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Relevance to Autism

Genetic association has been found between the ARNT2 gene and both autism and Asperger syndrome (Chakrabarti et al., 2009). In addition, rare variants in the ARNT2 gene have been identified in patients with ASD (Vaags et al., 2012; Neale et al., 2012).

Molecular Function

A member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors

External Links

        

References

Type
Title
Type of Disorder
Associated Disorders
Author, Year
Primary
Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.
ASD
Asperger syndrome
Positive Association
Genetic variant rs17225178 in the ARNT2 gene is associated with Asperger Syndrome.
ASD
Asperger syndrome
Support
Integrating de novo and inherited variants in 42
ASD
Support
Mutational Landscape of Autism Spectrum Disorder Brain Tissue
ASD
Support
Whole-genome deep-learning analysis identifies contribution of noncoding mutations to autism risk
ASD
Support
Patterns and rates of exonic de novo mutations in autism spectrum disorders.
ASD
Support
Rare deletions at the neurexin 3 locus in autism spectrum disorder.
ASD
Highly Cited
Defective development of secretory neurones in the hypothalamus of Arnt2-knockout mice.
Highly Cited
Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor mRNAs in the developing mouse.
Highly Cited
Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt.
Recent Recommendation
Tissue-specific enhancer functional networks for associating distal regulatory regions to disease
ASD
Recent Recommendation
De Novo Synonymous Mutations in Regulatory Elements Contribute to the Genetic Etiology of Autism and Schizophrenia.
Recent Recommendation
Human variants in the neuronal basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function.
Recent Recommendation
Zebrafish diencephalic A11-related dopaminergic neurons share a conserved transcriptional network with neuroendocrine cell lineages.
Recent Recommendation
Genome-wide detection and analysis of hippocampus core promoters using DeepCAGE.

Rare

Variant ID
Variant Type
Allele Change
Residue Change
Inheritance Pattern
Inheritance Association
Family Type
Author, Year
 GEN016R001 
 missense_variant 
 c.1148G>A 
 p.Arg383His 
 Familial 
 Paternal 
 Multiplex 
 GEN016R002 
 synonymous_variant 
 c.828A>G 
 p.Gln276= 
 De novo 
  
 Simplex 
 GEN016R003 
 intergenic_variant 
 C>T 
  
 De novo 
  
 Simplex 
 GEN016R004 
 missense_variant 
 c.931C>T 
 p.Leu311Phe 
 Unknown 
  
  
 GEN016R005 
 missense_variant 
 c.125G>A 
 p.Arg42His 
 De novo 
  
  
 GEN016R006 
 missense_variant 
 c.1115A>C 
 p.Glu372Ala 
 De novo 
  
 Simplex 

Common

Variant ID
Polymorphism
SNP ID
Allele Change
Residue Change
Population Origin
Population Stage
Author, Year
 GEN016C001 
 intron_variant 
 rs4778599 
 c.622+14199G>A;c.589+14199G>A 
 A to G 
 Caucasian 
 Discovery 
 GEN016C002 
 intron_variant 
 rs3901896 
 c.32-9124C>T;c.-192+378C>T;c.-3+378C>T 
 T to C 
 Caucasian 
 Discovery 
 GEN016C003 
 intron_variant 
 rs3848173 
 c.32-8633C>T;c.-191-590C>T;c.-3+869C>T 
 C/T 
 118 AS cases, 412 controls (Caucasian origin) 
 Discovery 
 GEN016C004 
 intron_variant 
 rs17225178 
 c.146+531T>A;c.113+531T>A 
  
 118 AS cases, 412 controls (Caucasian origin) 
 Discovery 
 GEN016C005 
 intron_variant 
 rs17225178 
 c.146+531T>A;c.113+531T>A 
  
 ASC cohort of PGC: 161 cases, 526 controls, 4788 trio cases, and 4788 trio psuedocontrols (all Caucasian) 
 Replication 
Chromosome
CNV Locus
CNV Type
# of studies
Animal Model
15
Duplication
 81
  construct
15
Duplication
 1
 
15
Duplication
 1
 
15
Duplication
 1
 
15
Deletion-Duplication
 7
 

Model Summary

Arnt2 null zebrafish show no expressing of myt1la in the hypothalamus.

References

Type
Title
Author, Year
Primary
MYT1L mutations cause intellectual disability and variable obesity by dysregulating gene expression and development of the neuroendocrine hypothala...

