| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
General locomotor activity: ambulatory activity1 |
Restored
Description: Increased expression of gabrb3 in mutants show increase in total distance travelled in mutants.
Exp Paradigm: NA
|
Open field test |
6 weeks |
| |
|
Description: Increased expression of gabrb3 in mutants show increase in total distance travelled in mutants.
Exp Paradigm: NA |
|
|
| Motor phenotype |
General locomotor activity1 |
No adverse effect
Description: Increased expression of gabrb3 in mutants show no change in total arm entries in the elevated plus maze.
Exp Paradigm: NA
|
Elevated plus maze test |
6 weeks |
| |
|
Description: Increased expression of gabrb3 in mutants show no change in total arm entries in the elevated plus maze.
Exp Paradigm: NA |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Neuronal number: interneurons1 |
Refractory
Description: Increased gabrb3 did not change the increased parvalbumin positive interneuron numbers in the visual cortex in mutants.
Exp Paradigm: NA
|
Immunohistochemistry |
6 weeks |
| |
|
Description: Increased gabrb3 did not change the increased parvalbumin positive interneuron numbers in the visual cortex in mutants.
Exp Paradigm: NA |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Neuronal number: interneurons1 |
Restored
Description: Increased expression of gabrb3 decreased parvalbumin positive neurons in the primary somatosensory cortex to control levels in mutants. increased expression of gabrb3 increased parvalbumin positive neurons in the basolateral amygdala to control levels in mutants.
Exp Paradigm: NA
|
Immunohistochemistry |
6 weeks |
| |
|
Description: Increased expression of gabrb3 decreased parvalbumin positive neurons in the primary somatosensory cortex to control levels in mutants. increased expression of gabrb3 increased parvalbumin positive neurons in the basolateral amygdala to control levels in mutants.
Exp Paradigm: NA |
|
|
| Sensory |
Sensorimotor gating: tactile cue1 |
Restored
Description: Increased expression of gabrb3 decreased startle response to an air puff alone in mutants.
Exp Paradigm: NA
|
Response to air puff |
6 weeks |
| |
|
Description: Increased expression of gabrb3 decreased startle response to an air puff alone in mutants.
Exp Paradigm: NA |
|
|
| Sensory |
Sensorimotor gating: tactile cue1 |
Restored
Description: Increased expression of gabrb3 in somatosensory neurons decreased percent inhibition of the startle response to a 125 db noise, when the startle noise is preceded by a light air puff, in mutants.
Exp Paradigm: NA
|
Prepulse inhibition |
6 weeks |
| |
|
Description: Increased expression of gabrb3 in somatosensory neurons decreased percent inhibition of the startle response to a 125 db noise, when the startle noise is preceded by a light air puff, in mutants.
Exp Paradigm: NA |
|
|
| Sensory |
Sensorimotor gating1 |
Refractory
Description: Increased expression of gabrb3 in mutants show no change in percent inhibition of the startle response to a 125 db noise pulse when the startle noise is preceded by an 80 db tone prepulse, in mutants.
Exp Paradigm: NA
|
Prepulse inhibition |
6 weeks |
| |
|
Description: Increased expression of gabrb3 in mutants show no change in percent inhibition of the startle response to a 125 db noise pulse when the startle noise is preceded by an 80 db tone prepulse, in mutants.
Exp Paradigm: NA |
|
|
| Sensory |
Sensorimotor gating: tactile cue1 |
Refractory
Description: Increased expression of gabrb3 in mutants show no change in responsivity to an air puff stimulus delivered to back hairy skin in mutants.
Exp Paradigm: NA
|
Response to air puff |
6 weeks |
| |
|
Description: Increased expression of gabrb3 in mutants show no change in responsivity to an air puff stimulus delivered to back hairy skin in mutants.
Exp Paradigm: NA |
|
|
| Sensory |
Tactile memory1 |
Restored
Description: Increased expression of gabrb3 increased preference for object with a novel texture.
