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M_MECP2_49_KI_HE_R133C
Model Details
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Phenotypic Profile
Category Entity Quantity Experimental Paradigm Age at Testing
Motor phenotype Gait1
Abnormal
Description: Knockin r133c mutant mice showed an increase in phenotypic severity scores compared to wt controls.
Exp Paradigm: NA

General observations 4-28 weeks
Motor phenotype Tremor1
Abnormal
Description: Knockin r133c mutant mice showed an increase in phenotypic severity scores compared to wt controls.
Exp Paradigm: NA

General observations 4-28 weeks
Motor phenotype Limb posture1
Abnormal
Description: Knockin r133c mutant mice showed an increase in phenotypic severity scores compared to wt controls.
Exp Paradigm: NA

General observations 4-28 weeks
Motor phenotype General locomotor activity1
Abnormal
Description: Knockin r133c mutant mice showed an increase in phenotypic severity scores compared to wt controls.
Exp Paradigm: NA

General observations 4-28 weeks
Developmental profile Size/growth1
Decreased
Description: Knockin r133c mutant mice showed significant decrease in growth compared to controls.
Exp Paradigm: NA

Body weight measurement 4-52 weeks
Developmental profile Mortality/lethality1
Increased
Description: Mecp2 knockin r133c mutant mice showed an increase in mortality compared to wt controls.
Exp Paradigm: NA

General observations 0-30 weeks
Not Reported: Circadian sleep/wake cycle,  Communications,  Emotion,  Immune response,  Learning & memory,  Maternal behavior,  Molecular profile,  Neuroanatomy / ultrastructure / cytoarchitecture,  Neurophysiology,  Physiological parameters,  Repetitive behavior,  Seizure,  Sensory,  Social behavior,  
 
References: 1:  Tillotson R , et al. 2017
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