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Relevance to Autism

Decreased social interaction in GRIN1-knockout mice was observed in two separate studies (Gandal et al., 2012; Saunders et al., 2013).

Molecular Function

The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning.

External Links

        

References

Type
Title
Type of Disorder
Associated Disorders
Author, Year
Primary
GABAB-mediated rescue of altered excitatory-inhibitory balance, gamma synchrony and behavioral deficits following constitutive NMDAR-hypofunction.
Support
Paradigmatic De Novo GRIN1 Variants Recapitulate Pathophysiological Mechanisms Underlying GRIN1-Related Disorder Clinical Spectrum
ID, epilepsy/seizures
Autistic features, stereotypy
Support
Efficient strategy for the molecular diagnosis of intellectual disability using targeted high-throughput sequencing.
ID
Support
Epilepsy/seizures
Support
De novo GRIN1 mutations: An emerging cause of severe early infantile encephalopathy.
DD
Early onset encephalopathy, hypotonia
Support
Control of Long-Term Synaptic Potentiation and Learning by Alternative Splicing of the NMDA Receptor Subunit GluN1.
ASD
Support
De novo mutations in epileptic encephalopathies.
Epilepsy
Support
Integrating de novo and inherited variants in 42
ASD
Support
GRIN1 mutation associated with intellectual disability alters NMDA receptor trafficking and function.
DD, ID
Hypotonia, stereotypic behavior
Support
De novo GRIN variants in NMDA receptor M2 channel pore-forming loop are associated with neurological diseases.
Support
Complex Diagnostics of Non-Specific Intellectual Developmental Disorder
DD, ID
Support
Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology.
Support
Abnormal circadian rhythm in patients with GRIN1-related developmental epileptic encephalopathy.
Autosomal dominant neurodevelopmental disorder wit
Stereotypies
Support
Comprehensive genome sequencing analyses identify novel gene mutations and copy number variations associated with infant developmental delay or intellectual disability (DD/ID)
DD, ID
Support
Novel homozygous missense variant of GRIN1 in two sibs with intellectual disability and autistic features without epilepsy.
ID, autistic features
Stereotypic movements of the midline, hypotonia, a
Support
Support
The combination of whole-exome sequencing and copy number variation sequencing enables the diagnosis of rare neurological disorders.
Epilepsy/seizures
DD, ID, autistic behavior
Support
2022 Jul
Support
Meta-analysis of 2,104 trios provides support for 10 new genes for intellectual disability
ID
Support
DD, ID
Support
De novo mutations in GRIN1 cause extensive bilateral polymicrogyria.
DD, epilepsy/seizures, polymicrogyria
Autistic features
Support
Overlapping cortical malformations in patients with pathogenic variants in GRIN1 and GRIN2B
DD, epilepsy/seizures
Support
Mutations in HECW2 are associated with intellectual disability and epilepsy.
ID, epilepsy/seizures
Support
ID, epilepsy/seizures
Support
Rare loss of function mutations in N-methyl-D-aspartate glutamate receptors and their contributions to schizophrenia susceptibility.
SCZ
Recent Recommendation
Delineating the GRIN1 phenotypic spectrum: A distinct genetic NMDA receptor encephalopathy.
DD, ID, epilepsy/seizures
ASD
Recent Recommendation
Repetitive behavior profile and supersensitivity to amphetamine in the C58/J mouse model of autism.
Recent Recommendation
Knockout of NMDA receptors in parvalbumin interneurons recreates autism-like phenotypes.