Z_ARNT2^HI2639TG_1_KO_HM

Model Type: Genetic
Model Genotype: Homozygous
Mutation: Zebrafish homozygous null for arnt2, a protein that encodes a dimerization partner required for SIM1 function in hypothalamic development. The authors sought to investigate the role of SIM1-ARNT2 in regulating myt1la/mytl1b expression.
Allele Type: Knockout
Strain of Origin: Not specified
Genetic Background: Not specified
ES Cell Line: Not specified
Mutant ES Cell Line: Not specified
Model Source: PMID 26833329

Z_ARNT2^HI2639TG_1_KO_HM

Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Targeted expression1
Decreased
Description: Arnt2 null mutant zebrafish show no mytl1a expression in the hypothalamus compared to controls, indicating mytl1a lies downstream of SIM1-ARNT2 in the leptin-melanocortin-SIM1 pathway.
 In situ hybridization (ish)
 Unreported
 Not Reported: Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Learning & memory, Maternal behavior, Motor phenotype, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior





Download ARNT2's Cytoscape file

Interactor Symbol Interactor Name Interactor Organism Entrez ID Uniprot ID Interaction Type Evidence Reference
ADAMTSL4 ATP10A 54507 Q6UY14 Y2H
Corominas R , et al. 2014
ATF1 activating transcription factor 1 466 P18846 DIGR; ChIP
Jishage M , et al. 2003
BCL6 B-cell CLL/lymphoma 6 604 P41182 IP; MS
Miles RR , et al. 2005
BDNF brain-derived neurotrophic factor 627 P23560 EMSA; ChIP
Pruunsild P , et al. 2011
BZRAP1 benzodiazapine receptor (peripheral) associated protein 1 9256 O95153 Y2H
Corominas R , et al. 2014
CALCOCO2 calcium binding and coiled-coil domain 2 10241 Q13137 Y2H
Corominas R , et al. 2014
CCDC33 coiled-coil domain containing 33 80125 Q8N5R6 Y2H
Corominas R , et al. 2014
CDR2 cerebellar degeneration-related protein 2, 62kDa 1039 Q01850 Y2H
Corominas R , et al. 2014
CEP57L1 centrosomal protein 57kDa-like 1 285753 Q8IYX8 Y2H
Corominas R , et al. 2014
CEP63 centrosomal protein 63kDa 80254 Q96MT8 Y2H
Corominas R , et al. 2014
CLPP ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli) 8192 Q16740 IP; LC-MS/MS
Huttlin EL , et al. 2015
CTBP1 C-terminal binding protein 1 1487 Q13363 Y2H
Corominas R , et al. 2014
DGCR6 DiGeorge syndrome critical region gene 6 8214 Q14129 Y2H
Corominas R , et al. 2014
DTX2 PPP1R1B 113878 Q86UW9 Y2H
Corominas R , et al. 2014
DYDC1 DPY30 domain-containing protein 1 143241 Q8WWB3 Y2H
Corominas R , et al. 2014
EPAS1 endothelial PAS domain protein 1 2034 Q99814 M2H
Ravasi T , et al. 2010
FNTA farnesyltransferase, CAAX box, alpha 2339 P49354 IP; LC-MS/MS
Huttlin EL , et al. 2015
FNTB Protein farnesyltransferase subunit beta 100529261 P49356 IP; LC-MS/MS
Huttlin EL , et al. 2015
GOLGA2 golgin A2 2801 Q08379 Y2H
Corominas R , et al. 2014
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 3091 Q16665 Y2H
Corominas R , et al. 2014
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 3091 Q16665 IP; LC-MS/MS
Huttlin EL , et al. 2015
IKZF3 IKAROS family zinc finger 3 (Aiolos) 22806 Q9UKT9 Y2H
Corominas R , et al. 2014
KIFC3 kinesin family member C3 3801 Q9BVG8 Y2H
Corominas R , et al. 2014
LZTS2 leucine zipper, putative tumor suppressor 2 84445 Q9BRK4 Y2H
Corominas R , et al. 2014
MAGEA4 melanoma antigen family A4 4103 A0A024RC12 Y2H
Corominas R , et al. 2014
MEIS2 Meis homeobox 2 4212 B7Z6F6 Y2H
Corominas R , et al. 2014
MEOX2 Homeobox protein MOX-2 4223 P50222 Y2H
Corominas R , et al. 2014
MIPOL1 mirror-image polydactyly 1 145282 Q8TD10 Y2H
Corominas R , et al. 2014
MTUS2 microtubule associated tumor suppressor candidate 2 23281 J3KQA9 Y2H
Corominas R , et al. 2014
NCOA3 nuclear receptor coactivator 3 8202 Q9Y6Q9 Y2H
Corominas R , et al. 2014
NDE1 nudE nuclear distribution E homolog 1 (A. nidulans) 54820 Q9NXR1 Y2H
Corominas R , et al. 2014
NPAS2 neuronal PAS domain protein 2 4862 Q99743 Y2H
Corominas R , et al. 2014
