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2q11.2CNV Type: Deletion-Duplication


Largest CNV size: 379342 bp

Statistics Box:
Number of Reports: 24



Summary Information

Summary statement in development

Additional Locus Information

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References

Major Reports

Title
Author, Year
Report Class
CNV Type
Functional impact of global rare copy number variation in autism spectrum disorders.
Duplication
An evidence-based approach to establish the functional and clinical significance of copy number variants in intellectual and developmental disabili...
Deletion-Duplication
Phenotypic heterogeneity of genomic disorders and rare copy-number variants.
Deletion
A discovery resource of rare copy number variations in individuals with autism spectrum disorder.
Duplication
Refinement and discovery of new hotspots of copy-number variation associated with autism spectrum disorder.
Deletion
Transmission disequilibrium of small CNVs in simplex autism.
Duplication
Both rare and de novo copy number variants are prevalent in agenesis of the corpus callosum but not in cerebellar hypoplasia or polymicrogyria.
Deletion-Duplication
Convergence of genes and cellular pathways dysregulated in autism spectrum disorders.
Duplication
Excess of rare, inherited truncating mutations in autism.
Deletion-Duplication

Minor Reports

Title
Author, Year
Report Class
CNV Type
Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism.
Deletion-Duplication
Rare de novo and transmitted copy-number variation in autistic spectrum disorders.
Duplication
Phenotypic spectrum associated with duplication of Xp11.22-p11.23 includes Autism Spectrum Disorder.
Deletion
Use of array CGH to detect exonic copy number variants throughout the genome in autism families detects a novel deletion in TMLHE.
Deletion
Identification of small exonic CNV from whole-exome sequence data and application to autism spectrum disorder.
Deletion-Duplication
Refining analyses of copy number variation identifies specific genes associated with developmental delay.
Deletion-Duplication
The clinical utility of molecular karyotyping for neurocognitive phenotypes in a consanguineous population.
Deletion
Performance of case-control rare copy number variation annotation in classification of autism.
Deletion-Duplication
RYR2, PTDSS1 and AREG genes are implicated in a Lebanese population-based study of copy number variation in autism.
Deletion
Genome-wide analysis of copy number variations identifies PARK2 as a candidate gene for autism spectrum disorder.
Deletion
NA
Duplication
NA
Duplication
Paternally inherited cis-regulatory structural variants are associated with autism.
Deletion
Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights.
Deletion
NA
Duplication

Cases

Cohort ID
Author, Year
Descripton
Cohort Size
Diagnosis
Age
Gender
CNV Size
Deletion
Duplication
Total CNV's
 al-qattan_14_DD/ID/ASD/ADHD/EP_discovery_cases
 Retrospective chart review of patients (n=584) with a neurocognitive phenotype (mainly referred from pediatric neurology clinics) seen by a single clinical geneticist from September 2007 to July 2013
 584
 Inclusion criteria: presence of a neurocognitive phenotype (i.e., syndromic and non-syndromic cases of developmental delay, autism, intellectual disability, and epilepsy) with a normal karyotype
 N/A
 N/A
 294516
 1
 0
 1
 brandler_18_ASD_replication_cases
 Affected individuals from MSSNG cohort (1395 cases from 1187 families) and the Simons Simplex 2 (SSC2) cohort (584 cases from simplex quad families)
 1979
 Cases diagnosed with ASD
 N/A
 N/A
 7390
 1
 0
 1
 celestino-soper_11_ASD_discovery_cases
 ASD probands from Simons Simplex Collection (SSC) trios. 90 of the probands in this study were also used in the Sanders et al. 2011 CNV report.
 99
 ASD
 
 87.88% Male
 2758
 2
 0
 2
 chaves_24_ASD/DD/ID_discovery_cases
  NA NA
 CMA read files performed by the Laboratrio Neurogene in Florianpolis, Santa Catarina, Brazil, upon request by medical geneticists and neurologists for investigative/diagnostic purposes, primarily from the Joana de Gusmo Children's Hospital, but also from MDs from the University Hospital Professor Polydoro Ernani de So Thiago and from private clinics in Florianpolis, State of Santa Catarina, betwee
 1012
 83% of cases presented with developmental delay (DD) and/or intellectual disability (ID), with 33% of cases presented with autism spectrum disorder.
 Mean age, 10yrs. (median7.15 yrs., standard deviation10.2).
 60.77% Male
 2696626
 0
 1
 1
 chung_11_ASD_discovery_cases
 Autistic female proband; second child of healthy, non-consanguineous parents (first child developmentally normal)
 1
 ASD (ADI-R and ADOS, Module 3)
 12
 Female
 20878
 1
 0
 1
 coe_14_ASD/DD/ID_discovery_cases
 Primarily pediatric cases with intellectual disability, developmental delay, and/or ASD (cohort consists of 13,318 previously unpublished cases and 15,767 cases originally published in Cooper et al., Nature Genetics 2011); annotated CNVs extracted from Table 1 ("New CNVs") and Supplementary Table 2 ("Newly Significant Genomic Disorders").
 29085
 Intellectual disability, developmental delay, and/or ASD
 N/A
 N/A
 950000
 6
 4
 10
 digregorio_17_DD/ID_discovery_cases
  NA NA
 Consecutive cases examined in the Medical Genetics Unit at the "Citta della Salte e della Scienza" University Hospital (Turin, Italy) from 2008 to 2014 (cases with CNVs are present in DECIPHER database)
 1015
 Cases diagnosed with idiopathic developmental delay and/or intellectual disability (DD/ID)
 N/A
 N/A
 42000
 0
 1
 1
 engchuan_15_ASD_discovery_cases
 Samples from the Autism Genome Project (AGP)
 1892
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 N/A
 85.78% Male
 2015254
 4
 13
 17
 girirajan_12_ASD/DD/ID_discovery_cases
 Samples from affected children submitted to Signature Genomic Laboratories from 2008-2010.
 32587
 Developmental delay with or without congenital malformations
 
 
 927965
 1
 0
 1
 girirajan_13a_ASD_discovery_cases
 1979 simplex cases from the Simons Simplex Collection (SSC), 579 multiplex cases from AGRE.
 2588
 Diagnosis of ASD based on meeting criteria on the Autism Diagnostic Observation Schedule (ADOS) and on the Autism Diagnostic Interview, Revised (ADI-R)
 NA
 NA
 935911
 2
 0
 2
 girirajan_13a_DD_discovery_cases
 Data from individuals with developmental delay derived from two published reports (Cooper et al., 2011 & Kaminsky et al., 2011)
 31518
 Developmental delay
 NA
 NA
 935911
 2
 0
 2
 kaminsky_11_DD/ID/ASD_discovery_cases
 Cases from the International Standards for Cytogenomic Arrays (ISCA) consortium
 15749
 Unexplained developmental delay, intellectual disability, dysmorphic features, multiple congenital anomalies, autism spectrum disorders, or clinical features suggestive of a chromosomal syndrome
 NA
 NA
 1997995
 3
 8
 11
 krumm_13_ASD_discovery_cases
 Probands from quad families ascertained as part of the Simons Simplex Collection (SSC); CNVs detected using data from four previously published exome sequencing studies (O'Roak et al., 2011; Iossifov et al., 2012; O'Roak et al., 2012; Sanders et al., 2012)
 411
 Diagnosis of ASD. Social Responsiveness Scale (SRS) used as a quantitative measure of social deficits
 N/A
 81.265% Male
 83099
 0
 4
 4
 krumm_15_ASD_discovery_cases
 Probands from the Simons Simplex Collection
 2377
 Diagnosis of ASD
 N/A
 N/A
 143385
 1
 5
 6
 kushima_18_SCZ_discovery_cases
 Individuals predominantly recruited from the middle of Honshu Island (Japan)
 2458
 Cases were diagnosed with schizophrenia (SCZ) according to DSM-5 criteria.
 Median age, 44 years
 55.0% Male
 1015583
 1
 0
 1
 larson_17_ASD_discovery_cases
  NA NA
 Participants with a dual diagnosis of ASD and psychosis that were recruited from clinical services in the public and independent sectors in the United Kingdom, as well as from charities and an Asperger's syndrome social networking website (study took place from January 2011 and April 2014)
 116
 All cases with a dual diagnosis of ASD and psychosis (affective, schizophrenic, and atypical)
 N/A
 N/A
 197025
 0
 13
 13
 levy_11_ASD_discovery_cases
 Autistic probands from 887 families from the Simons Simplex Collection (SSC)
 858
 ASD
 
 87.06% Male
 90411
 0
 2
 2
 pinto_10_ASD_discovery_cases
 Autism Genome Project (AGP) consortium patient cohort from families with at least two ASD individuals
 996
 ASD (ADI-R and ADOS): strict, broad, or spectrum ASD
 
 
 293432
 0
 1
 1
 pinto_14_ASD_discovery_cases
 ASD probands from simplex and multiplex families collected as part of stage 2 of the Autism Genome Project (AGP) after quality control (1,604 before QC)
 1359
 Cases classified according to ADOS and ADI-R
 N/A
 N/A
 84765
 0
 1
 1
 poultney_13_ASD_discovery_cases
 ASD cases of European ancestry from AGRE retained after filtering (original cohort size of 432 cases)
 299
 Cases diagnosed with ASD
 N/A
 79.86% Male (before filtering)
 122706
 1
 3
 4
 prasad_12_ASD_discovery_cases
 Unrelated ASD cases recruited from three Canadian sites (Hospital for Sick Children, McMaster University, and Memorial University of Newfoundland); the majority of cases had been previously genotyped with results published in Marshall et al., 2008 and Pinto et al., 2010. 20 cases from initial cohort of 696 were excluded from further analysis (due to CNVs > 5 Mb).
 676
 Diagnosis of ASD based on meeting criteria on ADI-R and/or ADOS
 NA
 82.84% Male
 780104
 0
 2
 2
 sajan_13_ACC/CBLH/PMG_discovery_cases
 Individuals with severe congenital brain malformations [agenesis of the corpus callosum (ACC), cerebellar hypoplasia (CBLH), and/or polymicrogyria (PMG)] and additional neurodevelopmental phenotypes
 487
 Diagnosis of agenesis of the corpus callosum (ACC), cerebellar hypoplasia (CBLH), and/or polymicrogyria (PMG); additional diagnoses of autism spectrum disorder (ASD), developmental delay (DD), intellectual disability (ID) and/or seizures in some patients
 N/A
 N/A
 201138
 2
 1
 3
 sanders_11_ASD_discovery_cases
 Autistic probands from the Simons Simplex Collection (SSC). 872 probands in quartet families, 272 probands in trios.
 1124
 ASD diagnosis: 89.5% autism; 8.5% PDD-NOS, 2% Asperger syndrome. Mean full-scale IQ 85.1 1.5 (mean verbal IQ, 81.9 1.7; mean non-verbal IQ, 88.4 1.4)
 Mean, 9.1 yrs.
 86.1% Male
 379342
 13
 5
 18
 soueid_16_ASD_discovery_cases
 Autistic children; 37/41 from 35 fully analyzed families (33 simplex, 2 multiplex)
 41
 All cases fulfilled DSM-V criteria for autism
 Range, 3-18 yrs.
 92.68% Male
 129000
 1
 0
 1
 soueid_16_DD/ID_discovery_cases
 Individuals referred to clinical neurogenetics service with non-syndromic developmental delay and intellectual disabilities (DD/ID) or rare neurological syndromes
 35
 Cases present with non-syndromic developmental delay and intellectual disabilities (DD/ID) or rare neurological syndromes
 N/A
 N/A
 0
 0
 0
 0
 yin_16_ASD_discovery_cases
 Discovery cohort of ASD cases recruited from the Department of Psychiatry of National Taiwan University Hospital (NTUH), Chang Gung Memorial Hospital (CGMH), Taoyuan, and Taoyuan Mental Hospital (TMH), Taiwan.
 335
 Cases diagnosed with autistic disorder according to DSM-IV and confirmed by using the Chinese version of ADI-R. Cases' autistic behaviors assessed by Social Responsiveness Scale (SRS), and cognitive functions assessed by the Weschler Intelligence Scale for Children-Third Edition (WISC-III) and the Wisconsin Card Sorting Test (WCST).
 Mean, 9.39 4.04 yrs.
 89.3% Male
 50604
 1
 0
 1

Controls

Cohort ID
Author, Year
Descripton
Cohort Size
Diagnosis
Age
Gender
CNV Size
Deletion
Duplication
Total CNV's
 brandler_18_ASD_discovery_controls
 Unaffected individuals from the Relating Genes with Adolescent and Child Health (REACH) cohort (112 individuals from 311 families) and the Simons Simplex 1 (SSC1) cohort (518 controls from simplex quad families)
 630
 Control
 N/A
 N/A
 119212
 1
 1
 2
 coe_14_ASD/DD/ID_discovery_controls
 Adult population controls (cohort consists of 11,255 new controls and 8329 controls originally published in Cooper et al., Nature Genetics 2011); annotated CNVs extracted from Table 1 ("New CNVs") and Supplementary Table 2 ("Newly Significant Genomic Disorders").
 19584
 Control
 N/A
 N/A
 950000
 0
 0
 0
 engchuan_15_ASD_discovery_controls
 Platform-matched controls from three large studies: SAGE (Study of Addiction Genetics and Environment), Ontario Colorectal Cancer study, and HABC (Health Aging and Body Composition)
 2342
 Controls; subjects had no previous psychiatric history
 N/A
 46.67% Male
 566353
 10
 9
 19
 girirajan_12_ASD/DD/ID_discovery_controls
 Persons found to have no overt neurological disorders during screening for other studies
 8329
 Control
 