Rare

Variant ID
Variant Type
Allele Change
Residue Change
Inheritance Pattern
Inheritance Association
Family Type
Author, Year
 GEN626R001 
 missense_variant 
 c.1733C>G 
 p.Pro578Arg 
 De novo 
  
 Simplex 
 GEN626R002a 
 missense_variant 
 c.649C>T 
 p.Gln217Ter 
 Familial 
 Both parents 
 Multiplex 
 GEN626R003 
 missense_variant 
 c.1654A>C 
 p.Lys552Gln 
 De novo 
  
  
 GEN626R004 
 missense_variant 
 c.1656C>A 
 p.Asp552Glu 
 De novo 
  
  
 GEN626R005 
 missense_variant 
 c.1656C>A 
 p.Asp552Glu 
 De novo 
  
  
 GEN626R006a 
 stop_gained 
 c.1666C>T 
 p.Gln556Ter 
 Familial 
 Both parents 
 Multiplex 
 GEN626R007 
 missense_variant 
 c.1670C>G 
 p.Pro557Arg 
 De novo 
  
  
 GEN626R008 
 inframe_insertion 
 c.1616_1618dup 
 p.Thr539dup 
 De novo 
  
  
 GEN626R009 
 missense_variant 
 c.1852G>C 
 p.Glu618Gln 
 De novo 
  
  
 GEN626R010 
 missense_variant 
 c.1795G>C 
 p.Asp599His 
 De novo 
  
  
 GEN626R011 
 missense_variant 
 c.1923G>A 
 p.Gly641= 
 De novo 
  
  
 GEN626R012 
 missense_variant 
 c.1933G>T 
 p.Ala645Ser 
 De novo 
  
  
 GEN626R013 
 missense_variant 
 c.1940A>C 
 p.Tyr647Ser 
 De novo 
  
  
 GEN626R014 
 missense_variant 
 c.1950C>G 
 p.Asn650Lys 
 De novo 
  
  
 GEN626R015 
 missense_variant 
 c.1984G>A 
 p.Glu662Lys 
 De novo 
  
  
 GEN626R016 
 missense_variant 
 c.2443G>A 
 p.Gly815Arg 
 De novo 
  
  
 GEN626R017 
 missense_variant 
 c.2443G>A 
 p.Gly815Arg 
 De novo 
  
  
 GEN626R018 
 missense_variant 
 c.2443G>A 
 p.Gly815Arg 
 De novo 
  
  
 GEN626R019 
 missense_variant 
 c.2444G>T 
 p.Arg815Leu 
 De novo 
  
  
 GEN626R020 
 missense_variant 
 c.2449T>C 
 p.Phe817Leu 
 De novo 
  
  
 GEN626R021 
 missense_variant 
 c.2449T>C 
 p.Phe817Leu 
 De novo 
  
  
 GEN626R022 
 missense_variant 
 c.2416G>A 
 p.Ala806Thr 
 De novo 
  
  
 GEN626R023 
 missense_variant 
 c.2479G>A 
 p.Ala827Thr 
 Unknown 
  
  
 GEN626R024 
 missense_variant 
 c.2416G>A 
 p.Ala806Thr 
 De novo 
  
  
 GEN626R025 
 missense_variant 
 c.2530C>T 
 p.Arg844Cys 
 De novo 
  
  
 GEN626R026 
 missense_variant 
 c.2530C>T 
 p.Arg844Cys 
 De novo 
  
  
 GEN626R027 
 missense_variant 
 c.1191A>C 
 p.Arg397Ser 
 De novo 
  
 Simplex 
 GEN626R028 
 missense_variant 
 c.2272G>A 
 p.Glu758Lys 
 De novo 
  
  
 GEN626R029a 
 missense_variant 
 c.679G>C 
 p.Ala227Pro 
 Familial 
 Both parents 
 Multiplex 
 GEN626R030 
 missense_variant 
 c.1858G>A 
 p.Asp620Asn 
 De novo 
  