NPAS3 neuronal PAS domain protein 3 64067 Q8IXF0 Y2H
Corominas R , et al. 2014
NPAS4 neuronal PAS domain protein 4 266743 Q8IUM7 M2H
Ooe N , et al. 2004
PDE4DIP phosphodiesterase 4D interacting protein 9659 Q5VU43 Y2H
Corominas R , et al. 2014
PLSCR1 phospholipid scramblase 1 5359 O15162 Y2H
Corominas R , et al. 2014
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 10616 Q9BYM8 Y2H
Corominas R , et al. 2014
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 54715 Q9NWB1 qRT-PCR; IP/WB; in situ hybridization; in silico target prediction
Fogel BL , et al. 2012
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 5966 Q04864 Y2H
Corominas R , et al. 2014
RFX6 regulatory factor X, 6 222546 Q8HWS3 Y2H
Corominas R , et al. 2014
RIMBP3 RIMS binding protein 3 85376 Q9UFD9 Y2H
Corominas R , et al. 2014
RINT1 RAD50 interactor 1 60561 Q6NUQ1 Y2H
Corominas R , et al. 2014
SIM2 single-minded homolog 2 (Drosophila) 6493 Q14190 M2H
Ooe N , et al. 2004
SIM2 single-minded homolog 2 (Drosophila) 6493 Q14190 IP; LC-MS/MS
Huttlin EL , et al. 2015
SORBS3 sorbin and SH3 domain containing 3 10174 O60504 Y2H
Corominas R , et al. 2014
SPAG5 sperm associated antigen 5 10615 Q96R06 Y2H
Corominas R , et al. 2014
SSBP3 single stranded DNA binding protein 3 23648 Q9BWW4 Y2H
Corominas R , et al. 2014
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein 117178 Q9Y2D8 Y2H
Corominas R , et al. 2014
SYCE1 synaptonemal complex central element protein 1 93426 A0A0B4J1R9 Y2H
Corominas R , et al. 2014
TACC3 transforming, acidic coiled-coil containing protein 3 10460 Q9Y6A5 Y2H
Corominas R , et al. 2014
TACC3 transforming, acidic coiled-coil containing protein 3 21335 Q9JJ11 GST
Sadek CM , et al. 2000
TADA2A transcriptional adaptor 2A 6871 O75478 Y2H
Corominas R , et al. 2014
TFIP11 tuftelin interacting protein 11 24144 Q9UBB9 Y2H
Corominas R , et al. 2014
TOP3B topoisomerase (DNA) III beta 8940 O95985 HITS-CLIP
Xu D , et al. 2013
TRAF1 TNF receptor-associated factor 1 7185 Q13077 Y2H
Corominas R , et al. 2014
TRAF2 TNF receptor-associated factor 2 7186 Q12933 Y2H
Corominas R , et al. 2014
TRAF4 TNF receptor-associated factor 4 9618 Q9BUZ4 Y2H
Corominas R , et al. 2014
TRAF4 TNF receptor-associated factor 4 9618 Q9BUZ4 IP; LC-MS/MS
Huttlin EL , et al. 2015
TRIM23 tripartite motif containing 23 373 P36406 Y2H
Corominas R , et al. 2014
TRIM27 tripartite motif-containing 27 5987 P14373 Y2H
Corominas R , et al. 2014
TRIM37 tripartite motif containing 37 NM_015294 A8K0V9 Y2H
Corominas R , et al. 2014
TRIM42 tripartite motif containing 42 287015 Q8IWZ5 Y2H
Corominas R , et al. 2014
TRIP6 thyroid hormone receptor interactor 6 7205 Q15654 Y2H
Corominas R , et al. 2014
USHBP1 Usher syndrome 1C binding protein 1 83878 B4DUE8 Y2H
Corominas R , et al. 2014
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 7874 Q93009 Y2H
Lim J , et al. 2006
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae) 6293 Q8N1B4 Y2H
Corominas R , et al. 2014
ZNF341 zinc finger protein 341 84905 B3KU97 Y2H
Corominas R , et al. 2014
2810040C05Rik RIKEN cDNA 2810040C05 gene 72719 N/A Gene microarray
Liu C , et al. 2003
A930012N16Rik RIKEN cDNA A930012N16 gene 77813 N/A Gene microarray
Liu C , et al. 2003
AA516738 expressed sequence AA516738 100519 N/A Gene microarray
Liu C , et al. 2003
AA517864 expressed sequence AA517864 100529 N/A Gene microarray
Liu C , et al. 2003
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 11307 Q64343 Gene microarray
Liu C , et al. 2003
ABI1 abl-interactor 1 11308 Q8CBW3 Gene microarray
Liu C , et al. 2003
ADAM28 a disintegrin and metallopeptidase domain 28 13522 Q9JLN6 Gene microarray
Liu C , et al. 2003
AGER advanced glycosylation end product-specific receptor 11596 Q62151 Gene microarray
Liu C , et al. 2003
AKR1B1 aldo-keto reductase family 1, member B3 (aldose reductase) 11677 P45376 Gene microarray
Liu C , et al. 2003
