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M_MECP2_5.12_CKO_HE
Model Details
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Phenotypic Profile
Category Entity Quantity Experimental Paradigm Age at Testing
Motor phenotype Spontaneous movement1
Decreased
Description: Decreased spontaneous movement
Exp Paradigm: Open field test

Open field test 3-8 weeks
Motor phenotype Limb posture1
Abnormal
Description: Abnormal limb postures; hindlimb clasping
Exp Paradigm: Tail suspension test

Tail suspension test Unreported
Motor phenotype Gait1
Abnormal
Description: Abnormal stiff, uncoordinated gait
Exp Paradigm: General observations

General observations 3-8 weeks
Developmental profile Mortality/lethality1
Increased
Description: Increased lethality
Exp Paradigm: General observations

General observations 7.5 weeks
Developmental profile Developmental trajectory1
Abnormal
Description: Abnormal developmental trajectory: irregular breathing, uneven wearing of the teeth, misaligned jaws, and internalized testes of males
Exp Paradigm: General observations

General observations Unreported
Developmental profile Size/growth1
Decreased
Description: Decreased average body weight
Exp Paradigm: General observations

General observations 4 weeks
Motor phenotype Grip strength1 No change Grip strength test Unreported
Sensory Vision1 No change Forepaw reaching test Unreported
Not Reported: Circadian sleep/wake cycle,  Communications,  Emotion,  Immune response,  Learning & memory,  Maternal behavior,  Molecular profile,  Neuroanatomy / ultrastructure / cytoarchitecture,  Neurophysiology,  Physiological parameters,  Repetitive behavior,  Seizure,  Social behavior,  
 
References: 1:  Guy J , et al. 2001
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