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10q23.1CNV Type: Deletion-Duplication


Largest CNV size: 146429 bp

Statistics Box:
Number of Reports: 25



Summary Information

Summary statement in development

Additional Locus Information

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References

Major Reports

Title
Author, Year
Report Class
CNV Type
An evidence-based approach to establish the functional and clinical significance of copy number variants in intellectual and developmental disabili...
Deletion-Duplication
Evaluation of copy number variations reveals novel candidate genes in autism spectrum disorder-associated pathways.
Deletion
Refinement and discovery of new hotspots of copy-number variation associated with autism spectrum disorder.
Deletion-Duplication
Convergence of genes and cellular pathways dysregulated in autism spectrum disorders.
Deletion
Performance of chromosomal microarray for patients with intellectual disabilities/developmental delay, autism, and multiple congenital anomalies in...
Deletion
Excess of rare, inherited truncating mutations in autism.
Duplication

Minor Reports

Title
Author, Year
Report Class
CNV Type
Recurrent 10q22-q23 deletions: a genomic disorder on 10q associated with cognitive and behavioral abnormalities.
Deletion
Rare structural variation of synapse and neurotransmission genes in autism.
Deletion
Reduced transcript expression of genes affected by inherited and de novo CNVs in autism.
Deletion
Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism.
Deletion-Duplication
Rare deletions at the neurexin 3 locus in autism spectrum disorder.
Deletion
A discovery resource of rare copy number variations in individuals with autism spectrum disorder.
Deletion-Duplication
Contribution of copy number variants involving nonsense-mediated mRNA decay pathway genes to neuro-developmental disorders.
Deletion
Global increases in both common and rare copy number load associated with autism.
Duplication
Diagnostic yield of array comparative genomic hybridization in adults with autism spectrum disorders.
Deletion
Identification of small exonic CNV from whole-exome sequence data and application to autism spectrum disorder.
Duplication
Copy number variation in Han Chinese individuals with autism spectrum disorder.
Deletion
Performance of case-control rare copy number variation annotation in classification of autism.
Deletion-Duplication
Copy-number variations are enriched for neurodevelopmental genes in children with developmental coordination disorder.
Deletion
Rare Inherited and De Novo CNVs Reveal Complex Contributions to ASD Risk in Multiplex Families.
Duplication
NA
Duplication
Chromosomal microarray in clinical diagnosis: a study of 337 patients with congenital anomalies and developmental delays or intellectual disability.
Deletion
Chromosomal microarray analysis in a cohort of underrepresented population identifies SERINC2 as a novel candidate gene for autism spectrum disorder.
Deletion
Genetic testing including targeted gene panel in a diverse clinical population of children with autism spectrum disorder: Findings and implications.
Duplication
NA
Deletion

Cases

Cohort ID
Author, Year
Descripton
Cohort Size
Diagnosis
Age
Gender
CNV Size
Deletion
Duplication
Total CNV's
 balciuniene_07_ASD_discovery_cases
 Three unrelated patients with behavioral and/or neurodevelopmental abnormalities who presented to clinics at the University of Minnesota (n=1) and Johns Hopkins Hospital (n=2).
 3
 Autism (n=1; diagnosis based on ADOS); developmental delay (n=1); learning disability (n=1)
 Range, 18 mos.-11 yrs.
 100% Male
 96000
 1
 0
 1
 chaves_19_ASD/DD/ID_discovery_cases
  NA NA
 Patients from the south of Brazil with neurodevelopmental disorders
 420
 Developmental delay/intellectual disability present in 80% of cases, ASD in 32%
 Range, 0-49 years (mean 9.5 9.73 years)
 61.90% Male
 399403
 2
 0
 2
 chong_14_DD/ID/ASD/MCA_discovery_cases
 Patients referred to clinical genetics service and recruited for CMA application study
 105
 Developmental delay/intellectual disability (DD/ID), autism (ASD), and/or multiple congenital anomalies (MCA)
 N/A
 N/A
 130000
 1
 0
 1
 digregorio_17_DD/ID_discovery_cases
  NA NA
 Consecutive cases examined in the Medical Genetics Unit at the "Citta della Salte e della Scienza" University Hospital (Turin, Italy) from 2008 to 2014 (cases with CNVs are present in DECIPHER database)
 1015
 Cases diagnosed with idiopathic developmental delay and/or intellectual disability (DD/ID)
 N/A
 N/A
 99000
 0
 1
 1
 engchuan_15_ASD_discovery_cases
 Samples from the Autism Genome Project (AGP)
 1892
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 N/A
 85.78% Male
 292152
 2
 2
 4
 gai_11_ASD_replication_cases
 Replication case samples derived from AGRE sets 1-3
 593
 Idiopathic autism; cases designated as 'spectrum' and 'not quite autism' excluded, as were cases with known genetic syndromes or other non-idiopathic causes
 
 
 33472
 2
 0
 2
 gazzellone_14_ASD_discovery_cases
 ASD-affected individuals referred to the Children Development and Behavior Research Center (CDRBC) at Harbin Medical University, China, between January 2007 and June 2011.
 104
 Diagnosis of ASD made using Autism Behavior Checklist (ABC) and Childhood Autism Rating Scale (CARS)
 Mean age at enrollment, 4.31 1.80 yrs.
 87.5% Male
 21575
 1
 0
 1
 girirajan_13a_ASD_discovery_cases
 1979 simplex cases from the Simons Simplex Collection (SSC), 579 multiplex cases from AGRE.
 2588
 Diagnosis of ASD based on meeting criteria on the Autism Diagnostic Observation Schedule (ADOS) and on the Autism Diagnostic Interview, Revised (ADI-R)
 NA
 NA
 86469
 1
 8
 9
 girirajan_13b_ASD_discovery_cases
 Children with autism ascertained from the Childhood Autism Risks from Genetics and Environment (CHARGE) study conducted through the Medical Investigation of Neurodevelopmental Disorders (MIND) Institute at UC-Davis after passing QC criteria (274 initial cases)
 243
 Diagnosis of autism confirmed by ADOS and ADI-R. Exclusion criteria: children with developmental delay but lacking symptoms and autism, as well as children with ASD as defined by the CHARGE protocol
 N/A
 N/A
 323845
 0
 1
 1
 griswold_12_ASD_discovery_cases
 Unrelated ASD cases from the Collaborative Autism Project (CAP) ascertained through clinical groups at the University of Miami (HIHG), the University of South Carolina, and Vanderbilt University. 260 cases from multiplex families, 483 from simplex families, 62 from families with siblings having autistic-like traits without a confirmed ASD diagnosis, and 8 from families with monozygotic twins.
 813
 Daignosis of ASD/autism. Inclusion criteria: (1) age between 3-21 years, (2) presumptive clinical diagnosis of autism, (3) expert clinical determination of autism diagnosis using DSM-IV criteria supported by ADI-R in the majority of cases and all available clinical information, (4) minimal developmental level of 18 months as determined by VABS or VABS-II or IQ equivalent >35. Exclusion criteria: severe sensory problems, significant motor impairments, or previously identified metabolic, genetic, or progressive neurological disorder.
 Range, 3-21 yrs.
 NA
 84276
 1
 0
 1
 hnoonual_17_ASD_discovery_cases
 Cohort of 114 Thai ASD probands (68 retrospective ASD cases with the use of chromosomal microarray/CMA as a second line test; 46 prospective ASD and developmental delay cases with the use of CMA as the first-tier test)
 114
 68 cases with non-syndromic ASD (61 of which also presented with intellectual disability) were diagnosed with ASD based on meeting DSM-IV criteria for ASD, whereas an additional 46 prospective ASD and DD cases were given a clinical diagnosis of ASD based on DSM-5 criteria.
 Range, 1-18 years (at time of recruitment)
 79.82% Male
 97000
 1
 0
 1
 kalsner_17_ASD_discovery_cases
 Consecutive children with ASD evaluated in the Connecticut Children's Medical Center (CCMC) Autism Neurogenetics Program
 100
 All children enrolled in this study (i) had a confirmed diagnosis of ASD by a developmental-behavioral pediatrician or child neurologist experienced in ASD, (ii) scored in the full autism range on ADOS-2 and (iii) either met DSM-5 criteria for ASD or scored in the autism range on CARS-2
 Range, 21 mos.-17 yrs.
 76.0% Male
 1800000
 0
 1
 1
 kaminsky_11_DD/ID/ASD_discovery_cases
 Cases from the International Standards for Cytogenomic Arrays (ISCA) consortium
 15749
 Unexplained developmental delay, intellectual disability, dysmorphic features, multiple congenital anomalies, autism spectrum disorders, or clinical features suggestive of a chromosomal syndrome
 NA
 NA
 1788703
 1
 2
 3
 krumm_15_ASD_discovery_cases
 Probands from the Simons Simplex Collection
 2377
 Diagnosis of ASD
 N/A
 N/A
 16446
 0
 4
 4
 leppa_16_ASD_discovery_cases
 Children affected with ASD from 1,464 families from the Autism Genetic Resource Exchange (AGRE)
 1764
 Diagnosis according to ADOS and ADI-R
 N/A
 N/A
 1600000
 0
 1
 1
 mosca_16_DCD_discovery_cases
 Participants recruited as part of a multidisciplinary study at the Alberta Children's Hospital (Calgary, Alberta, Canada)
 82
 All cases met diagnostic criteria for developmental coordination disorder (DCD) with or without co-occurring ADHD and/or reading disorder.
 Range, 8-17 years (Mean, 10.06 2.92 yrs.)
 N/A
 65639
 1
 0
 1
 nguyen_13_DD/ID/MCA/ASD_discovery_cases
 Patients from the Developmental Gene Anatomy Project at Harvard Medical School (DGAP), the Developmental Gene Discovery Project at Georgia Health Sciences University (DGDP), the National Institute of General Medical Sciences Human Genetic Cell Repository (NIGMS), the Signature Genomic Laboratories Genoglyphix Chromosome Aberration Database, and DECIPHER
 57365
 Predominant cohort diagnosis of developmental delay/intellectual disability and/or mulitple congenital anomalies (MCA); 5 cases with additional diagnosis of autism/ASD
 N/A
 N/A
 1683773
 1
 0
 1
 nord_11_ASD_discovery_cases
 Youth with ASD (as part of mother-father-child trios)
 41
 ASD
 
