NEO1
Homo sapiens
Gene Name: Neogenin 1
Aliases: IGDCC2, NGN, NTN1R2
Chromosome No: 15
Chromosome Band: 15q24.1
Genetic Category: Multigenic CNV, rare single gene variant-Rare single gene variant
Aliases: IGDCC2, NGN, NTN1R2
Chromosome No: 15
Chromosome Band: 15q24.1
Genetic Category: Multigenic CNV, rare single gene variant-Rare single gene variant
Summary Statistics:
ASD Reports: 3
Recent Reports: 0
Annotated variants: 10
Associated CNVs: 9
Evidence score: 2
ASD Reports: 3
Recent Reports: 0
Annotated variants: 10
Associated CNVs: 9
Evidence score: 2
| Associated Disorders: |
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Relevance to Autism
Biallelic variants in the NEO1 gene were identified in two ASD patients of Han Chinese descent (Siu et al., 2015).
Molecular Function
Multi-functional cell surface receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families that regulates cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion.
External Links
References
Type
Title
Type of Disorder
Associated Disorders
Author, Year
Primary
Unmasking a novel disease gene NEO1 associated with autism spectrum disorders by a hemizygous deletion on chromosome 15 and a functional polymorphism.
ASD