Akr1c21 aldo-keto reductase family 1, member C21 77337 Q91WR5 Gene microarray
Liu C , et al. 2003
ALAS2 aminolevulinic acid synthase 2, erythroid 11656 P08680 Gene microarray
Liu C , et al. 2003
ANG angiogenin, ribonuclease, RNase A family, 5 11727 P21570 Gene microarray
Liu C , et al. 2003
Ang2 angiogenin, ribonuclease A family, member 2 11731 Q64438 Gene microarray
Liu C , et al. 2003
ANGPTL4 angiopoietin-like 4 57875 Q9Z1P8 Gene microarray
Liu C , et al. 2003
AOX1 aldehyde oxidase 1 11761 O54754 Gene microarray
Liu C , et al. 2003
APOA5 apolipoprotein A-V 66113 Q8C7G5 Gene microarray
Liu C , et al. 2003
APOC4 apolipoprotein C-IV 11425 Q61268 Gene microarray
Liu C , et al. 2003
APOE apolipoprotein E 11816 P08226 Gene microarray
Liu C , et al. 2003
AQP4 aquaporin 4 11829 P55088 Gene microarray
Liu C , et al. 2003
AQP7 aquaporin 7 11832 O54794 Gene microarray
Liu C , et al. 2003
ARID1A AT rich interactive domain 1A (SWI-like) 93760 A2BH40 Gene microarray
Liu C , et al. 2003
ARNT aryl hydrocarbon receptor nuclear translocator 405 P27540 Y2H
Ema M , et al. 1996
ARNT2 aryl hydrocarbon receptor nuclear translocator 2 11864 Q61324 Y2H
Ema M , et al. 1996
AW011956 expressed sequence AW011956 105332 N/A Gene microarray
Liu C , et al. 2003
BAG6 BCL2-associated athanogene 6 224727 Q9Z1R2 Gene microarray
Liu C , et al. 2003
Bpifa2e BPI fold containing family A, member 2 19194 P07743 Gene microarray
Liu C , et al. 2003
BST1 bone marrow stromal cell antigen 1 12182 Q64277 Gene microarray
Liu C , et al. 2003
C3 complement component 3 12266 P01027 Gene microarray
Liu C , et al. 2003
C77068 expressed sequence C77068 96867 N/A Gene microarray
Liu C , et al. 2003
C77614 EST C77614 30873 N/A Gene microarray
Liu C , et al. 2003
C78513 EST C78513 30865 N/A Gene microarray
Liu C , et al. 2003
C78704 expressed sequence C78704 97868 N/A Gene microarray
Liu C , et al. 2003
C79709 expressed sequence C79709 97373 N/A Gene microarray
Liu C , et al. 2003
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 12299 O70578 Gene microarray
Liu C , et al. 2003
CALB2 calbindin 2 12308 Q08331 Gene microarray
Liu C , et al. 2003
CAMLG calcium modulating ligand 12328 P49070 Gene microarray
Liu C , et al. 2003
CASC3 cancer susceptibility candidate 3 192160 Q8K3W3 Gene microarray
Liu C , et al. 2003
CBFA2T3 core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) 12398 O54972 Gene microarray
Liu C , et al. 2003
CBFB core binding factor beta 12400 Q08024 Gene microarray
Liu C , et al. 2003
CCR1 chemokine (C-C motif) receptor 1 12768 P51675 Gene microarray
Liu C , et al. 2003
CCS copper chaperone for superoxide dismutase 12460 Q9WU84 Gene microarray
Liu C , et al. 2003
Cd1d2 CD1d2 antigen 12480 P11610 Gene microarray
Liu C , et al. 2003
CD52 CD52 antigen 23833 Q64389 Gene microarray
Liu C , et al. 2003
CD86 CD86 antigen 12524 P42082 Gene microarray
Liu C , et al. 2003
CDH3 cadherin 3 12560 P10287 Gene microarray
Liu C , et al. 2003
CELF2 CUGBP, Elav-like family member 2 14007 Q9Z0H4 Gene microarray
Liu C , et al. 2003
CFL2 cofilin 2, muscle 12632 P45591 Gene microarray
Liu C , et al. 2003
CHRM4 cholinergic receptor, muscarinic 4 12672 P32211 Gene microarray
Liu C , et al. 2003
CHRNE cholinergic receptor, nicotinic, epsilon polypeptide 11448 P20782 Gene microarray
Liu C , et al. 2003
CLCN1 chloride channel 1 12723 Q64347 Gene microarray
Liu C , et al. 2003
CMKLR1 chemokine-like receptor 1 14747 P97468 Gene microarray
Liu C , et al. 2003
CNOT7 CCR4-NOT transcription complex, subunit 7 18983 Q60809 Gene microarray
Liu C , et al. 2003
COL11A1 collagen, type XI, alpha 1 12814 Q61245 Gene microarray
Liu C , et al. 2003
COL12A1 collagen, type XII, alpha 1 12816 Q60847 Gene microarray
Liu C , et al. 2003
COPZ2 coatomer protein complex, subunit zeta 2 56358 Q9JHH9 Gene microarray
Liu C , et al. 2003
CPXM2 carboxypeptidase X 2 (M14 family) 55987 Q9D2L5 Gene microarray