 85.4% Male
 19177
 2
 0
 2
 pinto_14_ASD_discovery_cases
 ASD probands from simplex and multiplex families collected as part of stage 2 of the Autism Genome Project (AGP) after quality control (1,604 before QC)
 1359
 Cases classified according to ADOS and ADI-R
 N/A
 N/A
 84277
 1
 0
 1
 poultney_13_ASD_discovery_cases
 ASD cases of European ancestry from AGRE retained after filtering (original cohort size of 432 cases)
 299
 Cases diagnosed with ASD
 N/A
 79.86% Male (before filtering)
 16450
 0
 3
 3
 prasad_12_ASD_discovery_cases
 Unrelated ASD cases recruited from three Canadian sites (Hospital for Sick Children, McMaster University, and Memorial University of Newfoundland); the majority of cases had been previously genotyped with results published in Marshall et al., 2008 and Pinto et al., 2010. 20 cases from initial cohort of 696 were excluded from further analysis (due to CNVs > 5 Mb).
 676
 Diagnosis of ASD based on meeting criteria on ADI-R and/or ADOS
 NA
 82.84% Male
 23307
 2
 1
 3
 sanders_11_ASD_discovery_cases
 Autistic probands from the Simons Simplex Collection (SSC). 872 probands in quartet families, 272 probands in trios.
 1124
 ASD diagnosis: 89.5% autism; 8.5% PDD-NOS, 2% Asperger syndrome. Mean full-scale IQ 85.1 1.5 (mean verbal IQ, 81.9 1.7; mean non-verbal IQ, 88.4 1.4)
 Mean, 9.1 yrs.
 86.1% Male
 146429
 50
 5
 55
 sansovic_17_DD/ID/ASD_discovery_cases
 Unrelated patients from Croatia referred to the Department of Medical Genetics and Reproductive Health, Children's Hospital Zagreb, University of Zagreb School of Medicine
 337
 Cases diagnosed by clinical geneticists or pediatricians to have developmental delay/intellectual disability (DD/ID), ASD, congenital anomalies, or a combination of those features
 Mean, 7 years (range, 1 month-25 years)
 N/A
 14000
 1
 0
 1
 stobbe_13_ASD_discovery_cases
 Adult ASD cases referred for genetic evaluation of autism from July 2009 through April 2012
 36
 Diagnosis of ASD confirmed in 34 of 36 patients; diagnosis of ASD based on DSM-IV criteria and confirmed by chart review by neurologist specializing in autism.
 Range, 18-45 yrs. (mean 25.3 yrs.)
 77.78% Male
 45000
 1
 0
 1
 vaags_11_ASD_discovery_cases
 Discovery cohort of Canadian individuals with ASD
 1158
 ASD
 NA
 NA
 12179
 1
 0
 1

Controls

Cohort ID
Author, Year
Descripton
Cohort Size
Diagnosis
Age
Gender
CNV Size
Deletion
Duplication
Total CNV's
 brandler_18_ASD_discovery_controls
 Unaffected individuals from the Relating Genes with Adolescent and Child Health (REACH) cohort (112 individuals from 311 families) and the Simons Simplex 1 (SSC1) cohort (518 controls from simplex quad families)
 630
 Control
 N/A
 N/A
 36112
 1
 0
 1
 engchuan_15_ASD_discovery_controls
 Platform-matched controls from three large studies: SAGE (Study of Addiction Genetics and Environment), Ontario Colorectal Cancer study, and HABC (Health Aging and Body Composition)
 2342
 Controls; subjects had no previous psychiatric history
 N/A
 46.67% Male
 531241
 4
 2
 6
 girirajan_13a_ASD_discovery_controls1
 NIMH control cohort consisting of 207 DNA samples obtained from Rutgers Univ. Cell and DNA Repository, and 373 individuals from ClinSeq study of artherosclerotic disease
 580
 Control. Individuals from NIMH control cohort negative for DSM-IV criteria for major depression and history of bipolar disorder or psychosis.
 NA
 NA
 0
 0
 0
 0
 girirajan_13a_ASD_discovery_controls2
 Controls characterized through the Wellcome Trust Case-Control Consortium (WTCCC) for smaller hotspot regions and candidate-gene events
 2090
 Control
 NA
 NA
 N/A
 N/A
 N/A
 N/A
 girirajan_13b_ASD_discovery_controls
 Controls ascertained from the Childhood Autism Risks from Genetics and Environment (CHARGE) study conducted through the Medical Investigation of Neurodevelopmental Disorders (MIND) Institute at UC-Davis after passing QC criteria (242 initial controls)
 223
 Control
 N/A
 N/A
 0
 0
 0
 0
 griswold_12_ASD_discovery_controls
 Children recruited as pediatric controls from HIHG (Miami, FL) and preterm birth study at Centennial Medical Center (Nashville, TN)
 592
 Control
 Range, preterm-21 yrs.
 NA
 84276
 0
 0
 0
 kaminsky_11_DD/ID/ASD_discovery_controls
 Controls from the International Standards for Cytogenomic Arrays (ISCA) consortium
 10118
 Controls
 NA
 NA
 NA
 NA
 NA
 NA
 kanduri_15_ASD_discovery_controls
 Unrelated Finnish samples from the cohort of Health 2000 survey from an initial sample of 288 individuals following quality control
 269
 Controls screened for DSM-IV mental disorders using the Composite International Diagnostic Interview and psychotic disorders using the research version of the Structured Clinical Interview for DSM-IV
 N/A
 N/A
 4061
 3
 0
 3
 krumm_15_ASD_discovery_controls
 Unaffected siblings from quad families from the Simons Simplex Collection
 1786
 Control
 N/A
 N/A
 0
 0
 0
 0
 nguyen_13_DD/ID/MCA/ASD_discovery_controls
 Control data from the Database of Genomic Variants (DGV, n=12,145) and a published dataset of 8,329 individuals from Moriarty et al., 1998.
 20474
 Control
 N/A
 N/A
 N/A
 N/A
 N/A
 N/A
 nord_11_ASD_discovery_controls
 Samples from 367 total control individuals (319 European American, 48 African American) used to test for differences in rare CNV prevalence compared with autism cases
 123
 Controls (no history of psychiatric symptoms by self-report)
 30 yrs.
 
 958776
 0
 1
 1
 poultney_13_ASD_discovery_controls
 Controls matched for European ancestry from NIMH and CEPH retained after filtering (original cohort size of 379 controls)
 260
 Control
 N/A
 47.49% Male (before filtering)
 0
 0
 0
 0
 prasad_12_ASD_discovery_controls
 PDx controls [1000 DNA samples from reportedly healthy donors (50.2% male) from BioServe (Beltsville, MD)] and 4139 in-house controls previously reported in Krawcak et al. 2006, Stewart et al. 2009, and Bierut et al. 2010. CNVs identified in controls were used to define rare ASD-specific CNVs.
 5139
 Control
 NA
 NA (PDx controls 50.2% male)
 23307
 0
 0
 0
 sanders_11_ASD_discovery_controls
 Matched siblings of autistic probands from the Simons Simplex Collection (SSC).
 872
 Controls
 Mean, 10.0 yrs.
 
 146429
 45
 2
 47

Cases

Cohort ID
Geographical Ancestry
Discovery Method
Platform
Algorithm
Software
Validation Method
 balciuniene_07_ASD_discovery_cases
  1 African-American, 2 NA
 aCGH
 
 
 
 None
 chaves_19_ASD/DD/ID_discovery_cases
  Brazil
 Array SNP
  Affymetrix CytoScan 750K, Affymetrix CytoScan HD
 
 Affymetrix ChAS
 None
 chong_14_DD/ID/ASD/MCA_discovery_cases
  Chinese
 aCGH
  High-resolution 180K oligoarray
 
 
 aCGH (NimbleGen)
 digregorio_17_DD/ID_discovery_cases
  Italian
 aCGH
  Agilent 60K (SurePrint G3 Human CGH Microarray 8x60K)
 ADM-2
 Agilent CGH Analytics software ver. 4.0.81
 None
 engchuan_15_ASD_discovery_cases
  Caucasian
 Solid phase hybridization
  Illumina 1M
 
 
 None
 gai_11_ASD_replication_cases
  European
 Solid phase hybridization
  Illumina Infinium II HumanHap550 BeadChip
 
 BeadStudio 3.0
 None
 gazzellone_14_ASD_discovery_cases
  Han Chinese
 Array SNP
  Affymetrix CytoScan HD
 ChAS, iPattern, Nexus, Partek
 
 None
 girirajan_13a_ASD_discovery_cases
  NA
 aCGH
  Custom microarray with a high density of probes targeted to 1,367 regions with a susceptible genomic architecture
 ADM-2
 Agilent Genomic Workbench
 aCGH (NimbleGen 135K array)
 girirajan_13b_ASD_discovery_cases
  133 European, 57 Hispanic, 27 Mixed Race, 20 Asian, 6 African-American
 aCGH
  Roche NimbleGen custom targeted hotspot array comprised of 135,000 probes with higher density probe coverage in genomic hotspots (regions flanked by segmental duplications)
 DNA Copy Number v1.6
 
