| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
General locomotor activity1 |
Decreased
Description: Decreased general locomotor activity
Exp Paradigm: Female mice: activity chamber monitoring
|
Open field test |
Unreported |
| |
|
Description: Decreased general locomotor activity
Exp Paradigm: Female mice: activity chamber monitoring |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Dendritic architecture: spine density2 |
Decreased
Description: There is a decrease in the number of spines per 10 micro meter on distal dendrites in the mexp2 308 t mice
Exp Paradigm: Males only
|
Sholl analysis |
2-4 months |
| |
|
Description: There is a decrease in the number of spines per 10 micro meter on distal dendrites in the mexp2 308 t mice
Exp Paradigm: Males only |
|
|
| Social behavior |
Social interaction1 |
Decreased
Description: Decreased social barrier interaction as measured by time active near stranger
Exp Paradigm: Female mice: barrier social interaction
|
Partition test |
Unreported |
| |
|
Description: Decreased social barrier interaction as measured by time active near stranger
Exp Paradigm: Female mice: barrier social interaction |
|
|
| Learning & memory |
Eye blink conditioning2 |
Decreased
Description: Response amplitude is reduced in mecp2 308t mice, even though there is no deficit in learning conditioned response
Exp Paradigm: Males only
|
Eyeblink conditioning |
2-4 months |
| |
|
Description: Response amplitude is reduced in mecp2 308t mice, even though there is no deficit in learning conditioned response
Exp Paradigm: Males only |
|
|
| Communications |
Ultrasonic vocalization1 |
No change |
Monitoring ultrasonic vocalizations |
P16 |
| Developmental profile |
Size/growth1 |
No change |
General observations |
P8-p18 |
| Emotion |
Anxiety1 |
No change |
Elevated plus maze test |
Unreported |
| Learning & memory |
Eye blink conditioning2 |
No change |
Eyeblink conditioning |
2-4 months |
| Learning & memory |
Eye blink conditioning: extinction and reactivation2 |
No change |
Eyeblink conditioning |
2-4 months |
| Learning & memory |
Spatial reference memory1 |
No change |
Morris water maze test |
Unreported |
| Molecular profile |
Dna methylation1 |
No change |
Dot-blot analysis |
Unreported |
| Molecular profile |
Gene expression1 |
No change |
Quantitative pcr (qrt-pcr) |
Unreported |
| Molecular profile |
Protein expression level evidence1 |
No change |
Laser scanning cytometry |
Unreported |
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Cerebellar morphology: granule cell layer thickness2 |
No change |
Histology |
2-4 months |
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Cerebellar morphology: molecular layer thickness2 |
No change |
Histology |
2-4 months |
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Dendritic architecture: dendritic tree complexity2 |
No change |
Sholl analysis |
2-4 months |
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Neuronal number: purkinje cells2 |
No change |
Histology |
2-4 months |
| Social behavior |
Social interaction1 |
No change |
Three-chamber social approach test |
Unreported |
| Social behavior |
Social interaction1 |
No change |
Three-chamber social approach test |
Unreported |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Maternal behavior, Molecular profile, Motor phenotype, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior, |
