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4q28.1CNV Type: Deletion-Duplication


Largest CNV size: 649211 bp

Statistics Box:
Number of Reports: 11



Summary Information

Summary statement in development

Additional Locus Information

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References

Major Reports

Title
Author, Year
Report Class
CNV Type
Functional impact of global rare copy number variation in autism spectrum disorders.
Duplication
An evidence-based approach to establish the functional and clinical significance of copy number variants in intellectual and developmental disabili...
Deletion
Screening of 50 cypriot patients with autism spectrum disorders or autistic features using 400K custom array-CGH.
Deletion
Copy number variation in Han Chinese individuals with autism spectrum disorder.
Deletion-Duplication

Minor Reports

Title
Author, Year
Report Class
CNV Type
Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism.
Deletion
A discovery resource of rare copy number variations in individuals with autism spectrum disorder.
Deletion-Duplication
Identification of candidate intergenic risk loci in autism spectrum disorder.
Deletion
Performance of case-control rare copy number variation annotation in classification of autism.
Deletion-Duplication
Genome-wide analysis of copy number variations identifies PARK2 as a candidate gene for autism spectrum disorder.
Duplication
Chromosomal microarray analysis in clinical evaluation of neurodevelopmental disorders-reporting a novel deletion of SETDB1 and illustration of cou...
Deletion
Copy number variation analysis of patients with intellectual disability from North-West Spain.
Deletion-Duplication

Cases

Cohort ID
Author, Year
Descripton
Cohort Size
Diagnosis
Age
Gender
CNV Size
Deletion
Duplication
Total CNV's
 engchuan_15_ASD_discovery_cases
 Samples from the Autism Genome Project (AGP)
 1892
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 N/A
 85.78% Male
 378293
 8
 1
 9
 gazzellone_14_ASD_discovery_cases
 ASD-affected individuals referred to the Children Development and Behavior Research Center (CDRBC) at Harbin Medical University, China, between January 2007 and June 2011.
 104
 Diagnosis of ASD made using Autism Behavior Checklist (ABC) and Childhood Autism Rating Scale (CARS)
 Mean age at enrollment, 4.31 1.80 yrs.
 87.5% Male
 981970
 1
 1
 2
 kaminsky_11_DD/ID/ASD_discovery_cases
 Cases from the International Standards for Cytogenomic Arrays (ISCA) consortium
 15749
 Unexplained developmental delay, intellectual disability, dysmorphic features, multiple congenital anomalies, autism spectrum disorders, or clinical features suggestive of a chromosomal syndrome
 NA
 NA
 2275904
 1
 0
 1
 kousoulidou_13_ASD_discovery_cases
 Cypriot patients with ASD or autistic features
 50
 Children with preliminary diagnosis of ASD [reevaluated by clinical geneticist to rule out autistic-like syndromes and retested for ASD based on DSM-IV-TR and ICD-10 using Gilliam Autism Rating Scale-2 (GARS-2)]
 Range, 3-18 yrs.
 90% Male
 132000
 1
 0
 1
 pinto_10_ASD_discovery_cases
 Autism Genome Project (AGP) consortium patient cohort from families with at least two ASD individuals
 996
 ASD (ADI-R and ADOS): strict, broad, or spectrum ASD
 