 
 927965
 NA
 NA
 NA
 girirajan_13a_ASD_discovery_controls3
 Controls assessed for CNVs within 120 SD-mediated hotspots; includes 2090 controls from Wellcome Trust Case-Control Consortium (girirajan_13_ASD_discovery_controls2)
 8329
 Control
 NA
 NA
 0
 0
 0
 0
 girirajan_13b_ASD_discovery_controls
 Controls ascertained from the Childhood Autism Risks from Genetics and Environment (CHARGE) study conducted through the Medical Investigation of Neurodevelopmental Disorders (MIND) Institute at UC-Davis after passing QC criteria (242 initial controls)
 223
 Control
 N/A
 N/A
 378721
 1
 1
 2
 kaminsky_11_DD/ID/ASD_discovery_controls
 Controls from the International Standards for Cytogenomic Arrays (ISCA) consortium
 10118
 Controls
 NA
 NA
 NA
 NA
 NA
 NA
 krumm_13_ASD_discovery_controls
 Unaffected siblings of ASD probands from quad families ascertained as part of the Simons Simplex Collection (SSC); CNVs detected using data from four previously published exome sequencing studies (O'Roak et al., 2011; Iossifov et al., 2012; O'Roak et al., 2012; Sanders et al., 2012)
 411
 Control (unaffected siblings of ASD probands). Social Responsiveness Scale (SRS) used as a quantitative measure of social deficits
 N/A
 46.47% Male
 81938
 1
 3
 4
 krumm_15_ASD_discovery_controls
 Unaffected siblings from quad families from the Simons Simplex Collection
 1786
 Control
 N/A
 N/A
 82625
 0
 5
 5
 kushima_18_ASD/SCZ_discovery_controls
 Individuals selected from the general population and predominantly recruited from the middle of Honshu Island (Japan)
 2095
 Controls had no history of mental disorders based upon responses to questionnaires or self-reporting.
 Median age, 37 years
 52.0% Male
 0
 0
 0
 0
 larson_17_ASD_discovery_controls
  NA NA
 Entries listed in the Database of Genomic Variants (up to October 2017)
 N/A
 Control
 N/A
 N/A
 197025
 0
 1
 1
 levy_11_ASD_discovery_controls
 Unaffected siblings of autistic probands from 887 families from the Simons Simplex Collection (SSC)
 863
 Control
 
 47.97% Male
 90411
 0
 1
 1
 poultney_13_ASD_discovery_controls
 Controls matched for European ancestry from NIMH and CEPH retained after filtering (original cohort size of 379 controls)
 260
 Control
 N/A
 47.49% Male (before filtering)
 424300
 2
 4
 6
 prasad_12_ASD_discovery_controls
 PDx controls [1000 DNA samples from reportedly healthy donors (50.2% male) from BioServe (Beltsville, MD)] and 4139 in-house controls previously reported in Krawcak et al. 2006, Stewart et al. 2009, and Bierut et al. 2010. CNVs identified in controls were used to define rare ASD-specific CNVs.
 5139
 Control
 NA
 NA (PDx controls 50.2% male)
 780104
 0
 0
 0
 sanders_11_ASD_discovery_controls
 Matched siblings of autistic probands from the Simons Simplex Collection (SSC).
 872
 Controls
 Mean, 10.0 yrs.
 
 846552
 9
 8
 17
 soueid_16_ASD_discovery_controls
 Control cohort of normal participants
 37
 Control
 N/A
 51.35% Male
 129000
 1
 0
 1
 yin_16_ASD_discovery_controls
 Individuals from the Han Chinese Cell and Genome Bank (HCCGB) in Taiwan
 1093
 Controls
 Mean, 68.07 10.12 yrs.
 48.0% Male
 50604
 0
 0
 0

Cases

Cohort ID
Geographical Ancestry
Discovery Method
Platform
Algorithm
Software
Validation Method
 al-qattan_14_DD/ID/ASD/ADHD/EP_discovery_cases
  Saudi Arabia
 Array SNP
  Affymetrix 6.0, Affymetrix Cyto-V2, Affymetrix CytoScan HD
 HMM
 Affymetrix GeneChip Command Console v.1.2, Affymetrix ChAS version Cyto 2.0.0.195
 None
 brandler_18_ASD_replication_cases
  N/A
 WGS
  Illumina HiSeq X10
 ForestSV, Lumpy, Manta, Mobster, SV2
 
 None
 celestino-soper_11_ASD_discovery_cases
 
 aCGH
  Agilent 1M
 ADM-2
 Agilent Feature Extraction v10.7.3.1, Agilent DNA Analytics v4.0.76
 None
 chaves_24_ASD/DD/ID_discovery_cases
  Brazil
 Array SNP
  Affymetrix CytoScan 750K, Affymetrix CytoScan HD
 
 Affymetrix ChAS
 
 chung_11_ASD_discovery_cases
  Scottish-Canadian
 Array SNP
  Affymetrix 6.0
 HMM
 Affymetrix Genotyping Console v.2.1, Birdseed v.2
 
 coe_14_ASD/DD/ID_discovery_cases
  N/A
 aCGH
  N/A
 
 
 None
 digregorio_17_DD/ID_discovery_cases
  Italian
 aCGH
  Agilent 60K (SurePrint G3 Human CGH Microarray 8x60K)
 ADM-2
 Agilent CGH Analytics software ver. 4.0.81
 None
 engchuan_15_ASD_discovery_cases
  Caucasian
 Solid phase hybridization
  Illumina 1M
 
 
 None
 girirajan_12_ASD/DD/ID_discovery_cases
 
 aCGH
  BACs aCGH, SignatureChipOS
 
 
 FISH, aCGH, or confirmation by inheritance
 girirajan_13a_ASD_discovery_cases
  NA
 aCGH
  Custom microarray with a high density of probes targeted to 1,367 regions with a susceptible genomic architecture
 ADM-2
 Agilent Genomic Workbench
 aCGH (NimbleGen 135K array)
 girirajan_13a_DD_discovery_cases
  NA
 N/A
  N/A
 
 
 None
 kaminsky_11_DD/ID/ASD_discovery_cases
  NA
 aCGH
  Agilent 44K, Agilent 105K
 
 Feature Extraction, DNA Analytics
 FISH, qPCR, MLPA, aCGH, standard G-banded chromosome analysis
 krumm_13_ASD_discovery_cases
  N/A
 WES
  Whole exome sequencing platforms used in four recent publications (O'Roak et al., 2011; Sanders et al., 2012; O'Roak et al., 2012, and Iossifov et al., 2012)
 DNACopy, CGHCall
 CoNIFER
 Solid phase hybridization (Illumina 1M), aCGH (Agilent SurePrint G3 4x180K), or confirmed by manual inspection
 krumm_15_ASD_discovery_cases
  N/A
 WES
 
 CoNIFER, XHMM
 
 Solid phase hybridization (Illumina 1M, 1 M Duo, or Omni 2.5)
 kushima_18_SCZ_discovery_cases
  Japanese
 aCGH
  NimbleGen 720K, Agilent 400K
 FASST2
 Nexus Copy Number v.9.0
 N/A
 larson_17_ASD_discovery_cases
  United Kingdom
 Array SNP
  Affymetrix CytoScan HD 2.8M, Affymetrix Cytogenetics
 SNP-FASST2 Segmentation
 Nexus Copy Number 7 (BioDiscovery), Affymetrix ChAS
 None
 levy_11_ASD_discovery_cases
 
 aCGH
  NimbleGen HD2
 HMM
 
 
 pinto_10_ASD_discovery_cases
  European
 Solid phase hybridization
  Illumina Infinium 1M SNP microarray
 QuantiSNP, iPattern
 
 qPCR, long-range PCR (LR-PCR), MLPA, FISH, aCGH (Agilent 1M), array SNP (Affymetrix 500K)
 pinto_14_ASD_discovery_cases
  Predominantly European
 Solid phase hybridization
  Illumina 1M (v.1 and v.3)
 
 
 qPCR, MLPA, long-range PCR
 poultney_13_ASD_discovery_cases
  European
 WES
  Agilent SureSelect Human All Exon v.2
 XHMM
 
 None
 prasad_12_ASD_discovery_cases
  Canada
 aCGH
  Agilent 1M
 ADM-2, DNAcopy (R Bioconductor)
 DNA Analytics v4.0.85 (Agilent), DNAcopy
 qPCR
 sajan_13_ACC/CBLH/PMG_discovery_cases
  81.31% Caucasian
 Solid phase hybridization
  Illumina InfiniumII HumanHap610
 PennCNV
 
 qPCR
 sanders_11_ASD_discovery_cases
  White non-Hispanic, 74.5%; mixed, 9.3%, Asian, 4.3%, White Hispanic, 4.0%, African-American, 3.8%; other, 4.2&
 Solid phase hybridization
  Illumina 1M v1, Illumina 1M v3
 PennCNV, QuantiSNP, GNOSIS
 
 
 soueid_16_ASD_discovery_cases
  Lebanon
 Array SNP
  Affymetrix 2.7M, Affymetrix CytoScan
 
 Affymetrix ChAS
 None
 soueid_16_DD/ID_discovery_cases
  Lebanon
 Array SNP
  Affymetrix 2.7M, Affymetrix CytoScan
 
 Affymetrix ChAS
 None
 yin_16_ASD_discovery_cases
  Han Chinese
 Array SNP
  Affymetrix 6.0
 
 Affymetrix Genotyping Console v.4.1
 None

Controls

Cohort ID
Geographical Ancestry
Discovery Method
Platform
Algorithm
Software
Validation Method
  brandler_18_ASD_discovery_controls
  N/A
  WGS
  Illumina HiSeq X10 or HiSeq 2500
  ForestSV, Lumpy, Manta, Mobster, SV2
 
  PCR, array SNP
  coe_14_ASD/DD/ID_discovery_controls
  N/A
  aCGH, solid phase hybridization
  Multiple platforms used (including HumanHap, Illumina, and Human610-Quad)
 
 
  None
  engchuan_15_ASD_discovery_controls
  Caucasian
  Solid phase hybridization
  Illumina 1M
 
 
  None
  girirajan_12_ASD/DD/ID_discovery_controls
 
  aCGH
  BACs ACGH (SignatureChipoWG) or oligoarray (SignatureChipOS)
 
 
 
  girirajan_13a_ASD_discovery_controls3
  NA
  Array SNP
  N/A
 
 
  None
  girirajan_13b_ASD_discovery_controls
  116 European, 70 Hispanic, 27 Mixed Race, 7 Asian, 3 African-American
  aCGH
  Roche NimbleGen custom targeted hotspot array comprised of 135,000 probes with higher density probe coverage in genomic hotspots (regions flanked by segmental duplications)
  DNA Copy Number v1.6
 
 
  kaminsky_11_DD/ID/ASD_discovery_controls
  NA
  aCGH
  Agilent 44K, Agilent 105K
 
  Feature Extraction, DNA Analytics
 
  krumm_13_ASD_discovery_controls
  N/A
  WES
  Whole exome sequencing platforms used in four recent publications (O'Roak et al., 2011; Sanders et al., 2012; O'Roak et al., 2012, and Iossifov et al., 2012)
  DNACopy, CGHCall
  CoNIFER
  Solid phase hybridization (Illumina 1M), aCGH (Agilent SurePrint G3 4x180K), or confirmed by manual inspection
  krumm_15_ASD_discovery_controls
  N/A
  WES
 
  CoNIFER, XHMM
 
  Solid phase hybridization (Illumina 1M, 1 M Duo, or Omni 2.5)
  kushima_18_ASD/SCZ_discovery_controls
  Japanese
  aCGH
  NimbleGen 720K, Agilent 400K
  FASST2
  Nexus Copy Number v.9.0
  N/A
  larson_17_ASD_discovery_controls
  N/A
  N/A
  N/A
 
 
 
  levy_11_ASD_discovery_controls
 
  aCGH
  NimbleGen HD2
  HMM
 
 
  poultney_13_ASD_discovery_controls
  European
  WES
  Agilent SureSelect Human All Exon v.2
  XHMM
 
  None
  prasad_12_ASD_discovery_controls
  NA
  aCGH
  Agilent 1M
  ADM-2, DNAcopy (R Bioconductor)
  DNA Analytics v4.0.85 (Agilent), DNAcopy
 
  sanders_11_ASD_discovery_controls
 
  Solid phase hybridization
  Illumina 1M v1 or Illumina 1M v3
  PennCNV, QuantiSNP, GNOSIS
 
 
  soueid_16_ASD_discovery_controls
  Lebanon
  Array SNP
  Affymetrix 2.7M, Affymetrix CytoScan
 
  Affymetrix ChAS
  None
  yin_16_ASD_discovery_controls
  Han Chinese
  Array SNP
  Affymetrix 6.0
 
  Affymetrix Genotyping Console v.4.1
  None

Cases

Patient ID
Author, Year
Age
Gender
Primary Diagnosis
Clinical Profile
Cognitive Profile
CNV Start
CNV End
CNV Size
Genome Build
Type Method
Validation
  al-qattan_14_DD/ID/ASD/ADHD/EP_discovery_cases-case12DG0055
 N/A
 N/A
 MCA
 Coloboma, bilateral microphthalmia and microcornea, right facial nerve palsy, dysphagia, conductive hearing loss, hemivertebra, scoliosis, and bifid spine (CHARGE-like). Non-consanguineous parents.
 
