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Relevance to Autism

Rare variants in the GABRB3 gene have been identified with autism (e.g. Cook et al., 1998) and genetic association has been found between GABRB3 and childhood absence epilepsy (CAE) (Urak et al., 2006). As well, a number of studies have found genetic association between the GABRB3 gene and autism (including one that enriched for savant skills). Populations studied include Caucasian, African-American, Hispanic, as well as AGRE, SARC and CLSA cohorts. However, other studies found no genetic association between the GABRB3 gene and autism in IMGSAC and other cohorts.

Molecular Function

The encoded protein is a subunit of GABA-A receptor. Neurotransmission is predominantly mediated by a gated chloride channel activity intrinsic to the receptor.

External Links

        

References

Type
Title
Type of Disorder
Associated Disorders
Author, Year
Primary
Linkage-disequilibrium mapping of autistic disorder, with 15q11-13 markers.
ASD
Positive Association
A linkage disequilibrium map of the 1-Mb 15q12 GABA(A) receptor subunit cluster and association to autism.
ASD
Positive Association
GABAA receptor subunit gene polymorphisms predict symptom-based and developmental deficits in Chinese Han children and adolescents with autistic sp...
ASD subphenotypes (CARS and ABC)
Positive Association
Exploratory subsetting of autism families based on savant skills improves evidence of genetic linkage to 15q11-q13.
ASD
Positive Association
Genetic variation in GABRB3 is associated with Asperger syndrome and multiple endophenotypes relevant to autism.
ASD
ALTs
Positive Association
Association analysis of chromosome 15 gabaa receptor subunit genes in autistic disorder.
ASD
Positive Association
De novo mutations in epileptic encephalopathies.
Epilepsy
IS, LGS, DD, ID, ASD, ADHD
Positive Association
Association between a GABRB3 polymorphism and autism.
ASD
Positive Association
Maternal transmission of a rare GABRB3 signal peptide variant is associated with autism.
ASD
Positive Association
An analysis paradigm for investigating multi-locus effects in complex disease: examination of three GABA receptor subunit genes on 15q11-q13 as ris...
ASD
Positive Association
An association analysis of microsatellite markers across the Prader-Willi/Angelman critical region on chromosome 15 (q11-13) and autism spectrum di...
ASD
Negative Association
Meta-analysis of GABRB3 Gene Polymorphisms and Susceptibility to Autism Spectrum Disorder.
ASD
Negative Association
Genetic analysis of GABRB3 as a candidate gene of autism spectrum disorders.
ASD
Negative Association
Absence of linkage and linkage disequilibrium to chromosome 15q11-q13 markers in 139 multiplex families with autism.
ASD
Negative Association
Serotonin transporter (5-HTT) and gamma-aminobutyric acid receptor subunit beta3 (GABRB3) gene polymorphisms are not associated with autism in the ...
ASD
Support
De novo mutations in moderate or severe intellectual disability.
DD, epilepsy/seizures
Autistic features
Support
Meta-analysis of 2,104 trios provides support for 10 new genes for intellectual disability
ID
Support
Refinement and discovery of new hotspots of copy-number variation associated with autism spectrum disorder.
ASD
Support
De Novo Mutations in SLC1A2 and CACNA1A Are Important Causes of Epileptic Encephalopathies.
Epilepsy/seizures
Support
De novo gene disruptions in children on the autistic spectrum.
ASD
Support
Comprehensive molecular testing in patients with high functioning autism spectrum disorder.
ASD
Support
Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders
ASD, DD
Support
Gene Mutation Analysis in 253 Chinese Children with Unexplained Epilepsy and Intellectual/Developmental Disabilities.
DD, ID, epilepsy/seizures
Support
Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism
ASD
Support
Excess of rare, inherited truncating mutations in autism.
ASD
Support
Diagnostic Targeted Resequencing in 349 Patients with Drug-Resistant Pediatric Epilepsies Identifies Causative Mutations in 30 Different Genes.
Epilepsy/seizures
Microcephaly
Support
Large-scale discovery of novel genetic causes of developmental disorders.
DD, epilepsy
Support
De novo genic mutations among a Chinese autism spectrum disorder cohort.
ASD
Highly Cited
GABAA-receptor heterogeneity in the adult rat brain: differential regional and cellular distribution of seven major subunits.
Recent Recommendation
Low load for disruptive mutations in autism genes and their biased transmission.
ASD
Recent Recommendation
A GABRB3 promoter haplotype associated with childhood absence epilepsy impairs transcriptional activity.
CAE
Recent Recommendation
Incorporating Functional Information in Tests of Excess De Novo Mutational Load.
Recent Recommendation
Synaptic, transcriptional and chromatin genes disrupted in autism.
ASD
Recent Recommendation
Variation in the autism candidate gene GABRB3 modulates tactile sensitivity in typically developing children.
Recent Recommendation
Altered ultrasonic vocalization and impaired learning and memory in Angelman syndrome mouse model with a large maternal deletion from Ube3a to Gabrb3.
Recent Recommendation
Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease.
Recent Recommendation
Somatosensory and sensorimotor consequences associated with the heterozygous disruption of the autism candidate gene, Gabrb3.
Recent Recommendation
Compromising the phosphodependent regulation of the GABAAR 3 subunit reproduces the core phenotypes of autism spectrum disorders.
Recent Recommendation
Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors, deficits in non-selective attention and hypoplasia of cerebellar verm...