 None
 griswold_12_ASD_discovery_cases
  Range of self-reported ethnicities (specifics NA)
 Solid phase hybridization
  Illumina Human 1M-v1_C BeadChip, Illumina 1M-DuoV3 BeadChip
 Penn CNV, QuantiSNP
 BeadStudio
 qPCR
 hnoonual_17_ASD_discovery_cases
  Thai
 Solid phase hybridization
  Illumina Infinium CytoSNP-850K v1.1 BeadChip
 
 BlueFuse Multi v4.3, GenomeStudio Data Analysis v.2011.1
 None
 kalsner_17_ASD_discovery_cases
  52 Caucasian (not Latino), 14.5 Hispanic/Latino, 7 African-American, 5 Asian, 21 more than one race/ethnicity
 CMA
  Platform not reported
 
 
 None
 kaminsky_11_DD/ID/ASD_discovery_cases
  NA
 aCGH
  Agilent 44K, Agilent 105K
 
 Feature Extraction, DNA Analytics
 FISH, qPCR, MLPA, aCGH, standard G-banded chromosome analysis
 krumm_15_ASD_discovery_cases
  N/A
 WES
 
 CoNIFER, XHMM
 
 Solid phase hybridization (Illumina 1M, 1 M Duo, or Omni 2.5)
 leppa_16_ASD_discovery_cases
  N/A
 Solid phase hybridization
  Illumina 550v1 and 550v3, Omni-1.0-B and -H, Omni 2.5
 PennCNV, QuantiSNP, GNOSIS
 GenomeStudio, CNVision
 None
 mosca_16_DCD_discovery_cases
  Canada
 Solid phase hybridization
  Illumina HumanOmni2.5-Quad BeadChip
 iPattern, PennCNV, QuantiSNP, CNVPartition
 
 None
 nguyen_13_DD/ID/MCA/ASD_discovery_cases
  N/A
 aCGH
  SignatureChip BACs aCGH, SignatureChip Oligo whole-genome microarray
 
 
 N/A
 nord_11_ASD_discovery_cases
  29 European American, 3 Asian American, 2 Hispanic, 2 African American, 5 unknown ancestry
 aCGH
  NimbleGen HD2
 Sliding-window algorithm, ~10 kb minumum size threshold
 
 None
 pinto_14_ASD_discovery_cases
  Predominantly European
 Solid phase hybridization
  Illumina 1M (v.1 and v.3)
 
 
 qPCR, MLPA, long-range PCR
 poultney_13_ASD_discovery_cases
  European
 WES
  Agilent SureSelect Human All Exon v.2
 XHMM
 
 None
 prasad_12_ASD_discovery_cases
  Canada
 aCGH
  Agilent 1M
 ADM-2, DNAcopy (R Bioconductor)
 DNA Analytics v4.0.85 (Agilent), DNAcopy
 None
 sanders_11_ASD_discovery_cases
  White non-Hispanic, 74.5%; mixed, 9.3%, Asian, 4.3%, White Hispanic, 4.0%, African-American, 3.8%; other, 4.2&
 Solid phase hybridization
  Illumina 1M v1, Illumina 1M v3
 PennCNV, QuantiSNP, GNOSIS
 
 
 sansovic_17_DD/ID/ASD_discovery_cases
  Croatia
 aCGH
  Agilent SurePrint G3 Unrestricted CGH ISCA v2
 
 Agilent Feature Extraction (v12.0), Agilent CytoGenomics (v3.0 and v4.0)
 None
 stobbe_13_ASD_discovery_cases
  N/A
 aCGH
  NimbleGen CGX-3v1.0
 ADM-1
 NimbleScan 2.5, DNA Analytics 4.0
 None
 vaags_11_ASD_discovery_cases
  Canadian
 aCGH, array SNP, solid phase hybridization
  Affymetrix 6.0, Illumina Infinium 1M, Illumina Omni 2.5M, Agilent 1M
 
 
 None

Controls

Cohort ID
Geographical Ancestry
Discovery Method
Platform
Algorithm
Software
Validation Method
  brandler_18_ASD_discovery_controls
  N/A
  WGS
  Illumina HiSeq X10 or HiSeq 2500
  ForestSV, Lumpy, Manta, Mobster, SV2
 
  PCR, array SNP
  engchuan_15_ASD_discovery_controls
  Caucasian
  Solid phase hybridization
  Illumina 1M
 
 
  None
  girirajan_13a_ASD_discovery_controls1
  NA
  aCGH
  Custom microarray with a high density of probes targeted to 1,367 regions with a susceptible genomic architecture
  ADM-2
  Agilent Genomic Workbench
  None
  girirajan_13a_ASD_discovery_controls2
  NA
  Solid phase hybridization
  Illumina 1.2M SNP microarray
 
 
  None
  girirajan_13b_ASD_discovery_controls
  116 European, 70 Hispanic, 27 Mixed Race, 7 Asian, 3 African-American
  aCGH
  Roche NimbleGen custom targeted hotspot array comprised of 135,000 probes with higher density probe coverage in genomic hotspots (regions flanked by segmental duplications)
  DNA Copy Number v1.6
 
 
  griswold_12_ASD_discovery_controls
  Caucasian
  Solid phase hybridization
  Illumina Human 1M-v1_C BeadChip, Illumina 1M-DuoV3 BeadChip
  Penn CNV, QuantiSNP
  BeadStudio
 
  kaminsky_11_DD/ID/ASD_discovery_controls
  NA
  aCGH
  Agilent 44K, Agilent 105K
 
  Feature Extraction, DNA Analytics
 
  kanduri_15_ASD_discovery_controls
  Finnish
  Solid phase hybridization
  Illumina Infinium HD Human610-Quad BeadChip
  QuantiSNP, PennCNV
  Illumina BeadStudio
  None
  krumm_15_ASD_discovery_controls
  N/A
  WES
 
  CoNIFER, XHMM
 
  None
  nguyen_13_DD/ID/MCA/ASD_discovery_controls
  N/A
  N/A
  N/A
 
 
  N/A
  nord_11_ASD_discovery_controls
 
  aCGH
  NimbleGen HD2
  Sliding-window algorithm, ~10 kb minumum size threshold
 
  None
  poultney_13_ASD_discovery_controls
  European
  WES
  Agilent SureSelect Human All Exon v.2
  XHMM
 
 
  prasad_12_ASD_discovery_controls
  NA
  aCGH
  Agilent 1M
  ADM-2, DNAcopy (R Bioconductor)
  DNA Analytics v4.0.85 (Agilent), DNAcopy
 
  sanders_11_ASD_discovery_controls
 
  Solid phase hybridization
  Illumina 1M v1 or Illumina 1M v3
  PennCNV, QuantiSNP, GNOSIS
 
 

Cases

Patient ID
Author, Year
Age
Gender
Primary Diagnosis
Clinical Profile
Cognitive Profile
CNV Start
CNV End
CNV Size
Genome Build
Type Method
Validation
  balciuniene_07_ASD_discovery_cases-case3
 11 yrs.
 M
 Learning disability
 Presented to Genetic Clinics, Johns Hopkins Hospital, at 18 months for evaluation of presumptive Bannayan-Riley-Ruvalcaba syndrome (BRRS), with a history of macrosomia at birth, persistent macrocephaly due to megencephaly, subcutaneous lipomas, gastrointestinal polyps, and developmental delay. Underwent colectomy at 3 years of age.
 Mild learning disabilities, but attending regular classes
 82575044
 82671226
  96000
 Unknown
 Deletion
 No
  chaves_19_ASD/DD/ID_discovery_cases-case248
  NA NA
 N/A
 M
 Developmental delay
 Abnormal brain structure, developmental delay, speech and/or language delay or impairment, facial dysmorphism and microcephaly
 
 85632525
 86031927
  399403
 GRCh38
 Deletion
 No
  chaves_19_ASD/DD/ID_discovery_cases-case255
  NA NA
 N/A
 M
 Developmental delay
 Developmental delay
 
 85931710
 86083870
  152161
 GRCh38
 Deletion
 No
  chong_14_DD/ID/ASD/MCA_discovery_cases-caseaCGH3832
 N/A
 F
 Developmental delay
 Mild to moderate developmental delay, mild ataxia
 Mild to moderate developmental delay
 82080307
 82213188
  132882
 GRCh38
 Deletion
 Yes
  digregorio_17_DD/ID_discovery_cases-DECIPHER_296557
  NA NA
 N/A
 F
 Developmental delay/intellectual disability
 
 
 80412353
 80511100
  98748
 GRCh38
 Duplication
 No
  engchuan_15_ASD_discovery_cases-case14153_2520
 N/A
 N/A
 ASD
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 
 80620909
 80913061
  292153
 GRCh38
 Duplication
 No
  engchuan_15_ASD_discovery_cases-case14383_1300
 N/A
 N/A
 ASD
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 
 80620909
 80912912
  292004
 GRCh38
 Duplication
 No
  engchuan_15_ASD_discovery_cases-case4446_1
 N/A
 N/A
 ASD
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 
 86005021
 86089297
  84277
 GRCh38
 Deletion
 No
  engchuan_15_ASD_discovery_cases-case8663_201
 N/A
 N/A
 ASD
 Diagnosis of ASD based on Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R)
 
 82265827
 82331275
  65449
 GRCh38
 Deletion
 No
  gai_11_ASD_replication_cases-AU001203
 