 97065382
 97285797
  220416
 GRCh38
 Deletion
 No
  brandler_18_ASD_replication_cases-case2-1561-003
 N/A
 M
 ASD
 Case from MSSNG cohort
 
 99421919
 99429308
  7390
 GRCh38
 Deletion
 No
  celestino-soper_11_ASD_discovery_cases-11098
 NA
 M
 ASD
 NA
 NA
 97513266
 97516024
  2759
 GRCh38
 Deletion
 No
  celestino-soper_11_ASD_discovery_cases-11399
 NA
 M
 ASD
 NA
 NA
 101698006
 101698472
  467
 GRCh38
 Deletion
 No
  chaves_24_ASD/DD/ID_discovery_cases-case511
  NA NA
 
 M
 ASD and intellectual disability
 ASD, tall stature, congenital anomalies and facial dysmorphism. Karyotype: 47,XY+mar(64%)/48,XY, ++mar(6%).
 Intellectual disability
 98606452
 101303077
  2696626
 GRCh38
 Duplication
 No
  chung_11_ASD_discovery_cases-proband
 12
 F
 ASD
 Diagnosed with ASD at 8 using ADI-R & ADOS, Module 3. Moderate language delay. Comorbid behavior includes anxiety disorders, aggressive behaviors, self-injurious behaviors, sleep disturbances, & trichotillomania. No history of developmental regression. No history of seizures; normal EEG. Dysmorphic features: high anterior hairline, long face with prognathism, long nose, broad nasal bridge with underdeveloped alae nasi, asymmetic ears, narrow mouth. Camptodactyly, mild 2/3 cutaneous syndactyly, flat narrow feet, shortened 5th toes. Normal eyes and eyebrows. Prominent hypotonia. Brain MRI at 5 revealed mild prominence of Virchow-Robin spaces without any structural abnormalities. Growth parameters: height, weight, & head circumference all >97th %ile.
 WISC-IV assessment: at 7 yrs., 32nd %ile (average range); at 9 yrs., 2nd-8th %ile (borderline range)
 97524837
 97545714
  20878
 GRCh38
 Deletion
 No
  coe_14_ASD/DD/ID_discovery_cases-case541
 N/A
 N/A
 Intellectual disability, developmental delay, and/or ASD
 N/A
 N/A
 96060525
 97010536
  950012
 GRCh38
 Deletion
 No
  coe_14_ASD/DD/ID_discovery_cases-case542
 N/A
 N/A
 Intellectual disability, developmental delay, and/or ASD
 N/A
 N/A
 96060525
 97010536
  950012
 GRCh38
 Deletion
 No
  coe_14_ASD/DD/ID_discovery_cases-case543
 N/A
 N/A
 Intellectual disability, developmental delay, and/or ASD
 N/A
 N/A
 96060525
 97010536
  950012
 GRCh38
 Deletion
 No
  coe_14_ASD/DD/ID_discovery_cases-case544
 N/A
 N/A
 Intellectual disability, developmental delay, and/or ASD
 N/A
 N/A
 96060525
 97010536
  950012
 GRCh38
 Deletion
 No
  coe_14_ASD/DD/ID_discovery_cases-case545
 N/A
 N/A
 Intellectual disability, developmental delay, and/or ASD
 N/A
 N/A
 96060525
 97010536
  950012
 GRCh38
 Deletion
 No
  coe_14_ASD/DD/ID_discovery_cases-case546
 N/A
 N/A
 Intellectual disability, developmental delay, and/or ASD
 N/A
 N/A
 96060525
 97010536
  950012
 GRCh38
 Deletion
 No
  coe_14_ASD/DD/ID_discovery_cases-case547
 N/A
 N/A
 Intellectual disability, developmental delay, and/or ASD
 N/A
 N/A
 96060525
 97010536
  950012
 GRCh38
 Duplication
 No
  coe_14_ASD/DD/ID_discovery_cases-case548
 N/A
 N/A
 Intellectual disability, developmental delay, and/or ASD
 N/A
 N/A
 96060525
 97010536
  950012
 GRCh38
 Duplication
 No
  coe_14_ASD/DD/ID_discovery_cases-case549
 N/A
 N/A
 Intellectual disability, developmental delay, and/or ASD
 N/A
 N/A
 96060525
 97010536
  950012
 GRCh38
 Duplication
 No
  coe_14_ASD/DD/ID_discovery_cases-case550
 N/A
 N/A
 Intellectual disability, developmental delay, and/or ASD
 N/A
 N/A
 96060525
 97010536
  950012
 GRCh38
 Duplication
 No
  digregorio_17_DD/ID_discovery_cases-DECIPHER_300074
  NA NA
 N/A
 F
 Developmental delay/intellectual disability
 
 
 99127005
 99169617
  42613
 GRCh38
 Duplication
 No
  engchuan_15_ASD_discovery_cases-case14056_970
 N/A
 N/A
 ASD
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 
 99221740
 99306504
  84765
 GRCh38
 Duplication
 No
  engchuan_15_ASD_discovery_cases-case17009_1
 N/A
 N/A
 ASD
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 
 101266584
 101344441
  77858
 GRCh38
 Duplication
 No
  engchuan_15_ASD_discovery_cases-case20000_1010002
 N/A
 N/A
 ASD
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 
 99221740
 99306504
  84765
 GRCh38
 Duplication
 No
  engchuan_15_ASD_discovery_cases-case2288_1
 N/A
 N/A
 ASD
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 
 97861227
 98070485
  209259
 GRCh38
 Duplication
 No
  engchuan_15_ASD_discovery_cases-case3309_3
 N/A
 N/A
 ASD
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 
 97200092
 97659389
  459298
 GRCh38
 Duplication
 No
  engchuan_15_ASD_discovery_cases-case3385_3
 N/A
 N/A
 ASD
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 
 97087398
 97267355
  179958
 GRCh38
 Duplication
 No
  engchuan_15_ASD_discovery_cases-case3418_3
 N/A
 N/A
 ASD
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 
 99221740
 99299884
  78145
 GRCh38
 Duplication
 No
  engchuan_15_ASD_discovery_cases-case3484_3
 N/A
 N/A
 ASD
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 
 97117673
 97267355
  149683
 GRCh38
 Deletion
 No
  engchuan_15_ASD_discovery_cases-case3571_4
 N/A
 N/A
 ASD
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 
 99216756
 99306504
  89749
 GRCh38
 Duplication
 No
  engchuan_15_ASD_discovery_cases-case3616_3
 N/A
 N/A
 ASD
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 
 97489619
 97658891
  169273
 GRCh38
 Duplication
 No
  engchuan_15_ASD_discovery_cases-case4236_1
 N/A
 N/A
 ASD
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 
 98377951
 100393206
  2015256
 GRCh38
 Duplication
 No
  engchuan_15_ASD_discovery_cases-case4548_1
 N/A
 N/A
 ASD
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 
 97085273
 97499218
  413946
 GRCh38
 Deletion
 No
  engchuan_15_ASD_discovery_cases-case5000_3
 N/A
 N/A
 ASD
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 
 97068081
 97267355
  199275
 GRCh38
 Duplication
 No
  engchuan_15_ASD_discovery_cases-case5244_3
 N/A
 N/A
 ASD
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 
 97051608
 97267355
  215748
 GRCh38
 Deletion
 No
  engchuan_15_ASD_discovery_cases-case6312_4
 N/A
 N/A
 ASD
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 
 99221740
 99300136
  78397
 GRCh38
 Duplication
 No
  engchuan_15_ASD_discovery_cases-case8451_201
 N/A
 N/A
 ASD
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 
 99221740
 99306504
  84765
 GRCh38
 Duplication
 No
  engchuan_15_ASD_discovery_cases-case8651_201
 N/A
 N/A
 ASD
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 
 97073320
 97267355
  194036
 GRCh38
 Deletion
 No
  girirajan_12_ASD/DD/ID_discovery_cases-case51723
 3 yrs. 4 mos.
 M
 Developmental delay
 Speech delay. Normal tone. Frontal lobe atrophy, hearing loss. Dysmorphic features: micrognathia, low-set ears, blepharophimosis. Congenital anomalies: cryptorchidism. Other features: strabismus, retinopathy, astigmatism. Growth parameters: weight 97th %ile, OFC 97th %ile. Family history: healthy parents.
 NA
 96077682
 97005658
  927977
 GRCh38
 Deletion
 Yes
  girirajan_13a_ASD_discovery_cases-12550.p1
 N/A
 N/A
 ASD
 Diagnosis of ASD based on meeting criteria on the Autism Diagnostic Observation Schedule (ADOS) and on the Autism Diagnostic Interview, Revised (ADI-R)
 N/A
 96084424
 97020346
  935923
 GRCh38
 Deletion
 Yes
  girirajan_13a_ASD_discovery_cases-14043.p1
 N/A
 N/A
 ASD
 Diagnosis of ASD based on meeting criteria on the Autism Diagnostic Observation Schedule (ADOS) and on the Autism Diagnostic Interview, Revised (ADI-R)
 N/A
 96084424
 97020346
  935923
 GRCh38
 Deletion
 Yes
  girirajan_13a_DD_discovery_cases-DDcase100
 N/A
 N/A
 Developmental delay
 N/A
 N/A
 96084424
 97020346
  935923
 GRCh38
 Deletion
 No
  girirajan_13a_DD_discovery_cases-DDcase99
 N/A
 N/A
 Developmental delay
 N/A
 N/A
 96084424
 97020346
  935923
 GRCh38
 Deletion
 No
  kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00000835
 NA
 NA
 Developmental delay/intellectual disability/ASD
 Clinical profile NA
 Cognitive profile NA
 95879602
 97029672
  1150071
 GRCh38
 Duplication
 Yes
  kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00001088
 NA
 NA
 Developmental delay/intellectual disability/ASD
 Clinical profile NA
 Cognitive profile NA
 96100812
 97267355
  1166544
 GRCh38
 Deletion
 Yes
  kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00002200
 NA
 NA
 Developmental delay/intellectual disability/ASD
 Clinical profile NA
 Cognitive profile NA
 101080018
 101646523
  566506
 GRCh38
 Duplication
 Yes
  kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00002259
 NA
 NA
 Developmental delay/intellectual disability/ASD
 Clinical profile NA
 Cognitive profile NA
 95880668
 97131646
  1250979
 GRCh38
 Duplication
 Yes
  kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00002743
 NA
 NA
 Developmental delay/intellectual disability/ASD
 Clinical profile NA
 Cognitive profile NA
 97634165
 97841153
  206989
 GRCh38
 Duplication
 Yes
  kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00002785
 NA
 NA
 Developmental delay/intellectual disability/ASD
 Clinical profile NA
 Cognitive profile NA
 95806265
 97267355
  1461091
 GRCh38
 Duplication
 Yes
  kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00004015
 NA
 NA
 Developmental delay/intellectual disability/ASD
 Clinical profile NA
 Cognitive profile NA
 95810453
 97024341
  1213889
 GRCh38
 Duplication
 Yes
  kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00004706
 NA
 NA
 Developmental delay/intellectual disability/ASD
 Clinical profile NA
 Cognitive profile NA
 95879602
 97267355
  1387754
 GRCh38
 Deletion
 Yes
  kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00005076
 NA
 NA
 Developmental delay/intellectual disability/ASD
 Clinical profile NA
 Cognitive profile NA
 98787057
 100785053
  1997997
 GRCh38
 Deletion
 Yes
  kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00005087
 NA
 NA
 Developmental delay/intellectual disability/ASD
 Clinical profile NA
 Cognitive profile NA
 95916534
 97024341
  1107808
 GRCh38
 Duplication
 Yes
  kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00005242
 NA
 NA
 Developmental delay/intellectual disability/ASD
 Clinical profile NA
 Cognitive profile NA
 96100612
 97267355
  1166744
 GRCh38
 Duplication
 Yes
  krumm_13_ASD_discovery_cases-case11045.p1
 N/A
 F
 ASD
 ASD proband from SSC quad family 11045. SRS score of 60.
 Full-scale IQ (FSIQ) score of 79.
 101790719
 101799643
  8925
 GRCh38
 Duplication
 Yes
  krumm_13_ASD_discovery_cases-case11484.p1
 N/A
 M
 ASD
 ASD proband from SSC quad family 11484. SRS score of 76.
 Full-scale IQ (FSIQ) score of 106.
 97646086
 97659477
  13392
 GRCh38
 Duplication
 No (not tested)
  krumm_13_ASD_discovery_cases-case13507.p1
 N/A
 M
 ASD
 ASD proband from SSC quad family 13507. SRS score of 46.
 Full-scale IQ (FSIQ) score of 101.
 97576378
 97659477
  83100
 GRCh38
 Duplication
 No (not tested)
  krumm_13_ASD_discovery_cases-case13795.p1
 N/A
 F
 ASD
 ASD proband from SSC quad family 13795. SRS score of 90.
 Full-scale IQ (FSIQ) score of 34.
 99284392
 99292640
  8249
 GRCh38
 Duplication
 No (not tested)
  krumm_15_ASD_discovery_cases-case11045.p1
 N/A
 Female
 ASD
 Proband from the Simons Simplex Collection (SSC). Family type: Quad
 
 101790719
 101799643
  8925
 GRCh38
 Duplication
 Yes
  krumm_15_ASD_discovery_cases-case11099.p1
 N/A
 Male
 ASD
 Proband from the Simons Simplex Collection (SSC). Family type: Quad
 
 97584943
 97659003
  74061
 GRCh38
 Duplication
 Yes
  krumm_15_ASD_discovery_cases-case11765.p1
 N/A
 Male
 ASD
 Proband from the Simons Simplex Collection (SSC). Family type: Quad
 
 99242363
 99295670
  53308
 GRCh38
 Duplication
 Yes
  krumm_15_ASD_discovery_cases-case12853.p1
 N/A
 Male
 ASD
 Proband from the Simons Simplex Collection (SSC). Family type: Quad
 
 99242363
 99295670
  53308
 GRCh38
 Duplication
 Yes
  krumm_15_ASD_discovery_cases-case13507.p1
 N/A
 Male
 ASD
 Proband from the Simons Simplex Collection (SSC). Family type: Quad
 
 97555059
 97660646
  105588
 GRCh38
 Duplication
 Yes
  krumm_15_ASD_discovery_cases-case13968.p1
 N/A
 Male
 ASD
 Proband from the Simons Simplex Collection (SSC). Family type: Quad
 
 98093092
 98236477
  143386
 GRCh38
 Deletion
 Yes
  kushima_18_SCZ_discovery_cases-caseSCZ1051
 48 yrs.
 M
 Schizophrenia, ID
 Behavioral/psychiatric evaluation: onset of schizophrenia at 16 years of age (core symptoms include delusions, hallucinations, agitated and violent behavior, negative symptoms). Brain imaging: hippocampal atrophy on brain CT. Family history: positive for intellectual disability (ID).
 Intellectual disability (IQ < 70)
 96063558
 97079140
  1015583
 GRCh38
 Deletion
 N/A
  larson_17_ASD_discovery_cases-case28
  NA NA
 N/A
 N/A
 ASD and psychosis
 No additional clinical information available. Patient carries CNV that is present in DGV (less than 1.5%) but was not present in 1124 ASD cases without psychosis from the Simons Simplex Collection.
 
