| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Sensory |
Tactile memory1 |
Decreased
Description: Mice with loss of mecp2 from primary somatosensory neurons in adulthood still leads to decreased glabrous skin tactile discrimination of objects differing only in texture
Exp Paradigm: NA
|
Textured novel object recognition test (t-nort) |
6-8 weeks |
| |
|
Description: Mice with loss of mecp2 from primary somatosensory neurons in adulthood still leads to decreased glabrous skin tactile discrimination of objects differing only in texture
Exp Paradigm: NA |
|
|
| Sensory |
Sensorimotor gating: tactile cue1 |
Decreased
Description: Mice with loss of mecp2 from primary somatosensory neurons in adulthood have decreased sensorimotor gating in prepulse inhibition with hairy skin tactile prepulse
Exp Paradigm: NA
|
Prepulse inhibition |
6-8 weeks |
| |
|
Description: Mice with loss of mecp2 from primary somatosensory neurons in adulthood have decreased sensorimotor gating in prepulse inhibition with hairy skin tactile prepulse
Exp Paradigm: NA |
|
|
| Sensory |
Touch1 |
Increased
Description: Mice with loss of mecp2 from primary somatosensory neurons in adulthood have increased sensitivity to air puff alone
Exp Paradigm: NA
|
Response to air puff |
6-8 weeks |
| |
|
Description: Mice with loss of mecp2 from primary somatosensory neurons in adulthood have increased sensitivity to air puff alone
Exp Paradigm: NA |
|
|
| Social behavior |
Social memory1 |
Decreased
Description: Mice with loss of mecp2 from primary somatosensory neurons in adulthood have decreased preference for novel mouse over familiar mouse
Exp Paradigm: NA
|
Three-chamber social approach test |
6-8 weeks |
| |
|
Description: Mice with loss of mecp2 from primary somatosensory neurons in adulthood have decreased preference for novel mouse over familiar mouse
Exp Paradigm: NA |
|
|
| Social behavior |
Social dominance1 |
Increased
Description: Mice with loss of mecp2 from primary somatosensory neurons in adulthood have increased number of wins compared to controls (and embryonic avl-cre mecp2 mice) in the tube test of dominance
Exp Paradigm: NA
|
Tube test of social dominance |
6-8 weeks |
| |
|
Description: Mice with loss of mecp2 from primary somatosensory neurons in adulthood have increased number of wins compared to controls (and embryonic avl-cre mecp2 mice) in the tube test of dominance
Exp Paradigm: NA |
|
|
| Social behavior |
Nest building behavior1 |
Decreased
Description: Mice with loss of mecp2 from primary somatosensory neurons in adulthood have reduced nest building ability
Exp Paradigm: NA
|
Nest building assay |
6-8 weeks |
| |
|
Description: Mice with loss of mecp2 from primary somatosensory neurons in adulthood have reduced nest building ability
Exp Paradigm: NA |
|
|
| Developmental profile |
Mortality/lethality1 |
No change |
Survival analysis |
1-10 months |
| Emotion |
Anxiety1 |
No change |
Elevated plus maze test |
6-8 weeks |
| Emotion |
Anxiety1 |
No change |
Open field test |
6-8 weeks |
| Emotion |
Exploratory activity1 |
No change |
Textured novel object recognition test (t-nort) |
6-8 weeks |
| Emotion |
Habituation to aversive stimuli1 |
No change |
Startle response test |
6-8 weeks |
| Learning & memory |
Object recognition memory: long-term recall1 |
No change |
Novel object recognition test |
6-8 weeks |
| Motor phenotype |
General locomotor activity1 |
No change |
Open field test |
6-8 weeks |
| Motor phenotype |
Motor coordination and balance1 |
No change |
Accelerating rotarod test |
6-8 weeks |
| Sensory |
Sensorimotor gating1 |
No change |
Prepulse inhibition |
6-8 weeks |
| Sensory |
Startle response: acoustic stimulus1 |
No change |
Startle response test |
6-8 weeks |
| Social behavior |
Social approach1 |
No change |
Three-chamber social approach test |
6-8 weeks |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Immune response, Maternal behavior, Molecular profile, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, |