Liu C , et al. 2003
CRISP2 cysteine-rich secretory protein 2 22024 P16563 Gene microarray
Liu C , et al. 2003
CRYGD crystallin, gamma D 12967 P04342 Gene microarray
Liu C , et al. 2003
CXCR5 chemokine (C-X-C motif) receptor 5 12145 Q04683 Gene microarray
Liu C , et al. 2003
CYBA cytochrome b-245, alpha polypeptide 13057 Q61462 Gene microarray
Liu C , et al. 2003
Cyct cytochrome c, testis 13067 P00015 Gene microarray
Liu C , et al. 2003
D3Wsu167e DNA segment, Chr 3, Wayne State University 167, expressed 28044 N/A Gene microarray
Liu C , et al. 2003
D7Ertd128e DNA segment, Chr 7, ERATO Doi 128, expressed 52222 N/A Gene microarray
Liu C , et al. 2003
D9Ertd720e DNA segment, Chr 9, ERATO Doi 720, expressed 52145 N/A Gene microarray
Liu C , et al. 2003
Defa-rs1 defensin, alpha, related sequence 1 13218 P17533 Gene microarray
Liu C , et al. 2003
DEGS2 degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase 70059 Q8R2F2 Gene microarray
Liu C , et al. 2003
DLL1 delta-like 1 (Drosophila) 13388 Q61483 Gene microarray
Liu C , et al. 2003
DNASE1 deoxyribonuclease I 13419 P49183 Gene microarray
Liu C , et al. 2003
EGF epidermal growth factor 13645 P01132 Gene microarray
Liu C , et al. 2003
EGFR epidermal growth factor receptor 13649 Q01279 Gene microarray
Liu C , et al. 2003
EGR1 early growth response 1 13653 P08046 Gene microarray
Liu C , et al. 2003
EIF5A eukaryotic translation initiation factor 5A 276770 P63242 Gene microarray
Liu C , et al. 2003
ELK4 ELK4, member of ETS oncogene family 13714 P41158 Gene microarray
Liu C , et al. 2003
ELL2 elongation factor RNA polymerase II 2 192657 Q3UKU1 Gene microarray
Liu C , et al. 2003
EYA1 eyes absent 1 homolog (Drosophila) 14048 P97767 Gene microarray
Liu C , et al. 2003
Fcgr3 Fc receptor, IgG, low affinity III 14131 P08508 Gene microarray
Liu C , et al. 2003
FGF17 fibroblast growth factor 17 14171 P63075 Gene microarray
Liu C , et al. 2003
FHIT fragile histidine triad gene 14198 O89106 Gene microarray
Liu C , et al. 2003
FIGLA folliculogenesis specific basic helix-loop-helix 26910 O55208 Gene microarray
Liu C , et al. 2003
FKBP3 FK506 binding protein 3 30795 Q00688 Gene microarray
Liu C , et al. 2003
FMR1 fragile X mental retardation 1 14265 P35922 HITS-CLIP
Darnell JC , et al. 2011
FNBP1 formin binding protein 1 14269 Q80TY0 Gene microarray
Liu C , et al. 2003
FOXH1 forkhead box H1 14106 O88621 Gene microarray
Liu C , et al. 2003
G6pd2 glucose-6-phosphate dehydrogenase 2 14380 P97324 Gene microarray
Liu C , et al. 2003
GABRA6 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6 14399 P16305 Gene microarray
Liu C , et al. 2003
GALNT4 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 14426 O08832 Gene microarray
Liu C , et al. 2003
GCG glucagon 14526 P55095 Gene microarray
Liu C , et al. 2003
GDNF glial cell line derived neurotrophic factor 14573 P48540 Gene microarray
Liu C , et al. 2003
GIMAP4 GTPase, IMAP family member 4 107526 Q99JY3 Gene microarray
Liu C , et al. 2003
GLI1 GLI-Kruppel family member GLI1 14632 P47806 Gene microarray
Liu C , et al. 2003
GLUL glutamate-ammonia ligase (glutamine synthetase) 14645 P15105 Gene microarray
Liu C , et al. 2003
GMCL1 germ cell-less homolog 1 (Drosophila) 23885 Q920G9 Gene microarray
Liu C , et al. 2003
GPX3 glutathione peroxidase 3 14778 P46412 Gene microarray
Liu C , et al. 2003
GRIN1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 14810 P35438 Gene microarray
Liu C , et al. 2003
GRM8 glutamate receptor, metabotropic 8 14823 P47743 Gene microarray
Liu C , et al. 2003
GSTA3 glutathione S-transferase, alpha 3 14859 P30115 Gene microarray
Liu C , et al. 2003
GTF3A general transcription factor III A 66596 Q8VHT7 Gene microarray
Liu C , et al. 2003
GUCY2C guanylate cyclase 2c 14917 Q3UWA6 Gene microarray
Liu C , et al. 2003
GYPA glycophorin A 14934 P14220 Gene microarray
Liu C , et al. 2003
