| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
General locomotor activity: ambulatory activity1 |
Decreased
Description: Mutants show decrease in distance travelled.
Exp Paradigm: NA
|
Open field test |
6-8 weeks |
| |
|
Description: Mutants show decrease in distance travelled.
Exp Paradigm: NA |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Neuronal number: interneurons1 |
Increased
Description: Mutants show increase in number of parvalbumin positive interneurons in primary somatosensory cortex, but not primary visual cortex. mutants show decrease in number of parvalbumin positive interneurons in the basolateral amygdala.
Exp Paradigm: Primary somatosensory cortex, primary visual cortex
|
Immunohistochemistry |
Adult |
| |
|
Description: Mutants show increase in number of parvalbumin positive interneurons in primary somatosensory cortex, but not primary visual cortex. mutants show decrease in number of parvalbumin positive interneurons in the basolateral amygdala.
Exp Paradigm: Primary somatosensory cortex, primary visual cortex |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Morphology of the spinal cord: sensory and motor tracts1 |
Decreased
Description: Mutants show decrease in hcn1 expression at spinal cord dorsal horn lamina iii/iv in vglut1+ presynaptic terminals, in large but not small diameter drg cell bodies.
Exp Paradigm: Spinal cord
|
Immunohistochemistry |
Adult |
| |
|
Description: Mutants show decrease in hcn1 expression at spinal cord dorsal horn lamina iii/iv in vglut1+ presynaptic terminals, in large but not small diameter drg cell bodies.
Exp Paradigm: Spinal cord |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Neuroreceptor levels: gaba-r: gabaa1 |
Decreased
Description: Mutants show decrease in the levels of gabrb3 expression in low-threshold mechanoreceptor neuron (ltmr) central terminals at spinal cord dorsal horn lamina iii/iv in vglut1+ presynaptic terminals.
Exp Paradigm: Spinal cord
|
Immunohistochemistry |
Adult |
| |
|
Description: Mutants show decrease in the levels of gabrb3 expression in low-threshold mechanoreceptor neuron (ltmr) central terminals at spinal cord dorsal horn lamina iii/iv in vglut1+ presynaptic terminals.
Exp Paradigm: Spinal cord |
|
|
| Neurophysiology |
Spontaneous post synaptic event frequency: inhibitory currents1 |
Increased
Description: Mutants show increase in spontaneous inhibitory postsynaptic current (sipsc) frequency in layer 2/3 pyramidal neurons from acute primary somatosensory cortex slices resulting in a decrease in e/i ratio. mutants show no change in spontaneous inhibitory postsynaptic current (sipsc) frequency in the visual cortex.
Exp Paradigm: Primary somatosensory cortex, primary visual cortex
|
Whole-cell patch clamp |
Adult |
| |
|
Description: Mutants show increase in spontaneous inhibitory postsynaptic current (sipsc) frequency in layer 2/3 pyramidal neurons from acute primary somatosensory cortex slices resulting in a decrease in e/i ratio. mutants show no change in spontaneous inhibitory postsynaptic current (sipsc) frequency in the visual cortex.
Exp Paradigm: Primary somatosensory cortex, primary visual cortex |
|
|
| Repetitive behavior |
Repetitive digging1 |
Decreased
Description: Mutants show decrease in the number of marbles buried.
Exp Paradigm: NA
|
Marble-burying test |
6-8 weeks |
| |
|
Description: Mutants show decrease in the number of marbles buried.
Exp Paradigm: NA |
|
|
| Sensory |
Sensorimotor gating: tactile cue1 |
Increased
Description: Mutants exhibited hairy skin hypersensitivity, measured by an increase of tactile prepulse inhibition of an acoustic startle response assay.
Exp Paradigm: NA
|
Prepulse inhibition |
6-8 weeks |
| |
|
Description: Mutants exhibited hairy skin hypersensitivity, measured by an increase of tactile prepulse inhibition of an acoustic startle response assay.
