| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
Motor learning1 |
Restored
Description: Sl372 reversed the increased motor learning
|
Accelerating rotarod test |
4-5 months |
| |
|
Description: Sl372 reversed the increased motor learning
|
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Dendritic architecture: spine turnover1 |
Restored
Description: Increased clustered spine stabilization in apical dendrites from gfp-expressing l5 pyramidal neurons is normalized by sl372; sl327 had a negligible effect on the stabilization of isolated new-spines in mutants
|
Two-photon microscopy |
12-14 weeks |
| |
|
Description: Increased clustered spine stabilization in apical dendrites from gfp-expressing l5 pyramidal neurons is normalized by sl372; sl327 had a negligible effect on the stabilization of isolated new-spines in mutants
|
|
|
| Molecular profile |
Signaling: MAPK pathway1 |
Restored
Description: M1 erk phosphorylation was normalized in sl327-treated mutants
|
Western blot |
4-5 months |
| |
|
Description: M1 erk phosphorylation was normalized in sl327-treated mutants
|
|
|
|
| Not Reported: |
|