Gzmf granzyme F 14943 P08883 Gene microarray
Liu C , et al. 2003
H2-K2 histocompatibility 2, K region locus 2 630499 P04223 Gene microarray
Liu C , et al. 2003
H2-M10.1 histocompatibility 2, M region locus 10.1 14985 O19443 Gene microarray
Liu C , et al. 2003
H2-Q1 histocompatibility 2, Q region locus 1 15006 O19441 Gene microarray
Liu C , et al. 2003
H2-Q5 histocompatibility 2, Q region locus 5 15016 N/A Gene microarray
Liu C , et al. 2003
HGFAC hepatocyte growth factor activator 54426 Q9R098 Gene microarray
Liu C , et al. 2003
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 3091 Q16665 Y2H
Ema M , et al. 1996
HOMER1 homer homolog 1 (Drosophila) 26556 Q9Z2Y3 Gene microarray
Liu C , et al. 2003
ICMT isoprenylcysteine carboxyl methyltransferase 57295 Q9EQK7 Gene microarray
Liu C , et al. 2003
Ifi204 interferon activated gene 204 15951 P15092 Gene microarray
Liu C , et al. 2003
IFNA2 interferon alpha 2 15965 P01573 Gene microarray
Liu C , et al. 2003
IFNA4 interferon alpha 4 15967 P07351 Gene microarray
Liu C , et al. 2003
IGFBP4 insulin-like growth factor binding protein 4 16010 P47879 Gene microarray
Liu C , et al. 2003
Ighv1-54 immunoglobulin heavy variable V1-54 211331 N/A Gene microarray
Liu C , et al. 2003
Igk immunoglobulin kappa chain complex 243469 N/A Gene microarray
Liu C , et al. 2003
Igkv16-104 immunoglobulin kappa variable 16-104 381778 N/A Gene microarray
Liu C , et al. 2003
Iigp1 interferon inducible GTPase 1 60440 Q9QZ85 Gene microarray
Liu C , et al. 2003
IL5 interleukin 5 16191 P04401 Gene microarray
Liu C , et al. 2003
IL6R interleukin 6 receptor, alpha 16194 P22272 Gene microarray
Liu C , et al. 2003
ITGB3 integrin beta 3 16416 O54890 Gene microarray
Liu C , et al. 2003
ITIH3 inter-alpha trypsin inhibitor, heavy chain 3 16426 Q61704 Gene microarray
Liu C , et al. 2003
JAK2 Janus kinase 2 16452 Q62120 Gene microarray
Liu C , et al. 2003
Kap kidney androgen regulated protein 16483 P61110 Gene microarray
Liu C , et al. 2003
KCNE1L potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene 66240 Q9QZ26 Gene microarray
Liu C , et al. 2003
KCNJ15 potassium inwardly-rectifying channel, subfamily J, member 15 16516 O88932 Gene microarray
Liu C , et al. 2003
KCNQ1 potassium voltage-gated channel, subfamily Q, member 1 16535 P97414 Gene microarray
Liu C , et al. 2003
Klk1b22 kallikrein 1-related peptidase b22 13646 P15948 Gene microarray
Liu C , et al. 2003
Klk1b9 kallikrein 1-related peptidase b9 13648 P15949 Gene microarray
Liu C , et al. 2003
KRT5 keratin 5 110308 Q922U2 Gene microarray
Liu C , et al. 2003
KRTAP6-1 keratin associated protein 6-1 16700 O09048 Gene microarray
Liu C , et al. 2003
LAMA2 laminin, alpha 2 16773 Q60675 Gene microarray
Liu C , et al. 2003
LAMB3 laminin, beta 3 16780 Q61087 Gene microarray
Liu C , et al. 2003
LCAT lecithin cholesterol acyltransferase 16816 P16301 Gene microarray
Liu C , et al. 2003
LCP1 lymphocyte cytosolic protein 1 18826 Q61233 Gene microarray
Liu C , et al. 2003
LDB2 LIM domain binding 2 16826 O55203 Gene microarray
Liu C , et al. 2003
LGALS9 lectin, galactose binding, soluble 9 16859 O08573 Gene microarray
Liu C , et al. 2003
LHX8 LIM homeobox protein 8 16875 O35652 Gene microarray
Liu C , et al. 2003
LIFR leukemia inhibitory factor receptor 16880 P42703 Gene microarray
Liu C , et al. 2003
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 16978 Q3UZ39 Gene microarray
Liu C , et al. 2003
LTF lactotransferrin 17002 P08071 Gene microarray
Liu C , et al. 2003
MC3R melanocortin 3 receptor 17201 P33033 Gene microarray
Liu C , et al. 2003
MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) 17220 Q61881 Gene microarray
Liu C , et al. 2003
MDM4 transformed mouse 3T3 cell double minute 4 17248 O35618 Gene microarray
Liu C , et al. 2003
MRPL2 mitochondrial ribosomal protein L2 27398 Q9D773 Gene microarray
Liu C , et al. 2003