Rare

Variant ID
Variant Type
Allele Change
Residue Change
Inheritance Pattern
Inheritance Association
Family Type
Author, Year
 GEN101R001 
 copy_number_gain 
  
  
 Familial 
 Maternal 
  
 GEN101R002 
 missense_variant 
 c.31C>T 
 p.Pro11Ser 
 Familial 
  
  
 GEN101R003 
 missense_variant 
 c.489G>A 
 p.Met163Ile 
 De novo 
 NA 
 Simplex 
 GEN101R004 
 copy_number_gain 
  
  
 De novo 
 NA 
 Simplex 
 GEN101R005 
 missense_variant 
 c.328A>C 
 p.Asn110His 
 De novo 
 NA 
  
 GEN101R006 
 missense_variant 
 c.905A>G 
 p.Tyr302Cys 
 De novo 
 NA 
  
 GEN101R007 
 missense_variant 
 c.358G>A 
 p.Asp120Asn 
 De novo 
 NA 
  
 GEN101R008 
 missense_variant 
 c.539A>G 
 p.Glu180Gly 
 De novo 
 NA 
  
 GEN101R009 
 2KB_upstream_variant 
  
  
 Unknown 
 Not maternal 
 Multiplex 
 GEN101R010 
 2KB_upstream_variant 
  
  
 Familial 
 Maternal 
 Simplex 
 GEN101R011 
 indel, 2KB_upstream_variant 
  
  
 Familial 
 Paternal 
 Simplex 
 GEN101R012 
 2KB_upstream_variant 
 NM_021912.4:c.-1442G>A 
  
 Unknown 
 Not maternal 
 Multiplex 
 GEN101R013 
 2KB_upstream_variant 
 NM_021912.5:c.-1437T>G 
  
 Familial 
 Paternal 
 Simplex 
 GEN101R014 
 2KB_upstream_variant 
 NM_021912.4:c.-1090G>A 
  
 Familial 
 Paternal 
 Simplex 
 GEN101R015 
 2KB_upstream_variant 
 NM_021912.4:c.-541C>T 
  
 Familial 
 Paternal 
 Simplex 
 GEN101R016 
 2KB_upstream_variant 
 NM_021912.4:c.-541C>T 
  
 Familial 
 Paternal 
 Simplex 
 GEN101R017 
 2KB_upstream_variant 
 NM_001278631.1:c.-232G>T 
  
 Familial 
 Paternal 
 Simplex 
 GEN101R018 
 2KB_upstream_variant 
 c.-169G>T 
  
 Familial 
 Paternal 
 Simplex 
 GEN101R019 
 2KB_upstream_variant 
 NM_000814.6:c.-142G>T 
  
 Familial 
 Paternal 
 Simplex 
 GEN101R020a 
 2KB_upstream_variant 
 NM_000814.6:c.-142G>T 
  
 Familial 
 Maternal 
 Simplex 
 GEN101R020b 
 2KB_upstream_variant 
 NM_021912.4:c.-140A>T 
  