 
 378294
 0
 1
 1
 prasad_12_ASD_discovery_cases
 Unrelated ASD cases recruited from three Canadian sites (Hospital for Sick Children, McMaster University, and Memorial University of Newfoundland); the majority of cases had been previously genotyped with results published in Marshall et al., 2008 and Pinto et al., 2010. 20 cases from initial cohort of 696 were excluded from further analysis (due to CNVs > 5 Mb).
 676
 Diagnosis of ASD based on meeting criteria on ADI-R and/or ADOS
 NA
 82.84% Male
 367683
 2
 2
 4
 quintela_17_DD/ID_discovery_cases
 Galician (NW Spain) patients recruited from the Complexo Hospitalario Universitario de Santiago de Compostela and referred to the Fundacion Publica Galega de Medicina Xenomica for genetic study
 573
 All participants had a clinical diagnosis of idiopathic intellectual disability (ID) or global developmental delay (DD) with or without another medical condition [e.g. autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), epilepsy, dysmorphic features, and/or congenital anomalies]
 Range, 3 months-18 years
 60.38% Male
 415963
 1
 1
 2
 sanders_11_ASD_discovery_cases
 Autistic probands from the Simons Simplex Collection (SSC). 872 probands in quartet families, 272 probands in trios.
 1124
 ASD diagnosis: 89.5% autism; 8.5% PDD-NOS, 2% Asperger syndrome. Mean full-scale IQ 85.1 1.5 (mean verbal IQ, 81.9 1.7; mean non-verbal IQ, 88.4 1.4)
 Mean, 9.1 yrs.
 86.1% Male
 649211
 3
 0
 3
 walker_13_ASD_discovery_cases
 Unrelated ASD probands previously described in Lionel et al., 2011 and Pinto et al., 2010 CNV reports
 1491
 Diagnosis of ASD based on gold-standard instruments including ADI and ADOS.
 N/A
 N/A
 44105
 1
 0
 1
 xu_16_ASD/DD/ID_discovery_cases
 Patients referred to the Duke Autism Genetics Clinic for clinical genetic evaluation of ASD and DD/ID from 2010-2014
 115
 66 cases with confirmed primary diagnosis of ASD (DSM-IV, DSM-5, ADOS, and ADI-R used to support ASD diagnosis), 49 cases with primary diagnosis of DD or ID (based on IQ and DQ scores).
 Range, 18 months-15.1 years (mean age, 5.7 years)
 72.17% Male
 363000
 1
 0
 1
 yin_16_ASD_discovery_cases
 Discovery cohort of ASD cases recruited from the Department of Psychiatry of National Taiwan University Hospital (NTUH), Chang Gung Memorial Hospital (CGMH), Taoyuan, and Taoyuan Mental Hospital (TMH), Taiwan.
 335
 Cases diagnosed with autistic disorder according to DSM-IV and confirmed by using the Chinese version of ADI-R. Cases' autistic behaviors assessed by Social Responsiveness Scale (SRS), and cognitive functions assessed by the Weschler Intelligence Scale for Children-Third Edition (WISC-III) and the Wisconsin Card Sorting Test (WCST).
 Mean, 9.39 4.04 yrs.
 89.3% Male
 78774
 0
 1
 1

Controls

Cohort ID
Author, Year
Descripton
Cohort Size
Diagnosis
Age
Gender
CNV Size
Deletion
Duplication
Total CNV's
 engchuan_15_ASD_discovery_controls
 Platform-matched controls from three large studies: SAGE (Study of Addiction Genetics and Environment), Ontario Colorectal Cancer study, and HABC (Health Aging and Body Composition)
 2342
 Controls; subjects had no previous psychiatric history
 N/A
 46.67% Male
 378293
 3
 2
 5
 kaminsky_11_DD/ID/ASD_discovery_controls
 Controls from the International Standards for Cytogenomic Arrays (ISCA) consortium
 10118
 Controls
 NA
 NA
 NA
 NA
 NA
 NA
 kanduri_15_ASD_discovery_controls
 Unrelated Finnish samples from the cohort of Health 2000 survey from an initial sample of 288 individuals following quality control
 269
 Controls screened for DSM-IV mental disorders using the Composite International Diagnostic Interview and psychotic disorders using the research version of the Structured Clinical Interview for DSM-IV
 N/A
 N/A
 11339
 1
 0
 1
 kousoulidou_13_ASD_discovery_controls
 Control cohort consisting of 50 normal participants (36% male) older than 30 years of age with at least two biological children with no mental, neurological, or developmental disorder; and 80 normal individuals having children with syndromic or nonsyndromic intellectual disability, developmental delay, or rare neurological syndromes.
 130
 Controls
 N/A
 N/A
 0
 0
 0
 0
 prasad_12_ASD_discovery_controls
 PDx controls [1000 DNA samples from reportedly healthy donors (50.2% male) from BioServe (Beltsville, MD)] and 4139 in-house controls previously reported in Krawcak et al. 2006, Stewart et al. 2009, and Bierut et al. 2010. CNVs identified in controls were used to define rare ASD-specific CNVs.
 5139
 Control
 NA
 NA (PDx controls 50.2% male)
 367683
 0
 0
 0
 sanders_11_ASD_discovery_controls
 Matched siblings of autistic probands from the Simons Simplex Collection (SSC).
 872
 Controls
 Mean, 10.0 yrs.
 