 Simplex 
 GEN626R031 
 missense_variant 
 c.1858G>C 
 p.Asp620His 
 De novo 
  
  
 GEN626R032 
 missense_variant 
 c.2063C>A 
 p.Ser688Tyr 
 De novo 
  
  
 GEN626R033 
 missense_variant 
 c.2479G>A 
 p.Ala827Thr 
 De novo 
  
  
 GEN626R034 
 missense_variant 
 c.1045G>A 
 p.Ala349Thr 
 Unknown 
  
  
 GEN626R035 
 missense_variant 
 c.2021A>T 
 p.Asn674Ile 
 De novo 
  
  
 GEN626R036 
 missense_variant 
 c.2381G>A 
 p.Arg794Gln 
 De novo 
  
  
 GEN626R037 
 missense_variant 
 c.1975C>T 
 p.Arg659Trp 
 De novo 
  
  
 GEN626R038 
 missense_variant 
 c.1940A>G 
 p.Tyr647Cys 
 De novo 
  
  
 GEN626R039 
 missense_variant 
 c.2365G>A 
 p.Asp789Asn 
 De novo 
  
  
 GEN626R040 
 missense_variant 
 c.1652T>C 
 p.Leu551Pro 
 De novo 
  
  
 GEN626R041 
 missense_variant 
 c.1958C>G 
 p.Ala653Gly 
 De novo 
  
  
 GEN626R042 
 missense_variant 
 c.1949A>T 
 p.Asn650Ile 
 De novo 
  
  
 GEN626R043 
 missense_variant 
 c.1975C>T 
 p.Arg659Trp 
 De novo 
  
  
 GEN626R044 
 missense_variant 
 c.2365G>A 
 p.Asp789Asn 
 De novo 
  
  
 GEN626R045 
 missense_variant 
 c.1658C>T 
 p.Pro553Leu 
 De novo 
  
  
 GEN626R046 
 missense_variant 
 c.2530C>T 
 p.Arg844Cys 
 De novo 
  
  
 GEN626R047 
 missense_variant 
 c.2443G>A 
 p.Gly815Arg 
 De novo 
  
 Simplex 
 GEN626R048 
 missense_variant 
 c.2443G>T 
 p.Gly815Trp 
 De novo 
  
 Simplex 
 GEN626R049 
 missense_variant 
  
 p.Arg548Trp 
 De novo 
  
  
 GEN626R050 
 missense_variant 
  
 p.Ser617Cys 
 De novo 
  
  
 GEN626R051 
 inframe_insertion 
  
 p.Ile619_Gly620dup 
 De novo 
  
  
 GEN626R052 
 missense_variant 
 c.1858G>A 
 p.Gly620Arg 
 De novo 
  
  
 GEN626R053 
 missense_variant 
 c.1858G>A 
 p.Gly620Arg 
 De novo 
  
  
 GEN626R054 
 missense_variant 
 c.1921A>G 
 p.Met641Val 
 De novo 
  
  
 GEN626R055 
 missense_variant 
  
 p.Asp732Glu 
 De novo 
  
  
 GEN626R056 
 missense_variant 
  
 p.Asp732Glu 
 De novo 
  
  
 GEN626R057 
 missense_variant 
  
 p.Pro805Ser 
 De novo 
  
  
 GEN626R058 
 missense_variant 
 c.2414C>T 
 p.Pro805Leu 
 De novo 
  
  
 GEN626R059 
 missense_variant 
 c.2441C>A 
 p.Ala814Asp 
 De novo 
  
  
 GEN626R060 
 missense_variant 
  
 p.Met818Val 
 De novo 
  
  
 GEN626R061 
 missense_variant 
 c.2479G>A 
 p.Gly827Arg 
 De novo 
  
  
 GEN626R062 
 missense_variant 
 c.2500G>C 
 p.Glu834Gln 
 De novo 
  
  
 GEN626R063 
 missense_variant 
 c.2500G>C 
 p.Glu834Gln 
 De novo 
  
  
 GEN626R064 
 missense_variant 
 c.1658C>T 
 p.Pro553Leu 
 De novo 
  
 Simplex 
 GEN626R065 
 missense_variant 
 c.1972G>T 
 p.Ala658Ser 
 De novo 
  
 Simplex 
 GEN626R066 
 missense_variant 
 c.1957G>A 
 p.Ala653Thr 
 De novo 
  
 Simplex 
 GEN626R067 
 missense_variant 
 c.2231G>A 
 p.Cys744Tyr 
 De novo 
  
 Simplex 
 GEN626R068a 
 stop_gained 
 c.1422C>A 
 p.Tyr474Ter 
 Familial 
 Both parents 
 Simplex 
 GEN626R069 
 missense_variant 
 c.230C>T 
 p.Ser77Leu 
 De novo 
  
