| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
Motor coordination and balance1 |
Decreased
Description: Emx1- mecp2 cko mice have reduced latency to fall off an accelerating rotarod
Exp Paradigm: NA
|
Accelerating rotarod test |
6-8 weeks |
| |
|
Description: Emx1- mecp2 cko mice have reduced latency to fall off an accelerating rotarod
Exp Paradigm: NA |
|
|
| Motor phenotype |
General locomotor activity1 |
Decreased
Description: Emx1-mecp2 cko mice have reduced distance traveled in the open field test
Exp Paradigm: NA
|
Open field test |
6-8 weeks |
| |
|
Description: Emx1-mecp2 cko mice have reduced distance traveled in the open field test
Exp Paradigm: NA |
|
|
| Sensory |
Startle response: acoustic stimulus1 |
Decreased
Description: Emx1-mecp2 cko mice have normal startle response to 125 db noise
Exp Paradigm: NA
|
Startle response test |
6-8 weeks |
| |
|
Description: Emx1-mecp2 cko mice have normal startle response to 125 db noise
Exp Paradigm: NA |
|
|
| Developmental profile |
Mortality/lethality1 |
No change |
Survival analysis |
1-10 months |
| Emotion |
Anxiety1 |
No change |
Elevated plus maze test |
6-8 weeks |
| Emotion |
Anxiety1 |
No change |
Open field test |
6-8 weeks |
| Emotion |
Exploratory activity1 |
No change |
Textured novel object recognition test (t-nort) |
6-8 weeks |
| Emotion |
Habituation to aversive stimuli1 |
No change |
Startle response test |
6-8 weeks |
| Learning & memory |
Object recognition memory1 |
No change |
Novel object recognition test |
6-8 weeks |
| Learning & memory |
Object recognition memory: long-term recall1 |
No change |
Novel object recognition test |
6-8 weeks |
| Sensory |
Sensorimotor gating1 |
No change |
Prepulse inhibition |
6-8 weeks |
| Sensory |
Sensorimotor gating: tactile cue1 |
No change |
Prepulse inhibition |
6-8 weeks |
| Sensory |
Tactile memory1 |
No change |
Textured novel object recognition test (t-nort) |
6-8 weeks |
| Sensory |
Touch1 |
No change |
Response to air puff |
6-8 weeks |
| Social behavior |
Nest building behavior1 |
No change |
Nest building assay |
6-8 weeks |
| Social behavior |
Social approach1 |
No change |
Three-chamber social approach test |
6-8 weeks |
| Social behavior |
Social dominance1 |
No change |
Tube test of social dominance |
6-8 weeks |
| Social behavior |
Social memory1 |
No change |
Three-chamber social approach test |
6-8 weeks |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Immune response, Maternal behavior, Molecular profile, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, |