MSC musculin 17681 O88940 Gene microarray
Liu C , et al. 2003
MTCP1 mature T cell proliferation 1 17763 Q60945 Gene microarray
Liu C , et al. 2003
MTPN myotrophin 14489 P62774 Gene microarray
Liu C , et al. 2003
MYCL1 v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) 16918 P10166 Gene microarray
Liu C , et al. 2003
MYH6 myosin, heavy polypeptide 6, cardiac muscle, alpha 17888 Q02566 Gene microarray
Liu C , et al. 2003
MYH7 myosin, heavy polypeptide 7, cardiac muscle, beta 140781 Q91Z83 Gene microarray
Liu C , et al. 2003
NAA20 N-acetyltransferase 3 17962 P50296 Gene microarray
Liu C , et al. 2003
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 72560 Q9CZR2 Gene microarray
Liu C , et al. 2003
NACA nascent polypeptide-associated complex alpha polypeptide 17938 Q60817 Gene microarray
Liu C , et al. 2003
NAP1L4 nucleosome assembly protein 1-like 4 17955 Q78ZA7 Gene microarray
Liu C , et al. 2003
NDN necdin 17984 P25233 Y2H; IP/WB
Friedman ER and Fan CM 2007
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1 54405 O35683 Gene microarray
Liu C , et al. 2003
NFATC2 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 18019 Q60591 Gene microarray
Liu C , et al. 2003
NFE2 nuclear factor, erythroid derived 2 18022 Q07279 Gene microarray
Liu C , et al. 2003
NGEF neuronal guanine nucleotide exchange factor 53972 Q8CHT1 Gene microarray
Liu C , et al. 2003
NKX6-2 NK6 homeobox 2 14912 D3Z4R4 Gene microarray
Liu C , et al. 2003
NMBR neuromedin B receptor 18101 O54799 Gene microarray
Liu C , et al. 2003
NPAS1 neuronal PAS domain protein 1 18142 P97459 CAT reporter assay
Teh CH , et al. 2006
NR5A1 nuclear receptor subfamily 5, group A, member 1 26423 P33242 Gene microarray
Liu C , et al. 2003
NUDC nuclear distribution gene C homolog (Aspergillus) 18221 O35685 Gene microarray
Liu C , et al. 2003
OAZ1 ornithine decarboxylase antizyme 1 18245 P54369 Gene microarray
Liu C , et al. 2003
PADI3 peptidyl arginine deiminase, type III 18601 Q9Z184 Gene microarray
Liu C , et al. 2003
PDLIM4 PDZ and LIM domain 4 30794 P70271 Gene microarray
Liu C , et al. 2003
Pea15a phosphoprotein enriched in astrocytes 15A 18611 Q62048 Gene microarray
Liu C , et al. 2003
PFN1 profilin 1 18643 P62962 Gene microarray
Liu C , et al. 2003
PKIB protein kinase inhibitor beta, cAMP dependent, testis specific 18768 Q04758 Gene microarray
Liu C , et al. 2003
PLA2G5 phospholipase A2, group V 18784 P97391 Gene microarray
Liu C , et al. 2003
PLCB1 phospholipase C, beta 1 18795 Q9Z1B3 Gene microarray
Liu C , et al. 2003
PLP1 proteolipid protein (myelin) 1 18823 P60202 Gene microarray
Liu C , et al. 2003
PMFBP1 polyamine modulated factor 1 binding protein 1 56523 Q9WVQ0 Gene microarray
Liu C , et al. 2003
POLD4 polymerase (DNA-directed), delta 4 69745 Q9CWP8 Gene microarray
Liu C , et al. 2003
POSTN periostin, osteoblast specific factor 50706 Q62009 Gene microarray
Liu C , et al. 2003
POU5F1 POU domain, class 5, transcription factor 1 18999 P20263 Gene microarray
Liu C , et al. 2003
Prl8a2 prolactin family 8, subfamily a, member 2 13529 O35258 Gene microarray
Liu C , et al. 2003
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 19260 P29352 Gene microarray
Liu C , et al. 2003
RBL2 retinoblastoma-like 2 19651 Q64700 Gene microarray
Liu C , et al. 2003
RGS10 regulator of G-protein signalling 10 67865 Q9CQE5 Gene microarray
Liu C , et al. 2003
RPL29 ribosomal protein L29 19944 P47915 Gene microarray
Liu C , et al. 2003
RYR2 ryanodine receptor 2, cardiac 20191 E9Q401 Gene microarray
Liu C , et al. 2003
S100G S100 calcium binding protein G 12309 P97816 Gene microarray
Liu C , et al. 2003
SELENBP1 selenium binding protein 1 20341 P17563 Gene microarray
Liu C , et al. 2003
SEMA5B sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B 20357 Q60519 Gene microarray
Liu C , et al. 2003
SERPINA5 serine (or cysteine) peptidase inhibitor, clade A, member 5 268591 P70458 Gene microarray
