic Laboratories from 2008-2010.
 32587
 Developmental delay with or without congenital malformations
 
 
 5900000
 23
 12
 35
 kaminsky_11_DD/ID/ASD_discovery_cases
 Cases from the International Standards for Cytogenomic Arrays (ISCA) consortium
 15749
 Unexplained developmental delay, intellectual disability, dysmorphic features, multiple congenital anomalies, autism spectrum disorders, or clinical features suggestive of a chromosomal syndrome
 NA
 NA
 6119836
 6
 1
 7
 tonoki_11_DD_discovery_cases
 Two Japanese cases presenting with developmental delay and Axenfeld-Rieger anomalies; both cases with 6p25 deletions
 2
 Axenfeld-Rieger anomalies & developmental delay. One case with autistic features (autistic behavior).
 Range, 8 mos.-5 yrs.
 50% Male
 6610000
 2
 0
 2
 yuen_17_ASD_discovery_cases
 ASD genomes (1745 ASD probands, 879 ASD-affected siblings, 1 ASD-affected father, and 1 ASD-affected grandfather) from AGRE (n=730), the AGRE; Autism Treatment Network cohort (n=192) ,the ASD: Genomes to Outcomes Study cohort (n=1421), the Baby Siblings Research Consortium (n=43), the Baby Siblings Research Consortium; The Autism Simplex Collection cohort (n=6), the Infant Sibling Study (n=62), th
 2626
 ASD diagnosis of research quality when meeting criteria on one (n=437) or both (n=1361) of the diagnostic measures ADI-R and ADOS; clinical diagnosis of ASD (n=819) when given by expert clinician according to DSM-IV or DSM-5
 N/A
 78.71% Male
 6540999
 0
 1
 1

Controls

Cohort ID
Author, Year
Descripton
Cohort Size
Diagnosis
Age
Gender
CNV Size
Deletion
Duplication
Total CNV's
 girirajan_12_ASD/DD/ID_discovery_controls
 Persons found to have no overt neurological disorders during screening for other studies
 8329
 Control
 
 
 5900000
 0
 0
 0
 kaminsky_11_DD/ID/ASD_discovery_controls
 Controls from the International Standards for Cytogenomic Arrays (ISCA) consortium
 10118
 Controls
 NA
 NA
 NA
 NA
 NA
 NA

Cases

Cohort ID
Geographical Ancestry
Discovery Method
Platform
Algorithm
Software
Validation Method
 girirajan_12_ASD/DD/ID_discovery_cases
 
 aCGH
  BACs aCGH, SignatureChipOS
 
 
 FISH, aCGH, or confirmation by inheritance
 kaminsky_11_DD/ID/ASD_discovery_cases
  NA
 aCGH
  Agilent 44K, Agilent 105K
 
 Feature Extraction, DNA Analytics
 FISH, qPCR, MLPA, aCGH, standard G-banded chromosome analysis
 tonoki_11_DD_discovery_cases
  Japanese
 Array SNP, FISH
  Affymetrix GeneChip 250K Nsp array
 
 CNAG 3.0
 None
 yuen_17_ASD_discovery_cases
  N/A
 WGS
  Complete Genomics, Illumina HiSeq 2000, HiSeq X
 
 
 aCGH (Agilent 1M), array SNP (Affymetrix 6.0, Affymetrix CytoScan HD), solid phase hybridization (Illumina 1M, Illumina OMNI 2.5M)

Controls

Cohort ID
Geographical Ancestry
Discovery Method
Platform
Algorithm
Software
Validation Method
  girirajan_12_ASD/DD/ID_discovery_controls
 
  aCGH
  BACs ACGH (SignatureChipoWG) or oligoarray (SignatureChipOS)
 
 
 
  kaminsky_11_DD/ID/ASD_discovery_controls
  NA
  aCGH
  Agilent 44K, Agilent 105K
 
  Feature Extraction, DNA Analytics
 

Cases

Patient ID
Author, Year
Age
Gender
Primary Diagnosis
Clinical Profile
Cognitive Profile
CNV Start
CNV End
CNV Size
Genome Build
Type Method
Validation
  girirajan_12_ASD/DD/ID_discovery_cases-case2013
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Deletion
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2014
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Deletion
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2015
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Deletion
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2016
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Deletion
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2017
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Deletion
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2018
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Deletion
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2019
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Deletion
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2020
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Deletion
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2021
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Deletion
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2022
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Deletion
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2023
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Deletion
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2024
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Deletion
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2025
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Deletion
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2026
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Deletion
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2027
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Deletion
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2028
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Deletion
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2029
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Deletion
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2030
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Deletion
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2031
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Deletion
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2032
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Deletion
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2033
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Deletion
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2034
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Deletion
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2035
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Duplication
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2036
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Duplication
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2037
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Duplication
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2038
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Duplication
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2039
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Duplication
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2040
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Duplication
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2041
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Duplication
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2042
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Duplication
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2043
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Duplication
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2044
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Duplication
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2045
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Duplication
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case2046
 NA
 NA
 Developmental delay
 NA
 NA
 155000
 6054768
  5899769
 GRCh38
 Duplication
 NA
  girirajan_12_ASD/DD/ID_discovery_cases-case43001
 NA
 NA
 ADD
 Attention deficit disorder of childhood with hyperactivity, failure to thrive, microcephaly.
 NA
 155000
 6054768
  5899769
 GRCh38
 Deletion
 Yes
  kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00000454
 NA
 NA
 Developmental delay/intellectual disability/ASD
 Clinical profile NA
 Cognitive profile NA
 163083
 6062800
  5899718
 GRCh38
 Deletion
 Yes
  kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00001180
 NA
 NA
 Developmental delay/intellectual disability/ASD
 Clinical profile NA
 Cognitive profile NA
 163083
 5875402
  5712320
 GRCh38
 Deletion
 Yes
  kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00001784
 NA
 NA
 Developmental delay/intellectual disability/ASD
 Clinical profile NA
 Cognitive profile NA
 144957
 5239181
  5094225
 GRCh38
 Duplication
 Yes
  kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00001808
 NA
 NA
 Developmental delay/intellectual disability/ASD
 Clinical profile NA
 Cognitive profile NA
 107682
 4978781
  4871100
 GRCh38
 Deletion
 Yes
  kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00001970
 NA
 NA
 Developmental delay/intellectual disability/ASD
 Clinical profile NA
 Cognitive profile NA
 164633
 6284237
  6119605
 GRCh38
 Deletion
 Yes
  kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00004537
 NA
 NA
 Developmental delay/intellectual disability/ASD
 Clinical profile NA
 Cognitive profile NA
 162883
 5979198
  5816316
 GRCh38
 Deletion
 Yes
  kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00005162
 NA
 NA
 Developmental delay/intellectual disability/ASD
 Clinical profile NA
 Cognitive profile NA
 164633
 5823601
  5658969
 GRCh38
 Deletion
 Yes
  tonoki_11_DD_discovery_cases-patient1
 5 yrs.
 F
 Developmental delay + autistic features
 Diagnosis of Axenfeld-Rieger anomaly. Birth/neonatal history: born after 42 weeks of gestation with birth weight of 2258 g (<5th %ile), length of 47.4 cm (32nd %ile), and head circumference of 33.0 cm (47th %ile); exhibited a number of congenital anomalies. Developmental milestones: delayed developmental milestones (head control at 4 months, sitting without support at 11 months, walking at 22 months, lack of meaningful words at 24 months). Behavioral/psychiatric evaluation: autistic features (autistic behaviors) displayed at 5 years of age. Vision: neonatal buphthalmos, posterior embryotoxon, strabismus; normal intraocula pressure and pupil shape. Hearing: bilateral sensorineural deafness. Cardiac defects: atrial septal defect. Brain imaging: agenesis of corpus callosum. Dysmorphic features: apparent hypertelorism, downslanting palpebral fissures, high palate, strabismus, fusion of labia minor, redundant peri-umbilical skin. Growth parameters (at 19 months): height, 80.2 cm (49th %ile); weight, 9.2 kg (21st %ile). Karyotype: 46, XX, del(6)(p25.1); parental karyotypes normal. Family history: phenotypically normal, unrelated parents.
 Developmental delay
 NA (approx. 74360)
 NA (approx. 4978093)
  NA (5.0-5.7 Mb)
 NCBI35
 Deletion
 No
  tonoki_11_DD_discovery_cases-patient3
 8 mos.
 M
 Developmental delay
 Diagnosis of Axenfeld-Rieger anomaly. Birth/neonatal history: born after 40 weeks of gestation with birth weight of3230 g (56th %ile), length of 49.1 cm (39th %ile), and head circumference of 32.5 cm (28th %ile); atrial septal defect and pulmonary stenosis detected in neonatal period, but no treatment was needed; buphthalmose noted at 4 months of age. Developmental milestones: mildly delayed development. Motor and musculoskeletal evaluation: hypotonia. Vision: ophthalmological examination revealed increased intraocular pressure & posterior embryotoxon; no srugery necessary to treat intraocular pressure. Brain MRI: normal. Hearing: normal brainstem auditory evoked potential. Cardiac defects: atrial septal defect, pulmonary stenosis. Dysmorphic features: broad forehead, apparent hypertelorism, downslanting palpebral fissures, low-set and malformed ears, small anteverted nose. Karyotype: 46,XY,der(6)t(X;6)(p22.3;p25)dn or 46,XY,der(6)t(Y;6)(p22.3;p25)dn; parental karyotypes normal. Family history: phenotypically normal, unrelated parents.
 Mild developmental delay
 174769
 6790632
  6615864
 GRCh38
 Deletion
 No
  yuen_17_ASD_discovery_cases-case1-0324-003
 N/A
 M
 ASD
 Case cohort: ASD: Genomes to Outcome Study. Clinical description: N/A. Additional genetic information: 46 XY.ish der (9)t(6;9)(p24;p23)(6ptell48+,9ptel-)mat.
 
