| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
Motor coordination and balance1 |
Abnormal
Description: Abnormal muscle coordination demonstrated by impaired dowel walk
Exp Paradigm: Dowel walking test
|
Dowel walk test |
9 weeks |
| |
|
Description: Abnormal muscle coordination demonstrated by impaired dowel walk
Exp Paradigm: Dowel walking test |
|
|
| Motor phenotype |
Motor coordination and balance1 |
Abnormal
Description: Abnormal muscle coordinaion demonstrated by shorter latency to fall on an accelerating rotarod
Exp Paradigm: Accelerating rotarod test
|
Accelerating rotarod test |
19 weeks |
| |
|
Description: Abnormal muscle coordinaion demonstrated by shorter latency to fall on an accelerating rotarod
Exp Paradigm: Accelerating rotarod test |
|
|
| Motor phenotype |
Motor coordination and balance1 |
Abnormal
Description: Abnormal muscle coordination demonstrated by increased foot slips
Exp Paradigm: Wire grid assay
|
Footslip test |
5 weeks |
| |
|
Description: Abnormal muscle coordination demonstrated by increased foot slips
Exp Paradigm: Wire grid assay |
|
|
| Repetitive behavior |
Stereotypy1 |
Increased
Description: Increased forelimb stereotypies reminiscent of mid-line hand wringing
Exp Paradigm: NA
|
General observations |
Unreported |
| |
|
Description: Increased forelimb stereotypies reminiscent of mid-line hand wringing
Exp Paradigm: NA |
|
|
| Repetitive behavior |
Head bobbing1 |
Increased
Description: Increased head bobbing stereotypy
Exp Paradigm: Holeboard assay
|
Hole-board test |
Unreported |
| |
|
Description: Increased head bobbing stereotypy
Exp Paradigm: Holeboard assay |
|
|
| Sensory |
Sensorimotor gating1 |
Increased
Description: Increased prepulse inhibition at 78 and 82 db prepulses demonstrating dysfunction of sensorimotor gating
Exp Paradigm: Prepulse inhibtion of the startle response: acoustic stimulus
|
Prepulse inhibition |
8 weeks |
| |
|
Description: Increased prepulse inhibition at 78 and 82 db prepulses demonstrating dysfunction of sensorimotor gating
Exp Paradigm: Prepulse inhibtion of the startle response: acoustic stimulus |
|
|
| Sensory |
Startle response: acoustic stimulus1 |
Decreased
Description: Decreased startle response: acoustic stimulus response to 120 db
Exp Paradigm: Response to 120 db white noise stimulus
|
Startle response test |
8 weeks |
| |
|
Description: Decreased startle response: acoustic stimulus response to 120 db
Exp Paradigm: Response to 120 db white noise stimulus |
|
|
| Social behavior |
Social interaction1 |
Increased
Description: Increased interaction with partner mouse through sniffing, pawing, or rearing
Exp Paradigm: Partition test for social interest
|
Partition test |
12-13 weeks |
| |
|
Description: Increased interaction with partner mouse through sniffing, pawing, or rearing
Exp Paradigm: Partition test for social interest |
|
|
| Developmental profile |
Mortality/lethality1 |
No change |
General observations |
18 months |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Emotion, Immune response, Learning & memory, Maternal behavior, Molecular profile, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Seizure, |