 160952
 1
 2
 3
 walker_13_ASD_discovery_controls
 Control samples from the SAGE cohort (n=1287), from the Ottawa Heart Institute (n=1234), and from the POPGEN collection (n=1123)
 3644
 Control
 N/A
 N/A
 44105
 N/A
 N/A
 N/A
 yin_16_ASD_discovery_controls
 Individuals from the Han Chinese Cell and Genome Bank (HCCGB) in Taiwan
 1093
 Controls
 Mean, 68.07 10.12 yrs.
 48.0% Male
 78774
 0
 0
 0

Cases

Cohort ID
Geographical Ancestry
Discovery Method
Platform
Algorithm
Software
Validation Method
 engchuan_15_ASD_discovery_cases
  Caucasian
 Solid phase hybridization
  Illumina 1M
 
 
 None
 gazzellone_14_ASD_discovery_cases
  Han Chinese
 Array SNP
  Affymetrix CytoScan HD
 ChAS, iPattern, Nexus, Partek
 
 qPCR, Taqman assay
 kaminsky_11_DD/ID/ASD_discovery_cases
  NA
 aCGH
  Agilent 44K, Agilent 105K
 
 Feature Extraction, DNA Analytics
 FISH, qPCR, MLPA, aCGH, standard G-banded chromosome analysis
 kousoulidou_13_ASD_discovery_cases
  Cyprus
 aCGH
  Agilent 400K custom array-CGH
 
 Agilent Feature Extraction 9.1, Nexus Copy Number 5.1
 qPCR
 pinto_10_ASD_discovery_cases
  European
 Solid phase hybridization
  Illumina Infinium 1M SNP microarray
 QuantiSNP, iPattern
 
 qPCR, long-range PCR (LR-PCR), MLPA, FISH, aCGH (Agilent 1M), array SNP (Affymetrix 500K)
 prasad_12_ASD_discovery_cases
  Canada
 aCGH
  Agilent 1M
 ADM-2, DNAcopy (R Bioconductor)
 DNA Analytics v4.0.85 (Agilent), DNAcopy
 None
 quintela_17_DD/ID_discovery_cases
  North West Spain
 Array SNP
  Affymetrix Cytogenetics Whole-Genome 2M SNP array, Affymetrix CytoScan HD
 
 Affymetrix ChAS v.1.2.2
 None
 sanders_11_ASD_discovery_cases
  White non-Hispanic, 74.5%; mixed, 9.3%, Asian, 4.3%, White Hispanic, 4.0%, African-American, 3.8%; other, 4.2&
 Solid phase hybridization
  Illumina 1M v1, Illumina 1M v3
 PennCNV, QuantiSNP, GNOSIS
 
 
 walker_13_ASD_discovery_cases
  N/A
 Array SNP, solid phase hybridization
  Illumina 1M, Affymetrix 6.0
 
 QuantiSNP, PennCNV, Birdsuite, iPattern, Affymetrix Genotyping Console
 None
 xu_16_ASD/DD/ID_discovery_cases
  N/A
 aCGH, array SNP
  BlueGnome CytoChip v2, Affymetrix 6.0, Affymetrix Cytoscan HD
 
