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M_MECP2_5.15_CKO_HT
Model Details
Change
No Change
Phenotypic Profile
Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Sensory
Touch
1
Increased
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Description:
Avl-cre mecp2 have increased sensitivity towards touch or air puff on hairy skin
Exp Paradigm:
NA
Response to air puff
6-8 weeks
Description:
Avl-cre mecp2 have increased sensitivity towards touch or air puff on hairy skin
Exp Paradigm:
NA
Sensory
Tactile memory
1
Decreased
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Description:
Avl-cre mecp2 have decreased glabrous skin tactile discrimination and cannot differentiate between novel or familiar object differing in texture
Exp Paradigm:
NA
Textured novel object recognition test (t-nort)
6-8 weeks
Description:
Avl-cre mecp2 have decreased glabrous skin tactile discrimination and cannot differentiate between novel or familiar object differing in texture
Exp Paradigm:
NA
Emotion
Exploratory activity
1
No change
Textured novel object recognition test (t-nort)
6-8 weeks
Learning & memory
Object recognition memory
1
No change
Novel object recognition test
6-8 weeks
Sensory
Sensorimotor gating
1
No change
Prepulse inhibition
6-8 weeks
Sensory
Startle response: acoustic stimulus
1
No change
Startle response test
6-8 weeks
Not Reported:
Circadian sleep/wake cycle
,
Communications
,
Developmental profile
,
Immune response
,
Maternal behavior
,
Molecular profile
,
Motor phenotype
,
Neuroanatomy / ultrastructure / cytoarchitecture
,
Neurophysiology
,
Physiological parameters
,
Repetitive behavior
,
Seizure
,
Social behavior
,
References:
1:
Orefice LL , et al. 2016
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