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construct
M_MECP2_5.14_CKO_HE
Model Details
Change
No Change
     
Phenotypic Profile
Category Entity Quantity Experimental Paradigm Age at Testing
Motor phenotype Motor coordination and balance1
Decreased
Description: Cdx-mecp2 cko have reduced balance and coordination and fall off the accelerating rotarod at a shorter latency compared to controls
Exp Paradigm: NA

Accelerating rotarod test 6-8 weeks
Sensory Tactile memory1
Decreased
Description: Cdx-mecp2 cko have decreased glabrous skin tactile discrimination and cannot differentiate between novel or familiar object differing in texture
Exp Paradigm: NA

Textured novel object recognition test (t-nort) 6-8 weeks
Sensory Startle response: acoustic stimulus1
Decreased
Description: Cdx-mecp2 cko have decreased response to acoustic startle compared to controls at 125 db noise level
Exp Paradigm: NA

Startle response test 6-8 weeks
Sensory Sensorimotor gating: tactile cue1
Decreased
Description: Cdx-mecp2 cko have decreased sensorimotor gating resulting in enhanced response in hairy skin tactile cue based prepulse inhibition compared to controls
Exp Paradigm: NA

Prepulse inhibition 6-8 weeks
Sensory Touch1
Increased
Description: Cdx-mecp2 cko have increased sensitivity towards touch or air puff on hairy skin
Exp Paradigm: NA

Response to air puff 6-8 weeks
Physiological parameters Respiratory function1
Decreased
Description: Cdx-mecp2 cko mice have impaired respiratory tidal volume, expiration and breathing rate
Exp Paradigm: NA

Whole body plethysmography 2-2.5 months
Developmental profile Size/growth1
Decreased
Description: Cdx-mecp2 cko mice have reduced body weight compared to controls
Exp Paradigm: NA

Body weight measurement 2-2.5 months
Developmental profile Mortality/lethality1
Increased
Description: Cdx-mecp2 cko mice have increased mortality at about 50% by 16 weeks
Exp Paradigm: NA

Survival analysis 1-10 months
Learning & memory Object recognition memory1 No change Novel object recognition test 6-8 weeks
Learning & memory Object recognition memory: long-term recall1 No change Novel object recognition test 6-8 weeks
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size1 No change Histology 3-6 months
Sensory Sensorimotor gating1 No change Prepulse inhibition 6-8 weeks
Not Reported: Circadian sleep/wake cycle,  Communications,  Emotion,  Immune response,  Maternal behavior,  Molecular profile,  Neurophysiology,  Physiological parameters,  Repetitive behavior,  Seizure,  Social behavior,  
 
References: 1:  Orefice LL , et al. 2016
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