 97099593
 97212320
  112728
 GRCh38
 Duplication
 No
  larson_17_ASD_discovery_cases-case29
  NA NA
 N/A
 N/A
 ASD and psychosis
 No additional clinical information available. Patient carries CNV that is present in DGV (less than 1.5%) but was not present in 1124 ASD cases without psychosis from the Simons Simplex Collection.
 
 97099593
 97212320
  112728
 GRCh38
 Duplication
 No
  larson_17_ASD_discovery_cases-case30
  NA NA
 N/A
 N/A
 ASD and psychosis
 No additional clinical information available. Patient carries CNV that is present in DGV (less than 1.5%) but was not present in 1124 ASD cases without psychosis from the Simons Simplex Collection.
 
 97099593
 97212320
  112728
 GRCh38
 Duplication
 No
  larson_17_ASD_discovery_cases-case31
  NA NA
 N/A
 N/A
 ASD and psychosis
 No additional clinical information available. Patient carries CNV that is present in DGV (less than 1.5%) but was not present in 1124 ASD cases without psychosis from the Simons Simplex Collection.
 
 97099593
 97212320
  112728
 GRCh38
 Duplication
 No
  larson_17_ASD_discovery_cases-case32
  NA NA
 N/A
 N/A
 ASD and psychosis
 No additional clinical information available. Patient carries CNV that is present in DGV (less than 1.5%) but was not present in 1124 ASD cases without psychosis from the Simons Simplex Collection.
 
 97099593
 97212320
  112728
 GRCh38
 Duplication
 No
  larson_17_ASD_discovery_cases-case33
  NA NA
 N/A
 N/A
 ASD and psychosis
 No additional clinical information available. Patient carries CNV that is present in DGV (less than 1.5%) but was not present in 1124 ASD cases without psychosis from the Simons Simplex Collection.
 
 97099593
 97212320
  112728
 GRCh38
 Duplication
 No
  larson_17_ASD_discovery_cases-case34
  NA NA
 N/A
 N/A
 ASD and psychosis
 No additional clinical information available. Patient carries CNV that is present in DGV (less than 1.5%) but was not present in 1124 ASD cases without psychosis from the Simons Simplex Collection.
 
 97099593
 97212320
  112728
 GRCh38
 Duplication
 No
  larson_17_ASD_discovery_cases-case35
  NA NA
 N/A
 N/A
 ASD and psychosis
 No additional clinical information available. Patient carries CNV that is present in DGV (less than 1.5%) but was not present in 1124 ASD cases without psychosis from the Simons Simplex Collection.
 
 97099593
 97212320
  112728
 GRCh38
 Duplication
 No
  larson_17_ASD_discovery_cases-case36
  NA NA
 N/A
 N/A
 ASD and psychosis
 No additional clinical information available. Patient carries CNV that is present in DGV (less than 1.5%) but was not present in 1124 ASD cases without psychosis from the Simons Simplex Collection.
 
 97521961
 97549529
  27569
 GRCh38
 Duplication
 No
  larson_17_ASD_discovery_cases-case37
  NA NA
 N/A
 N/A
 ASD and psychosis
 No additional clinical information available. Patient carries CNV that is present in DGV (less than 1.5%) but was not present in 1124 ASD cases without psychosis from the Simons Simplex Collection.
 
 97521961
 97549529
  27569
 GRCh38
 Duplication
 No
  larson_17_ASD_discovery_cases-case38
  NA NA
 N/A
 N/A
 ASD and psychosis
 No additional clinical information available. Patient carries CNV that is present in DGV (less than 1.5%) but was not present in 1124 ASD cases without psychosis from the Simons Simplex Collection.
 
 97521961
 97549529
  27569
 GRCh38
 Duplication
 No
  larson_17_ASD_discovery_cases-case39
  NA NA
 N/A
 N/A
 ASD and psychosis
 No additional clinical information available. Patient carries CNV that is present in DGV (less than 1.5%) but was not present in 1124 ASD cases without psychosis from the Simons Simplex Collection.
 
 97521961
 97549529
  27569
 GRCh38
 Duplication
 No
  larson_17_ASD_discovery_cases-case44
  NA NA
 N/A
 N/A
 ASD and psychosis
 No additional clinical information available. Patient carries CNV that is present in DGV (less than 1.5%) but was not present in 1124 ASD cases without psychosis from the Simons Simplex Collection.
 
 97015295
 97212320
  197026
 GRCh38
 Duplication
 No
  levy_11_ASD_discovery_cases-11045.p1
 NA
 F
 ASD
 NA
 NA
 101759366
 101812346
  52981
 GRCh38
 Duplication
 No
  levy_11_ASD_discovery_cases-11765.p1
 NA
 M
 ASD
 NA
 NA
 99217230
 99307640
  90411
 GRCh38
 Duplication
 No
  pinto_10_ASD_discovery_cases-case5000_3
 NA
 F
 ASD
 NA
 NA
 97068081
 97267355
  199275
 GRCh38
 Duplication
 Yes
  pinto_14_ASD_discovery_cases2-case20000_1010002
 N/A
 F
 ASD
 Clinical profile: N/A.
 Cognitive profile: N/A.
 99221740
 99306504
  84765
 GRCh38
 Duplication
 Yes
  poultney_13_ASD_discovery_cases-case00HI1465A
 N/A
 M
 ASD
 ASD case from AGRE (AGRE ID AU032706; NDAR ID NDAR_INVTU259PHM)
 
 97084167
 97118525
  34359
 GRCh38
 Deletion
 No
  poultney_13_ASD_discovery_cases-case04HI3272A
 N/A
 M
 ASD
 ASD case from AGRE (AGRE ID AU1158302; NDAR ID NDAR_INVHN818LB9)
 
 97536300
 97659005
  122706
 GRCh38
 Duplication
 No
  poultney_13_ASD_discovery_cases-case98HI0098B
 N/A
 M
 ASD
 ASD case from AGRE (AGRE ID AU015703; NDAR ID N/A)
 
 100566501
 100576498
  9998
 GRCh38
 Duplication
 No
  poultney_13_ASD_discovery_cases-case99HI1043A
 N/A
 M
 ASD
 ASD case from AGRE (AGRE ID AU006305; NDAR ID NDAR_INVRH216ZC3)
 
 100566501
 100576498
  9998
 GRCh38
 Duplication
 No
  prasad_12_ASD_discovery_cases-case47173L
 NA
 F
 ASD
 Diagnosis of ASD based on meeting criteria on ADI-R and/or ADOS. Novel CNV
 
 99091635
 99871738
  780104
 Unknown
 Duplication
 Yes
  prasad_12_ASD_discovery_cases-case86605L
 NA
 M
 ASD
 Diagnosis of ASD based on meeting criteria on ADI-R and/or ADOS. CNV identified by previous SNP microarray study
 
 99109302
 99165206
  55905
 Unknown
 Duplication
 No
  sajan_13_ACC/CBLH/PMG_discovery_cases-caseDR08-020a1
 N/A
 N/A
 CBLH
 Diagnosis of cerebellar hypoplasia (CBLH).
 
 97160375
 97267355
  106981
 GRCh38
 Deletion
 No
  sajan_13_ACC/CBLH/PMG_discovery_cases-caseLR07-125
 N/A
 N/A
 ACC
 Diagnosis of agenesis of the corpus callosum (ACC). ASD: N/A. Seizures: N/A.
 Developmental delay: N/A. Intellectual disability: N/A.
 98099401
 98222904
  123504
 GRCh38
 Deletion
 Yes
  sajan_13_ACC/CBLH/PMG_discovery_cases-caseLR08-375
 N/A
 N/A
 CBLH-PMG
 Diagnosis of cerebellar hypoplasia (CBLH) and polymicrogyria (PMG).
 
 99221740
 99306504
  84765
 GRCh38
 Duplication
 No
  sanders_11_ASD_discovery_cases-11004.p1
 15.8
 M
 ASD
 NA
 Full-scale IQ, 59; non-verbal IQ, 74; verbal IQ, 31
 97194096
 97227072
  32977
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-11111.p1
 7.4
 M
 Autism
 NA
 Full-scale IQ, 86; non-verbal IQ, 81; verbal IQ 100
 97194096
 97215530
  21435
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-11134.p1
 13.6
 M
 Autism
 NA
 Full-scale IQ, 117; non-verbal IQ, 115; verbal IQ 116
 98957008
 99216756
  259749
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-11252.p1
 6.3
 M
 Autism
 NA
 Full-scale IQ, 78; non-verbal IQ, 72; verbal IQ, 96
 97085273
 97267355
  182083
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-11258.p1
 14.8
 M
 Autism
 NA
 Full-scale IQ, 108; non-verbal IQ, 119; verbal IQ, 96
 97194096
 97215530
  21435
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-11378.p1
 9.8
 M
 Autism
 NA
 Full-scale IQ, 77; non-verbal IQ, 91; verbal IQ, 48
 97194096
 97227072
  32977
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-11484.p1
 10.8
 M
 Autism
 NA
 Full-scale IQ, 106; non-verbal IQ, 110; verbal IQ, 104
 97489619
 97657198
  167580
 GRCh38
 Duplication
 No
  sanders_11_ASD_discovery_cases-11526.p1
 7.6
 M
 Autism
 NA
 Full-scale IQ, 89; non-verbal IQ, 92; verbal IQ, 85
 97194096
 97227072
  32977
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-11657.p1
 4.9
 M
 Autism
 NA
 Full-scale IQ, 71; non-verbal IQ, 75; verbal IQ, 73
 100179786
 100213886
  34101
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-11679.p1
 6.4
 M
 Autism
 NA
 Full-scale IQ, 97; non-verbal IQ, 106; verbal IQ, 84
 102045710
 102054606
  8897
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-11765.p1
 11.2
 M
 Autism
 NA
 Full-scale IQ, 34; non-verbal IQ, 39; verbal IQ, 24
 99216756
 99306504
  89749
 GRCh38
 Duplication
 No
  sanders_11_ASD_discovery_cases-11917.p1
 8
 M
 Autism
 NA
 Full-scale IQ, 98; non-verbal IQ, 115; verbal IQ, 71
 97179363
 97513270
  333908
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-11981.p1
 6.6
 F
 Aspergers
 NA
 Full-scale IQ, 99; non-verbal IQ, 99; verbal IQ, 100
 97861227
 98070485
  209259
 GRCh38
 Duplication
 No
  sanders_11_ASD_discovery_cases-12158.p1
 5.7
 M
 Autism
 NA
 Full-scale IQ, 86; non-verbal IQ, 81; verbal IQ, 100
 97194096
 97205577
  11482
 GRCh38
 Duplication
 No
  sanders_11_ASD_discovery_cases-12785.p1
 7.6
 M
 Autism
 NA
 Full-scale IQ, 84; non-verbal IQ, 85; verbal IQ, 88
 97073320
 97499231
  425912
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-12828.p1
 9.3
 F
 Autism
 NA
 Full-scale IQ, 59; non-verbal IQ, 57; verbal IQ, 66
 97044562
 97267355
  222794
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-12853.p1
 9.8
 M
 Autism
 NA
 Full-scale IQ, 96; non-verbal IQ, 97; verbal IQ, 94
 99221740
 99271994
  50255
 GRCh38
 Duplication
 No
  sanders_11_ASD_discovery_cases-13152.p1
 7.3
 M
 Autism
 NA
 Full-scale IQ, 77; non-verbal IQ, 79; verbal IQ, 78
 97348020
 97359885
  11866
 GRCh38
 Deletion
 No
  soueid_16_ASD_discovery_cases-caseSAI36
 N/A
 
 Autism
 Case fulfilled DSM-V criteria for autism; no other information available
 
 97307772
 97422164
  114393
 GRCh38
 Deletion
 No
  yin_16_ASD_discovery_cases-case74
 N/A
 N/A
 ASD
 Cases diagnosed with autistic disorder according to DSM-IV and confirmed by using the Chinese version of ADI-R.
 