 
 Autism
 
 
 83958683
 83992154
  33472
 Unknown
 Deletion
 No
  gai_11_ASD_replication_cases-AU001204
 
 
 Autism
 
 
 83958683
 83992154
  33472
 Unknown
 Deletion
 No
  gazzellone_14_ASD_discovery_cases-case485-3
 N/A
 M
 ASD
 ASD; no other clinical information provided
 N/A
 85578646
 85600221
  21576
 GRCh38
 Deletion
 No
  girirajan_13a_ASD_discovery_cases-11545.p1
 N/A
 N/A
 ASD
 Diagnosis of ASD based on meeting criteria on the Autism Diagnostic Observation Schedule (ADOS) and on the Autism Diagnostic Interview, Revised (ADI-R)
 N/A
 80334950
 80356863
  21914
 GRCh38
 Duplication
 Yes
  girirajan_13a_ASD_discovery_cases-12378.p1
 N/A
 N/A
 ASD
 Diagnosis of ASD based on meeting criteria on the Autism Diagnostic Observation Schedule (ADOS) and on the Autism Diagnostic Interview, Revised (ADI-R)
 N/A
 80334950
 80356863
  21914
 GRCh38
 Duplication
 Yes
  girirajan_13a_ASD_discovery_cases-13611.p1
 N/A
 N/A
 ASD
 Diagnosis of ASD based on meeting criteria on the Autism Diagnostic Observation Schedule (ADOS) and on the Autism Diagnostic Interview, Revised (ADI-R)
 N/A
 80334950
 80356863
  21914
 GRCh38
 Duplication
 Yes
  girirajan_13a_ASD_discovery_cases-13634.p1
 N/A
 N/A
 ASD
 Diagnosis of ASD based on meeting criteria on the Autism Diagnostic Observation Schedule (ADOS) and on the Autism Diagnostic Interview, Revised (ADI-R)
 N/A
 80334950
 80356863
  21914
 GRCh38
 Duplication
 Yes
  girirajan_13a_ASD_discovery_cases-13889.p1
 N/A
 N/A
 ASD
 Diagnosis of ASD based on meeting criteria on the Autism Diagnostic Observation Schedule (ADOS) and on the Autism Diagnostic Interview, Revised (ADI-R)
 N/A
 82844100
 82930569
  86470
 GRCh38
 Duplication
 Yes
  girirajan_13a_ASD_discovery_cases-14055.p1
 N/A
 N/A
 ASD
 Diagnosis of ASD based on meeting criteria on the Autism Diagnostic Observation Schedule (ADOS) and on the Autism Diagnostic Interview, Revised (ADI-R)
 N/A
 80334950
 80356863
  21914
 GRCh38
 Duplication
 Yes
  girirajan_13a_ASD_discovery_cases-14343.p1
 N/A
 N/A
 ASD
 Diagnosis of ASD based on meeting criteria on the Autism Diagnostic Observation Schedule (ADOS) and on the Autism Diagnostic Interview, Revised (ADI-R)
 N/A
 80334950
 80356863
  21914
 GRCh38
 Duplication
 Yes
  girirajan_13a_ASD_discovery_cases-14348.p1
 N/A
 N/A
 ASD
 Diagnosis of ASD based on meeting criteria on the Autism Diagnostic Observation Schedule (ADOS) and on the Autism Diagnostic Interview, Revised (ADI-R)
 N/A
 80610197
 80616467
  6271
 GRCh38
 Deletion
 Yes
  girirajan_13a_ASD_discovery_cases-AU1763301
 N/A
 N/A
 ASD
 Diagnosis of ASD based on meeting criteria on the Autism Diagnostic Observation Schedule (ADOS) and on the Autism Diagnostic Interview, Revised (ADI-R)
 N/A
 80334950
 80356863
  21914
 GRCh38
 Duplication
 Yes
  girirajan_13b_ASD_discovery_cases-44106106924
 N/A
 N/A
 Autism
 Diagnosis of autism confirmed by ADOS and ADI-R. Ethnicity: Caucasian
 N/A
 85398279
 85722123
  323845
 GRCh38
 Duplication
 No
  griswold_12_ASD_discovery_cases-case37276
 NA
 NA
 ASD/autism
 NA
 NA
 86005021
 86089297
  84277
 GRCh38
 Deletion
 Yes
  hnoonual_17_ASD_discovery_cases-casePS37-3
 N/A
 M
 ASD
 Seizures
 
 82257852
 82355261
  97410
 GRCh38
 Deletion
 No
  kalsner_17_ASD_discovery_cases-case8
 N/A
 N/A
 ASD
 Case (i) had a confirmed diagnosis of ASD by a developmental behavioral pediatrician or child neurologist experienced in ASD, (ii) scored in the full autism range on ADOS-2 and (iii) either met DSM-5 criteria for ASD or scored in the autism range on CARS-2
 
 83524214
 85350860
  1826647
 GRCh38
 Duplication
 No
  kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00001665
 NA
 NA
 Developmental delay/intellectual disability/ASD
 Clinical profile NA
 Cognitive profile NA
 82081625
 83870328
  1788704
 GRCh38
 Duplication
 Yes
  kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00002246
 NA
 NA
 Developmental delay/intellectual disability/ASD
 Clinical profile NA
 Cognitive profile NA
 82794503
 84537954
  1743452
 GRCh38
 Duplication
 Yes
  kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00002272
 NA
 NA
 Developmental delay/intellectual disability/ASD
 Clinical profile NA
 Cognitive profile NA
 82322554
 82359096
  36543
 GRCh38
 Deletion
 Yes
  krumm_15_ASD_discovery_cases-case11545.p1
 N/A
 Male
 ASD
 Proband from the Simons Simplex Collection (SSC). Family type: Trio
 
 80336155
 80352601
  16447
 GRCh38
 Duplication
 Yes
  krumm_15_ASD_discovery_cases-case12378.p1
 N/A
 Female
 ASD
 Proband from the Simons Simplex Collection (SSC). Family type: Trio
 
 80336155
 80352601
  16447
 GRCh38
 Duplication
 Yes
  krumm_15_ASD_discovery_cases-case13634.p1
 N/A
 Male
 ASD
 Proband from the Simons Simplex Collection (SSC). Family type: Quad
 
 80336155
 80352601
  16447
 GRCh38
 Duplication
 Yes
  krumm_15_ASD_discovery_cases-case14343.p1
 N/A
 Male
 ASD
 Proband from the Simons Simplex Collection (SSC). Family type: Quad
 
 80336155
 80352601
  16447
 GRCh38
 Duplication
 Yes
  leppa_16_ASD_discovery_cases-AU3057301
 N/A
 F
 ASD
 
 
 83346244
 84899244
  1553001
 GRCh38
 Duplication
 No
  mosca_16_DCD_discovery_cases-case113903
 N/A
 M
 DCD (with or without ADHD and/or RD)
 Ancestry: unknown. Family history: maternal diagnosis unknown; paternal diagnosis unknown.
 
 80666929
 80732567
  65639
 GRCh38
 Deletion
 No
  nguyen_13_DD/ID/MCA/ASD_discovery_cases-251690
 N/A
 F
 Developmental delay/intellectual disability
 Database: DECIPHER. Indication for study: intellectual disability/developmental delay
 Developmental delay/intellectual disability
 80711826
 82395599
  1683774
 GRCh38
 Deletion
 N/A
  nord_11_ASD_discovery_cases-239-1
 
 
 ASD
 
 
 87428567
 87438790
  10224
 Unknown
 Deletion
 No
  nord_11_ASD_discovery_cases-239-1
 
 
 ASD
 
 
 84003515
 84022691
  19177
 Unknown
 Deletion
 No
  pinto_14_ASD_discovery_cases2-case4446_1
 N/A
 M
 ASD
 Clinical profile: N/A.
 Cognitive profile: N/A.
 86005021
 86089297
  84277
 GRCh38
 Deletion
 Yes
  poultney_13_ASD_discovery_cases-case05HI2544A
 N/A
 M
 ASD
 ASD case from AGRE (AGRE ID AU0911302; NDAR ID NDAR_INVBZ963FL8)
 
 80338465
 80352603
  14139
 GRCh38
 Duplication
 No
  poultney_13_ASD_discovery_cases-case05HI4548A
 N/A
 M
 ASD
 ASD case from AGRE (AGRE ID AU1549303; NDAR ID NDAR_INVVJ971KMF)
 
 80336154
 80352603
  16450
 GRCh38
 Duplication
 No
  poultney_13_ASD_discovery_cases-case98HI0245A
 N/A
 F
 ASD
 ASD case from AGRE (AGRE ID AU009205; NDAR ID NDAR_INVCY103EWN)
 
 80336154
 80352603
  16450
 GRCh38
 Duplication
 No
  prasad_12_ASD_discovery_cases-case139157
 NA
 F
 ASD
 Diagnosis of ASD based on meeting criteria on ADI-R and/or ADOS. CNV identified by previous SNP microarray study
 
 87190259
 87208882
  18624
 Unknown
 Deletion
 No
  prasad_12_ASD_discovery_cases-case55310
 NA
 M
 ASD
 Diagnosis of ASD based on meeting criteria on ADI-R and/or ADOS. Novel CNV
 
 83770261
 83793567
  23307
 Unknown
 Deletion
 No
  prasad_12_ASD_discovery_cases-case60635
 NA
 M
 ASD
 Diagnosis of ASD based on meeting criteria on ADI-R and/or ADOS. CNV identified by previous SNP microarray study
 