 Affymeytrix Genotyping Console v3.0.2
 None
 yin_16_ASD_discovery_cases
  Han Chinese
 Array SNP
  Affymetrix 6.0
 
 Affymetrix Genotyping Console v.4.1
 None

Controls

Cohort ID
Geographical Ancestry
Discovery Method
Platform
Algorithm
Software
Validation Method
  engchuan_15_ASD_discovery_controls
  Caucasian
  Solid phase hybridization
  Illumina 1M
 
 
  None
  kaminsky_11_DD/ID/ASD_discovery_controls
  NA
  aCGH
  Agilent 44K, Agilent 105K
 
  Feature Extraction, DNA Analytics
 
  kanduri_15_ASD_discovery_controls
  Finnish
  Solid phase hybridization
  Illumina Infinium HD Human610-Quad BeadChip
  QuantiSNP, PennCNV
  Illumina BeadStudio
  None
  kousoulidou_13_ASD_discovery_controls
  Cyprus
  aCGH
  Agilent 400K custom array-CGH
 
  Agilent Feature Extraction 9.1, Nexus Copy Number 5.1
 
  prasad_12_ASD_discovery_controls
  NA
  aCGH
  Agilent 1M
  ADM-2, DNAcopy (R Bioconductor)
  DNA Analytics v4.0.85 (Agilent), DNAcopy
 
  sanders_11_ASD_discovery_controls
 
  Solid phase hybridization
  Illumina 1M v1 or Illumina 1M v3
  PennCNV, QuantiSNP, GNOSIS
 
 
  walker_13_ASD_discovery_controls
  N/A
  Array SNP, solid phase hybridization
  Illumina 1M, Affymetrix 6.0
 
  QuantiSNP, PennCNV, Birdsuite, iPattern, Affymetrix Genotyping Console
  None
  yin_16_ASD_discovery_controls
  Han Chinese
  Array SNP
  Affymetrix 6.0
 
  Affymetrix Genotyping Console v.4.1
  None

Cases

Patient ID
Author, Year
Age
Gender
Primary Diagnosis
Clinical Profile
Cognitive Profile
CNV Start
CNV End
CNV Size
Genome Build
Type Method
Validation
  engchuan_15_ASD_discovery_cases-case14164_2680
 N/A
 N/A
 ASD
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 
 124359697
 124403802
  44106
 GRCh38
 Deletion
 No
  engchuan_15_ASD_discovery_cases-case14251_3750
 N/A
 N/A
 ASD
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 
 124359697
 124403802
  44106
 GRCh38
 Deletion
 No
  engchuan_15_ASD_discovery_cases-case14313_4300
 N/A
 N/A
 ASD
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 
 124352338
 124403802
  51465
 GRCh38
 Deletion
 No
  engchuan_15_ASD_discovery_cases-case16093_1571132001
 N/A
 N/A
 ASD
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 
 125750625
 125798311
  47687
 GRCh38
 Deletion
 No
  engchuan_15_ASD_discovery_cases-case1968_301
 N/A
 N/A
 ASD
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 
 124359697
 124403802
  44106
 GRCh38
 Deletion
 No
  engchuan_15_ASD_discovery_cases-case3156_3
 N/A
 N/A
 ASD
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 
 126675914
 126746789
  70876
 GRCh38
 Deletion
 No
  engchuan_15_ASD_discovery_cases-case3606_3
 N/A
 N/A
 ASD
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 
 125817678
 125910967
  93290
 GRCh38
 Deletion
 No
  engchuan_15_ASD_discovery_cases-case5139_3
 N/A
 N/A
 ASD
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 
 124091835
 124470128
  378294
 GRCh38
 Duplication
 No
  engchuan_15_ASD_discovery_cases-case8532_201
 N/A
 N/A
 ASD
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 
 125377990
 125453744
  75755
 GRCh38
 Deletion
 No
  gazzellone_14_ASD_discovery_cases-case527-3
 N/A
 M
 ASD
 ASD; no other clinical information provided
 N/A
 123141991
 124123961
  981971
 GRCh38
 Duplication
 Yes
  gazzellone_14_ASD_discovery_cases-case622-3
 N/A
 M
 ASD
 ASD; no other clinical information provided
 N/A
 126830327
 126856063
  25737
 GRCh38
 Deletion
 No
  kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00005065
 NA
 NA
 Developmental delay/intellectual disability/ASD
 Clinical profile NA
 Cognitive profile NA
 124055204
 126331108
  2275905
 GRCh38
 Deletion
 Yes
  kousoulidou_13_ASD_discovery_cases-patient11
 N/A
 M
 ID and autistic features
 Autistic features. Poor concentration. EEG: normal. Family history: affected father with autistic features.
 Intellectual disability (mild), learning difficulties
 122979186
 123111346
  132161
 GRCh38
 Deletion
 Yes
  pinto_10_ASD_discovery_cases-case5139_3
 NA
 F
 ASD
 NA
 NA
 124091835
 124470128
  378294
 GRCh38
 Duplication
 Yes
  prasad_12_ASD_discovery_cases-case129914
 NA
 M
 ASD
 Diagnosis of ASD based on meeting criteria on ADI-R and/or ADOS. Novel CNV
 