Exp Paradigm: NA
|
Textured novel object recognition test (t-nort) |
6 weeks |
| |
|
Description: Increased expression of gabrb3 increased preference for object with a novel texture.
Exp Paradigm: NA |
|
|
| Sensory |
Sensorimotor gating: tactile cue1 |
Refractory
Description: Increased expression of gabrb3 in mutants show no change in percent prepulse inhibition of the startle response to a 125 db noise, when the startle noise is preceded by a light air puff, in mutants.
Exp Paradigm: NA
|
Prepulse inhibition |
6 weeks |
| |
|
Description: Increased expression of gabrb3 in mutants show no change in percent prepulse inhibition of the startle response to a 125 db noise, when the startle noise is preceded by a light air puff, in mutants.
Exp Paradigm: NA |
|
|
| Sensory |
Startle response: acoustic stimulus1 |
Refractory
Description: Increased expression of gabrb3 in mutants show no change in amplitude of startle response to a 125 db startling noise or to a prepulse 80db noise.
Exp Paradigm: NA
|
Acoustic startle reflex test |
6 weeks |
| |
|
Description: Increased expression of gabrb3 in mutants show no change in amplitude of startle response to a 125 db startling noise or to a prepulse 80db noise.
Exp Paradigm: NA |
|
|
| Social behavior |
Social memory1 |
Restored
Description: Increased expression of gabrb3 increased preference for novel mouse in mutants.
Exp Paradigm: NA
|
Three-chamber social approach test |
6 weeks |
| |
|
Description: Increased expression of gabrb3 increased preference for novel mouse in mutants.
Exp Paradigm: NA |
|
|
| Social behavior |
Social approach1 |
Restored
Description: Increased expression of gabrb3 increased preference for novel mouse in mutants.
Exp Paradigm: NA
|
Three-chamber social approach test |
6 weeks |
| |
|
Description: Increased expression of gabrb3 increased preference for novel mouse in mutants.
Exp Paradigm: NA |
|
|
| Emotion |
Habituation to aversive stimuli1 |
Restored
Description: Increased expression of gabrb3 in mutants increased startle amplitude to a 125 db noise during a 30-minute tactile ppi session, when comparing the first five startle responses to the last five responses.
Exp Paradigm: NA
|
Prepulse inhibition |
6 weeks |
| |
|
Description: Increased expression of gabrb3 in mutants increased startle amplitude to a 125 db noise during a 30-minute tactile ppi session, when comparing the first five startle responses to the last five responses.
Exp Paradigm: NA |
|
|
| Emotion |
Exploratory activity1 |
No adverse effect
Description: Increased expression of gabrb3 show no change in the time spent investigating objects in mutants.
Exp Paradigm: NA
|
Novel object recognition test |
6 weeks |
| |
|
Description: Increased expression of gabrb3 show no change in the time spent investigating objects in mutants.
Exp Paradigm: NA |
|
|
| Emotion |
Anxiety1 |
Restored
Description: Increased expression of gabrb3 increased time spent in the open arms in mutants.
Exp Paradigm: NA
|
Elevated plus maze test |
6 weeks |
| |
|
Description: Increased expression of gabrb3 increased time spent in the open arms in mutants.
Exp Paradigm: NA |
|
|
| Emotion |
Anxiety1 |
Restored
Description: Increased expression of gabrb3 increased time spent in the center in mutants.
Exp Paradigm: NA
|
Open field test |
6 weeks |
| |
|
Description: Increased expression of gabrb3 increased time spent in the center in mutants.
Exp Paradigm: NA |
|
|
| Learning & memory |
Object recognition memory: long-term recall1 |
Refractory
Description: Increased expression of gabrb3 in mutants did not change preference for novel textured object after 5 min or 1hr retention in mutants.
Exp Paradigm: NA
|
Textured novel object recognition test (t-nort) |
6 weeks |
| |
|
Description: Increased expression of gabrb3 in mutants did not change preference for novel textured object after 5 min or 1hr retention in mutants.
Exp Paradigm: NA |
|
|
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Immune response, Maternal behavior, Molecular profile, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, |