 Familial 
 Paternal 
 Simplex 
 GEN101R021 
 2KB_upstream_variant 
 c.-53G>T 
  
 Familial 
 Paternal 
 Simplex 
 GEN101R022 
 missense_variant 
 c.557C>T 
 p.Thr186Met 
 Familial 
 Paternal 
 Simplex 
 GEN101R023 
 synonymous_variant 
 c.942C>T 
 p.Phe314= 
 Familial 
 Paternal 
 Simplex 
 GEN101R024 
 missense_variant 
 c.1006C>T 
 p.Pro336Ser 
 Familial 
 Maternal 
 Simplex 
 GEN101R025 
 frameshift_variant 
 c.1295del 
 p.Ser432PhefsTer11 
 De novo 
 NA 
 Simplex 
 GEN101R026 
 stop_gained 
 c.70G>T 
 p.Glu24Ter 
 Unknown 
  
 Unknown 
 GEN101R027 
 frameshift_variant 
 insA 
  
 Unknown 
  
 Unknown 
 GEN101R028 
 missense_variant 
 c.662T>C 
 p.Ile221Thr 
 De novo 
 NA 
 Simplex 
 GEN101R029 
 missense_variant 
 c.232G>A 
 p.Val78Ile 
 De novo 
 NA 
 Simplex 
 GEN101R030 
 missense_variant 
 c.241-2710C>T 
  
 De novo 
 NA 
 Simplex 
 GEN101R031 
 missense_variant 
 c.241-3248T>G 
  
 De novo 
 NA 
 Simplex 
 GEN101R032 
 missense_variant 
 c.31C>T 
 p.Pro11Ser 
 Familial 
 Paternal 
 Simplex 
 GEN101R033 
 missense_variant 
 c.358G>A 
 p.Asp120Asn 
 De novo 
 NA 
  
 GEN101R034 
 missense_variant 
 c.470C>T 
 p.Thr157Met 
 Familial 
  
  
 GEN101R035 
 missense_variant 
 c.545A>T 
 p.Tyr182Phe 
 De novo 
 NA 
  
 GEN101R036 
 missense_variant 
 c.745C>A 
 p.Gln249Lys 
 De novo 
 NA 
  
 GEN101R037 
 missense_variant 
 c.767T>A 
 p.Leu256Gln 
 De novo 
 NA 
  
 GEN101R038 
 missense_variant 
 c.878T>A 
 p.Leu293His 
 Unknown 
  
  
 GEN101R039 
 missense_variant 
 c.913G>A 
 p.Ala305Thr 
 De novo 
 NA 
  
 GEN101R040 
 missense_variant 
 c.1412A>G 
 p.Tyr471Cys 
 De novo 
 NA 
  
 GEN101R041 
 stop_gained 
 c.5G>A 
 p.Trp2Ter 
 Familial 
 Maternal 
  
 GEN101R042 
 stop_gained 
 c.5G>A 
 p.Trp2Ter 
 Familial 
 Paternal 
  
 GEN101R043 
 missense_variant 
 c.844C>T 
 p.Arg282Cys 
 Familial 
  
  
 GEN101R044 
 missense_variant 
 c.761C>T 
 p.Ser254Phe 
 De novo 
 NA 
  
 GEN101R045 
 missense_variant 
 c.372A>C 
 p.Leu124Phe 
 De novo 
 NA 
  
 GEN101R046 
 inframe_insertion 
 c.413_414insACC 
 p.Asn138delinsLysPro 
 De novo 
 NA 
 Simplex 
 GEN101R047 
 intron_variant 
 c.461+5271T>C 
  
 De novo 
 NA 
 Simplex 
 GEN101R048 
 stop_gained 
 c.753T>G 
 p.Tyr251Ter 
 Unknown 
  
  
 GEN101R049 
 missense_variant 
 c.1058G>C 
 p.Arg353Pro 
 Unknown 
  
  
 GEN101R050 
 missense_variant 
 c.1057C>T 
 p.Arg353Cys 
 Unknown 
  
  
 GEN101R051 
 stop_gained 
 c.1240C>T 
 p.Arg414Ter 
 Unknown 
  
  
 GEN101R052 
 missense_variant 
 c.358G>A 
 p.Asp120Asn 
 Unknown 
  
  
 GEN101R053 
 missense_variant 
 c.1057C>T 
 p.Arg353Cys 
 Unknown 
  
  