 126959553
 127011262
  51710
 Unknown
 Duplication
 No
  prasad_12_ASD_discovery_cases-case143189
 NA
 M
 ASD
 Diagnosis of ASD based on meeting criteria on ADI-R and/or ADOS. CNV identified by previous SNP microarray study
 
 124656940
 124680991
  24052
 Unknown
 Deletion
 No
  prasad_12_ASD_discovery_cases-case64714L
 NA
 M
 ASD
 Diagnosis of ASD based on meeting criteria on ADI-R and/or ADOS. Novel CNV
 
 126515534
 126528308
  12775
 Unknown
 Deletion
 No
  prasad_12_ASD_discovery_cases-case82369L
 NA
 M
 ASD
 Diagnosis of ASD based on meeting criteria on ADI-R and/or ADOS. CNV identified by previous SNP microarray study
 
 125241306
 125608988
  367683
 Unknown
 Duplication
 No
  quintela_17_DD/ID_discovery_cases-caseID_305
 10 yrs.
 M
 Intellectual disability and ADHD
 ADHD. Incomplete parental clinical history.
 Mild intellectual disability
 125365287
 125587627
  222341
 GRCh38
 Duplication
 No
  quintela_17_DD/ID_discovery_cases-caseID_515
 6 yrs.
 M
 Intellectual disability
 Additional clinical information N/A
 Intellectual disability
 125391972
 125807934
  415963
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-11264.p1
 10.7
 F
 Autism
 NA
 Full-scale IQ, 83; non-verbal IQ, 88; verbal IQ 80
 125248997
 125255488
  6492
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-12754.p1
 7.9
 M
 Autism
 NA
 Full-scale IQ, 125; non-verbal IQ, 125; verbal IQ, 115
 126222580
 126871791
  649212
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-13301.p1
 13.6
 M
 Autism
 NA
 Full-scale IQ, 105; non-verbal IQ, 95; verbal IQ, 124
 124385942
 124715271
  329330
 GRCh38
 Deletion
 No
  walker_13_ASD_discovery_cases-case8-14251-3750
 N/A
 M
 ASD
 N/A
 N/A
 124359697
 124403802
  44106
 GRCh38
 Deletion
 No
  xu_16_ASD/DD/ID_discovery_cases-case39
 N/A
 N/A
 ASD
 Case with confirmed primary diagnosis of ASD (DSM-IV, DSM-5, ADOS, and ADI-R used to support ASD diagnosis)
 
 125644148
 126007909
  363762
 GRCh38
 Deletion
 No
  yin_16_ASD_discovery_cases-case208
 N/A
 N/A
 ASD
 Cases diagnosed with autistic disorder according to DSM-IV and confirmed by using the Chinese version of ADI-R.
 