Liu C , et al. 2003
SIM1 single-minded homolog 1 (Drosophila) 20464 Q61045 Y2H
Ema M , et al. 1996
SIN3B transcriptional regulator, SIN3B (yeast) 20467 Q62141 Gene microarray
Liu C , et al. 2003
SIRT1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 93759 Q923E4 Gene microarray
Liu C , et al. 2003
SLC12A3 solute carrier family 12, member 3 20497 P59158 Gene microarray
Liu C , et al. 2003
SLC17A1 solute carrier family 17 (sodium phosphate), member 1 20504 Q61983 Gene microarray
Liu C , et al. 2003
SMAD3 MAD homolog 3 (Drosophila) 17127 Q8BUN5 Gene microarray
Liu C , et al. 2003
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 83796 Q99JR8 Gene microarray
Liu C , et al. 2003
SNN stannin 20621 P61807 Gene microarray
Liu C , et al. 2003
SNX5 sorting nexin 5 69178 Q9D8U8 Gene microarray
Liu C , et al. 2003
SOX10 SRY-box containing gene 10 20665 Q04888 Gene microarray
Liu C , et al. 2003
SP100 nuclear antigen Sp100 20684 O35892 Gene microarray
Liu C , et al. 2003
SPRR1A small proline-rich protein 1A 20753 Q62266 Gene microarray
Liu C , et al. 2003
ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 50935 Q9JM95 Gene microarray
Liu C , et al. 2003
ST8SIA5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 225742 P70126 Gene microarray
Liu C , et al. 2003
STRN striatin, calmodulin binding protein 268980 O55106 Gene microarray
Liu C , et al. 2003
SYT5 synaptotagmin V 53420 Q9R0N5 Gene microarray
Liu C , et al. 2003
SYT7 synaptotagmin VII 54525 Q9R0N7 Gene microarray
Liu C , et al. 2003
T25656 expressed sequence T25656 97343 N/A Gene microarray
Liu C , et al. 2003
TACR2 tachykinin receptor 2 21337 P30549 Gene microarray
Liu C , et al. 2003
TCF3 transcription factor 3 21423 P15806 Gene microarray
Liu C , et al. 2003
TCL1A T cell lymphoma breakpoint 1 21432 P56280 Gene microarray
Liu C , et al. 2003
Tcrb-J T cell receptor beta, joining region 21580 N/A Gene microarray
Liu C , et al. 2003
TERF1 telomeric repeat binding factor 1 21749 P70371 Gene microarray
Liu C , et al. 2003
THEG testicular haploid expressed gene 21830 Q9JMB1 Gene microarray
Liu C , et al. 2003
THRB thyroid hormone receptor beta 21834 P37242 Gene microarray
Liu C , et al. 2003
TLX2 T cell leukemia, homeobox 2 21909 Q61663 Gene microarray
Liu C , et al. 2003
TNF tumor necrosis factor 21926 P06804 Gene microarray
Liu C , et al. 2003
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 21942 P20334 Gene microarray
Liu C , et al. 2003
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 21950 P41274 Gene microarray
Liu C , et al. 2003
TSC22D3 TSC22 domain family, member 3 14605 Q9Z2S7 Gene microarray
Liu C , et al. 2003
TSSK2 testis-specific serine kinase 2 22115 O54863 Gene microarray
Liu C , et al. 2003
TXNRD3 thioredoxin reductase 3 232223 Q99MD6 Gene microarray
Liu C , et al. 2003
TYK2 tyrosine kinase 2 54721 Q9R117 Gene microarray
Liu C , et al. 2003
TYROBP TYRO protein tyrosine kinase binding protein 22177 O54885 Gene microarray
Liu C , et al. 2003
Ube1y1 ubiquitin-activating enzyme E1, Chr Y 1 22202 P31254 Gene microarray
Liu C , et al. 2003
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6A 94284 Q64435 Gene microarray
Liu C , et al. 2003
USP2 ubiquitin specific peptidase 2 53376 O88623 Gene microarray
Liu C , et al. 2003
WNT7B wingless-related MMTV integration site 7B 22422 P28047 Gene microarray
Liu C , et al. 2003
ZDHHC14 zinc finger, DHHC domain containing 14 224454 Q8BQQ1 Gene microarray
Liu C , et al. 2003
ZFP36L1 zinc finger protein 36, C3H type-like 1 12192 P23950 Gene microarray
Liu C , et al. 2003
ZG16 zymogen granule protein 16 69036 Q8K0C5 Gene microarray
Liu C , et al. 2003
ZNF235 zinc finger protein 93 22755 Q61116 Gene microarray
Liu C , et al. 2003
AHR aryl hydrocarbon receptor 373907 Q9PTI7 EMSA
Lee JS , et al. 2010

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