| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
Clasping reflex1 |
Increased
Description: Mecp2- pvn ko mice develop clear hind limb retraction (clasping) after 15 weeks of age
Exp Paradigm: NA
|
General observations |
5 months |
| |
|
Description: Mecp2- pvn ko mice develop clear hind limb retraction (clasping) after 15 weeks of age
Exp Paradigm: NA |
|
|
| Repetitive behavior |
Repetitive nose pokes1 |
Increased
Description: Mecp2- somn ko show increased repetitive behavior in the hole board test assessed by the number of nose pokes
Exp Paradigm: NA
|
Hole-board test |
3 months |
| |
|
Description: Mecp2- somn ko show increased repetitive behavior in the hole board test assessed by the number of nose pokes
Exp Paradigm: NA |
|
|
| Seizure |
Seizures1 |
Increased
Description: Mecp2- somn ko have increased epileptic seizures and tonic cloni seizures while handling, about 50% of them develop seizures starting at 12 weeks of age
Exp Paradigm: NA
|
Observation of seizures |
3 - 10 months |
| |
|
Description: Mecp2- somn ko have increased epileptic seizures and tonic cloni seizures while handling, about 50% of them develop seizures starting at 12 weeks of age
Exp Paradigm: NA |
|
|
| Developmental profile |
Mortality/lethality1 |
Increased
Description: Mecp2- somn ko mice have increased mortality and do not survive beyond 29 - 30 weeks of age
Exp Paradigm: NA
|
Fear conditioning test |
7.5 months |
| |
|
Description: Mecp2- somn ko mice have increased mortality and do not survive beyond 29 - 30 weeks of age
Exp Paradigm: NA |
|
|
| Molecular profile |
Targeted expression1 |
Decreased
Description: Mecp2 protein is ablated in the somatostatin (som) expressing interneurons
Exp Paradigm: NA
|
Western blot |
6 weeks, 5 months, 2.5 months |
| |
|
Description: Mecp2 protein is ablated in the somatostatin (som) expressing interneurons
Exp Paradigm: NA |
|
|
| Developmental profile |
Size/growth1 |
No change |
Body weight measurement |
1-6 months |
| Emotion |
Anxiety1 |
No change |
Elevated plus maze test |
5 weeks |
| Emotion |
Anxiety1 |
No change |
Light-dark exploration test |
5 weeks |
| Learning & memory |
Cued or contextual fear conditioning: memory of cue1 |
No change |
Fear conditioning test |
3.7 months |
| Motor phenotype |
Ataxia1 |
No change |
General observations |
6 weeks, 5 months, 2.5 months |
| Motor phenotype |
General locomotor activity1 |
No change |
Open field test |
4.75 months |
| Motor phenotype |
Motor coordination and balance1 |
No change |
Accelerating rotarod test |
6 weeks, 5 months, 2.5 months |
| Repetitive behavior |
Repetitive digging1 |
No change |
Marble-burying test |
3 - 5 months |
| Sensory |
Sensorimotor gating1 |
No change |
Prepulse inhibition |
8 weeks |
| Sensory |
Startle response: acoustic stimulus1 |
No change |
Startle response test |
8 weeks |
| Social behavior |
Social interaction1 |
No change |
Partition test |
3.5 months |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Immune response, Maternal behavior, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, |