 82084686
 82105154
  20469
 Unknown
 Duplication
 No
  sanders_11_ASD_discovery_cases-11073.p1
 9.7
 M
 Autism
 NA
 Full-scale IQ, 100; non-verbal IQ, 100; verbal IQ, 101
 82953362
 82956767
  3406
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-11114.p1
 8.8
 F
 Autism
 NA
 Full-scale IQ, 40; non-verbal IQ, 45; verbal IQ, 30
 81119963
 81128126
  8164
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-11133.p1
 17
 M
 Autism
 NA
 Full-scale IQ, 128; non-verbal IQ, 110; verbal IQ 140
 83768092
 83779789
  11698
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-11144.p1
 10.9
 M
 Autism
 NA
 Full-scale IQ, 111; non-verbal IQ, 127; verbal IQ, 99
 82504001
 82505413
  1413
 GRCh38
 Duplication
 No
  sanders_11_ASD_discovery_cases-11165.p1
 5.2
 M
 Autism
 NA
 Full-scale IQ, 104; non-verbal IQ, 112; verbal IQ 89
 81118160
 81133375
  15216
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-11205.p1
 7.9
 M
 Autism
 NA
 Full-scale IQ, 63; non-verbal IQ, 70; verbal IQ, 61
 81177862
 81185794
  7933
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-11218.p1
 10.5
 M
 Autism
 NA
 Full-scale IQ, 109; non-verbal IQ, 119; verbal IQ, 98
 81119963
 81128126
  8164
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-11232.p1
 8.7
 M
 ASD
 NA
 Full-scale IQ, 74; non-verbal IQ, 68; verbal IQ 91
 81119963
 81128126
  8164
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-11294.p1
 6.2
 M
 Autism
 NA
 Full-scale IQ, 80; non-verbal IQ, 79; verbal IQ 87
 81119963
 81128126
  8164
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-11429.p1
 11.3
 M
 Autism
 NA
 Full-scale IQ, 99; non-verbal IQ, 97; verbal IQ, 102
 81797431
 81807191
  9761
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-11458.p1
 16.4
 M
 Autism
 NA
 Full-scale IQ, 117; non-verbal IQ, 106; verbal IQ, 126
 81118732
 81128126
  9395
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-11472.p1
 13.7
 F
 Autism
 NA
 Full-scale IQ, 30; non-verbal IQ, 30; verbal IQ, 31
 81177862
 81185794
  7933
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-11504.p1
 8.2
 M
 Autism
 NA
 Full-scale IQ, 112; non-verbal IQ, 108; verbal IQ, 119
 81115973
 81128126
  12154
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-11540.p1
 8.2
 M
 Autism
 NA
 Full-scale IQ, 59; non-verbal IQ, 67; verbal IQ, 55
 82953362
 82956767
  3406
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-11545.p1
 7.9
 M
 Autism
 NA
 Full-scale IQ, 103; non-verbal IQ, 114; verbal IQ, 83
 80340672
 80352732
  12061
 GRCh38
 Duplication
 No
  sanders_11_ASD_discovery_cases-11592.p1
 10.1
 M
 Autism
 NA
 Full-scale IQ, 115; non-verbal IQ, 109; verbal IQ, 122
 81125293
 81128126
  2834
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-11630.p1
 10.6
 M
 Autism
 NA
 Full-scale IQ, 104; non-verbal IQ, 105; verbal IQ, 106
 81119963
 81128126
  8164
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-11711.p1
 5.3
 M
 Autism
 NA
 Full-scale IQ, 94; non-verbal IQ, 97; verbal IQ, 93
 81119963
 81128126
  8164
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-11712.p1
 5.5
 M
 ASD
 NA
 Full-scale IQ, 79; non-verbal IQ, 94; verbal IQ, 60
 81177862
 81185794
  7933
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-11740.p1
 11.7
 M
 Autism
 NA
 Full-scale IQ, 98; non-verbal IQ, 89; verbal IQ, 115
 81119963
 81128126
  8164
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-11768.p1
 8.4
 M
 Autism
 NA
 Full-scale IQ, 85; non-verbal IQ, 84; verbal IQ, 89
 81119963
 81128126
  8164
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-11972.p1
 8.5
 F
 Autism
 NA
 Full-scale IQ, 77; non-verbal IQ, 80; verbal IQ, 77
 81119963
 81128126
  8164
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-11982.p1
 9.3
 M
 Autism
 NA
 Full-scale IQ, 79; non-verbal IQ, 78; verbal IQ, 86
 81119963
 81128126
  8164
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-12029.p1
 8.6
 M
 Autism
 NA
 Full-scale IQ, 103; non-verbal IQ, 108; verbal IQ, 94
 81118160
 81128126
  9967
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-12030.p1
 6.8
 M
 Autism
 NA
 Full-scale IQ, 107; non-verbal IQ, 109; verbal IQ, 101
 81119963
 81128126
  8164
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-12076.p1
 9.8
 M
 Autism
 NA
 Full-scale IQ, 106; non-verbal IQ, 110; verbal IQ, 98
 82650138
 82670332
  20195
 GRCh38
 Duplication
 No
  sanders_11_ASD_discovery_cases-12096.p1
 11.7
 M
 Autism
 NA
 Full-scale IQ, 119; non-verbal IQ, 119; verbal IQ, 114
 81125293
 81128126
  2834
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-12108.p1
 13.9
 M
 Autism
 NA
 Full-scale IQ, 66; non-verbal IQ, 63; verbal IQ, 74
 81119963
 81128126
  8164
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-12162.p1
 4.3
 M
 Autism
 NA
 Full-scale IQ, 67; non-verbal IQ, 68; verbal IQ, 75
 80688425
 80834854
  146430
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-12224.p1
 4.3
 M
 Autism
 NA
 Full-scale IQ, 80; non-verbal IQ, 85; verbal IQ, 78
 81115973
 81128126
  12154
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-12227.p1
 12.4
 M
 Autism
 NA
 Full-scale IQ, 137; non-verbal IQ, 146; verbal IQ, 106
 81598168
 81634964
  36797
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-12238.p1
 8
 M
 Autism
 NA
 Full-scale IQ, 87; non-verbal IQ, 90; verbal IQ, 84
 81150002
 81160611
  10610
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-12287.p1
 7.9
 M
 Autism
 NA
 Full-scale IQ, 43; non-verbal IQ, 55; verbal IQ, 28
 85056582
 85086388
  29807
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-12296.p1
 15.3
 M
 Autism
 NA
 Full-scale IQ, 73; non-verbal IQ, 88; verbal IQ, 52
 81119963
 81126219
  6257
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-12306.p1
 8.4
 M
 Autism
 NA
 Full-scale IQ, 66; non-verbal IQ, 57; verbal IQ, 84
 81119963
 81128126
  8164
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-12315.p1
 5.8
 M
 ASD
 NA
 Full-scale IQ, 53; non-verbal IQ, 54; verbal IQ, 61
 82650138
 82670332
  20195
 GRCh38
 Duplication
 No
  sanders_11_ASD_discovery_cases-12337.p1
 11.6
 M
 ASD
 NA
 Full-scale IQ, 121; non-verbal IQ, 112; verbal IQ, 131
 80810297
 80813434
  3138
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-12361.p1
 4.8
 M
 ASD
 NA
 Full-scale IQ, 115; non-verbal IQ, 123; verbal IQ, 98
 81119963
 81128126
  8164
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-12378.p1
 6.2
 F
 Autism
 NA
 Full-scale IQ, 82; non-verbal IQ, 84; verbal IQ, 81
 80340672
 80353117
  12446
 GRCh38
 Duplication
 No
  sanders_11_ASD_discovery_cases-12429.p1
 4.8
 M
 Autism
 NA
 Full-scale IQ, 74; non-verbal IQ, 71; verbal IQ, 82
 83761496
 83794477
  32982
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-12493.p1
 15.3
 F
 ASD
 NA
 Full-scale IQ, 88; non-verbal IQ, 92; verbal IQ, 86
 81119963
 81128126
  8164
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-12552.p1
 8.7
 M
 Autism
 NA
 Full-scale IQ, 104; non-verbal IQ, 107; verbal IQ, 98
 81125293
 81128126
  2834
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-12579.p1
 6.6
 M
 Autism
 NA
 Full-scale IQ, 33; non-verbal IQ, 52; verbal IQ, 18
 81125293
 81128126
  2834
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-12603.p1
 11.7
 M
 Autism
 NA
 Full-scale IQ, 23; non-verbal IQ, 26; verbal IQ, 20
 81119963
 81128126
  8164
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-12607.p1
 5.3
 M
 ASD
 NA
 Full-scale IQ, 105; non-verbal IQ, 104; verbal IQ, 104
 81119963
 81128126
  8164
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-12628.p1
 11.2
 M
 Autism
 NA
 Full-scale IQ, 118; non-verbal IQ, 102; verbal IQ, 120
 81119963
 81128126
  8164
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-12656.p1
 10.9
 M
 Autism
 NA
 Full-scale IQ, 40; non-verbal IQ, 46; verbal IQ, 29
 81119963
 81128126
  8164
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-12708.p1
 10.3
 M
 Autism
 NA
 Full-scale IQ, 79; non-verbal IQ, 91; verbal IQ, 63
 81119963
 81128126
  8164
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-12764.p1
 15.2
 F
 ASD
 NA
 Full-scale IQ, 94; non-verbal IQ, 99; verbal IQ, 86
 81115973
 81128126
  12154
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-12799.p1
 4
 M
 Autism
 NA
 Full-scale IQ, 58; non-verbal IQ, 55; verbal IQ, 49
 83768092
 83794477
  26386
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-12969.p1
 12.2
 M
 Autism
 NA
 Full-scale IQ, 73; non-verbal IQ, 78; verbal IQ, 70
 81115973
 81128126
  12154
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-13057.p1
 4.2
 M
 Autism
 NA
 Full-scale IQ, 108; non-verbal IQ, 118; verbal IQ, 87
 81177862
 81185794
  7933
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-13070.p1
 8.9
 M
 Autism
 NA
 Full-scale IQ, 86; non-verbal IQ, 96; verbal IQ, 85
 81119963
 81128126
  8164
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-13096.p1
 5.6
 M
 Autism
 NA
 Full-scale IQ, 107; non-verbal IQ, 111; verbal IQ, 99
 81119963
 81128126
  8164
 GRCh38
 Deletion
 No
  sanders_11_ASD_discovery_cases-13322.p1
 16.9
 M
 Autism
 NA
 Full-scale IQ, 59; non-verbal IQ, 62; verbal IQ, 56
 81119963
 81128126
  8164
 GRCh38
 Deletion
 No
  sansovic_17_DD/ID/ASD_discovery_cases-case29
 8 yrs.
 F
 Developmental delay/intellectual disability
 Developmental delay/intellectual disability, Congenital anomalies, Dysmorphism
 
 82510252
 82523786
  13535
 GRCh38
 Deletion
 No
  stobbe_13_ASD_discovery_cases-case6
 26 yrs.
 M
 Autism and epilepsy
 Family history: paternal grandmother with epilepsy. Karyotype: not performed. Fragile X testing: normal.
 
