| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
General locomotor activity: ambulatory activity1 |
Decreased
Description: Mutants show decrease in distance travelled.
Exp Paradigm: NA
|
Open field test |
6-8 weeks |
| |
|
Description: Mutants show decrease in distance travelled.
Exp Paradigm: NA |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Neuronal number: interneurons1 |
Abnormal
Description: Mutants show increase of parvalbumin positive interneurons in the primary somatosensory cortex and in the primary visual cortex but decrease in parvalbumin positive interneurons in the basolateral amygdala.
Exp Paradigm: Primary somatosensory cortex, primary visual cortex
|
Immunohistochemistry |
Adult |
| |
|
Description: Mutants show increase of parvalbumin positive interneurons in the primary somatosensory cortex and in the primary visual cortex but decrease in parvalbumin positive interneurons in the basolateral amygdala.
Exp Paradigm: Primary somatosensory cortex, primary visual cortex |
|
|
| Neurophysiology |
Intrinsic membrane properties1 |
Increased
Description: Mutants show a small increase in excitability of large diameter neurons, measured by a decrease in rheobase.
Exp Paradigm: Spinal cord
|
Whole-cell current clamp |
Adult |
| |
|
Description: Mutants show a small increase in excitability of large diameter neurons, measured by a decrease in rheobase.
Exp Paradigm: Spinal cord |
|
|
| Repetitive behavior |
Repetitive digging1 |
Decreased
Description: Mutants show decrease in the number of marbles buried.
Exp Paradigm: NA
|
Marble-burying test |
6-8 weeks |
| |
|
Description: Mutants show decrease in the number of marbles buried.
Exp Paradigm: NA |
|
|
| Sensory |
Sensorimotor gating: tactile cue1 |
Increased
Description: Mutants show increased responsivity to an air puff stimulus delivered to back hairy skin.
Exp Paradigm: NA
|
Response to air puff |
6 weeks |
| |
|
Description: Mutants show increased responsivity to an air puff stimulus delivered to back hairy skin.
Exp Paradigm: NA |
|
|
| Sensory |
Sensorimotor gating1 |
Increased
Description: Mutants show increase in percent inhibition of the startle response to a 125 db noise pulse when the startle noise is preceded by an 80 db tone prepulse.
Exp Paradigm: NA
|
Prepulse inhibition |
6 weeks |
| |
|
Description: Mutants show increase in percent inhibition of the startle response to a 125 db noise pulse when the startle noise is preceded by an 80 db tone prepulse.
Exp Paradigm: NA |
|
|
| Sensory |
Tactile memory1 |
Decreased
Description: Mutants show decrease in preference for the object with the novel texture.
Exp Paradigm: NA
|
Textured novel object recognition test (t-nort) |
6 weeks |
| |
|
Description: Mutants show decrease in preference for the object with the novel texture.
Exp Paradigm: NA |
|
|
| Sensory |
Startle response: acoustic stimulus1 |
Decreased
Description: Mutants show decrease in amplitude of startle response to a 125 db startling noise but not to a 80db non-startling noise pulse.
Exp Paradigm: NA
|
Acoustic startle reflex test |
6 weeks |
| |
|
Description: Mutants show decrease in amplitude of startle response to a 125 db startling noise but not to a 80db non-startling noise pulse.
Exp Paradigm: NA |
|
|
| Social behavior |
Social approach1 |
Decreased
Description: Mutants spent less time investigating a novel mouse than a novel object.
Exp Paradigm: NA
|
Three-chamber social approach test |
6 weeks |
| |
|
Description: Mutants spent less time investigating a novel mouse than a novel object.
Exp Paradigm: NA |
|
|
| Social behavior |
Social memory1 |
Decreased
Description: Mutants spent less time investigating a novel mouse than a familiar mouse.
Exp Paradigm: NA
|
Three-chamber social approach test |
6 weeks |
| |
|
Description: Mutants spent less time investigating a novel mouse than a familiar mouse.
Exp Paradigm: NA |
|
|
| Emotion |
Anxiety1 |
Increased
Description: Mutants spent less time in the open arms.
Exp Paradigm: NA
|
Elevated plus maze test |
6 weeks |
| |
|
Description: Mutants spent less time in the open arms.
Exp Paradigm: NA |
|
|
| Emotion |
Anxiety1 |
Increased
Description: Mutants spent less time in the center of the open field.
Exp Paradigm: NA
|
Open field test |
6 weeks |
| |
|
Description: Mutants spent less time in the center of the open field.
Exp Paradigm: NA |
|
|
| Emotion |
Habituation to aversive stimuli1 |
Decreased
Description: Mutants show lower percent decrease in startle response to a 125 db noise during a 30-minute tactile ppi session, when comparing the first five startle responses to the last five responses to a 125 db noise for mutant mice and their control littermates, indicating lack of habituation to an acoustic startle noise.
Exp Paradigm: NA
|
Prepulse inhibition |
6-8 weeks |
| |
|
Description: Mutants show lower percent decrease in startle response to a 125 db noise during a 30-minute tactile ppi session, when comparing the first five startle responses to the last five responses to a 125 db noise for mutant mice and their control littermates, indicating lack of habituation to an acoustic startle noise.
Exp Paradigm: NA |
|
|
| Learning & memory |
Object recognition memory: long-term recall1 |
Decreased
Description: Mutants show no decrease in preference for an object with a novel shape after 1 hour retention but not after 5 min retention.
Exp Paradigm: NA
|
Novel object recognition test |
6 weeks |
| |
|
Description: Mutants show no decrease in preference for an object with a novel shape after 1 hour retention but not after 5 min retention.
Exp Paradigm: NA |
|
|
| Emotion |
Exploratory activity1 |
No change |
Novel object recognition test |
6 weeks |
| Motor phenotype |
General locomotor activity1 |
No change |
Elevated plus maze test |
6-8 weeks |
| Neurophysiology |
Action potential property: firing rate1 |
No change |
Whole-cell voltage clamp |
Adult |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Immune response, Maternal behavior, Molecular profile, Physiological parameters, Seizure, |
