| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
General locomotor activity1 |
Decreased
Description: Mecp2 r306 mutants have reduced distance traveled in the open field
Exp Paradigm: NA
|
Open field test |
6-8 weeks |
| |
|
Description: Mecp2 r306 mutants have reduced distance traveled in the open field
Exp Paradigm: NA |
|
|
| Sensory |
Startle response: acoustic stimulus1 |
Decreased
Description: Mecp2 r306 mutants have reduced startle reflex to 125 db noise
Exp Paradigm: NA
|
Startle response test |
6-8 weeks |
| |
|
Description: Mecp2 r306 mutants have reduced startle reflex to 125 db noise
Exp Paradigm: NA |
|
|
| Sensory |
Sensorimotor gating: tactile cue1 |
Decreased
Description: Mecp2 r306 mutants have enhanced response to startle when the prepulse is a tactile cue (airpuff) unlike controls
Exp Paradigm: NA
|
Prepulse inhibition |
6-8 weeks |
| |
|
Description: Mecp2 r306 mutants have enhanced response to startle when the prepulse is a tactile cue (airpuff) unlike controls
Exp Paradigm: NA |
|
|
| Sensory |
Touch1 |
Increased
Description: Mecp2 r306 mutants are hypersensitive or have increased response to air puff
Exp Paradigm: NA
|
Response to air puff |
6-8 weeks |
| |
|
Description: Mecp2 r306 mutants are hypersensitive or have increased response to air puff
Exp Paradigm: NA |
|
|
| Sensory |
Sensorimotor gating1 |
Decreased
Description: Mecp2 r306 mutants have enhanced response to startle when the prepulse is acoustic as well
Exp Paradigm: NA
|
Prepulse inhibition |
6-8 weeks |
| |
|
Description: Mecp2 r306 mutants have enhanced response to startle when the prepulse is acoustic as well
Exp Paradigm: NA |
|
|
| Sensory |
Tactile memory1 |
Decreased
Description: Mecp2 r306 mutants have reduced memory for discriminating objects that differ only in texture
Exp Paradigm: NA
|
Textured novel object recognition test (t-nort) |
6-8 weeks |
| |
|
Description: Mecp2 r306 mutants have reduced memory for discriminating objects that differ only in texture
Exp Paradigm: NA |
|
|
| Social behavior |
Social dominance1 |
Decreased
Description: Mecp2 r306 mutants exhibit decreased dominance and aggression and lose majority of matches compared to controls
Exp Paradigm: NA
|
Tube test of social dominance |
6-8 weeks |
| |
|
Description: Mecp2 r306 mutants exhibit decreased dominance and aggression and lose majority of matches compared to controls
Exp Paradigm: NA |
|
|
| Social behavior |
Nest building behavior1 |
Decreased
Description: Mecp2 r306 mutants have reduced nest building skills
Exp Paradigm: NA
|
Nest building assay |
6-8 weeks |
| |
|
Description: Mecp2 r306 mutants have reduced nest building skills
Exp Paradigm: NA |
|
|
| Developmental profile |
Mortality/lethality1 |
Increased
Description: Mecp2 r306 mutants have reduced survival rates (observed upto 40 weeks)
Exp Paradigm: NA
|
Survival analysis |
1-10 months |
| |
|
Description: Mecp2 r306 mutants have reduced survival rates (observed upto 40 weeks)
Exp Paradigm: NA |
|
|
| Emotion |
Anxiety1 |
Increased
Description: Mecp2 r306 mutants have reduced time spent in the center of of and reduced preference for the open arms in the elevated plus maze test indicating increased anxiety
Exp Paradigm: Elevated plus maze test
|
Elevated plus maze test |
6-8 weeks |
| |
|
Description: Mecp2 r306 mutants have reduced time spent in the center of of and reduced preference for the open arms in the elevated plus maze test indicating increased anxiety
Exp Paradigm: Elevated plus maze test |
|
|
| Emotion |
Habituation to aversive stimuli1 |
Decreased
Description: Mecp2 r306 mutants have reduced habituation to aversive acoustic stimuli unlike controls
Exp Paradigm: NA
|
Startle response test |
6-8 weeks |
| |
|
Description: Mecp2 r306 mutants have reduced habituation to aversive acoustic stimuli unlike controls
Exp Paradigm: NA |
|
|
| Emotion |
Anxiety1 |
Increased
Description: Mecp2 r306 mutants have reduced time spent in the center of of and reduced preference for the open arms in the elevated plus maze test indicating increased anxiety
Exp Paradigm: Open field test
|
Open field test |
6-8 weeks |
| |
|
Description: Mecp2 r306 mutants have reduced time spent in the center of of and reduced preference for the open arms in the elevated plus maze test indicating increased anxiety
Exp Paradigm: Open field test |
|
|
| Learning & memory |
Object recognition memory: long-term recall1 |
Decreased
Description: Mecp2 r306 mutants have decreased recall of familiar objects when the novel object phase is conducted after a longer interval (1 hr)
Exp Paradigm: NA
|
Novel object recognition test |
6-8 weeks |
| |
|
Description: Mecp2 r306 mutants have decreased recall of familiar objects when the novel object phase is conducted after a longer interval (1 hr)
Exp Paradigm: NA |
|
|
| Emotion |
Exploratory activity1 |
No change |
Textured novel object recognition test (t-nort) |
6-8 weeks |
| Learning & memory |
Object recognition memory1 |
No change |
Novel object recognition test |
6-8 weeks |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Immune response, Maternal behavior, Molecular profile, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, |