 82380463
 82425994
  45532
 GRCh38
 Deletion
 No
  vaags_11_ASD_discovery_cases-probandF2-003
 3 yrs. 5 mos.
 M
 Autism
 Diagnosis of autism based on ADI-R and ADOS-1. Language: Oral and Written Language Scales/OWLS, incomplete; Peabody Picture Vocabulary Test/PPVT-4, SS = 67 (<1%). Adaptive Behavior (measured by VABS-II): adaptive behavior composite (ABC) = 61 (<1%), communication (COM) = 63 (1%), daily living skills (DLS) = 60 (<1%), socialization (SOC) = 59 (<1%), and motor skills (MOT) = 72 (3%). Born at 31 weeks, asthma, juvenile arthritis. Family history: proband was one of three trizygotic triplets; sister with autism & nonabsent seizures (has NRXN3 deletion).
 Leiter-R IQ: incomplete (test attempted but proband failed to complete)
 81119490
 81131668
  12179
 GRCh38
 Deletion
 No

Controls

Patient ID
Author, Year
Age
Gender
Primary Diagnosis
Clinical Profile
Cognitive Profile
CNV Start
CNV End
CNV Size
Genome Build
Type Method
Validation
  brandler_18_ASD_discovery_controls-controlSSC08632
  N/A
  M
  Control
  Control from SSC cohort
 
  80974588
  81010700
  36113
  GRCh38
  Deletion
  Yes
  engchuan_15_ASD_discovery_controls-controlB248665_1007854152
  N/A
  N/A
  Control
  No previous psychiatric history
 
  82528792
  82581943
  53152
  GRCh38
  Deletion
  No
  engchuan_15_ASD_discovery_controls-controlB524961_1007872292
  N/A
  N/A
  Control
  No previous psychiatric history
 
  85179517
  85274340
  94824
  GRCh38
  Deletion
  No
  engchuan_15_ASD_discovery_controls-controlHABC_900270_900270
  N/A
  N/A
  Control
  No previous psychiatric history
 
  80302905
  80348854
  45950
  GRCh38
  Duplication
  No
  engchuan_15_ASD_discovery_controls-controlHABC_900270_900270
  N/A
  N/A
  Control
  No previous psychiatric history
 
  80445650
  80976891
  531242
  GRCh38
  Duplication
  No
  engchuan_15_ASD_discovery_controls-controlHABC_900629_900629
  N/A
  N/A
  Control
  No previous psychiatric history
 
  82528792
  82575935
  47144
  GRCh38
  Deletion
  No
  engchuan_15_ASD_discovery_controls-controlHABC_902550_902550
  N/A
  N/A
  Control
  No previous psychiatric history
 
  82528792
  82575935
  47144
  GRCh38
  Deletion
  No
  kanduri_15_ASD_discovery_controls-control_split1305
  N/A
  N/A
  Control
  Control screened for DSM-IV mental disorders using the Composite International Diagnostic Interview and psychotic disorders using the research version of the Structured Clinical Interview for DSM-IV
 
  84502161
  84505577
  3417
  Unknown
  Deletion
  No
  kanduri_15_ASD_discovery_controls-control_split1394
  N/A
  N/A
  Control
  Control screened for DSM-IV mental disorders using the Composite International Diagnostic Interview and psychotic disorders using the research version of the Structured Clinical Interview for DSM-IV
 
  83950540
  83954600
  4061
  Unknown
  Deletion
  No
  kanduri_15_ASD_discovery_controls-control_split1522
  N/A
  N/A
  Control
  Control screened for DSM-IV mental disorders using the Composite International Diagnostic Interview and psychotic disorders using the research version of the Structured Clinical Interview for DSM-IV
 
  83950540
  83954600
  4061
  Unknown
  Deletion
  No
  nord_11_ASD_discovery_controls-04C27962
 
 
  Control
 
 
  84445724
  85404499
  958776
  Unknown
  Duplication
 
  sanders_11_ASD_discovery_controls-11032.s1
  3.7
  M
  Control (matched sibling)
  NA
  NA
  80340672
  80353117
  12446
  GRCh38
  Duplication
  No
  sanders_11_ASD_discovery_controls-11051.s1
  9.6
  F
  Control (matched sibling)
  NA
  NA
  81118732
  81128126
  9395
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-11205.s1
  4.8
  F
  Control (matched sibling)
  NA
  NA
  81177862
  81185794
  7933
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-11218.s1
  8.5
  M
  Control (matched sibling)
  NA
  NA
  81119963
  81128126
  8164
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-11325.s1
  12.3
  M
  Control (matched sibling)
  NA
  NA
  81115973
  81128126
  12154
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-11429.s1
  18.6
  M
  Control (matched sibling)
  NA
  NA
  81797431
  81807191
  9761
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-11433.s1
  11.8
  F
  Control (matched sibling)
  NA
  NA
  81177862
  81185794
  7933
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-11446.s1
  11
  F
  Control (matched sibling)
  NA
  NA
  81119963
  81128126
  8164
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-11450.s1
  12.5
  F
  Control (matched sibling)
  NA
  NA
  81115973
  81128126
  12154
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-11488.s1
  7.7
  M
  Control (matched sibling)
  NA
  NA
  81119963
  81128126
  8164
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-11504.s1
  5.8
  M
  Control (matched sibling)
  NA
  NA
  81118732
  81128126
  9395
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-11518.s1
  12.2
  F
  Control (matched sibling)
  NA
  NA
  81119963
  81128126
  8164
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-11545.s1
  11.2
  M
  Control (matched sibling)
  NA
  NA
  80340672
  80355863
  15192
  GRCh38
  Duplication
  No
  sanders_11_ASD_discovery_controls-11554.s1
  4.6
  M
  Control (matched sibling)
  NA
  NA
  82080137
  82128587
  48451
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-11592.s1
  8
  F
  Control (matched sibling)
  NA
  NA
  81119963
  81128126
  8164
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-11600.s1
  19.2
  M
  Control (matched sibling)
  NA
  NA
  81119963
  81128126
  8164
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-11712.s1
  8.6
  F
  Control (matched sibling)
  NA
  NA
  81177862
  81185794
  7933
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-11715.s1
  6.6
  F
  Control (matched sibling)
  NA
  NA
  81172427
  81185794
  13368
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-11722.s1
  9.8
  M
  Control (matched sibling)
  NA
  NA
  83768092
  83773742
  5651
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-11740.s1
  9.3
  M
  Control (matched sibling)
  NA
  NA
  81119963
  81128126
  8164
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-11798.s1
  7.2
  F
  Control (matched sibling)
  NA
  NA
  82777611
  82806095
  28485
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-11798.s1
  7.2
  F
  Control (matched sibling)
  NA
  NA
  81119963
  81128126
  8164
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-11920.s1
  18.3
  M
  Control (matched sibling)
  NA
  NA
  81119963
  81128126
  8164
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-11982.s1
  5.1
  F
  Control (matched sibling)
  NA
  NA
  81119963
  81128126
  8164
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-12052.s1
  5.4
  F
  Control (matched sibling)
  NA
  NA
  83394530
  83454968
  60439
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-12162.s1
  11
  F
  Control (matched sibling)
  NA
  NA
  80688425
  80834854
  146430
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-12162.s1
  11
  F
  Control (matched sibling)
  NA
  NA
  81119963
  81128126
  8164
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-12225.s1
  16.4
  M
  Control (matched sibling)
  NA
  NA
  81119963
  81133375
  13413
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-12227.s1
  10.3
  M
  Control (matched sibling)
  NA
  NA
  81598168
  81634964
  36797
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-12238.s1
  11
  F
  Control (matched sibling)
  NA
  NA
  81150002
  81160611
  10610
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-12261.s1
  21.5
  M
  Control (matched sibling)
  NA
  NA
  82528792
  82589963
  61172
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-12337.s1
  13.3
  M
  Control (matched sibling)
  NA
  NA
  80810297
  80813434
  3138
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-12351.s1
  15.3
  F
  Control (matched sibling)
  NA
  NA
  81119963
  81133375
  13413
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-12361.s1
  7.3
  M
  Control (matched sibling)
  NA
  NA
  81119963
  81128126
  8164
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-12382.s1
  12.4
  M
  Control (matched sibling)
  NA
  NA
  81119963
  81133375
  13413
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-12435.s1
  9
  F
  Control (matched sibling)
  NA
  NA
  81119963
  81128126
  8164
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-12536.s1
  4.9
  F
  Control (matched sibling)
  NA
  NA
  81119963
  81128126
  8164
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-12579.s1
  7.8
  F
  Control (matched sibling)
  NA
  NA
  81119963
  81128126
  8164
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-12603.s1
  11.7
  M
  Control (matched sibling)
  NA
  NA
  81119963
  81128126
  8164
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-12628.s1
  13.6
  F
  Control (matched sibling)
  NA
  NA
  81119963
  81128126
  8164
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-12653.s1
  8.5
  F
  Control (matched sibling)
  NA
  NA
  81125293
  81128126
  2834
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-12708.s1
  11.8
  F
  Control (matched sibling)
  NA
  NA
  81119963
  81128126
  8164
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-12817.s1
  15.7
  F
  Control (matched sibling)
  NA
  NA
  81119963
  81128126
  8164
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-12933.s1
  7.2
  F
  Control (matched sibling)
  NA
  NA
  81119963
  81128126
  8164
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-12969.s1
  5.8
  M
  Control (matched sibling)
  NA
  NA
  81119963
  81128126
  8164
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-13057.s1
  4.2
  F
  Control (matched sibling)
  NA
  NA
  81177862
  81185794
  7933
  GRCh38
  Deletion
  No
  sanders_11_ASD_discovery_controls-13070.s1
  11.6
  M
  Control (matched sibling)
  NA
  NA
  81119963
  81128126
  8164
  GRCh38
  Deletion
  No