Common

Variant ID
Polymorphism
SNP ID
Allele Change
Residue Change
Population Origin
Population Stage
Author, Year
 GEN101C001 
 intron_variant 
  
 N/A 
 N/A 
 Caucasian, African-American, Hispanic 
 Discovery 
 GEN101C002 
 intron_variant 
  
 N/A 
 N/A 
 AGRE, SARC 
 Replication 
 GEN101C003 
 intron_variant 
  
 N/A 
 N/A 
 AGRE, SARC 
 Discovery 
 GEN101C004 
 microsatellite, intron_variant 
  
  
  
 CLSA 
 Discovery 
 GEN101C005 
 intergenic_variant 
 rs8025575 
  
  
 98% Caucasian 
 Discovery 
 GEN101C006 
 intron_variant 
 rs1432007 
 c.835+2039T>C;c.580+2039T>C;c.622+2039T>C 
 A/G 
 98% Caucasian 
 Discovery 
 GEN101C007 
 intron_variant 
 rs2873027 
 c.241-728G>A 
  
 98% Caucasian 
 Discovery 
 GEN101C008 
 intron_variant 
 rs4542636 
 c.241-1250G>A;c.-15-1250G>A;c.28-1250G>A 
 T/C 
 98% Caucasian 
 Discovery 
 GEN101C009 
 intron_variant 
 rs878960 
 c.241-62255G>A;c.-16+32825G>A;c.-111-41261G>A 
 C/T 
 98% Caucasian 
 Discovery 
 GEN101C010 
 microsatellite 
  
 N/A 
 N/A 
  
 Discovery 
 GEN101C011 
 intron_variant 
 rs890317 
 c.241-55520T>G;c.-16+39560T>G;c.-111-34526T>G 
 N/A 
 Caucasian 
 Discovery 
 GEN101C012 
 2KB_upstream_variant 
 rs4273008 
 c.-1437T>G 
 T/G 
  
 Discovery 
 GEN101C013 
 2KB_upstream_variant 
 rs4243768 
 c.-1852G>A;c.-2203G>A;c.-1090G>A 
 G/A 
  
 Discovery 
 GEN101C014 
 2KB_upstream_variant 
 rs4906902 
 c.-1659T>C;c.-2010T>C;c.-897T>C 
 T/C 
  
 Discovery 
 GEN101C015 
 2KB_upstream_variant 
 rs8179184 
 c.-1493G>A;c.-1493G>C;c.-1493G>T;c.-1844G>A;c.-1844G>C;c.-1844G>T;c.-731G>A;c.-731G>C;c.-731G>T 
 G/A 
  
 Discovery 
 GEN101C016 
 2KB_upstream_variant 
 rs7171660 
 c.-1303C>T;c.-1654C>T;c.-541C>T 
 T/C 
  
 Discovery 
 GEN101C017 
 2KB_upstream_variant 
 rs4364842 
  
 T/C 
  
 Discovery 
 GEN101C018 
 2KB_upstream_variant 
 rs4906901 
 c.-931G>T;c.-1282G>T;c.-169G>T 
 T/G 
  
 Discovery 
 GEN101C019 
 2KB_upstream_variant 
 rs20317 
 c.-828C>G;c.-1179C>G;c.-66C>G 
 G/C 
  
 Discovery 
 GEN101C020 
 missense_variant, 2_KB_upstream_variant 
 rs25409 
 c.-732C>T;c.-1083C>T;c.31C>T 
 p.Pro11Ser 
  
 Discovery 
 GEN101C021 
 synonymous_variant, 2KB_upstream_variant 
 rs20318 
 c.-688C>T;c.-1039C>T;c.75C>T 
 p.(=) 
  