 Simplex 
 GEN626R070 
 missense_variant 
 c.1918G>C 
 p.Ala640Pro 
 De novo 
  
 Simplex 
 GEN626R071 
 missense_variant 
 c.421G>A 
 p.Val141Met 
 De novo 
  
  
 GEN626R072 
 missense_variant 
 c.1744C>T 
 p.Arg582Cys 
 De novo 
  
 Multiplex 
 GEN626R073 
 missense_variant 
 c.2530C>T 
 p.Arg844Cys 
 De novo 
  
 Simplex 
 GEN626R074 
 intron_variant 
 c.2590-363A>G 
  
 De novo 
  
 Simplex 
 GEN626R075 
 missense_variant 
 c.1906T>G 
 p.Trp636Gly 
 De novo 
  
  
 GEN626R076 
 missense_variant 
 c.2531G>C 
 p.Gly844Ala 
 De novo 
  
  
 GEN626R077 
 missense_variant 
 c.670A>G 
 p.Asn224Asp 
 De novo 
  
  
 GEN626R078 
 missense_variant 
 c.1861G>A 
 p.Ala621Thr 
 De novo 
  
  
 GEN626R079 
 missense_variant 
 c.2356G>A 
 p.Glu786Lys 
 Unknown 
  
 Simplex 
 GEN626R080 
 missense_variant 
 c.1852G>C 
 p.Gly618Arg 
 Unknown 
  
  
  et al.  
 GEN626R081 
 missense_variant 
 c.2479G>A 
 p.Gly827Arg 
 De novo 
  
 Simplex 
  et al.  

Common

No Common Variants Available
Chromosome
CNV Locus
CNV Type
# of studies
Animal Model
9
Duplication
 1
 
9
Deletion
 1
 
9
Duplication
 1
 
9
Duplication
 2
 
9
Deletion-Duplication
 9
 
9
Deletion-Duplication
 45
 
9
Deletion
 1
 

Model Summary

A clinically relevant, highly translatable neural-activity-based biomarker for preclinical screening and therapeutic development across a broad range of disorders that share common endophenotypes and disrupted NMDA-receptro signaling.

References

Type
Title
Author, Year
Primary
GABAB-mediated rescue of altered excitatory-inhibitory balance, gamma synchrony and behavioral deficits following constitutive NMDAR-hypofunction.
Additional
Knockout of NMDA receptors in parvalbumin interneurons recreates autism-like phenotypes.
Additional
Repetitive behavior profile and supersensitivity to amphetamine in the C58/J mouse model of autism.
Primary
Repetitive behavior profile and supersensitivity to amphetamine in the C58/J mouse model of autism.

M_GRIN1_1_KO_HM

Model Type: Genetic
Model Genotype: Homozygous
Mutation: Homologous recombination mediated insertion of neomycin resistance gene into intron 20 of Grin1.
Allele Type: Targeted (Knock Out)
Strain of Origin: Not specified
Genetic Background: Contains 129S6/SvEVTac and C57BL/6
ES Cell Line: Not specified
Mutant ES Cell Line: Not specified
Model Source: Not specified

M_GRIN1_2_CKO_HM_PVALBN

Model Type: Genetic
Model Genotype: Homozygous
Mutation: Conditional deletion of approximately 12 kbp of sequence that encodes the entire transmembrane domain and C-terminal region of Grin1 using PV-cre (parvalbumin) ,in parvalbumin expressing interneurons
Allele Type: Conditional loss-of-function
Strain of Origin: Not specified
Genetic Background:
ES Cell Line: Not specified
Mutant ES Cell Line: Not Specified
Model Source: Not Specified

