| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
General locomotor activity1 |
Decreased
Description: Mecp2-tg mice (f1 fvb/n * 129s6/svev), with more than 3 fold increase in mecp2 protein levels, show significantly reduced activity in open field
Exp Paradigm: NA
|
Open field test |
8-9 weeks |
| |
|
Description: Mecp2-tg mice (f1 fvb/n * 129s6/svev), with more than 3 fold increase in mecp2 protein levels, show significantly reduced activity in open field
Exp Paradigm: NA |
|
|
| Social behavior |
Social interaction1 |
Decreased
Description: Mecp2-tg mice (f1 fvb/n * 129s6/svev) spend less time at the partitition with a stimulus mouse compared to controls
Exp Paradigm: NA
|
Partition test |
12-13 weeks |
| |
|
Description: Mecp2-tg mice (f1 fvb/n * 129s6/svev) spend less time at the partitition with a stimulus mouse compared to controls
Exp Paradigm: NA |
|
|
| Social behavior |
Social approach1 |
Decreased
Description: Mecp2-tg mice (f1 fvb/n * 129s6/svev) spend less time investigating stimulus mouse compared to controls
Exp Paradigm: NA
|
Three-chamber social approach test |
12 weeks |
| |
|
Description: Mecp2-tg mice (f1 fvb/n * 129s6/svev) spend less time investigating stimulus mouse compared to controls
Exp Paradigm: NA |
|
|
| Social behavior |
Social memory1 |
Decreased
Description: Mecp2-tg mice (f1 fvb/n * 129s6/svev) spend similar amount of time with novel and familiar mouse indicating impaired memory
Exp Paradigm: NA
|
Partition test |
12-13 weeks |
| |
|
Description: Mecp2-tg mice (f1 fvb/n * 129s6/svev) spend similar amount of time with novel and familiar mouse indicating impaired memory
Exp Paradigm: NA |
|
|
| Emotion |
Anxiety1 |
Increased
Description: Mecp2-tg mice (f1 fvb/n * 129s6/svev) display increased anxiety and spend less time in the open arms of elevated plus maze and in the lit compartment of the light-dark box compared to respective wild-type littermate animals
Exp Paradigm: Light-dark exploration test
|
Light-dark exploration test |
9-10 weeks |
| |
|
Description: Mecp2-tg mice (f1 fvb/n * 129s6/svev) display increased anxiety and spend less time in the open arms of elevated plus maze and in the lit compartment of the light-dark box compared to respective wild-type littermate animals
Exp Paradigm: Light-dark exploration test |
|
|
| Emotion |
Anxiety1 |
Increased
Description: Mecp2-tg mice (f1 fvb/n * 129s6/svev) display increased anxiety and spend less time in the open arms of elevated plus maze and in the lit compartment of the light-dark box compared to respective wild-type littermate animals
Exp Paradigm: Elevated plus maze test
|
Elevated plus maze test |
9-10 weeks |
| |
|
Description: Mecp2-tg mice (f1 fvb/n * 129s6/svev) display increased anxiety and spend less time in the open arms of elevated plus maze and in the lit compartment of the light-dark box compared to respective wild-type littermate animals
Exp Paradigm: Elevated plus maze test |
|
|
| Molecular profile |
Gene expression1 |
Increased
Description: Mecp2-tg mice, f1 hybrids have increased in the expression of tacr3 in the amygdala
Exp Paradigm: NA
|
Quantitative pcr (qrt-pcr) |
6 weeks |
| |
|
Description: Mecp2-tg mice, f1 hybrids have increased in the expression of tacr3 in the amygdala
Exp Paradigm: NA |
|
|
| Molecular profile |
Gene expression1 |
Increased
Description: Mecp2-tg mice, f1 hybrids have greater than 50% increase in the expression of crh in the amygdala
Exp Paradigm: NA
|
Quantitative pcr (qrt-pcr) |
6 weeks |
| |
|
Description: Mecp2-tg mice, f1 hybrids have greater than 50% increase in the expression of crh in the amygdala
Exp Paradigm: NA |
|
|
| Molecular profile |
Gene expression1 |
Increased
Description: Mecp2-tg mice, f1 hybrids have greater than 50% increase in the expression of htr1a in the amygdala
Exp Paradigm: NA
|
Quantitative pcr (qrt-pcr) |
6 weeks |
| |
|
Description: Mecp2-tg mice, f1 hybrids have greater than 50% increase in the expression of htr1a in the amygdala
Exp Paradigm: NA |
|
|
| Molecular profile |
Gene expression1 |
Increased
Description: Mecp2-tg mice, f1 hybrids have greater than 50% increase in the expression of irs4 in the amygdala
Exp Paradigm: NA
|
Quantitative pcr (qrt-pcr) |
6 weeks |
| |
|
Description: Mecp2-tg mice, f1 hybrids have greater than 50% increase in the expression of irs4 in the amygdala
Exp Paradigm: NA |
|
|
| Molecular profile |
Gene expression1 |
Increased
Description: Mecp2-tg mice, f1 hybrids have greater than 50% increase in the expression of grpr in the amygdala
Exp Paradigm: NA
|
Quantitative pcr (qrt-pcr) |
6 weeks |
| |
|
Description: Mecp2-tg mice, f1 hybrids have greater than 50% increase in the expression of grpr in the amygdala
Exp Paradigm: NA |
|
|
| Molecular profile |
Gene expression1 |
Increased
Description: Mecp2-tg mice, f1 hybrids have increased expression of npas1 in the amygdala
Exp Paradigm: NA
|
Quantitative pcr (qrt-pcr) |
6 weeks |
| |
|
Description: Mecp2-tg mice, f1 hybrids have increased expression of npas1 in the amygdala
Exp Paradigm: NA |
|
|
| Molecular profile |
Gene expression1 |
Increased
Description: Mecp2-tg mice, f1 hybrids have greater than 50% increase in the expression of fabp7 in the amygdala
Exp Paradigm: NA
|
Quantitative pcr (qrt-pcr) |
6 weeks |
| |
|
Description: Mecp2-tg mice, f1 hybrids have greater than 50% increase in the expression of fabp7 in the amygdala
Exp Paradigm: NA |
|
|
| Molecular profile |
Gene expression1 |
Increased
Description: Mecp2-tg mice, f1 hybrids have increased expression of adcyap1 in the amygdala
Exp Paradigm: NA
|
Quantitative pcr (qrt-pcr) |
6 weeks |
| |
|
Description: Mecp2-tg mice, f1 hybrids have increased expression of adcyap1 in the amygdala
Exp Paradigm: NA |
|
|
| Emotion |
Exploratory activity: habituation1 |
No change |
Three-chamber social approach test |
12 weeks |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Immune response, Learning & memory, Maternal behavior, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, |