 202001
 6742767
  6540767
 GRCh38
 Duplication
 Yes

Controls

No Control Data Available

Cases

Patient ID
Validation Description
Primary Disorder Inheritence
Inheritence
Family Profile
Disease Segregation
Gene Content
Altered Gene Expression
 girirajan_12_ASD/DD/ID_discovery_cases-case2013
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2014
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2015
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2016
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2017
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2018
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2019
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2020
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2021
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2022
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2023
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2024
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2025
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2026
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2027
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2028
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2029
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2030
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2031
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2032
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2033
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2034
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2035
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2036
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2037
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2038
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2039
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2040
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2041
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2042
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2043
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2044
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2045
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case2046
 NA
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 girirajan_12_ASD/DD/ID_discovery_cases-case43001
 FISH, aCGH, or confirmation by inheritance
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00000454
 FISH, qPCR, MLPA, aCGH, or standard G-banded chromosome analysis
 
 Maternal
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00001180
 FISH, qPCR, MLPA, aCGH, or standard G-banded chromosome analysis
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00001784
 FISH, qPCR, MLPA, aCGH, or standard G-banded chromosome analysis
 
 Unknown
 Unknown
 Unknown
 CICP18,HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,GMDS,BPHL,LYRM4
 
 kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00001808
 FISH, qPCR, MLPA, aCGH, or standard G-banded chromosome analysis
 
 De novo
 Unknown
 Unknown
 CICP18,HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,GMDS,BPHL
 
 kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00001970
 FISH, qPCR, MLPA, aCGH, or standard G-banded chromosome analysis
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,MIR7853,MIR5683,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4,F13A1
 
 kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00004537
 FISH, qPCR, MLPA, aCGH, or standard G-banded chromosome analysis
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00005162
 FISH, qPCR, MLPA, aCGH, or standard G-banded chromosome analysis
 
 Unknown
 Unknown
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,GMDS,BPHL,LYRM4
 
 tonoki_11_DD_discovery_cases-patient1
 
 
 Unknown (possibly de novo based on normal parental karyotypes)
 Unknown
 Possibly segregated
 Est. gene content: DUSP22,IRF4,EXOC2,HUS1B,FOXQ1,FOXF2,FOXC1,GMDS,C6orf195,MYLK4,WRNIP1,SERPINB1,SERPINB9,SERPINB6,NQO2,RIPK1,BPHL,TUBB2A,TUBB2B,PSMG4,SLC22A23,PXDC1,FAM50B,PRPF4B,FAM217A,C6orf201,ECI2,CDYL,RPP40
 
 tonoki_11_DD_discovery_cases-patient3
 
 
 Unknown (possibly de novo based on normal parental karyotypes)
 Unknown
 Possibly segregated
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,MIR7853,MIR5683,SNAPC5P1,CNN3P1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,LY86,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,LY86-AS1,GMDS,BPHL,LYRM4,F13A1
 
 yuen_17_ASD_discovery_cases-case1-0324-003
 Illumina OMNI 2.5M
 
 Possibly maternal [unbalanced translocation 46 XY.ish der (9)t(6;9)(p24;p23)(6ptell48+,9ptel-)mat]
 Simplex
 Unknown
 HUS1B,FOXQ1,LINC01394,MIR6720,FOXC1,HMGN2P28,LINC01600,MIR4645,LINC01011,HTATSF1P2,FAM136BP,SERPINB8P1,RNA5SP201,TUBB2A,TDGF1P4,GLRX3P2,RNA5SP202,LINC02533,KU-MEL-3,PSMC1P11,LYRM4-AS1,PPP1R3G,MIR3691,HNRNPA1P37,RN7SL221P,PKMP5,NRN1,MIR7853,MIR5683,SNAPC5P1,CNN3P1,DUSP22,FOXF2,RN7SL352P,FOXCUT,MYLK4,WRNIP1,SERPINB1,SERPINB9P1,SERPINB9,SERPINB6,RIPK1,TUBB2BP1,LINC02525,TUBB2B,PXDC1,FAM50B,C6orf201,ECI2,RPP40,LY86,IRF4,EXOC2,GMDS-DT,LINC02521,NQO2,PSMG4,SLC22A23,PRPF4B,FAM217A,CDYL,FARS2,LY86-AS1,GMDS,BPHL,LYRM4,F13A1
 

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