M_GRIN1_3_KO_HT

Model Type: Genetic
Model Genotype: Heterozygous
Mutation: Grin1 Neo/+ heterozygous mice with the Grin1 KO present only in one copy.
Allele Type: Targeted (Knock Out)
Strain of Origin:
Genetic Background: 129S6 Or C57BL/6
ES Cell Line:
Mutant ES Cell Line:
Model Source:

M_GRIN1_3_KO_HT_MK-801

Model Type: Pharmaceutical intervention
Model Genotype: Heterozygous
Mutation: Grin1 Neo/+ heterozygous mice were treated with MK-801, an NMDA receptor antagonist, to further reduce NMDA receptor function.
Allele Type: Targeted (Knock Out)
Strain of Origin:
Genetic Background: 129S6 Or C57BL/6
ES Cell Line:
Mutant ES Cell Line:
Model Source:

M_GRIN1_1_KO_HM

Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Hyperactivity2
Increased
Description: Grin1 ko mice have significantly increased hyperactivity measured through number of rearings and distance travelledcompared to wt littermates
Exp Paradigm: Open field test: rearings and distance travelled
 Open field test
 2-5 mos.
General locomotor activity1
Increased
Description: Increased general locomotor activity
Exp Paradigm: Novel environment activity
 Open field test
 7.5 months
Neuronal number: interneurons1
Decreased
Description: Decreased cytonumber of parvalbumin positive immunolabeled fast spiking interneurons across prefrontal and sensorimotor cortices
Exp Paradigm: Pv
 Immunocytochemistry
 Unreported
Intrinsic membrane properties1
Increased
Description: Increased intrinsic excitability as measured by slope of spike frequency in current clamp
Exp Paradigm: Whole-cell current clamp recordings in ca3 pyramidal neurons from acute coronal hippocampal slices
 Whole-cell patch clamp
 3-4 months
Event related potential (erp) in electroencephalography (eeg)1
Decreased
Description: Decreased gamma signal-to-noise ratio (snr) demonstrated by negative correlation between background and stimulus-evoked gamma-band response
Exp Paradigm: NA
 NA
 Unreported
Event related potential (erp) in electroencephalography (eeg)1
Decreased
Description: Decreased evoked power selectively at gamma frequencies in response to auditory stimulation
Exp Paradigm: Baseline and auditory evoked electrophysiological signal recordings following paired-click stimuli using low-impedance macro electrodes in hippocampal ca3 and ipsilateral frontal sinus
 Event related potential (erp)
 6 months
Local field potential1
Increased
Description: Increased spontaenous local field potential (lfp) power most significantly at gamma frequency
Exp Paradigm: Whole-cell current clamp recordings in ca3 pyramidal neurons from acute coronal hippocampal slices
 Whole-cell patch clamp
 3-4 months
Repetitive digging2
Decreased
Description: Grin1 ko mice have reduced marble burying. females have significantly decreased number of marbles buried than males in grin1 ko mice. no difference in sexes is seen in wt controls
Exp Paradigm: Number of marbles buried, out of 20 in 30 min, are counted
 Marble-burying test
 Unreported
Sensorimotor gating1
Decreased
Description: Decreased sensorimotor gating demonstrated by prepulse inhibition deficit
Exp Paradigm: Prepulse inhibition test
 Prepulse inhibition
 8 months
Startle response: acoustic stimulus1
Increased
Description: Increased acoustic startle reflex
Exp Paradigm: Auditory startle response
 Acoustic startle reflex test
 8 months
Startle response: acoustic stimulus2
Increased
Description: Grin1 ko mice have increased in startle amplitude at every sound level compared to controls
Exp Paradigm: Acoustic startle response amplitudes were measured. no effects of sex were seen
 Prepulse inhibition
 2-5 mos.
Sensorimotor gating2
Decreased
Description: Grin1 ko mice have decreased prepulse inhibition of acoustic startle compared to controls
Exp Paradigm: NA
 NA
 2-5 months
Social interaction1
Decreased
Description: Decreased social preference
Exp Paradigm: Approach/avoidance paradigm
 Three-chamber social approach test
 7 months
Spatial working memory1
Decreased
Description: Decreased spatial memory
Exp Paradigm: Spontaenous alternation t-maze paradigm
 T-maze test
 9 months
Protein expression level evidence1
Decreased
Description: Decreased parvalbumin expression
Exp Paradigm: Pv expression
 Western blot
 Unreported
Protein expression level evidence1
Increased
Description: Increased expression of postsynaptic gabaa receptor subunit
Exp Paradigm: Postsynaptic gabaa receptor expression
 Quantitative pcr (qrt-pcr)
 Unreported
Protein localization: synapse1
 No change
 Quantitative pcr (qrt-pcr)
 Unreported
Miniature post synaptic currents: excitatory1
 No change
 Whole-cell patch clamp
 3-4 months
 Not Reported: Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Learning & memory, Maternal behavior, Molecular profile, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Social behavior

M_GRIN1_2_CKO_HM_PVALBN

Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Event related potential (erp) in electroencephalography (eeg)1
Abnormal
Description: Abnormal event related potentials indicated by significant delay in n1 latency and non-significant increase in n1 amplitude
Exp Paradigm: Eeg recordings followed by erp analysis
 Electroencephalogram (eeg)
 10-18 weeks
Social interaction1
Decreased
Description: Decreased sociability
Exp Paradigm: Sociability testing
 Three-chamber social approach test
 10-18 weeks
Ultrasonic vocalization1
Decreased
Description: Decreased premating ultrasonic vocalization power
Exp Paradigm: Usv testing
 Monitoring ultrasonic vocalizations
 10-18 weeks
Spatial working memory1
 No change
 T-maze test
 10-18 weeks
 Not Reported: Circadian sleep/wake cycle, Developmental profile, Emotion, Immune response, Maternal behavior, Molecular profile, Motor phenotype, Neuroanatomy / ultrastructure / cytoarchitecture, Physiological parameters, Repetitive behavior, Seizure, Sensory

M_GRIN1_3_KO_HT

Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Repetitive digging1
 No change
 Marble-burying test
 2-5 months
 Not Reported: Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Learning & memory, Maternal behavior, Molecular profile, Motor phenotype, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Seizure, Sensory, Social behavior

M_GRIN1_3_KO_HT_MK-801

Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Repetitive digging1
Decreased
Description: Grin1 het mice treated with mk801 show reduced marble buring compared to grin1 hets
Exp Paradigm: Number of marbles buried, out of 20 in 30 min, are counted
 Marble-burying test
 2-5 months
 Not Reported: Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Learning & memory, Maternal behavior, Molecular profile, Motor phenotype, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Seizure, Sensory, Social behavior