 98639438
 98690041
  50604
 GRCh38
 Deletion
 No

Controls

Patient ID
Author, Year
Age
Gender
Primary Diagnosis
Clinical Profile
Cognitive Profile
CNV Start
CNV End
CNV Size
Genome Build
Type Method
Validation
  brandler_18_ASD_discovery_controls-controlREACH000340
  N/A
  M
  Control
  Control from REACH cohort
 
  96455564
  96574776
  119213
  GRCh38
  Duplication
  Yes
  brandler_18_ASD_discovery_controls-controlSSC05183
  N/A
  F
  Control
  Control from SSC cohort
 
  99342009
  99348436
  6428
  GRCh38
  Deletion
  Yes
  engchuan_15_ASD_discovery_controls-control110036015501_
  N/A
  N/A
  Control
  No previous psychiatric history
 
  97087398
  97585795
  498398
  GRCh38
  Deletion
  No
  engchuan_15_ASD_discovery_controls-controlB140638_1007853950
  N/A
  N/A
  Control
  No previous psychiatric history
 
  97073320
  97492322
  419003
  GRCh38
  Deletion
  No
  engchuan_15_ASD_discovery_controls-controlB253888_1007853986
  N/A
  N/A
  Control
  No previous psychiatric history
 
  97489619
  97659389
  169771
  GRCh38
  Duplication
  No
  engchuan_15_ASD_discovery_controls-controlB285779_1007874679
  N/A
  N/A
  Control
  No previous psychiatric history
 
  97051608
  97267355
  215748
  GRCh38
  Deletion
  No
  engchuan_15_ASD_discovery_controls-controlB347545_0067942603
  N/A
  N/A
  Control
  No previous psychiatric history
 
  97051608
  97267355
  215748
  GRCh38
  Deletion
  No
  engchuan_15_ASD_discovery_controls-controlB524961_1007872292
  N/A
  N/A
  Control
  No previous psychiatric history
 
  97051608
  97585795
  534188
  GRCh38
  Deletion
  No
  engchuan_15_ASD_discovery_controls-controlB536568_1007854032
  N/A
  N/A
  Control
  No previous psychiatric history
 
  97073320
  97492322
  419003
  GRCh38
  Deletion
  No
  engchuan_15_ASD_discovery_controls-controlB613109_1007875803
  N/A
  N/A
  Control
  No previous psychiatric history
 
  100070024
  100144847
  74824
  GRCh38
  Duplication
  No
  engchuan_15_ASD_discovery_controls-controlB675310_1007874657
  N/A
  N/A
  Control
  No previous psychiatric history
 
  99221740
  99306504
  84765
  GRCh38
  Duplication
  No
  engchuan_15_ASD_discovery_controls-controlB747096_1007854180
  N/A
  N/A
  Control
  No previous psychiatric history
 
  99221740
  99302092
  80353
  GRCh38
  Duplication
  No
  engchuan_15_ASD_discovery_controls-controlB757128_1007874832
  N/A
  N/A
  Control
  No previous psychiatric history
 
  97984887
  98551240
  566354
  GRCh38
  Duplication
  No
  engchuan_15_ASD_discovery_controls-controlB809518_0057061032
  N/A
  N/A
  Control
  No previous psychiatric history
 
  97085273
  97492048
  406776
  GRCh38
  Deletion
  No
  engchuan_15_ASD_discovery_controls-controlHABC_900201_900201
  N/A
  N/A
  Control
  No previous psychiatric history
 
  97489619
  97659389
  169771
  GRCh38
  Duplication
  No
  engchuan_15_ASD_discovery_controls-controlHABC_900250_900250
  N/A
  N/A
  Control
  No previous psychiatric history
 
  97117673
  97267355
  149683
  GRCh38
  Deletion
  No
  engchuan_15_ASD_discovery_controls-controlHABC_900943_900943
  N/A
  N/A
  Control
  No previous psychiatric history
 
  97086560
  97492322
  405763
  GRCh38
  Duplication
  No
  engchuan_15_ASD_discovery_controls-controlHABC_901132_901132
  N/A
  N/A
  Control
  No previous psychiatric history
 
  97081697
  97492322
  410626
  GRCh38
  Deletion
  No
  engchuan_15_ASD_discovery_controls-controlHABC_901140_901140
  N/A
  N/A
  Control
  No previous psychiatric history
 
  97081697
  97492322
  410626
  GRCh38
  Deletion
  No
  engchuan_15_ASD_discovery_controls-controlHABC_901223_901223
  N/A
  N/A
  Control
  No previous psychiatric history
 
  99221740
  99306504
  84765
  GRCh38
  Duplication
  No
  engchuan_15_ASD_discovery_controls-controlHABC_901266_901266
  N/A
  N/A
  Control
  No previous psychiatric history
 
  97085273
  97267355
  182083
  GRCh38
  Duplication
  No
  girirajan_13b_ASD_discovery_controls-10208109404
  N/A
  N/A
  Control
  Ethnicity: Asian
  N/A
  95693087
  96071808
  378722
  GRCh38
  Duplication
  No
  girirajan_13b_ASD_discovery_controls-2105102564
  N/A
  N/A
  Control
  Ethnicity: Mixed Race
  N/A
  96711139
  96764130
  52992
  GRCh38
  Deletion
  No
  krumm_13_ASD_discovery_controls-control11484.s1
  N/A
  M
  Control
  Unaffected sibling from SSC quad family 11484. SRS score of 43.
 
  97647066
  97659477
  12412
  GRCh38
  Duplication
  Yes
  krumm_13_ASD_discovery_controls-control13166.s1
  N/A
  M
  Control
  Unaffected sibling from SSC quad family 13166. SRS score of 39.
 
  98250317
  98256174
  5858
  GRCh38
  Deletion
  No (not tested)
  krumm_13_ASD_discovery_controls-control13507.s1
  N/A
  M
  Control
  Unaffected sibling from SSC quad family 13507. SRS score of 37.
 
  97576378
  97658316
  81939
  GRCh38
  Duplication
  No (not tested)
  krumm_13_ASD_discovery_controls-control13508.s1
  N/A
  F
  Control
  Unaffected sibling from SSC quad family 13508. SRS score of 41.
 
  99242363
  99295670
  53308
  GRCh38
  Duplication
  No (not tested)
  krumm_15_ASD_discovery_controls-control11765.s1
  N/A
  Female
  Control
  Unaffected sibling from the Simons Simplex Collection (SSC)
 
  99242363
  99295670
  53308
  GRCh38
  Duplication
  Yes
  krumm_15_ASD_discovery_controls-control12091.s1
  N/A
  Male
  Control
  Unaffected sibling from the Simons Simplex Collection (SSC)
 
  97576378
  97659003
  82626
  GRCh38
  Duplication
  Yes
  krumm_15_ASD_discovery_controls-control12853.s1
  N/A
  Male
  Control
  Unaffected sibling from the Simons Simplex Collection (SSC)
 
  99242363
  99295670
  53308
  GRCh38
  Duplication
  Yes
  krumm_15_ASD_discovery_controls-control13508.s1
  N/A
  Female
  Control
  Unaffected sibling from the Simons Simplex Collection (SSC)
 
  99242363
  99295670
  53308
  GRCh38
  Duplication
  Yes
  krumm_15_ASD_discovery_controls-control13531.s1
  N/A
  Female
  Control
  Unaffected sibling from the Simons Simplex Collection (SSC)
 
  97584943
  97659477
  74535
  GRCh38
  Duplication
  Yes
  levy_11_ASD_discovery_controls-11765.s1
  NA
  F
  Control
  NA
  NA
  99217230
  99307640
  90411
  GRCh38
  Duplication
  No
  poultney_13_ASD_discovery_controls-control04C28851A
  N/A
  M
  Control
  NIMH Control (NIMH ID 46341)
 
  97513180
  97560860
  47681
  GRCh38
  Duplication
  No
  poultney_13_ASD_discovery_controls-control04C31069A
  N/A
  M
  Control
  NIMH Control (NIMH ID 68756)
 
  97888052
  98312351
  424300
  GRCh38
  Duplication
  No
  poultney_13_ASD_discovery_controls-control04C32509B
  N/A
  M
  Control
  NIMH Control (NIMH ID 73661)
 
  97083946
  97118525
  34580
  GRCh38
  Deletion
  No
  poultney_13_ASD_discovery_controls-control04C37424A
  N/A
  M
  Control
  NIMH Control (NIMH ID 98134)
 
  97084167
  97118525
  34359
  GRCh38
  Deletion
  No
  poultney_13_ASD_discovery_controls-control05C38812A
  N/A
  F
  Control
  NIMH Control (NIMH ID 76987)
 
  98093091
  98194494
  101404
  GRCh38
  Duplication
  No
  poultney_13_ASD_discovery_controls-control05C44633
  N/A
  F
  Control
  NIMH Control (NIMH ID 59719)
 
  97551452
  97659005
  107554
  GRCh38
  Duplication
  No
  sanders_11_ASD_discovery_controls-11032.s1
  3.7
  M
  Control (matched sibling)
  NA
  NA
  97194096
  97211854
  17759
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-11073.s1
  7.8
  F
  Control (matched sibling)
  NA
  NA
  97194096
  97211854
  17759
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-11124.s1
  13.3
  M
  Control (matched sibling)
  NA
  NA
  96006253
  96035209
  28957
  GRCh38
  Duplication
  No
  sanders_11_ASD_discovery_controls-11252.s1
  11.4
  M
  Control (matched sibling)
  NA
  NA
  97086560
  97499231
  412672
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-11330.s1
  11.8
  F
  Control (matched sibling)
  NA
  NA
  97073320
  97267355
  194036
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-11512.s1
  4.3
  F
  Control (matched sibling)
  NA
  NA
  97117673
  97227072
  109400
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-11679.s1
  4
  M
  Control (matched sibling)
  NA
  NA
  102045710
  102054606
  8897
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-11765.s1
  7.8
  F
  Control (matched sibling)
  NA
  NA
  99216756
  99306504
  89749
  GRCh38
  Duplication
  No
  sanders_11_ASD_discovery_controls-11917.s1
  4.3
  F
  Control (matched sibling)
  NA
  NA
  97208827
  97391818
  182991
  NCBI36
  Deletion
  No
  sanders_11_ASD_discovery_controls-11948.s1
  11.8
  M
  Control (matched sibling)
  NA
  NA
  97117673
  97205577
  87905
  GRCh38
  Duplication
  No
  sanders_11_ASD_discovery_controls-11990.s1
  13.4
  M
  Control (matched sibling)
  NA
  NA
  97117673
  97194486
  76814
  GRCh38
  Duplication
  No
  sanders_11_ASD_discovery_controls-12091.s1
  7.2
  M
  Control (matched sibling)
  NA
  NA
  97489619
  97658920
  169302
  GRCh38
  Duplication
  No
  sanders_11_ASD_discovery_controls-12701.s1
  10.4
  M
  Control (matched sibling)
  NA
  NA
  97086560
  97267355
  180796
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-12851.s1
  5.8
  M
  Control (matched sibling)
  NA
  NA
  97179363
  97585795
  406433
  GRCh38
  Duplication
  No
  sanders_11_ASD_discovery_controls-12851.s1
  5.8
  M
  Control (matched sibling)
  NA
  NA
  96065361
  96911924
  846564
  GRCh38
  Duplication
  No
  sanders_11_ASD_discovery_controls-12853.s1
  8
  M
  Control (matched sibling)
  NA
  NA
  99216756
  99302081
  85326
  GRCh38
  Duplication
  No
  sanders_11_ASD_discovery_controls-13166.s1
  5.6
  M
  Control (matched sibling)
  NA
  NA
  98245634
  98270203
  24570
  GRCh38
  Deletion
  No
  soueid_16_ASD_discovery_controls-control7
  N/A
  N/A
  Control
 
 
  97307772
  97422164
  114393
  GRCh38
  Deletion
  No

Cases

Patient ID
Validation Description
Primary Disorder Inheritence
Inheritence
Family Profile
Disease Segregation
Gene Content
Altered Gene Expression
 al-qattan_14_DD/ID/ASD/ADHD/EP_discovery_cases-case12DG0055
 
