| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
Hypoactivity1 |
Ameliorated
Description: Hypoactivity is improved by the treatment indicated by increased time before onset of hypoactivity (50%/13 weeks longer)
Exp Paradigm: General observations in separate cage
|
General observations |
0-10 months |
| |
|
Description: Hypoactivity is improved by the treatment indicated by increased time before onset of hypoactivity (50%/13 weeks longer)
Exp Paradigm: General observations in separate cage |
|
|
| Motor phenotype |
Clasping reflex1 |
Ameliorated
Description: Abnormal hindlimb clasping is partially restored indicated by significantly longer clasping-free time (33%/8 weeks longer)
Exp Paradigm: General observations in separate cage
|
General observations |
0-7.5 months |
| |
|
Description: Abnormal hindlimb clasping is partially restored indicated by significantly longer clasping-free time (33%/8 weeks longer)
Exp Paradigm: General observations in separate cage |
|
|
| Molecular profile |
Gene expression1 |
Ameliorated
Description: Expression of genes fkbp5 and sgk1 in brain is partially restored by the treatment
Exp Paradigm: Fkbp5 and sgk1 gene expression
|
Quantitative pcr (qrt-pcr) |
5 weeks |
| |
|
Description: Expression of genes fkbp5 and sgk1 in brain is partially restored by the treatment
Exp Paradigm: Fkbp5 and sgk1 gene expression |
|
|
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Learning & memory, Maternal behavior, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior, |