Cases

Patient ID
Validation Description
Primary Disorder Inheritence
Inheritence
Family Profile
Disease Segregation
Gene Content
Altered Gene Expression
 balciuniene_07_ASD_discovery_cases-case3
 
 
 Unknown
 Unknown
 Unknown
 0 genes
 
 chaves_19_ASD/DD/ID_discovery_cases-case248
 
 
 Unknown
 
 
 RN7SKP238,GRID1
 
 chaves_19_ASD/DD/ID_discovery_cases-case255
 
 
 Unknown
 
 
 RNA5SP322,GRID1
 
 chong_14_DD/ID/ASD/MCA_discovery_cases-caseaCGH3832
 Nimblegen aCGH
 
 De novo
 Unknown
 Unknown
 NRG3
 
 digregorio_17_DD/ID_discovery_cases-DECIPHER_296557
 
 
 Unknown
 
 
 PRXL2A,TSPAN14
 
 engchuan_15_ASD_discovery_cases-case14153_2520
 
 
 Unknown
 
 
 RPS7P9,FARSBP1,SH2D4B
 
 engchuan_15_ASD_discovery_cases-case14383_1300
 
 
 Unknown
 
 
 RPS7P9,FARSBP1,SH2D4B
 
 engchuan_15_ASD_discovery_cases-case4446_1
 
 
 Unknown
 
 
 RNA5SP322,GRID1
 
 engchuan_15_ASD_discovery_cases-case8663_201
 
 
 Unknown
 
 
 NRG3
 
 gai_11_ASD_replication_cases-AU001203
 
 
 Inherited
 
 
 NRG3 (intronic)
 
 gai_11_ASD_replication_cases-AU001204
 
 
 Inherited
 
 
 NRG3 (intronic)
 
 gazzellone_14_ASD_discovery_cases-case485-3
 
 
 Unknown
 Unknown
 Unknown
 GRID1-AS1,GRID1
 
 girirajan_13a_ASD_discovery_cases-11545.p1
 aCGH (NimbleGen 135K array)
 
 Maternal
 Simplex
 Unknown
 DYDC1,DYDC2
 
 girirajan_13a_ASD_discovery_cases-12378.p1
 aCGH (NimbleGen 135K array)
 
 Maternal
 Simplex
 Unknown
 DYDC1,DYDC2
 
 girirajan_13a_ASD_discovery_cases-13611.p1
 aCGH (NimbleGen 135K array)
 
 Maternal
 Simplex
 Unknown
 DYDC1,DYDC2
 
 girirajan_13a_ASD_discovery_cases-13634.p1
 aCGH (NimbleGen 135K array)
 
 Paternal
 Simplex
 Unknown
 DYDC1,DYDC2
 
 girirajan_13a_ASD_discovery_cases-13889.p1
 aCGH (NimbleGen 135K array)
 
 Maternal
 Simplex
 Unknown
 NRG3
 
 girirajan_13a_ASD_discovery_cases-14055.p1
 aCGH (NimbleGen 135K array)
 
 Maternal
 Simplex
 Unknown
 DYDC1,DYDC2
 
 girirajan_13a_ASD_discovery_cases-14343.p1
 aCGH (NimbleGen 135K array)
 
 Maternal
 Simplex
 Unknown
 DYDC1,DYDC2
 
 girirajan_13a_ASD_discovery_cases-14348.p1
 aCGH (NimbleGen 135K array)
 
 Paternal
 Simplex
 Unknown
 SH2D4B
 
 girirajan_13a_ASD_discovery_cases-AU1763301
 aCGH (NimbleGen 135K array)
 
 Maternal
 Multiplex
 Unknown
 DYDC1,DYDC2
 
 girirajan_13b_ASD_discovery_cases-44106106924
 
 
 Unknown
 Unknown
 Unknown
 RNU6-325P,RN7SKP238,LINC01520,GRID1-AS1,GRID1
 
 griswold_12_ASD_discovery_cases-case37276
 qPCR
 
 Paternal
 Simplex
 Not segregated
 RNA5SP322,GRID1
 
 hnoonual_17_ASD_discovery_cases-casePS37-3
 
 
 Maternal
 
 
 RNU6-441P,NRG3
 
 kalsner_17_ASD_discovery_cases-case8
 
 
 Maternal
 Unknown
 Unknown
 RNU6-129P,RNU1-65P,HMGN2P8,CERNA2,LRIT2,LRIT1,LINC00858,RPL12P29,TNPO1P1,CACYBPP1,RPS3AP5,C10orf99,CDHR1,RGR,GHITM,CCSER2,LINC01519
 
 kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00001665
 FISH, qPCR, MLPA, aCGH, or standard G-banded chromosome analysis
 
 Unknown
 Unknown
 Unknown
 RNU6-441P,RNU6-478P,RNU6-129P,NRG3-AS1,MARK2P15,NRG3
 
 kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00002246
 FISH, qPCR, MLPA, aCGH, or standard G-banded chromosome analysis
 
 Maternal
 Unknown
 Unknown
 RNU6-478P,RNU6-129P,RNU1-65P,HMGN2P8,CERNA2,LRIT2,LRIT1,LINC00858,RPL12P29,TNPO1P1,CACYBPP1,MARK2P15,C10orf99,CDHR1,RGR,GHITM,CCSER2,NRG3
 
 kaminsky_11_DD/ID/ASD_discovery_cases-ISCA00002272
 FISH, qPCR, MLPA, aCGH, or standard G-banded chromosome analysis
 
 Unknown
 Unknown
 Unknown
 RNU6-441P,NRG3
 
 krumm_15_ASD_discovery_cases-case11545.p1
 Illumina 1M
 
 Maternal
 Simplex
 Segregated
 DYDC1,DYDC2
 
 krumm_15_ASD_discovery_cases-case12378.p1
 Illumina 1MDuo
 
 Maternal
 Simplex
 Segregated
 DYDC1,DYDC2
 
 krumm_15_ASD_discovery_cases-case13634.p1
 1M-Duov3
 
 Paternal
 Simplex
 Segregated
 DYDC1,DYDC2
 
 krumm_15_ASD_discovery_cases-case14343.p1
 Omni2.5-4v1
 
 Maternal
 Simplex
 Segregated
 DYDC1,DYDC2
 
 leppa_16_ASD_discovery_cases-AU3057301
 
 
 Maternal
 Multiplex
 Not segregated (CNV not present in affected sibling)
 RNU6-129P,RNU1-65P,HMGN2P8,CERNA2,LRIT2,LRIT1,LINC00858,RPL12P29,TNPO1P1,CACYBPP1,RPS3AP5,C10orf99,CDHR1,RGR,GHITM,CCSER2
 
 mosca_16_DCD_discovery_cases-case113903
 
 
 Unknown
 Unknown
 Unknown
 RPS7P9
 
 nguyen_13_DD/ID/MCA/ASD_discovery_cases-251690
 
 
 Unknown
 Unknown
 Unknown
 RPS7P9,FARSBP1,WARS2P1,RPA2P2,RNU6-441P,NRG3-AS1,NRG3
 
 nord_11_ASD_discovery_cases-239-1
 
 
 Maternal
 
 
 GRID1
 
 nord_11_ASD_discovery_cases-239-1
 
 
 Paternal
 
 
 NRG3
 
 pinto_14_ASD_discovery_cases2-case4446_1
 qPCR (Griswold et al. 2011, PMID: 21360829)
 