 
 Unknown
 Unknown
 Unknown
 GPAT2P2,RN7SL313P,FAHD2B,ANKRD36
 
 brandler_18_ASD_replication_cases-case2-1561-003
 No validation step reported
 
 Paternal
 
 
 REV1
 
 celestino-soper_11_ASD_discovery_cases-11098
 
 
 Unknown
 Simplex
 NA
 ANKRD36B
 
 celestino-soper_11_ASD_discovery_cases-11399
 
 
 Unknown
 Simplex
 NA
 MAP4K4
 
 chaves_24_ASD/DD/ID_discovery_cases-case511
 
 
 Unknown
 
 
 MRPL30,REV1,LIPT1,CNOT11,PDCL3,TSGA10,RALBP1P2,NMS,MITD1,LYG1,LINC01104,C2orf15,CYCSP7,LONRF2,LYG2,RNF149,CRACDL,SMC3P1,COA5,ARPP19P2,SNORD89,YWHAQP5,NPAS2,AFF3,RNU7-46P,TBC1D8-AS1,NANOGNBP1,HMGN2P22,LINC02611,NPAS2-AS1,RPL31,LINC01849,BBIP1P1,RNU4-84P,LINC01868,EIF5B,CHST10,TXNDC9,MGAT4A,TBC1D8,UNC50
 
 chung_11_ASD_discovery_cases-proband
 
 
 Maternal
 Simplex
 NA
 ANKRD36B
 
 coe_14_ASD/DD/ID_discovery_cases-case541
 
 
 Unknown
 Unknown
 Unknown
 ADRA2B,DUSP2,ITPRIPL1,MIR3127,RNA5SP101,ASTL,STARD7-AS1,TMEM127,CIAO1,SNRNP200,NEURL3,ARID5A,FER1L5,CNNM4,CNNM3-DT,CNNM3,ANKRD23,ANKRD39,FAM178B,STARD7,NCAPH,KANSL3,LMAN2L,SEMA4C
 
 coe_14_ASD/DD/ID_discovery_cases-case542
 
 
 Unknown
 Unknown
 Unknown
 ADRA2B,DUSP2,ITPRIPL1,MIR3127,RNA5SP101,ASTL,STARD7-AS1,TMEM127,CIAO1,SNRNP200,NEURL3,ARID5A,FER1L5,CNNM4,CNNM3-DT,CNNM3,ANKRD23,ANKRD39,FAM178B,STARD7,NCAPH,KANSL3,LMAN2L,SEMA4C
 
 coe_14_ASD/DD/ID_discovery_cases-case543
 
 
 Unknown
 Unknown
 Unknown
 ADRA2B,DUSP2,ITPRIPL1,MIR3127,RNA5SP101,ASTL,STARD7-AS1,TMEM127,CIAO1,SNRNP200,NEURL3,ARID5A,FER1L5,CNNM4,CNNM3-DT,CNNM3,ANKRD23,ANKRD39,FAM178B,STARD7,NCAPH,KANSL3,LMAN2L,SEMA4C
 
 coe_14_ASD/DD/ID_discovery_cases-case544
 
 
 Unknown
 Unknown
 Unknown
 ADRA2B,DUSP2,ITPRIPL1,MIR3127,RNA5SP101,ASTL,STARD7-AS1,TMEM127,CIAO1,SNRNP200,NEURL3,ARID5A,FER1L5,CNNM4,CNNM3-DT,CNNM3,ANKRD23,ANKRD39,FAM178B,STARD7,NCAPH,KANSL3,LMAN2L,SEMA4C
 
 coe_14_ASD/DD/ID_discovery_cases-case545
 
 
 Unknown
 Unknown
 Unknown
 ADRA2B,DUSP2,ITPRIPL1,MIR3127,RNA5SP101,ASTL,STARD7-AS1,TMEM127,CIAO1,SNRNP200,NEURL3,ARID5A,FER1L5,CNNM4,CNNM3-DT,CNNM3,ANKRD23,ANKRD39,FAM178B,STARD7,NCAPH,KANSL3,LMAN2L,SEMA4C
 
 coe_14_ASD/DD/ID_discovery_cases-case546
 
 
 Unknown
 Unknown
 Unknown
 ADRA2B,DUSP2,ITPRIPL1,MIR3127,RNA5SP101,ASTL,STARD7-AS1,TMEM127,CIAO1,SNRNP200,NEURL3,ARID5A,FER1L5,CNNM4,CNNM3-DT,CNNM3,ANKRD23,ANKRD39,FAM178B,STARD7,NCAPH,KANSL3,LMAN2L,SEMA4C
 
 coe_14_ASD/DD/ID_discovery_cases-case547
 
 
 Unknown
 Unknown
 Unknown
 ADRA2B,DUSP2,ITPRIPL1,MIR3127,RNA5SP101,ASTL,STARD7-AS1,TMEM127,CIAO1,SNRNP200,NEURL3,ARID5A,FER1L5,CNNM4,CNNM3-DT,CNNM3,ANKRD23,ANKRD39,FAM178B,STARD7,NCAPH,KANSL3,LMAN2L,SEMA4C
 
 coe_14_ASD/DD/ID_discovery_cases-case548
 
 
 Unknown
 Unknown
 Unknown
 ADRA2B,DUSP2,ITPRIPL1,MIR3127,RNA5SP101,ASTL,STARD7-AS1,TMEM127,CIAO1,SNRNP200,NEURL3,ARID5A,FER1L5,CNNM4,CNNM3-DT,CNNM3,ANKRD23,ANKRD39,FAM178B,STARD7,NCAPH,KANSL3,LMAN2L,SEMA4C
 
 coe_14_ASD/DD/ID_discovery_cases-case549
 
 
 Unknown
 Unknown
 Unknown
 ADRA2B,DUSP2,ITPRIPL1,MIR3127,RNA5SP101,ASTL,STARD7-AS1,TMEM127,CIAO1,SNRNP200,NEURL3,ARID5A,FER1L5,CNNM4,CNNM3-DT,CNNM3,ANKRD23,ANKRD39,FAM178B,STARD7,NCAPH,KANSL3,LMAN2L,SEMA4C
 
 coe_14_ASD/DD/ID_discovery_cases-case550
 
 
 Unknown
 Unknown
 Unknown
 ADRA2B,DUSP2,ITPRIPL1,MIR3127,RNA5SP101,ASTL,STARD7-AS1,TMEM127,CIAO1,SNRNP200,NEURL3,ARID5A,FER1L5,CNNM4,CNNM3-DT,CNNM3,ANKRD23,ANKRD39,FAM178B,STARD7,NCAPH,KANSL3,LMAN2L,SEMA4C
 
 digregorio_17_DD/ID_discovery_cases-DECIPHER_300074
 
 
 Unknown
 
 
 C2orf15,LIPT1,MITD1,TSGA10
 
 engchuan_15_ASD_discovery_cases-case14056_970
 
 
 Unknown
 
 
 LYG2,LYG1
 
 engchuan_15_ASD_discovery_cases-case17009_1
 
 
 Unknown
 
 
 SNORD89,MIR5696,CNOT11,RNF149
 
 engchuan_15_ASD_discovery_cases-case20000_1010002
 
 
 Unknown
 
 
 LYG2,LYG1
 
 engchuan_15_ASD_discovery_cases-case2288_1
 
 
 Unknown
 
 
 RNU7-96P,TMEM131
 
 engchuan_15_ASD_discovery_cases-case3309_3
 
 
 Unknown
 
 
 IGKV1OR2-9,IGKV2OR2-10,IGKV2OR2-7D,IGKV3OR2-5,IGKV1OR2-6,IGKV2OR2-7,IGKV2OR2-8,IGKV1OR2-11,UBTFL6,COX5B,ACTR1B,ANKRD36,ANKRD36B
 
 engchuan_15_ASD_discovery_cases-case3385_3
 
 
 Unknown
 
 
 RN7SL313P,FAHD2B,ANKRD36
 
 engchuan_15_ASD_discovery_cases-case3418_3
 
 
 Unknown
 
 
 LYG2,LYG1
 
 engchuan_15_ASD_discovery_cases-case3484_3
 
 
 Unknown
 
 
 ANKRD36
 
 engchuan_15_ASD_discovery_cases-case3571_4
 
 
 Unknown
 
 
 LYG2,LYG1
 
 engchuan_15_ASD_discovery_cases-case3616_3
 
 
 Unknown
 
 
 UBTFL6,COX5B,ACTR1B,ANKRD36B
 
 engchuan_15_ASD_discovery_cases-case4236_1
 
 
 Unknown
 
 
 COA5,YWHAQP5,RNU4-84P,RNU7-46P,C2orf15,CNGA3,UNC50,LIPT1,MITD1,MRPL30,LYG2,LYG1,TXNDC9,LINC01104,LONRF2,MGAT4A,KIAA1211L,TSGA10,EIF5B,REV1,CHST10,INPP4A,AFF3
 
 engchuan_15_ASD_discovery_cases-case4548_1
 
 
 Unknown
 
 
 RN7SL313P,IGKV1OR2-9,IGKV2OR2-10,IGKV2OR2-7D,IGKV3OR2-5,IGKV1OR2-6,IGKV2OR2-7,IGKV2OR2-8,IGKV1OR2-11,FAHD2B,ANKRD36,ANKRD36B
 
 engchuan_15_ASD_discovery_cases-case5000_3
 
 
 Unknown
 
 
 GPAT2P2,RN7SL313P,FAHD2B,ANKRD36
 
 engchuan_15_ASD_discovery_cases-case5244_3
 
 
 Unknown
 
 
 IGKV1OR2-3,GPAT2P2,RN7SL313P,FAHD2B,ANKRD36
 
 engchuan_15_ASD_discovery_cases-case6312_4
 
 
 Unknown
 
 
 LYG2,LYG1
 
 engchuan_15_ASD_discovery_cases-case8451_201
 
 
 Unknown
 
 
 LYG2,LYG1
 
 engchuan_15_ASD_discovery_cases-case8651_201
 
 
 Unknown
 
 
 GPAT2P2,RN7SL313P,FAHD2B,ANKRD36
 
 girirajan_12_ASD/DD/ID_discovery_cases-case51723
 FISH, aCGH, or confirmation by inheritance
 
 Unknown
 Unknown
 Unknown
 ADRA2B,DUSP2,ITPRIPL1,MIR3127,RNA5SP101,ASTL,STARD7-AS1,TMEM127,CIAO1,SNRNP200,NEURL3,ARID5A,FER1L5,CNNM4,CNNM3-DT,CNNM3,ANKRD23,ANKRD39,FAM178B,STARD7,NCAPH,KANSL3,LMAN2L,SEMA4C
 
 girirajan_13a_ASD_discovery_cases-12550.p1
 aCGH (NimbleGen 135K array)
 
 Paternal
 Simplex
 Unknown
 ADRA2B,DUSP2,ITPRIPL1,MIR3127,RNA5SP101,ASTL,STARD7-AS1,TMEM127,CIAO1,SNRNP200,NEURL3,ARID5A,FER1L5,CNNM4,CNNM3-DT,CNNM3,ANKRD23,ANKRD39,FAM178B,STARD7,NCAPH,KANSL3,LMAN2L,SEMA4C
 
 girirajan_13a_ASD_discovery_cases-14043.p1
 aCGH (NimbleGen 135K array)
 
 Paternal
 Simplex
 Unknown
 ADRA2B,DUSP2,ITPRIPL1,MIR3127,RNA5SP101,ASTL,STARD7-AS1,TMEM127,CIAO1,SNRNP200,NEURL3,ARID5A,FER1L5,CNNM4,CNNM3-DT,CNNM3,ANKRD23,ANKRD39,FAM178B,STARD7,NCAPH,KANSL3,LMAN2L,SEMA4C
 
 girirajan_13a_DD_discovery_cases-DDcase100
 
 
 Unknown
 
 
 ADRA2B,DUSP2,ITPRIPL1,MIR3127,RNA5SP101,ASTL,STARD7-AS1,TMEM127,CIAO1,SNRNP200,NEURL3,ARID5A,FER1L5,CNNM4,CNNM3-DT,CNNM3,ANKRD23,ANKRD39,FAM178B,STARD7,NCAPH,KANSL3,LMAN2L,SEMA4C
 
 girirajan_13a_DD_discovery_cases-DDcase99
 
 
 Unknown
 
 
 ADRA2B,DUSP2,ITPRIPL1,MIR3127,RNA5SP101,ASTL,STARD7-AS1,TMEM127,CIAO1,SNRNP200,NEURL3,ARID5A,FER1L5,CNNM4,CNNM3-DT,CNNM3,ANKRD23,ANKRD39,FAM178B,STARD7,NCAPH,KANSL3,LMAN2L,SEMA4C
 
 kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00000835
 FISH, qPCR, MLPA, aCGH, or standard G-banded chromosome analysis
 
 De novo
 Unknown
 Unknown
 RN7SL210P,FAHD2CP,ADRA2B,DUSP2,ITPRIPL1,MIR3127,RNA5SP101,GPAT2,ASTL,STARD7-AS1,TMEM127,CIAO1,SNRNP200,NEURL3,ARID5A,FER1L5,CNNM4,CNNM3-DT,CNNM3,ANKRD23,ANKRD39,FAM178B,TRIM43CP,ANKRD36C,STARD7,NCAPH,KANSL3,LMAN2L,SEMA4C
 
 kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00001088
 FISH, qPCR, MLPA, aCGH, or standard G-banded chromosome analysis
 
 Unknown
 Unknown
 Unknown
 ADRA2B,DUSP2,ITPRIPL1,MIR3127,RNA5SP101,IGKV2OR2-1,IGKV2OR2-2,IGKV1OR2-3,GPAT2P2,RN7SL313P,ASTL,STARD7-AS1,TMEM127,CIAO1,SNRNP200,NEURL3,ARID5A,FER1L5,CNNM4,CNNM3-DT,CNNM3,ANKRD23,ANKRD39,FAM178B,TRIM43CP,FAHD2B,STARD7,NCAPH,KANSL3,LMAN2L,SEMA4C,ANKRD36
 
 kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00002200
 FISH, qPCR, MLPA, aCGH, or standard G-banded chromosome analysis
 
 Unknown
 Unknown
 Unknown
 SNORD89,MIR5696,TBC1D8-AS1,CNOT11,RNF149,CREG2,LINC01870,TBC1D8,RFX8
 
 kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00002259
 FISH, qPCR, MLPA, aCGH, or standard G-banded chromosome analysis
 
 Paternal
 Unknown
 Unknown
 RN7SL210P,FAHD2CP,ADRA2B,DUSP2,ITPRIPL1,MIR3127,RNA5SP101,IGKV2OR2-1,IGKV2OR2-2,IGKV1OR2-3,GPAT2P2,RN7SL313P,GPAT2,ASTL,STARD7-AS1,TMEM127,CIAO1,SNRNP200,NEURL3,ARID5A,FER1L5,CNNM4,CNNM3-DT,CNNM3,ANKRD23,ANKRD39,FAM178B,TRIM43CP,FAHD2B,ANKRD36C,STARD7,NCAPH,KANSL3,LMAN2L,SEMA4C,ANKRD36
 
 kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00002743
 FISH, qPCR, MLPA, aCGH, or standard G-banded chromosome analysis
 