 Discovery 
 GEN101C022 
 2KB_upstream_variant 
  
 C473A 
  
  
 Discovery 
 GEN101C023 
 2KB_upstream_variant 
  
 C662T 
  
  
 Discovery 
 GEN101C024 
 intron_variant 
 rs25408 
 c.240+12C>T;c.-112+12C>T 
  
  
 Discovery 
 GEN101C025 
 intron_variant 
 rs7180158 
 c.240+39311C>T;c.-112+39311C>T 
 A/G 
 Cases: 118 individuals with a DSM-IV or ICD-10 diagnosis of Asperger syndrome; controls: 412 individuals with an Autism Spectrum Quotient score below 24. All individuals of Caucasian ancestry. 
 Discovery 
 GEN101C026 
 intron_variant 
 rs7165604 
 c.240+23093A>G;c.-112+23093A>G 
 C/T 
 Cases: 118 individuals with a DSM-IV or ICD-10 diagnosis of Asperger syndrome; controls: 412 individuals with an Autism Spectrum Quotient score below 24. All individuals of Caucasian ancestry. 
 Discovery 
 GEN101C027 
 intron_variant 
 rs12593579 
 c.240+29417T>G;c.-112+29417T>G 
 C/A 
 Cases: 118 individuals with a DSM-IV or ICD-10 diagnosis of Asperger syndrome; controls: 412 individuals with an Autism Spectrum Quotient score below 24. All individuals of Caucasian ancestry. 
 Discovery 
 GEN101C028 
 intron_variant 
 rs11636966 
 c.241-26347G>A;c.-15-26347G>A;c.-111-5353G>A 
 T/C 
 413 individuals of Caucasian ancestry without a clinical diagnosis of Asperger syndrome 
 Discovery 
 GEN101C029 
 intron_variant 
 rs9806546 
 c.241-26705C>T;c.-15-26705C>T;c.-111-5711C>T 
 A/G 
 413 individuals of Caucasian ancestry without a clinical diagnosis of Asperger syndrome 
 Discovery 
 GEN101C030 
 intron_variant 
 rs2081648 
 c.1081-4918A>G;c.826-4918A>G;c.868-4918A>G;c.904-4918A>G 
  
 99 Han Chinese ASD children and adolescents (79 male, 20 female; age 8.53 0.42 years; 82 with autism, 17 with PDD-NOS) 
 Discovery 
Chromosome
CNV Locus
CNV Type
# of studies
Animal Model
15
Duplication
 10
  construct
15
Duplication
 1
 
15
Duplication
 3
 
15
Duplication
 7
 
15
Duplication
 2
 
15
Duplication
 2
 
15
Deletion
 1
 
15
Deletion-Duplication
 98
 
15
Duplication
 7
 
15
Duplication
 66
  construct
15
Duplication
 5
 
15
Duplication
 14
 
15
Duplication
 3
 
15
Deletion-Duplication
 9
 
15
Duplication
 4
 

Model Summary

Both Lcch3 mutants showed a habituation deficit.

References

Type
Title
Author, Year
Primary
Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases.

F_LCCH3_1_KD_GAL4:UAS;RNAI-VDRC109606

Model Type: Genetic
Model Genotype: Wild type
Mutation: Lcch3-Gal4 driver line expressing UAS-Lcch3-RNAi.
Allele Type: Loss-of-function
Strain of Origin: Not reported
Genetic Background: Not reported
ES Cell Line:
Mutant ES Cell Line:
Model Source:

F_LCCH3_2_KD_GAL4:UAS;RNAI-VDRC42546

Model Type: Genetic
Model Genotype: Wild type
Mutation: Lcch3-Gal4 driver line expressing UAS-Lcch3-RNAi.
Allele Type: Loss-of-function
Strain of Origin: Not reported
Genetic Background: Not reported
ES Cell Line:
Mutant ES Cell Line:
Model Source:

F_LCCH3_1_KD_GAL4:UAS;RNAI-VDRC109606

Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Habituation to aversive stimuli1
Decreased
Description: When challenged in the light-off jump paradigm, the mutants showed a habituation deficit compared to controls.
Exp Paradigm: Habituation was measured in number of trials to reach no-jump criterion.
 Light-off startle jump
 adult stage
Startle response1
 No change
 Light-off startle jump
 adult stage
 Not Reported: Circadian sleep/wake cycle, Communications, Developmental profile, Immune response, Learning & memory, Maternal behavior, Molecular profile, Motor phenotype, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior

F_LCCH3_2_KD_GAL4:UAS;RNAI-VDRC42546

Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Habituation to aversive stimuli1
Decreased
Description: When challenged in the light-off jump paradigm, the mutants showed a habituation deficit compared to controls.
Exp Paradigm: Habituation was measured in number of trials to reach no-jump criterion.
 Light-off startle jump
 adult stage
Startle response1
 No change
 Light-off startle jump
 adult stage
 Not Reported: Circadian sleep/wake cycle, Communications, Developmental profile, Immune response, Learning & memory, Maternal behavior, Molecular profile, Motor phenotype, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior


Interactor Symbol Interactor Name Interactor Organism Entrez ID Uniprot ID Interaction Type Evidence Reference
ACCN4 Acid-sensing ion channel 4 55515 Q96FT7-4 IP; LC-MS/MS
Huttlin EL , et al. 2015
CREB1 cAMP responsive element binding protein 1 1385 P16220 in silico target prediction; qRT-PCR
Drozdov I , et al. 2011
FMR1 fragile X mental retardation 1 2332 G8JLE9 PAR-CLIP; RNA immunoprecipitation (RIP)
Ascano M Jr , et al. 2012
GABRB2 Gamma-aminobutyric acid receptor subunit beta-2 2561 P47870 IP; LC-MS/MS
Huttlin EL , et al. 2015
MCOLN3 mucolipin 3 55283 Q8TDD5 IP; LC-MS/MS
Huttlin EL , et al. 2015
MECP2 methyl CpG binding protein 2 (Rett syndrome) 4204 P51608 ChIP
Hogart A , et al. 2007
MEF2A myocyte enhancer factor 2A 4205 Q02078 Luciferase reporter assay
Pernhorst K , et al. 2011
MEOX2 Homeobox protein MOX-2 4223 P50222 Y2H
Corominas R , et al. 2014
SP1 Sp1 transcription factor 6667 P08047 in silico target prediction; qRT-PCR
Thanseem I , et al. 2011
Arx aristaless related homeobox 11878 O35085 ChIP-qPCR
Quill ML , et al. 2011
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 25400 P11275 in vitro kinase assay
McDonald BJ and Moss SJ 1998
Cul1 cullin 1 26965 Q9WTX6 IP/WB
Nakamura Y , et al. 2016
Gabrb3 gamma-aminobutyric acid (GABA) A receptor, subunit beta 3 14402 P63080 Electrophysiology
Wooltorton JR , et al. 1998
Grm5 glutamate receptor, metabotropic 5 108071 Q3UVX5 IP/WB
Nakamura Y , et al. 2016
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 5566 P17612 in vitro kinase assay
McDonald BJ and Moss SJ 1998
PRKG1 protein kinase, cGMP-dependent, type I 5592 Q13976 in vitro kinase assay
McDonald BJ and Moss SJ 1998
AKAP5 A kinase (PRKA) anchor protein 5 9495 P24588 GST; IP/WB
Brandon NJ , et al. 2003
Ap2m1 adaptor-related protein complex 2, mu 1 subunit 116563 P84092 GST; Surface plasmon resonance (SPR)
Smith KR , et al. 2012
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 296380 Q7TSU1 Y2H; Far Western Blot
Charych EI , et al. 2004
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 29709 P18508 IP/WB
Sarto I , et al. 2002
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1 83427 P63245 IP/WB
Jovanovic JN , et al. 2004
PPP2CA protein phosphatase 2, catalytic subunit, alpha isoform 24672 P63331 IP/WB; GST; WB
Jovanovic JN , et al. 2004
PRKCA protein kinase C, alpha 24680 Q9EP80 GST
Brandon NJ , et al. 2003
UBC ubiquitin C 50522 Q63429 IP/WB
Saliba RS , et al. 2007
UBQLN1 ubiquilin 1 114590 Q9JJP9 Y2H; IP/WB
Bedford FK , et al. 2001
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 282235 P08219 IP/WB
Pollard S , et al. 1991
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 282236 P10063 IP/WB
Pollard S , et al. 1991
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 282237 P10064 IP/WB
Pollard S , et al. 1991

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