 124481859
 124560632
  78774
 GRCh38
 Duplication
 No

Controls

Patient ID
Author, Year
Age
Gender
Primary Diagnosis
Clinical Profile
Cognitive Profile
CNV Start
CNV End
CNV Size
Genome Build
Type Method
Validation
  engchuan_15_ASD_discovery_controls-control110036019727_
  N/A
  N/A
  Control
  No previous psychiatric history
 
  124030349
  124187929
  157581
  GRCh38
  Deletion
  No
  engchuan_15_ASD_discovery_controls-controlB322838_1007872284
  N/A
  N/A
  Control
  No previous psychiatric history
 
  125753917
  125806343
  52427
  GRCh38
  Deletion
  No
  engchuan_15_ASD_discovery_controls-controlB382816_1007872257
  N/A
  N/A
  Control
  No previous psychiatric history
 
  123138494
  123220316
  81823
  GRCh38
  Deletion
  No
  engchuan_15_ASD_discovery_controls-controlB391985_1007840230
  N/A
  N/A
  Control
  No previous psychiatric history
 
  124091835
  124470128
  378294
  GRCh38
  Duplication
  No
  engchuan_15_ASD_discovery_controls-controlB630497_1007872229
  N/A
  N/A
  Control
  No previous psychiatric history
 
  125824516
  125878499
  53984
  GRCh38
  Duplication
  No
  kanduri_15_ASD_discovery_controls-control_split1532
  N/A
  N/A
  Control
  Control screened for DSM-IV mental disorders using the Composite International Diagnostic Interview and psychotic disorders using the research version of the Structured Clinical Interview for DSM-IV
 
  125831214
  125842552
  11339
  Unknown
  Deletion
  No
  sanders_11_ASD_discovery_controls-11462.s1
  6.5
  M
  Control (matched sibling)
  NA
  NA
  125227473
  125238450
  10978
  GRCh38
  Duplication
  No
  sanders_11_ASD_discovery_controls-12083.s1
  5.5
  F
  Control (matched sibling)
  NA
  NA
  125081512
  125167332
  85821
  GRCh38
  Duplication
  No
  sanders_11_ASD_discovery_controls-12957.s1
  13.3
  F
  Control (matched sibling)
  NA
  NA
  124045370
  124206322
  160953
  GRCh38
  Deletion
  No

Cases

Patient ID
Validation Description
Primary Disorder Inheritence
Inheritence
Family Profile
Disease Segregation
Gene Content
Altered Gene Expression
 engchuan_15_ASD_discovery_cases-case14164_2680
 
 
 Unknown
 
 
 
 
 engchuan_15_ASD_discovery_cases-case14251_3750
 
 
 Unknown
 
 
 
 
 engchuan_15_ASD_discovery_cases-case14313_4300
 
 
 Unknown
 
 
 
 
 engchuan_15_ASD_discovery_cases-case16093_1571132001
 
 
 Unknown
 
 
 
 
 engchuan_15_ASD_discovery_cases-case1968_301
 
 
 Unknown
 
 
 
 
 engchuan_15_ASD_discovery_cases-case3156_3
 
 
 Unknown
 
 
 
 
 engchuan_15_ASD_discovery_cases-case3606_3
 
 
 Unknown
 
 
 
 
 engchuan_15_ASD_discovery_cases-case5139_3
 
 
 Unknown
 
 
 TECRP2
 
 engchuan_15_ASD_discovery_cases-case8532_201
 
 
 Unknown
 
 
 FAT4
 
 gazzellone_14_ASD_discovery_cases-case527-3
 qPCR or Taqman assay
 
 De novo
 Unknown
 Possibly segregated
 SPRY1,RPL21P50,PPIAP76,LINC02435,SPATA5,LINC01091
 
 gazzellone_14_ASD_discovery_cases-case622-3
 
 
 Unknown
 Unknown
 Unknown
 
 
 kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00005065
 FISH, qPCR, MLPA, aCGH, or standard G-banded chromosome analysis
 