 Paternal
 Simplex
 (not tested)
 RNA5SP322,GRID1
 
 poultney_13_ASD_discovery_cases-case05HI2544A
 
 
 Unknown
 Unknown (likely multiplex/AGRE)
 Unknown
 DYDC1,DYDC2
 
 poultney_13_ASD_discovery_cases-case05HI4548A
 
 
 Unknown
 Unknown (likely multiplex/AGRE)
 Unknown
 DYDC1,DYDC2
 
 poultney_13_ASD_discovery_cases-case98HI0245A
 
 
 Unknown
 Unknown (likely multiplex/AGRE)
 Unknown
 DYDC1,DYDC2
 
 prasad_12_ASD_discovery_cases-case139157
 
 
 Unknown
 Unknown
 Unknown
 0 genes
 
 prasad_12_ASD_discovery_cases-case55310
 
 
 Unknown
 Simplex
 Unknown
 NRG3
 
 prasad_12_ASD_discovery_cases-case60635
 
 
 Unknown
 Unknown
 Unknown
 DYDC1
 
 sanders_11_ASD_discovery_cases-11073.p1
 
 
 Paternal
 Simplex (quad-proband matched)
 Not segregated
 NRG3
 
 sanders_11_ASD_discovery_cases-11114.p1
 
 
 Paternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-11133.p1
 
 
 Unknown
 Simplex (trio)
 NA
 
 
 sanders_11_ASD_discovery_cases-11144.p1
 
 
 Maternal
 Simplex (quad-proband matched)
 Not segregated
 NRG3
 
 sanders_11_ASD_discovery_cases-11165.p1
 
 
 Maternal
 Simplex (trio)
 NA
 
 
 sanders_11_ASD_discovery_cases-11205.p1
 
 
 Paternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-11218.p1
 
 
 Paternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-11232.p1
 
 
 Paternal
 Simplex (quad-proband unmatched)
 Unknown
 
 
 sanders_11_ASD_discovery_cases-11294.p1
 
 
 Maternal
 Simplex (trio)
 NA
 
 
 sanders_11_ASD_discovery_cases-11429.p1
 
 
 Maternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-11458.p1
 
 
 Maternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-11472.p1
 
 
 Maternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-11504.p1
 
 
 Maternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-11540.p1
 
 
 Maternal
 Simplex (quad-proband matched)
 Not segregated
 NRG3
 
 sanders_11_ASD_discovery_cases-11545.p1
 
 
 Maternal
 Simplex (quad-proband matched)
 Not segregated
 DYDC1,DYDC2
 
 sanders_11_ASD_discovery_cases-11592.p1
 
 
 Maternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-11630.p1
 
 
 Maternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-11711.p1
 
 
 Paternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-11712.p1
 
 
 Paternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-11740.p1
 
 
 Both parents
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-11768.p1
 
 
 Maternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-11972.p1
 
 
 Maternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-11982.p1
 
 
 Paternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-12029.p1
 
 
 Maternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-12030.p1
 
 
 Paternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-12076.p1
 
 
 Maternal
 Simplex (quad-proband matched)
 Not segregated
 NRG3
 
 sanders_11_ASD_discovery_cases-12096.p1
 
 
 Paternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-12108.p1
 
 
 Paternal
 Simplex (quad-proband unmatched)
 Unknown
 
 
 sanders_11_ASD_discovery_cases-12162.p1
 
 
 Maternal
 Simplex (quad-proband matched)
 Not segregated
 RPS7P9,FARSBP1
 
 sanders_11_ASD_discovery_cases-12224.p1
 
 
 Maternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-12227.p1
 
 
 Maternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-12238.p1
 
 
 Maternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-12287.p1
 
 
 Maternal
 Simplex (trio)
 NA
 
 
 sanders_11_ASD_discovery_cases-12296.p1
 
 
 Maternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-12306.p1
 
 
 Both parents
 Simplex (trio)
 NA
 
 
 sanders_11_ASD_discovery_cases-12315.p1
 
 
 Maternal
 Simplex (trio)
 NA
 NRG3
 
 sanders_11_ASD_discovery_cases-12337.p1
 
 
 Maternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-12361.p1
 
 
 Paternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-12378.p1
 
 
 Maternal
 Simplex (quad-proband matched)
 Not segregated
 DYDC1,DYDC2
 
 sanders_11_ASD_discovery_cases-12429.p1
 
 
 Unknown
 Simplex (trio)
 NA
 RNU6-129P
 
 sanders_11_ASD_discovery_cases-12493.p1
 
 
 Paternal
 Simplex (quad-proband unmatched)
 Unknown
 
 
 sanders_11_ASD_discovery_cases-12552.p1
 
 
 Paternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-12579.p1
 
 
 Paternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-12603.p1
 
 
 Paternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-12607.p1
 
 
 Paternal
 Simplex (trio)
 NA
 
 
 sanders_11_ASD_discovery_cases-12628.p1
 
 
 Paternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-12656.p1
 
 
 Maternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-12708.p1
 
 
 Maternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-12764.p1
 
 
 Maternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-12799.p1
 
 
 Unknown
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-12969.p1
 
 
 Both parents
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-13057.p1
 
 
 Paternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-13070.p1
 
 
 Paternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sanders_11_ASD_discovery_cases-13096.p1
 
 
 Maternal
 Simplex (quad-proband unmatched)
 Unknown
 
 
 sanders_11_ASD_discovery_cases-13322.p1
 
 
 Maternal
 Simplex (quad-proband matched)
 Not segregated
 
 
 sansovic_17_DD/ID/ASD_discovery_cases-case29
 
 
 Unknown
 
 
 NRG3
 
 stobbe_13_ASD_discovery_cases-case6
 
 
 Unknown
 Unknown (possible simplex)
 Unknown
 NRG3
 
 vaags_11_ASD_discovery_cases-probandF2-003
 
 
 Unknown
 Multiplex
 Unknown
 
 

Controls

Patient ID
Validation Description
Primary Disorder Inheritence
Inheritence
Family Profile
Disease Segregation
Gene Content
Altered Gene Expression
brandler_18_ASD_discovery_controls-controlSSC08632
  SNP VCF
 
  De novo
 
 
 
 
engchuan_15_ASD_discovery_controls-controlB248665_1007854152
 
 
  Unknown
 
 
  NRG3
 
engchuan_15_ASD_discovery_controls-controlB524961_1007872292
 
 
  Unknown
 
 
  LINC01519
 
engchuan_15_ASD_discovery_controls-controlHABC_900270_900270
 
 
  Unknown
 
 
  DYDC1,DYDC2
 
engchuan_15_ASD_discovery_controls-controlHABC_900270_900270
 
 
  Unknown
 
 
  RPS7P9,FARSBP1,WARS2P1,TSPAN14,SH2D4B
 
engchuan_15_ASD_discovery_controls-controlHABC_900629_900629
 
 
  Unknown
 
 
  NRG3
 
engchuan_15_ASD_discovery_controls-controlHABC_902550_902550
 
 
  Unknown
 
 
  NRG3
 
kanduri_15_ASD_discovery_controls-control_split1305
 
 
  Unknown
 
 
  NRG3 (intronic)
 
kanduri_15_ASD_discovery_controls-control_split1394
 
 
  Unknown
 
 
  NRG3 (intronic)
 
kanduri_15_ASD_discovery_controls-control_split1522
 
 
  Unknown
 
 
  NRG3 (intronic)
 
nord_11_ASD_discovery_controls-04C27962
 
 
 
 
 
  NRG3
 
sanders_11_ASD_discovery_controls-11032.s1
 
 
  Maternal
  Simplex (quad)
  NA
  DYDC1,DYDC2
 
sanders_11_ASD_discovery_controls-11051.s1
 
 
  Paternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-11205.s1
 
 
  Paternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-11218.s1
 
 
  Paternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-11325.s1
 
 
  Paternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-11429.s1
 
 
  Maternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-11433.s1
 
 
  Paternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-11446.s1
 
 
  Paternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-11450.s1
 
 
  Maternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-11488.s1
 
 
  Paternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-11504.s1
 
 
  Maternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-11518.s1
 
 
  Paternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-11545.s1
 
 
  Maternal
  Simplex (quad)
  NA
  DYDC1,DYDC2
 
sanders_11_ASD_discovery_controls-11554.s1
 
 
  Maternal
  Simplex (quad)
  NA
  NRG3
 
sanders_11_ASD_discovery_controls-11592.s1
 
 
  Maternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-11600.s1
 
 
  Paternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-11712.s1
 
 
  Paternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-11715.s1
 
 
  Paternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-11722.s1
 
 
  Unknown
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-11740.s1
 
 
  Both parents
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-11798.s1
 
 
  Maternal
  Simplex (quad)
  NA
  NRG3
 
sanders_11_ASD_discovery_controls-11798.s1
 
 
  Maternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-11920.s1
 
 
  Paternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-11982.s1
 
 
  Paternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-12052.s1
 
 
  Maternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-12162.s1
 
 
  Maternal
  Simplex (quad)
  NA
  RPS7P9,FARSBP1
 
sanders_11_ASD_discovery_controls-12162.s1
 
 
  Maternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-12225.s1
 
 
  Maternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-12227.s1
 
 
  Maternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-12238.s1
 
 
  Maternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-12261.s1
 
 
  Paternal
  Simplex (quad)
  NA
  NRG3
 
sanders_11_ASD_discovery_controls-12337.s1
 
 
  Maternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-12351.s1
 
 
  Paternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-12361.s1
 
 
  Paternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-12382.s1
 
 
  Paternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-12435.s1
 
 
  Paternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-12536.s1
 
 
  Both parents
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-12579.s1
 
 
  Paternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-12603.s1
 
 
  Paternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-12628.s1
 
 
  Paternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-12653.s1
 
 
  Maternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-12708.s1
 
 
  Maternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-12817.s1
 
 
  Maternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-12933.s1
 
 
  Paternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-12969.s1
 
 
  Both parents
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-13057.s1
 
 
  Paternal
  Simplex (quad)
  NA
 
 
sanders_11_ASD_discovery_controls-13070.s1
 
 
  Paternal
  Simplex (quad)
  NA
 
 

No Animal Model Data Available
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