Download GRIN1's Cytoscape file

Interactor Symbol Interactor Name Interactor Organism Entrez ID Uniprot ID Interaction Type Evidence Reference
SYNGAP1 synaptic Ras GTPase activating protein 1 8831 Q96PV0 Affinity chromatography; MS
Husi H , et al. 2000
Ablim1 actin-binding LIM protein 1 226251 Q8K4G5-5 IP; LC-MS/MS
Frank RA , et al. 2016
Actg1 actin, gamma, cytoplasmic 1 11465 P63260 IP; LC-MS/MS
Frank RA , et al. 2016
Adam22 Disintegrin and metalloproteinase domain-containing protein 22 11496 Q9R1V6 IP; LC-MS/MS
Frank RA , et al. 2016
Adgra1 adhesion G protein-coupled receptor A1 52389 Q8C4G9 IP; LC-MS/MS
Frank RA , et al. 2016
Adgrb3 adhesion G protein-coupled receptor B3 210933 Q80ZF8 IP; LC-MS/MS
Frank RA , et al. 2016
Anks1b ankyrin repeat and sterile alpha motif domain containing 1B 77531 Q8BIZ1 IP; LC-MS/MS
Frank RA , et al. 2016
Ap2m1 adaptor-related protein complex 2, mu 1 subunit 11773 P84091 IP; LC-MS/MS
Frank RA , et al. 2016
Atp1a3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 232975 Q6PIC6 IP; LC-MS/MS
Frank RA , et al. 2016
Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 11941 Q9R0K7 IP; LC-MS/MS
Frank RA , et al. 2016
Atp5a1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1 11946 Q03265 IP; LC-MS/MS
Frank RA , et al. 2016
Atp5c1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 11949 Q91VR2 IP; LC-MS/MS
Frank RA , et al. 2016
Begain brain-enriched guanylate kinase-associated 380785 Q68EF6 IP; LC-MS/MS
Frank RA , et al. 2016
Camk2a calcium/calmodulin-dependent protein kinase II alpha 12322 P11798 IP; LC-MS/MS
Frank RA , et al. 2016
Camk2b calcium/calmodulin-dependent protein kinase II, beta 12323 P28652 IP; LC-MS/MS
Frank RA , et al. 2016
Dlg1 discs, large homolog 1 (Drosophila) 13383 Q811D0 IP; LC-MS/MS
Frank RA , et al. 2016
Dlg2 discs, large homolog 2 (Drosophila) 23859 Q91XM9 IP; LC-MS/MS; Co-localization
Frank RA , et al. 2016
Dlg3 discs, large homolog 3 (Drosophila) 53310 P70175 IP; LC-MS/MS
Frank RA , et al. 2016
Dlg4 Postsynaptic density protein 95 13385 Q62108 IP/WB; IP; LC-MS/MS; Co-localization
Frank RA , et al. 2016
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 224997 Q9D415 IP; LC-MS/MS
Frank RA , et al. 2016
Dlgap2 discs, large (Drosophila) homolog-associated protein 2 244310 Q8BJ42 IP; LC-MS/MS
Frank RA , et al. 2016
Dlgap3 discs, large (Drosophila) homolog-associated protein 3 242667 Q6PFD5 IP; LC-MS/MS
Frank RA , et al. 2016
Dlgap4 discs, large homolog-associated protein 4 (Drosophila) 228836 B1AZP2 IP; LC-MS/MS
Frank RA , et al. 2016
Dock3 dedicator of cyto-kinesis 3 208869 Q8CIQ7 IP; LC-MS/MS
Frank RA , et al. 2016
Erlin2 ER lipid raft associated 2 244373 Q8BFZ9 IP; LC-MS/MS
Frank RA , et al. 2016
Gda guanine deaminase 14544 Q9R111 IP; LC-MS/MS
Frank RA , et al. 2016
Gnao1 guanine nucleotide binding protein, alpha O 14681 P18872 IP; LC-MS/MS
Frank RA , et al. 2016
Gria2 glutamate receptor, ionotropic, AMPA2 (alpha 2) 14800 P23819 IP; LC-MS/MS
Frank RA , et al. 2016
Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) 14811 P35436 IP/WB; IP; LC-MS/MS; Co-localization
Frank RA , et al. 2016
Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) 14812 Q01097 IP/WB; IP; LC-MS/MS; Co-localization
Frank RA , et al. 2016
Grin2d glutamate receptor, ionotropic, NMDA2D (epsilon 4) 14814 Q03391 IP; LC-MS/MS
