Phenotypic Profile |
Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
Motor phenotype |
Motor coordination and balance1 |
Decreased
Description: Cdx-mecp2 cko have reduced balance and coordination and fall off the accelerating rotarod at a shorter latency compared to controls
Exp Paradigm: NA
|
Accelerating rotarod test |
6-8 weeks |
|
|
Description: Cdx-mecp2 cko have reduced balance and coordination and fall off the accelerating rotarod at a shorter latency compared to controls
Exp Paradigm: NA |
|
|
Sensory |
Tactile memory1 |
Decreased
Description: Cdx-mecp2 cko have decreased glabrous skin tactile discrimination and cannot differentiate between novel or familiar object differing in texture
Exp Paradigm: NA
|
Textured novel object recognition test (t-nort) |
6-8 weeks |
|
|
Description: Cdx-mecp2 cko have decreased glabrous skin tactile discrimination and cannot differentiate between novel or familiar object differing in texture
Exp Paradigm: NA |
|
|
Sensory |
Startle response: acoustic stimulus1 |
Decreased
Description: Cdx-mecp2 cko have decreased response to acoustic startle compared to controls at 125 db noise level
Exp Paradigm: NA
|
Startle response test |
6-8 weeks |
|
|
Description: Cdx-mecp2 cko have decreased response to acoustic startle compared to controls at 125 db noise level
Exp Paradigm: NA |
|
|
Sensory |
Sensorimotor gating: tactile cue1 |
Decreased
Description: Cdx-mecp2 cko have decreased sensorimotor gating resulting in enhanced response in hairy skin tactile cue based prepulse inhibition compared to controls
Exp Paradigm: NA
|
Prepulse inhibition |
6-8 weeks |
|
|
Description: Cdx-mecp2 cko have decreased sensorimotor gating resulting in enhanced response in hairy skin tactile cue based prepulse inhibition compared to controls
Exp Paradigm: NA |
|
|
Sensory |
Touch1 |
Increased
Description: Cdx-mecp2 cko have increased sensitivity towards touch or air puff on hairy skin
Exp Paradigm: NA
|
Response to air puff |
6-8 weeks |
|
|
Description: Cdx-mecp2 cko have increased sensitivity towards touch or air puff on hairy skin
Exp Paradigm: NA |
|
|
Physiological parameters |
Respiratory function1 |
Decreased
Description: Cdx-mecp2 cko mice have impaired respiratory tidal volume, expiration and breathing rate
Exp Paradigm: NA
|
Whole body plethysmography |
2-2.5 months |
|
|
Description: Cdx-mecp2 cko mice have impaired respiratory tidal volume, expiration and breathing rate
Exp Paradigm: NA |
|
|
Developmental profile |
Size/growth1 |
Decreased
Description: Cdx-mecp2 cko mice have reduced body weight compared to controls
Exp Paradigm: NA
|
Body weight measurement |
2-2.5 months |
|
|
Description: Cdx-mecp2 cko mice have reduced body weight compared to controls
Exp Paradigm: NA |
|
|
Developmental profile |
Mortality/lethality1 |
Increased
Description: Cdx-mecp2 cko mice have increased mortality at about 50% by 16 weeks
Exp Paradigm: NA
|
Survival analysis |
1-10 months |
|
|
Description: Cdx-mecp2 cko mice have increased mortality at about 50% by 16 weeks
Exp Paradigm: NA |
|
|
Learning & memory |
Object recognition memory1 |
No change |
Novel object recognition test |
6-8 weeks |
Learning & memory |
Object recognition memory: long-term recall1 |
No change |
Novel object recognition test |
6-8 weeks |
Neuroanatomy / Ultrastructure / Cytoarchitecture |
Brain size1 |
No change |
Histology |
3-6 months |
Sensory |
Sensorimotor gating1 |
No change |
Prepulse inhibition |
6-8 weeks |
|
Not Reported: |
Circadian sleep/wake cycle, Communications, Emotion, Immune response, Maternal behavior, Molecular profile, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Social behavior, |