 Maternal
 Unknown
 Unknown
 UBTFL6,COX5B,ACTR1B,RNU4-8P,HMGN1P36,C2orf92,ZAP70,TMEM131
 
 kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00002785
 FISH, qPCR, MLPA, aCGH, or standard G-banded chromosome analysis
 
 Maternal
 Unknown
 Unknown
 RN7SL210P,FAHD2CP,ADRA2B,DUSP2,ITPRIPL1,MIR3127,RNA5SP101,IGKV2OR2-1,IGKV2OR2-2,IGKV1OR2-3,GPAT2P2,RN7SL313P,GPAT2,ASTL,STARD7-AS1,TMEM127,CIAO1,SNRNP200,NEURL3,ARID5A,FER1L5,CNNM4,CNNM3-DT,CNNM3,ANKRD23,ANKRD39,FAM178B,TRIM43CP,FAHD2B,LINC00342,ANKRD36C,STARD7,NCAPH,KANSL3,LMAN2L,SEMA4C,ANKRD36
 
 kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00004015
 FISH, qPCR, MLPA, aCGH, or standard G-banded chromosome analysis
 
 Unknown
 Unknown
 Unknown
 RN7SL210P,FAHD2CP,ADRA2B,DUSP2,ITPRIPL1,MIR3127,RNA5SP101,GPAT2,ASTL,STARD7-AS1,TMEM127,CIAO1,SNRNP200,NEURL3,ARID5A,FER1L5,CNNM4,CNNM3-DT,CNNM3,ANKRD23,ANKRD39,FAM178B,LINC00342,ANKRD36C,STARD7,NCAPH,KANSL3,LMAN2L,SEMA4C
 
 kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00004706
 FISH, qPCR, MLPA, aCGH, or standard G-banded chromosome analysis
 
 Maternal
 Unknown
 Unknown
 RN7SL210P,FAHD2CP,ADRA2B,DUSP2,ITPRIPL1,MIR3127,RNA5SP101,IGKV2OR2-1,IGKV2OR2-2,IGKV1OR2-3,GPAT2P2,RN7SL313P,GPAT2,ASTL,STARD7-AS1,TMEM127,CIAO1,SNRNP200,NEURL3,ARID5A,FER1L5,CNNM4,CNNM3-DT,CNNM3,ANKRD23,ANKRD39,FAM178B,TRIM43CP,FAHD2B,ANKRD36C,STARD7,NCAPH,KANSL3,LMAN2L,SEMA4C,ANKRD36
 
 kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00005076
 FISH, qPCR, MLPA, aCGH, or standard G-banded chromosome analysis
 
 Unknown
 Unknown
 Unknown
 RNU7-46P,C2orf15,HMGN2P22,LINC01849,NANOGNBP1,LINC01868,LIPT1,MITD1,MRPL30,LYG2,LYG1,TXNDC9,LINC01104,LONRF2,NMS,PDCL3,KIAA1211L,TSGA10,EIF5B,REV1,CHST10,AFF3
 
 kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00005087
 FISH, qPCR, MLPA, aCGH, or standard G-banded chromosome analysis
 
 Maternal
 Unknown
 Unknown
 RN7SL210P,FAHD2CP,ADRA2B,DUSP2,ITPRIPL1,MIR3127,RNA5SP101,GPAT2,ASTL,STARD7-AS1,TMEM127,CIAO1,SNRNP200,NEURL3,ARID5A,FER1L5,CNNM4,CNNM3-DT,CNNM3,ANKRD23,ANKRD39,FAM178B,ANKRD36C,STARD7,NCAPH,KANSL3,LMAN2L,SEMA4C
 
 kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00005242
 FISH, qPCR, MLPA, aCGH, or standard G-banded chromosome analysis
 
 Unknown
 Unknown
 Unknown
 ADRA2B,DUSP2,ITPRIPL1,MIR3127,RNA5SP101,IGKV2OR2-1,IGKV2OR2-2,IGKV1OR2-3,GPAT2P2,RN7SL313P,ASTL,STARD7-AS1,TMEM127,CIAO1,SNRNP200,NEURL3,ARID5A,FER1L5,CNNM4,CNNM3-DT,CNNM3,ANKRD23,ANKRD39,FAM178B,TRIM43CP,FAHD2B,STARD7,NCAPH,KANSL3,LMAN2L,SEMA4C,ANKRD36
 
 krumm_13_ASD_discovery_cases-case11045.p1
 aCGH (Agilent SurePrint G3 4x180K)
 
 Maternal
 Simplex
 Segregated
 MAP4K4
 
 krumm_13_ASD_discovery_cases-case11484.p1
 
 
 Maternal
 Simplex
 Not segregated
 COX5B,ACTR1B
 
 krumm_13_ASD_discovery_cases-case13507.p1
 
 
 Paternal
 Simplex
 Not segregated
 UBTFL6,COX5B,ACTR1B,ANKRD36B
 
 krumm_13_ASD_discovery_cases-case13795.p1
 
 
 Maternal
 Simplex
 Not segregated
 LYG1
 
 krumm_15_ASD_discovery_cases-case11045.p1
 Illumina 1M
 
 Maternal
 Simplex
 Segregated
 MAP4K4
 
 krumm_15_ASD_discovery_cases-case11099.p1
 Illumina 1M
 
 Maternal
 Simplex
 Segregated
 UBTFL6,COX5B,ACTR1B,ANKRD36B
 
 krumm_15_ASD_discovery_cases-case11765.p1
 Illumina 1MDuo
 
 Paternal
 Simplex
 Not segregated (CNV in unaffected sibling)
 LYG2,LYG1
 
 krumm_15_ASD_discovery_cases-case12853.p1
 Illumina 1MDuo
 
 Maternal
 Simplex
 Not segregated (CNV in unaffected sibling)
 LYG2,LYG1
 
 krumm_15_ASD_discovery_cases-case13507.p1
 1M-Duov3
 
 Paternal
 Simplex
 Segregated
 UBTFL6,COX5B,ACTR1B,ANKRD36B
 
 krumm_15_ASD_discovery_cases-case13968.p1
 Omni2.5-4v1
 
 Paternal
 Simplex
 Segregated
 ATP5F1BP1,VWA3B
 
 kushima_18_SCZ_discovery_cases-caseSCZ1051
 While a subset of CNVs were reported to have been validated by qPCR in the report, precisely which CNVs were validated was not reported
 
 Unknown
 Not simplex
 Unknown
 ADRA2B,DUSP2,ITPRIPL1,MIR3127,RNA5SP101,IGKV2OR2-1,IGKV2OR2-2,IGKV1OR2-3,ASTL,STARD7-AS1,TMEM127,CIAO1,SNRNP200,NEURL3,ARID5A,FER1L5,CNNM4,CNNM3-DT,CNNM3,ANKRD23,ANKRD39,FAM178B,TRIM43CP,STARD7,NCAPH,KANSL3,LMAN2L,SEMA4C
 
 larson_17_ASD_discovery_cases-case28
 
 
 Unknown
 
 Unknown
 RN7SL313P,ANKRD36
 
 larson_17_ASD_discovery_cases-case29
 
 
 Unknown
 
 Unknown
 RN7SL313P,ANKRD36
 
 larson_17_ASD_discovery_cases-case30
 
 
 Unknown
 
 Unknown
 RN7SL313P,ANKRD36
 
 larson_17_ASD_discovery_cases-case31
 
 
 Unknown
 
 Unknown
 RN7SL313P,ANKRD36
 
 larson_17_ASD_discovery_cases-case32
 
 
 Unknown
 
 Unknown
 RN7SL313P,ANKRD36
 
 larson_17_ASD_discovery_cases-case33
 
 
 Unknown
 
 Unknown
 RN7SL313P,ANKRD36
 
 larson_17_ASD_discovery_cases-case34
 
 
 Unknown
 
 Unknown
 RN7SL313P,ANKRD36
 
 larson_17_ASD_discovery_cases-case35
 
 
 Unknown
 
 Unknown
 RN7SL313P,ANKRD36
 
 larson_17_ASD_discovery_cases-case36
 
 
 Unknown
 
 Unknown
 ANKRD36B
 
 larson_17_ASD_discovery_cases-case37
 
 
 Unknown
 
 Unknown
 ANKRD36B
 
 larson_17_ASD_discovery_cases-case38
 
 
 Unknown
 
 Unknown
 ANKRD36B
 
 larson_17_ASD_discovery_cases-case39
 
 
 Unknown
 
 Unknown
 ANKRD36B
 
 larson_17_ASD_discovery_cases-case44
 
 
 Unknown
 
 Unknown
 IGKV2OR2-1,IGKV2OR2-2,IGKV1OR2-3,GPAT2P2,RN7SL313P,TRIM43CP,FAHD2B,ANKRD36
 
 levy_11_ASD_discovery_cases-11045.p1
 
 
 Maternal
 Simplex
 Segregated
 MAP4K4
 
 levy_11_ASD_discovery_cases-11765.p1
 
 
 Paternal
 Simplex
 Not segregated
 LYG2,LYG1
 
 pinto_10_ASD_discovery_cases-case5000_3
 Agilent1M
 
 paternal
 NA
 NA
 GPAT2P2,RN7SL313P,FAHD2B,ANKRD36
 
 pinto_14_ASD_discovery_cases2-case20000_1010002
 qPCR
 
 Maternal
 Simplex
 (not tested)
 LYG2,LYG1
 
 poultney_13_ASD_discovery_cases-case00HI1465A
 
 
 Unknown
 Unknown (likely multiplex/AGRE)
 Unknown
 RN7SL313P,FAHD2B,ANKRD36
 
 poultney_13_ASD_discovery_cases-case04HI3272A
 
 
 Unknown
 Unknown (likely multiplex/AGRE)
 Unknown
 UBTFL6,COX5B,ACTR1B,ANKRD36B
 
 poultney_13_ASD_discovery_cases-case98HI0098B
 
 
 Unknown
 Unknown (likely multiplex/AGRE)
 Unknown
 PDCL3
 
 poultney_13_ASD_discovery_cases-case99HI1043A
 
 
 Unknown
 Unknown (likely multiplex/AGRE)
 Unknown
 PDCL3
 
 prasad_12_ASD_discovery_cases-case47173L
 qPCR
 
 Unknown
 Unknown
 Unknown
 MRPL30,LYG2,LIPT1,AFF3,MITD1,TXNDC9,TSGA10,C2orf15,REV1,EIF5B,LYG1
 
 prasad_12_ASD_discovery_cases-case86605L
 
 
 Unknown
 Unknown
 Unknown
 TSGA10,C2orf15,MRPL30,MITD1,LIPT1
 
 sajan_13_ACC/CBLH/PMG_discovery_cases-caseDR08-020a1
 Not tested by qPCR
 
 Unknown
 Unknown
 Unknown
 ANKRD36
 
 sajan_13_ACC/CBLH/PMG_discovery_cases-caseLR07-125
 qPCR
 
 Maternal
 Unknown
 Unknown
 ATP5F1BP1,VWA3B
 
 sajan_13_ACC/CBLH/PMG_discovery_cases-caseLR08-375
 Not tested by qPCR
 
 Unknown
 Unknown
 Unknown
 LYG2,LYG1
 
 sanders_11_ASD_discovery_cases-11004.p1
 
 
 Paternal
 Simplex (quad-proband matched)
 Segregated
 ANKRD36
 
 sanders_11_ASD_discovery_cases-11111.p1
 
 
 Unknown
 Simplex (trio)
 NA
 ANKRD36
 
 sanders_11_ASD_discovery_cases-11134.p1
 
 
 Maternal
 Simplex (trio)
 NA
 C2orf15,LIPT1,MITD1,MRPL30,TSGA10
 
 sanders_11_ASD_discovery_cases-11252.p1
 
 
 Unknown
 Simplex (quad-proband matched)
 Not segregated
 RN7SL313P,FAHD2B,ANKRD36
 
 sanders_11_ASD_discovery_cases-11258.p1
 
 
 Maternal
 Simplex (quad-proband matched)
 Not segregated
 ANKRD36
 
 sanders_11_ASD_discovery_cases-11378.p1
 
 
 Unknown
 Simplex (quad-proband matched)
 Not segregated
 ANKRD36
 
 sanders_11_ASD_discovery_cases-11484.p1
 
 
 Maternal
 Simplex (quad-proband matched)
 Segregated
 UBTFL6,COX5B,ACTR1B,ANKRD36B
 
 sanders_11_ASD_discovery_cases-11526.p1
 
 
 Unknown
 Simplex (quad-proband matched)
 Not segregated
 ANKRD36
 
 sanders_11_ASD_discovery_cases-11657.p1
 
 
 Both parents
 Simplex (quad-proband matched)
 Segregated
 LINC01104
 
 sanders_11_ASD_discovery_cases-11679.p1
 
 
 Maternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-11765.p1
 
 
 Paternal
 Simplex (quad-proband matched)
 Not segregated
 LYG2,LYG1
 
 sanders_11_ASD_discovery_cases-11917.p1
 
 
 Maternal
 Simplex (quad-proband matched)
 Not segregated
 IGKV1OR2-9,IGKV2OR2-10,IGKV2OR2-7D,IGKV3OR2-5,IGKV1OR2-6,IGKV2OR2-7,IGKV2OR2-8,IGKV1OR2-11,ANKRD36,ANKRD36B
 
 sanders_11_ASD_discovery_cases-11981.p1
 
 
 Maternal
 Simplex (quad-proband matched)
 Not segregated
 RNU7-96P,TMEM131
 
 sanders_11_ASD_discovery_cases-12158.p1
 
 
 Maternal
 Simplex (trio)
 NA
 ANKRD36
 
 sanders_11_ASD_discovery_cases-12785.p1
 
 
 Paternal
 Simplex (quad-proband matched)
 Not segregated
 GPAT2P2,RN7SL313P,IGKV1OR2-9,IGKV2OR2-10,IGKV2OR2-7D,IGKV3OR2-5,IGKV1OR2-6,IGKV2OR2-7,IGKV2OR2-8,IGKV1OR2-11,FAHD2B,ANKRD36,ANKRD36B
 
 sanders_11_ASD_discovery_cases-12828.p1
 
 
 Maternal
 Simplex (trio)
 NA
 IGKV2OR2-1,IGKV2OR2-2,IGKV1OR2-3,GPAT2P2,RN7SL313P,FAHD2B,ANKRD36
 
 sanders_11_ASD_discovery_cases-12853.p1
 
 
 Maternal
 Simplex (quad-proband matched)
 Not segregated
 LYG2
 
 sanders_11_ASD_discovery_cases-13152.p1
 
 
 Paternal
 Simplex (quad-proband unmatched)
 Unknown
 IGKV3OR2-5,IGKV1OR2-6
 
 soueid_16_ASD_discovery_cases-caseSAI36
 
 
 Paternal
 
 
 IGKV1OR2-9,IGKV2OR2-10,IGKV2OR2-7D,IGKV3OR2-5,IGKV1OR2-6,IGKV2OR2-7,IGKV2OR2-8,IGKV1OR2-11
 
 yin_16_ASD_discovery_cases-case74
 
 
 Unknown
 Unknown
 Unknown
 MGAT4A
 

Controls

Patient ID
Validation Description
Primary Disorder Inheritence
Inheritence
Family Profile
Disease Segregation
Gene Content
Altered Gene Expression
brandler_18_ASD_discovery_controls-controlREACH000340
  SNP VCF
 
