Homer2
Mus musculus
Gene Name: homer homolog 2
Aliases: VASP/Ena-related gene up-regulated during seizure and LTP 2; cupidin; homer protein homolog 2; homer, neuronal immediate early gene, 2; homer-2
Human Ortholog: HOMER2
Aliases: VASP/Ena-related gene up-regulated during seizure and LTP 2; cupidin; homer protein homolog 2; homer, neuronal immediate early gene, 2; homer-2
Human Ortholog: HOMER2
Summary Statistics:
# of Reports: 1
# of Models: 1
# of Reports: 1
# of Models: 1
External Links
Model Summary
Homer deletion mimics the behavioral and neurochemical phenotype produced by repeated cocaine administration.
References
Type
Title
Author, Year
M_HOMER2_1_KO_HM
Model Type:
Genetic
Model Genotype: Homozygous
Mutation: Homologous recombination mediated deletion of exon 3 of Homer2 gene.
Allele Type: Targeted (Knock Out)
Strain of Origin: Not specified
Genetic Background: Not specified
ES Cell Line: Not specified
Mutant ES Cell Line: Not specified
Model Source: Not specified
Model Genotype: Homozygous
Mutation: Homologous recombination mediated deletion of exon 3 of Homer2 gene.
Allele Type: Targeted (Knock Out)
Strain of Origin: Not specified
Genetic Background: Not specified
ES Cell Line: Not specified
Mutant ES Cell Line: Not specified
Model Source: Not specified
M_HOMER2_1_KO_HM
Category
Entity
Quantity
Experimental Paradigm
Age at Testing
General locomotor activity1
Increased
Description: Increased locomotor hyperactivity in response to phencyclidine
Exp Paradigm: Locomotor activity measurement in place conditioning apparatus after administration of phencyclidine (6 mg/kg)
Exp Paradigm: Locomotor activity measurement in place conditioning apparatus after administration of phencyclidine (6 mg/kg)
Conditioned place preference test
Unreported
General locomotor activity1
Increased
Description: Increased locomotor hyperactivity in response to acute cocaine administration
Exp Paradigm: Locomotor activity measurement in place conditioning apparatus after administration of acute cocaine
Exp Paradigm: Locomotor activity measurement in place conditioning apparatus after administration of acute cocaine
Conditioned place preference test
Unreported
Neurotransmitter release1
Decreased
Description: Decreased basal extracellular glutamate levels in nucleus accumbens
Exp Paradigm: In vivo microdialysis in nucleusaccumbens
Exp Paradigm: In vivo microdialysis in nucleusaccumbens
Microdialysis
Unreported
Neurotransmitter release1
Increased
Description: Increased extracellular glutamate in nucleus accumbens in response to acute cocaine injection
Exp Paradigm: In vivo microdialysis in nucleus accumbens after acute cocaine injection (15 mg/kg, i.p.)
Exp Paradigm: In vivo microdialysis in nucleus accumbens after acute cocaine injection (15 mg/kg, i.p.)
Microdialysis
Unreported
Reward reinforced choice behavior1
Increased
Description: Increased place conditioning assessed through locomotor response to injection of cocaine
Exp Paradigm: Place conditioning procedured assessing cocaine reward of 0.5 mg/kg
Exp Paradigm: Place conditioning procedured assessing cocaine reward of 0.5 mg/kg
Conditioned place preference test
Unreported
Reward reinforced choice behavior1
Increased
Description: Increased operant self administration of cocaine
Exp Paradigm: Operant responding for cocaine
Exp Paradigm: Operant responding for cocaine
Operant conditioning paradigm
Unreported
Protein expression level evidence1
Decreased
Description: Decreased levels of mglur1 alpha dimers
Exp Paradigm: Xct protein expression
Exp Paradigm: Xct protein expression
Western blot
Unreported
Protein expression level evidence1
Decreased
Description: Decreased levels of mglur1 alpha dimers
Exp Paradigm: Mglur1 alpha dimer levels
Exp Paradigm: Mglur1 alpha dimer levels
Western blot
Unreported
Not Reported:
Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Maternal behavior, Neuroanatomy / ultrastructure / cytoarchitecture, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior
