| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Neuronal number: interneurons1 |
Abnormal
Description: Mutants show decrease in number of parvalbumin positive interneurons in primary somatosensory cortex, but not primary visual cortex or in the basolateral amygdala.
Exp Paradigm: Primary somatosensory cortex, primary visual cortex, basolateral amygdala
|
Immunohistochemistry |
6 weeks |
| |
|
Description: Mutants show decrease in number of parvalbumin positive interneurons in primary somatosensory cortex, but not primary visual cortex or in the basolateral amygdala.
Exp Paradigm: Primary somatosensory cortex, primary visual cortex, basolateral amygdala |
|
|
| Repetitive behavior |
Repetitive digging1 |
Decreased
Description: Mutants show decrease in the number of marbles buried.
Exp Paradigm: NA
|
Marble-burying test |
6-8 weeks |
| |
|
Description: Mutants show decrease in the number of marbles buried.
Exp Paradigm: NA |
|
|
| Sensory |
Tactile memory1 |
Decreased
Description: Mutants show decrease in preference for the object with the novel texture.
Exp Paradigm: NA
|
Textured novel object recognition test (t-nort) |
6 weeks |
| |
|
Description: Mutants show decrease in preference for the object with the novel texture.
Exp Paradigm: NA |
|
|
| Sensory |
Sensorimotor gating: tactile cue1 |
Increased
Description: Mutants show increased responsivity to an air puff stimulus delivered to back hairy skin.
Exp Paradigm: NA
|
Response to air puff |
6 weeks |
| |
|
Description: Mutants show increased responsivity to an air puff stimulus delivered to back hairy skin.
Exp Paradigm: NA |
|
|
| Sensory |
Sensorimotor gating: tactile cue1 |
Increased
Description: Mutants exhibited hairy skin hypersensitivity, measured by an increase of tactile prepulse inhibition of an acoustic startle response assay.
Exp Paradigm: NA
|
Prepulse inhibition |
6 weeks |
| |
|
Description: Mutants exhibited hairy skin hypersensitivity, measured by an increase of tactile prepulse inhibition of an acoustic startle response assay.
Exp Paradigm: NA |
|
|
| Social behavior |
Social approach1 |
Decreased
Description: Mutants spent less time investigating a novel mouse than a novel object.
Exp Paradigm: NA
|
Three-chamber social approach test |
6 weeks |
| |
|
Description: Mutants spent less time investigating a novel mouse than a novel object.
Exp Paradigm: NA |
|
|
| Social behavior |
Social memory1 |
Decreased
Description: Mutants spent less time investigating a novel mouse than a familiar mouse.
Exp Paradigm: NA
|
Three-chamber social approach test |
6 weeks |
| |
|
Description: Mutants spent less time investigating a novel mouse than a familiar mouse.
Exp Paradigm: NA |
|
|
| Emotion |
Anxiety1 |
No change |
Open field test |
6 weeks |
| Emotion |
Anxiety1 |
No change |
Elevated plus maze test |
6 weeks |
| Emotion |
Exploratory activity1 |
No change |
Novel object recognition test |
6 weeks |
| Emotion |
Habituation to aversive stimuli1 |
No change |
Prepulse inhibition |
6-8 weeks |
| Learning & memory |
Object recognition memory: long-term recall1 |
No change |
Novel object recognition test |
6 weeks |
| Motor phenotype |
General locomotor activity1 |
No change |
Elevated plus maze test |
6-8 weeks |
| Motor phenotype |
General locomotor activity: ambulatory activity1 |
No change |
Open field test |
6-8 weeks |
| Sensory |
Sensorimotor gating1 |
No change |
Prepulse inhibition |
6 weeks |
| Sensory |
Startle response: acoustic stimulus1 |
No change |
Acoustic startle reflex test |
6 weeks |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Immune response, Maternal behavior, Molecular profile, Neurophysiology, Physiological parameters, Seizure, |