  De novo
 
 
  NEURL3,ARID5A
 
brandler_18_ASD_discovery_controls-controlSSC05183
  SNP VCF
 
  De novo
 
 
  EIF5B
 
engchuan_15_ASD_discovery_controls-control110036015501_
 
 
  Unknown
 
 
  RN7SL313P,IGKV1OR2-9,IGKV2OR2-10,IGKV2OR2-7D,IGKV3OR2-5,IGKV1OR2-6,IGKV2OR2-7,IGKV2OR2-8,IGKV1OR2-11,FAHD2B,ANKRD36,ANKRD36B
 
engchuan_15_ASD_discovery_controls-controlB140638_1007853950
 
 
  Unknown
 
 
  GPAT2P2,RN7SL313P,IGKV1OR2-9,IGKV2OR2-10,IGKV2OR2-7D,IGKV3OR2-5,IGKV1OR2-6,IGKV2OR2-7,IGKV2OR2-8,IGKV1OR2-11,FAHD2B,ANKRD36
 
engchuan_15_ASD_discovery_controls-controlB253888_1007853986
 
 
  Unknown
 
 
  UBTFL6,COX5B,ACTR1B,ANKRD36B
 
engchuan_15_ASD_discovery_controls-controlB285779_1007874679
 
 
  Unknown
 
 
  IGKV1OR2-3,GPAT2P2,RN7SL313P,FAHD2B,ANKRD36
 
engchuan_15_ASD_discovery_controls-controlB347545_0067942603
 
 
  Unknown
 
 
  IGKV1OR2-3,GPAT2P2,RN7SL313P,FAHD2B,ANKRD36
 
engchuan_15_ASD_discovery_controls-controlB524961_1007872292
 
 
  Unknown
 
 
  IGKV1OR2-3,GPAT2P2,RN7SL313P,IGKV1OR2-9,IGKV2OR2-10,IGKV2OR2-7D,IGKV3OR2-5,IGKV1OR2-6,IGKV2OR2-7,IGKV2OR2-8,IGKV1OR2-11,FAHD2B,ANKRD36,ANKRD36B
 
engchuan_15_ASD_discovery_controls-controlB536568_1007854032
 
 
  Unknown
 
 
  GPAT2P2,RN7SL313P,IGKV1OR2-9,IGKV2OR2-10,IGKV2OR2-7D,IGKV3OR2-5,IGKV1OR2-6,IGKV2OR2-7,IGKV2OR2-8,IGKV1OR2-11,FAHD2B,ANKRD36
 
engchuan_15_ASD_discovery_controls-controlB613109_1007875803
 
 
  Unknown
 
 
  AFF3
 
engchuan_15_ASD_discovery_controls-controlB675310_1007874657
 
 
  Unknown
 
 
  LYG2,LYG1
 
engchuan_15_ASD_discovery_controls-controlB747096_1007854180
 
 
  Unknown
 
 
  LYG2,LYG1
 
engchuan_15_ASD_discovery_controls-controlB757128_1007874832
 
 
  Unknown
 
 
  ATP5F1BP1,CNGA3,TMEM131,VWA3B,INPP4A
 
engchuan_15_ASD_discovery_controls-controlB809518_0057061032
 
 
  Unknown
 
 
  RN7SL313P,IGKV1OR2-9,IGKV2OR2-10,IGKV2OR2-7D,IGKV3OR2-5,IGKV1OR2-6,IGKV2OR2-7,IGKV2OR2-8,IGKV1OR2-11,FAHD2B,ANKRD36
 
engchuan_15_ASD_discovery_controls-controlHABC_900201_900201
 
 
  Unknown
 
 
  UBTFL6,COX5B,ACTR1B,ANKRD36B
 
engchuan_15_ASD_discovery_controls-controlHABC_900250_900250
 
 
  Unknown
 
 
  ANKRD36
 
engchuan_15_ASD_discovery_controls-controlHABC_900943_900943
 
 
  Unknown
 
 
  RN7SL313P,IGKV1OR2-9,IGKV2OR2-10,IGKV2OR2-7D,IGKV3OR2-5,IGKV1OR2-6,IGKV2OR2-7,IGKV2OR2-8,IGKV1OR2-11,FAHD2B,ANKRD36
 
engchuan_15_ASD_discovery_controls-controlHABC_901132_901132
 
 
  Unknown
 
 
  GPAT2P2,RN7SL313P,IGKV1OR2-9,IGKV2OR2-10,IGKV2OR2-7D,IGKV3OR2-5,IGKV1OR2-6,IGKV2OR2-7,IGKV2OR2-8,IGKV1OR2-11,FAHD2B,ANKRD36
 
engchuan_15_ASD_discovery_controls-controlHABC_901140_901140
 
 
  Unknown
 
 
  GPAT2P2,RN7SL313P,IGKV1OR2-9,IGKV2OR2-10,IGKV2OR2-7D,IGKV3OR2-5,IGKV1OR2-6,IGKV2OR2-7,IGKV2OR2-8,IGKV1OR2-11,FAHD2B,ANKRD36
 
engchuan_15_ASD_discovery_controls-controlHABC_901223_901223
 
 
  Unknown
 
 
  LYG2,LYG1
 
engchuan_15_ASD_discovery_controls-controlHABC_901266_901266
 
 
  Unknown
 
 
  RN7SL313P,FAHD2B,ANKRD36
 
girirajan_13b_ASD_discovery_controls-10208109404
 
 
  Unknown
 
 
  RN7SL210P,FAHD2CP,GPAT2P1,GPAT2,LINC00342,ANKRD36C
 
girirajan_13b_ASD_discovery_controls-2105102564
 
 
  Unknown
 
 
  CNNM4,LMAN2L
 
krumm_13_ASD_discovery_controls-control11484.s1
  aCGH (Agilent SurePrint G3 4x180K)
 
  Maternal
  Simplex
 
  COX5B,ACTR1B
 
krumm_13_ASD_discovery_controls-control13166.s1
 
 
  Paternal
  Simplex
 
  VWA3B
 
krumm_13_ASD_discovery_controls-control13507.s1
 
 
  Paternal
  Simplex
 
  UBTFL6,COX5B,ACTR1B,ANKRD36B
 
krumm_13_ASD_discovery_controls-control13508.s1
 
 
  Maternal
  Simplex
 
  LYG2,LYG1
 
krumm_15_ASD_discovery_controls-control11765.s1
  Illumina 1MDuo
 
  Paternal
 
 
  LYG2,LYG1
 
krumm_15_ASD_discovery_controls-control12091.s1
  Illumina 1MDuo
 
  Maternal
 
 
  UBTFL6,COX5B,ACTR1B,ANKRD36B
 
krumm_15_ASD_discovery_controls-control12853.s1
  Illumina 1MDuo
 
  Maternal
 
 
  LYG2,LYG1
 
krumm_15_ASD_discovery_controls-control13508.s1
  1M-Duov3
 
  Maternal
 
 
  LYG2,LYG1
 
krumm_15_ASD_discovery_controls-control13531.s1
  1M-Duov3
 
  Paternal
 
 
  UBTFL6,COX5B,ACTR1B,ANKRD36B
 
levy_11_ASD_discovery_controls-11765.s1
 
 
  Paternal
  Simplex
  NA
  LYG2,LYG1
 
poultney_13_ASD_discovery_controls-control04C28851A
 
 
  Unknown
 
 
  ANKRD36B
 
poultney_13_ASD_discovery_controls-control04C31069A
 
 
  Unknown
 
 
  RNU7-96P,ATP5F1BP1,TMEM131,VWA3B
 
poultney_13_ASD_discovery_controls-control04C32509B
 
 
  Unknown
 
 
  RN7SL313P,FAHD2B,ANKRD36
 
poultney_13_ASD_discovery_controls-control04C37424A
 
 
  Unknown
 
 
  RN7SL313P,FAHD2B,ANKRD36
 
poultney_13_ASD_discovery_controls-control05C38812A
 
 
  Unknown
 
 
  VWA3B
 
poultney_13_ASD_discovery_controls-control05C44633
 
 
  Unknown
 
 
  UBTFL6,COX5B,ACTR1B,ANKRD36B
 
sanders_11_ASD_discovery_controls-11032.s1
 
 
  Unknown
  Simplex (quad)
  NA
  ANKRD36
 
sanders_11_ASD_discovery_controls-11073.s1
 
 
  Paternal
  Simplex (quad)
  NA
  ANKRD36
 
sanders_11_ASD_discovery_controls-11124.s1
 
 
  Paternal
  Simplex (quad)
  NA
  FAHD2CP,GPAT2
 
sanders_11_ASD_discovery_controls-11252.s1
 
 
  Maternal
  Simplex (quad)
  NA
  RN7SL313P,IGKV1OR2-9,IGKV2OR2-10,IGKV2OR2-7D,IGKV3OR2-5,IGKV1OR2-6,IGKV2OR2-7,IGKV2OR2-8,IGKV1OR2-11,FAHD2B,ANKRD36,ANKRD36B
 
sanders_11_ASD_discovery_controls-11330.s1
 
 
  Unknown
  Simplex (quad)
  NA
  GPAT2P2,RN7SL313P,FAHD2B,ANKRD36
 
sanders_11_ASD_discovery_controls-11512.s1
 
 
  Unknown
  Simplex (quad)
  NA
  ANKRD36
 
sanders_11_ASD_discovery_controls-11679.s1
 
 
  Maternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-11765.s1
 
 
  Paternal
  Simplex (quad)
  NA
  LYG2,LYG1
 
sanders_11_ASD_discovery_controls-11917.s1
 
 
  Maternal
  Simplex (quad)
  NA
  0 genes
 
sanders_11_ASD_discovery_controls-11948.s1
 
 
  Paternal
  Simplex (quad)
  NA
  ANKRD36
 
sanders_11_ASD_discovery_controls-11990.s1
 
 
  Both parents
  Simplex (quad)
  NA
  ANKRD36
 
sanders_11_ASD_discovery_controls-12091.s1
 
 
  Maternal
  Simplex (quad)
  NA
  UBTFL6,COX5B,ACTR1B,ANKRD36B
 
sanders_11_ASD_discovery_controls-12701.s1
 
 
  Unknown
  Simplex (quad)
  NA
  RN7SL313P,FAHD2B,ANKRD36
 
sanders_11_ASD_discovery_controls-12851.s1
 
 
  Maternal
  Simplex (quad)
  NA
  IGKV1OR2-9,IGKV2OR2-10,IGKV2OR2-7D,IGKV3OR2-5,IGKV1OR2-6,IGKV2OR2-7,IGKV2OR2-8,IGKV1OR2-11,ANKRD36,ANKRD36B
 
sanders_11_ASD_discovery_controls-12851.s1
 
 
  Maternal
  Simplex (quad)
  NA
  ADRA2B,DUSP2,ITPRIPL1,MIR3127,ASTL,STARD7-AS1,TMEM127,CIAO1,SNRNP200,NEURL3,ARID5A,FER1L5,CNNM4,CNNM3-DT,CNNM3,ANKRD23,ANKRD39,FAM178B,STARD7,NCAPH,KANSL3,LMAN2L,SEMA4C
 
sanders_11_ASD_discovery_controls-12853.s1
 
 
  Maternal
  Simplex (quad)
  NA
  LYG2,LYG1
 
sanders_11_ASD_discovery_controls-13166.s1
 
 
  Paternal
  Simplex (quad)
  NA
  VWA3B
 
soueid_16_ASD_discovery_controls-control7
 
 
 
 
 
  IGKV1OR2-9,IGKV2OR2-10,IGKV2OR2-7D,IGKV3OR2-5,IGKV1OR2-6,IGKV2OR2-7,IGKV2OR2-8,IGKV1OR2-11
 

No Animal Model Data Available
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