Exp Paradigm: NA |
|
|
| Sensory |
Tactile memory1 |
Decreased
Description: Mutants show decrease in preference for the object with the novel texture.
Exp Paradigm: NA
|
Textured novel object recognition test (t-nort) |
6-8 weeks |
| |
|
Description: Mutants show decrease in preference for the object with the novel texture.
Exp Paradigm: NA |
|
|
| Sensory |
Sensorimotor gating: tactile cue1 |
Increased
Description: Mutants show increased responsivity to an air puff stimulus delivered to back hairy skin.
Exp Paradigm: NA
|
Response to air puff |
6-8 weeks |
| |
|
Description: Mutants show increased responsivity to an air puff stimulus delivered to back hairy skin.
Exp Paradigm: NA |
|
|
| Social behavior |
Social approach1 |
Decreased
Description: Mutants spent less time investigating a novel mouse than a novel object.
Exp Paradigm: NA
|
Three-chamber social approach test |
6-8 weeks |
| |
|
Description: Mutants spent less time investigating a novel mouse than a novel object.
Exp Paradigm: NA |
|
|
| Social behavior |
Social memory1 |
Decreased
Description: Mutants spent less time investigating a novel mouse than a familiar mouse.
Exp Paradigm: NA
|
Three-chamber social approach test |
6-8 weeks |
| |
|
Description: Mutants spent less time investigating a novel mouse than a familiar mouse.
Exp Paradigm: NA |
|
|
| Emotion |
Anxiety1 |
Increased
Description: Mutants spent less time in the open arms.
Exp Paradigm: NA
|
Elevated plus maze test |
6-8 weeks |
| |
|
Description: Mutants spent less time in the open arms.
Exp Paradigm: NA |
|
|
| Emotion |
Anxiety1 |
Increased
Description: Mutants spent less time in the center of the open field.
Exp Paradigm: NA
|
Open field test |
6-8 weeks |
| |
|
Description: Mutants spent less time in the center of the open field.
Exp Paradigm: NA |
|
|
| Emotion |
Habituation to aversive stimuli1 |
Decreased
Description: Mutants show lower percent decrease in startle response to a 125 db noise during a 30-minute tactile ppi session, when comparing the first five startle responses to the last five responses to a 125 db noise for mutant mice and their control littermates, indicating lack of habituation to an acoustic startle noise.
Exp Paradigm: NA
|
Prepulse inhibition |
6-8 weeks |
| |
|
Description: Mutants show lower percent decrease in startle response to a 125 db noise during a 30-minute tactile ppi session, when comparing the first five startle responses to the last five responses to a 125 db noise for mutant mice and their control littermates, indicating lack of habituation to an acoustic startle noise.
Exp Paradigm: NA |
|
|
| Emotion |
Exploratory activity1 |
No change |
Novel object recognition test |
6-8 weeks |
| Learning & memory |
Object recognition memory: long-term recall1 |
No change |
Novel object recognition test |
6-8 weeks |
| Motor phenotype |
General locomotor activity1 |
No change |
Elevated plus maze test |
6-8 weeks |
| Neurophysiology |
Spontaneous post synaptic event amplitude: excitatory currents1 |
No change |
Whole-cell patch clamp |
Adult |
| Neurophysiology |
Spontaneous post synaptic event amplitude: inhibitory currents1 |
No change |
Whole-cell patch clamp |
Adult |
| Neurophysiology |
Spontaneous post synaptic event frequency: excitatory currents1 |
No change |
Whole-cell patch clamp |
Adult |
| Repetitive behavior |
Self grooming: perseveration1 |
No change |
Open field test |
6-8 weeks |
| Sensory |
Sensorimotor gating1 |
No change |
Prepulse inhibition |
6-8 weeks |
| Sensory |
Startle response: acoustic stimulus1 |
No change |
Acoustic startle reflex test |
6-8 weeks |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Immune response, Maternal behavior, Molecular profile, Physiological parameters, Seizure, |
