DCUN1D1
Homo sapiens
Gene Name: DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)
Aliases: RP42, SCRO, Tes3, DCUN1L1
Chromosome No: 3
Chromosome Band: 3q26.33
Genetic Category: Functional-
Aliases: RP42, SCRO, Tes3, DCUN1L1
Chromosome No: 3
Chromosome Band: 3q26.33
Genetic Category: Functional-
Summary Statistics:
ASD Reports: 3
Recent Reports: 1
Annotated variants: 0
Associated CNVs: 8
Evidence score: null
ASD Reports: 3
Recent Reports: 1
Annotated variants: 0
Associated CNVs: 8
Evidence score: null
| Associated Disorders: |
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Relevance to Autism
DCUN1D1 (RP42) maps to an autism susceptibility locus on chromosome 6q16. Based on its developmentally regulated expression, particularly in proliferating neuroblasts, and its location in a cluster of embryonic neuronally expressed genes, it is a positional candidate susceptibility gene for autism (Mas et al., 2000).
Molecular Function
The encoded protein plays a role in the neddylation pathway.
External Links
References
Type
Title
Type of Disorder
Associated Disorders
Author, Year
Primary
Cloning and expression analysis of a novel gene, RP42, mapping to an autism susceptibility locus on 6q16.
ASD
Highly Cited
The role of novel oncogenes squamous cell carcinoma-related oncogene and phosphatidylinositol 3-kinase p110alpha in squamous cell carcinoma of the ...
Recent Recommendation
The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae.
