DLX2
Homo sapiens
Gene Name: distal-less homeobox 2
Aliases: DLX-2, TES1, TES-1
Chromosome No: 2
Chromosome Band: 2q31.1
Genetic Category: Genetic Association
Aliases: DLX-2, TES1, TES-1
Chromosome No: 2
Chromosome Band: 2q31.1
Genetic Category: Genetic Association
Summary Statistics:
ASD Reports: 11
Recent Reports: 6
Annotated variants: 2
Associated CNVs: 6
Evidence score: null
ASD Reports: 11
Recent Reports: 6
Annotated variants: 2
Associated CNVs: 6
Evidence score: null
| Associated Disorders: |
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Relevance to Autism
Genetic association has been found between the DLX2 gene and autism in AGRE and ASD-CARC cohorts (Liu et al., 2009).
Molecular Function
The encoded protein is a homeobox transcription factor.
External Links
References
Type
Title
Type of Disorder
Associated Disorders
Author, Year
Primary
The DLX1and DLX2 genes and susceptibility to autism spectrum disorders.
ASD
Highly Cited
Interneuron migration from basal forebrain to neocortex: dependence on Dlx genes.
Highly Cited
Mutations of the homeobox genes Dlx-1 and Dlx-2 disrupt the striatal subventricular zone and differentiation of late born striatal neurons.
Highly Cited
Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in th...
Recent Recommendation
Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs.
Recent Recommendation
A dlx2- and pax6-dependent transcriptional code for periglomerular neuron specification in the adult olfactory bulb.
Recent Recommendation
Dlx1 and Dlx2 control neuronal versus oligodendroglial cell fate acquisition in the developing forebrain.
Recent Recommendation
Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways.
Recent Recommendation
Generation of Cre-transgenic mice using Dlx1/Dlx2 enhancers and their characterization in GABAergic interneurons.
Recent Recommendation
Characterization of a distinct subpopulation of striatal projection neurons expressing the Dlx genes in the basal ganglia through the activity of t...
