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M_MECP2_50_KI_HE_STOP
Model Details
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Phenotypic Profile
Category Entity Quantity Experimental Paradigm Age at Testing
Motor phenotype Tremor1
Increased
Description: Mecp2-dnic-stop mice showed tremors.
Exp Paradigm: NA

General observations 4-28 weeks
Motor phenotype Limb posture1
Abnormal
Description: Mecp2-dnic-stop mice showed hindlimb clasping.
Exp Paradigm: NA

General observations 4-28 weeks
Motor phenotype General locomotor activity1
Abnormal
Description: Mecp2-dnic-stop mice showed abnormal activity compared to controls.
Exp Paradigm: NA

General observations 4-28 weeks
Motor phenotype Gait1
Abnormal
Description: Mecp2-dnic-stop mice showed abnormal gait compared to controls.
Exp Paradigm: NA

General observations 4-28 weeks
Developmental profile Mortality/lethality1
Increased
Description: Mecp2-dnic-stop mice showed increased mortality compared to controls.
Exp Paradigm: NA

General observations 0-28 weeks
Molecular profile Targeted expression1
Decreased
Description: Mecp2-dnic-stop mutant mice show reduced protein levels in the brain and in neurons compared to wt controls.
Exp Paradigm: NA

Flow cytometric analysis 28 weeks
Not Reported: Circadian sleep/wake cycle,  Communications,  Emotion,  Immune response,  Learning & memory,  Maternal behavior,  Neuroanatomy / ultrastructure / cytoarchitecture,  Neurophysiology,  Physiological parameters,  Repetitive behavior,  Seizure,  Sensory,  Social behavior,  
 
References: 1:  Tillotson R , et al. 2017
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