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M_MECP2_5.13_CKO_HT
Model Details
Change
No Change
     
Phenotypic Profile
Category Entity Quantity Experimental Paradigm Age at Testing
Sensory Tactile memory1
Decreased
Description: Mice with loss of mecp2 from primary somatosensory neurons in adulthood still leads to decreased glabrous skin tactile discrimination of objects differing only in texture
Exp Paradigm: NA

Textured novel object recognition test (t-nort) 6-8 weeks
Sensory Sensorimotor gating: tactile cue1
Decreased
Description: Mice with loss of mecp2 from primary somatosensory neurons in adulthood have decreased sensorimotor gating in prepulse inhibition with hairy skin tactile prepulse
Exp Paradigm: NA

Prepulse inhibition 6-8 weeks
Sensory Touch1
Increased
Description: Mice with loss of mecp2 from primary somatosensory neurons in adulthood have increased sensitivity to air puff alone
Exp Paradigm: NA

Response to air puff 6-8 weeks
Emotion Exploratory activity1 No change Textured novel object recognition test (t-nort) 6-8 weeks
Learning & memory Object recognition memory: long-term recall1 No change Novel object recognition test 6-8 weeks
Sensory Sensorimotor gating1 No change Prepulse inhibition 6-8 weeks
Sensory Startle response: acoustic stimulus1 No change Startle response test 6-8 weeks
Not Reported: Circadian sleep/wake cycle,  Communications,  Developmental profile,  Immune response,  Maternal behavior,  Molecular profile,  Motor phenotype,  Neuroanatomy / ultrastructure / cytoarchitecture,  Neurophysiology,  Physiological parameters,  Repetitive behavior,  Seizure,  Social behavior,  
 
References: 1:  Orefice LL , et al. 2016
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