| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
General locomotor activity: ambulatory activity1 |
Decreased
Description: Mutants show decrease in distance travelled.
Exp Paradigm: NA
|
Open field test |
6-8 weeks |
| |
|
Description: Mutants show decrease in distance travelled.
Exp Paradigm: NA |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Neuronal number: interneurons1 |
Abnormal
Description: Mutants show increase in number of parvalbumin positive interneurons in primary somatosensory cortex, but not primary visual cortex. mutants show decrease in number of parvalbumin positive interneurons in the basolateral amygdala.
Exp Paradigm: Primary somatosensory cortex, primary visual cortex, basolateral amygdala
|
Immunohistochemistry |
6 weeks |
| |
|
Description: Mutants show increase in number of parvalbumin positive interneurons in primary somatosensory cortex, but not primary visual cortex. mutants show decrease in number of parvalbumin positive interneurons in the basolateral amygdala.
Exp Paradigm: Primary somatosensory cortex, primary visual cortex, basolateral amygdala |
|
|
| Repetitive behavior |
Repetitive digging1 |
Decreased
Description: Mutants show decrease in the number of marbles buried.
Exp Paradigm: NA
|
Marble-burying test |
6-8 weeks |
| |
|
Description: Mutants show decrease in the number of marbles buried.
Exp Paradigm: NA |
|
|
| Sensory |
Tactile memory1 |
Decreased
Description: Mutants show decrease in preference for the object with the novel texture.
Exp Paradigm: NA
|
Textured novel object recognition test (t-nort) |
6 weeks |
| |
|
Description: Mutants show decrease in preference for the object with the novel texture.
Exp Paradigm: NA |
|
|
| Sensory |
Sensorimotor gating: tactile cue1 |
Increased
Description: Mutants show increased responsivity to an air puff stimulus delivered to back hairy skin.
Exp Paradigm: NA
|
Response to air puff |
6 weeks |
| |
|
Description: Mutants show increased responsivity to an air puff stimulus delivered to back hairy skin.
Exp Paradigm: NA |
|
|
| Sensory |
Sensorimotor gating: tactile cue1 |
Increased
Description: Mutants exhibited hairy skin hypersensitivity, measured by an increase of tactile prepulse inhibition of an acoustic startle response assay.
Exp Paradigm: NA
|
Prepulse inhibition |
6 weeks |
| |
|
Description: Mutants exhibited hairy skin hypersensitivity, measured by an increase of tactile prepulse inhibition of an acoustic startle response assay.
Exp Paradigm: NA |
|
|
| Social behavior |
Social memory1 |
Decreased
Description: Mutants spent less time investigating a novel mouse than a familiar mouse.
Exp Paradigm: NA
|
Three-chamber social approach test |
6 weeks |
| |
|
Description: Mutants spent less time investigating a novel mouse than a familiar mouse.
Exp Paradigm: NA |
|
|
| Social behavior |
Social approach1 |
Decreased
Description: Mutants spent less time investigating a novel mouse than a novel object.
Exp Paradigm: NA
|
Three-chamber social approach test |
6 weeks |
| |
|
Description: Mutants spent less time investigating a novel mouse than a novel object.
Exp Paradigm: NA |
|
|
| Emotion |
Anxiety1 |
Increased
Description: Mutants spent less time in the open arms.
Exp Paradigm: NA
|
Elevated plus maze test |
6 weeks |
| |
|
Description: Mutants spent less time in the open arms.
Exp Paradigm: NA |
|
|
| Emotion |
Anxiety1 |
Increased
Description: Mutants spent less time in the center of the open field.
Exp Paradigm: NA
|
Open field test |
6 weeks |
| |
|
Description: Mutants spent less time in the center of the open field.
Exp Paradigm: NA |
|
|
| Emotion |
Habituation to aversive stimuli1 |
Decreased
Description: Mutants show lower percent decrease in startle response to a 125 db noise during a 30-minute tactile ppi session, when comparing the first five startle responses to the last five responses to a 125 db noise for mutant mice and their control littermates, indicating lack of habituation to an acoustic startle noise.
Exp Paradigm: NA
|
Prepulse inhibition |
6-8 weeks |
| |
|
Description: Mutants show lower percent decrease in startle response to a 125 db noise during a 30-minute tactile ppi session, when comparing the first five startle responses to the last five responses to a 125 db noise for mutant mice and their control littermates, indicating lack of habituation to an acoustic startle noise.
Exp Paradigm: NA |
|
|
| Emotion |
Exploratory activity1 |
No change |
Novel object recognition test |
6 weeks |
| Learning & memory |
Object recognition memory: long-term recall1 |
No change |
Novel object recognition test |
6 weeks |
| Motor phenotype |
General locomotor activity1 |
No change |
Elevated plus maze test |
6-8 weeks |
| Sensory |
Sensorimotor gating1 |
No change |
Prepulse inhibition |
6 weeks |
| Sensory |
Startle response: acoustic stimulus1 |
No change |
Acoustic startle reflex test |
6 weeks |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Immune response, Maternal behavior, Molecular profile, Neurophysiology, Physiological parameters, Seizure, |