 Maternal
 Unknown
 Unknown
 PPIAP76,TECRP2,MIR2054,TMEM248P1,LINC02379,ANKRD50,NUP58P1,LINC02516,FAT4
 
 kousoulidou_13_ASD_discovery_cases-patient11
 qPCR
 
 Maternal
 Unknown
 Unknown
 SPATA5
 
 pinto_10_ASD_discovery_cases-case5139_3
 Agilent1M
 
 paternal
 NA
 NA
 TECRP2
 
 prasad_12_ASD_discovery_cases-case129914
 
 
 Unknown
 Unknown
 Unknown
 0 genes
 
 prasad_12_ASD_discovery_cases-case143189
 
 
 Unknown
 Unknown
 Unknown
 0 genes
 
 prasad_12_ASD_discovery_cases-case64714L
 
 
 Unknown
 Unknown
 Unknown
 FAT4
 
 prasad_12_ASD_discovery_cases-case82369L
 
 
 Unknown
 Unknown
 Unknown
 0 genes
 
 quintela_17_DD/ID_discovery_cases-caseID_305
 
 
 Maternal
 
 Unknown
 MIR2054,FAT4
 
 quintela_17_DD/ID_discovery_cases-caseID_515
 
 
 Unknown
 
 Unknown
 MIR2054,TMEM248P1,NUP58P1,FAT4
 
 sanders_11_ASD_discovery_cases-11264.p1
 
 
 Paternal
 Simplex (quad-proband unmatched)
 Unknown
 
 
 sanders_11_ASD_discovery_cases-12754.p1
 
 
 Paternal
 Simplex (trio)
 NA
 RBM48P1
 
 sanders_11_ASD_discovery_cases-13301.p1
 
 
 Maternal
 Simplex (quad-proband matched)
 Not segregated
 TECRP2,ANKRD50,LINC02516
 
 walker_13_ASD_discovery_cases-case8-14251-3750
 
 
 Unknown
 Simplex
 Unknown
 
 
 xu_16_ASD/DD/ID_discovery_cases-case39
 
 
 Paternal
 
 
 TMEM248P1,NUP58P1
 
 yin_16_ASD_discovery_cases-case208
 
 
 Unknown
 Unknown
 Unknown
 LINC02516
 

Controls

Patient ID
Validation Description
Primary Disorder Inheritence
Inheritence
Family Profile
Disease Segregation
Gene Content
Altered Gene Expression
engchuan_15_ASD_discovery_controls-control110036019727_
 
 
  Unknown
 
 
  PPIAP76
 
engchuan_15_ASD_discovery_controls-controlB322838_1007872284
 
 
  Unknown
 
 
 
 
engchuan_15_ASD_discovery_controls-controlB382816_1007872257
 
 
  Unknown
 
 
  SPATA5
 
engchuan_15_ASD_discovery_controls-controlB391985_1007840230
 
 
  Unknown
 
 
  TECRP2
 
engchuan_15_ASD_discovery_controls-controlB630497_1007872229
 
 
  Unknown
 
 
 
 
kanduri_15_ASD_discovery_controls-control_split1532
 
 
  Unknown
 
 
  Intergenic CNV: nearest genes, ANKRD50(dist=197327),FAT4(dist=395015)
 
sanders_11_ASD_discovery_controls-11462.s1
 
 
  Maternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-12083.s1
 
 
  Paternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-12957.s1
 
 
  Maternal
  Simplex (quad)
  NA
  PPIAP76
 

No Animal Model Data Available
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