Frank RA , et al. 2016
Grin3a glutamate receptor ionotropic, NMDA3A 242443 A2AIR5 IP; LC-MS/MS
Frank RA , et al. 2016
Hk1 hexokinase 1 15275 P17710 IP; LC-MS/MS
Frank RA , et al. 2016
Hspa1b heat shock protein 1B 15511 P17879 IP; LC-MS/MS
Frank RA , et al. 2016
Hspa8 heat shock protein 8 15481 P63017 IP; LC-MS/MS
Frank RA , et al. 2016
Ighg1 immunoglobulin heavy constant gamma 1 (G1m marker) 16017 P01869 IP; LC-MS/MS
Frank RA , et al. 2016
Iqsec1 IQ motif and Sec7 domain 1 232227 Q8R0S2 IP; LC-MS/MS
Frank RA , et al. 2016
Iqsec2 IQ motif and Sec7 domain 2 245666 Q5DU25 IP; LC-MS/MS
Frank RA , et al. 2016
Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 16520 P52189 IP; LC-MS/MS
Frank RA , et al. 2016
Lgi1 leucine-rich repeat LGI family, member 1 56839 Q9JIA1 IP; LC-MS/MS
Frank RA , et al. 2016
Lrrc7 leucine rich repeat containing 7 242274 Q80TE7 IP; LC-MS/MS
Frank RA , et al. 2016
Myo5a myosin VA 17918 Q99104 IP; LC-MS/MS
Frank RA , et al. 2016
NF1 neurofibromatosis 1 18015 Q04690 Affinity chromatography; IP/WB
Husi H , et al. 2000
Plp1 proteolipid protein (myelin) 1 18823 P60202 IP; LC-MS/MS
Frank RA , et al. 2016
PRKCB protein kinase C, beta 18751 P68404 Affinity chromatography; IP/WB
Husi H , et al. 2000
Prr7 proline rich 7 (synaptic) 432763 Q3V0I2 IP; LC-MS/MS
Frank RA , et al. 2016
Rpl6 ribosomal protein L6 19988 P47911 IP; LC-MS/MS
Frank RA , et al. 2016
Slc25a11 solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11 67863 Q9CR62 IP; LC-MS/MS
Frank RA , et al. 2016
Slc25a3 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 18674 Q8VEM8 IP; LC-MS/MS
Frank RA , et al. 2016
Slc25a4 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 11739 P48962 IP; LC-MS/MS
Frank RA , et al. 2016
Slc25a5 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 11740 P51881 IP; LC-MS/MS
Frank RA , et al. 2016
Syngap1 synaptic Ras GTPase activating protein 1 homolog (rat) 240057 F6SEU4 IP; LC-MS/MS
Frank RA , et al. 2016
Tuba4a tubulin, alpha 4A 22145 P68368 IP; LC-MS/MS
Frank RA , et al. 2016
Tubb4a tubulin, beta 4A class IVA 22153 Q9D6F9 IP; LC-MS/MS
Frank RA , et al. 2016
Ubb ubiquitin B 22187 P0CG49 IP; LC-MS/MS
Frank RA , et al. 2016
Vdac1 voltage-dependent anion channel 1 22333 Q60932 IP; LC-MS/MS
Frank RA , et al. 2016
Vdac2 voltage-dependent anion channel 2 22334 Q60930 IP; LC-MS/MS
Frank RA , et al. 2016
Vdac3 voltage-dependent anion channel 3 22335 Q60931 IP; LC-MS/MS
Frank RA , et al. 2016
Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 24211 P06685 IP/WB
Akkuratov EE , et al. 2014
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 24213 P06687 IP/WB
Akkuratov EE , et al. 2014
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 24215 P11506 IP/WB; GST
Garside ML , et al. 2009
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 24410 Q00960 IP/WB
Akkuratov EE , et al. 2014
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 24410 Q00960 IP/WB
Sheng M , et al. 1994
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 2904 Q13224 Cryo-electron microscopy; DEER spectroscopy
Zhu S , et al. 2016
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 24410 Q00960 Cryo-electron microscopy; Co-crystal structure
Tajima N , et al. 2016

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