| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
General locomotor activity1 |
No adverse effect
Description: Genetic reduction of oprm1 has no effect on distance traveled by mecp2-tg mice
Exp Paradigm: NA
|
Open field test |
2-3 month |
| |
|
Description: Genetic reduction of oprm1 has no effect on distance traveled by mecp2-tg mice
Exp Paradigm: NA |
|
|
| Sensory |
Olfaction1 |
No adverse effect
Description: Genetic reduction of oprm1 has no effect on olfaction as time spent sniffing water versus vanilla in oprm1 +/- mecp2 transgenic mice is similar to wild type
Exp Paradigm: NA
|
Olfactory discrimination test |
2-3 month |
| |
|
Description: Genetic reduction of oprm1 has no effect on olfaction as time spent sniffing water versus vanilla in oprm1 +/- mecp2 transgenic mice is similar to wild type
Exp Paradigm: NA |
|
|
| Social behavior |
Social approach1 |
Restored
Description: Genetic reduction of oprm1 improves preference for social target in the three chamber social interaction test
Exp Paradigm: NA
|
Three-chamber social approach test |
2-3 month |
| |
|
Description: Genetic reduction of oprm1 improves preference for social target in the three chamber social interaction test
Exp Paradigm: NA |
|
|
| Social behavior |
Social memory1 |
Restored
Description: Genetic reduction of oprm1 improves social behavior and time spent interacting with novel vs familiar mouse in the partition test
Exp Paradigm: NA
|
Partition test |
2-3 month |
| |
|
Description: Genetic reduction of oprm1 improves social behavior and time spent interacting with novel vs familiar mouse in the partition test
Exp Paradigm: NA |
|
|
| Social behavior |
Social interaction1 |
Restored
Description: Genetic reduction of oprm1 improves social behavior and time spent interacting with novel mouse in the partition test
Exp Paradigm: NA
|
Partition test |
2-3 month |
| |
|
Description: Genetic reduction of oprm1 improves social behavior and time spent interacting with novel mouse in the partition test
Exp Paradigm: NA |
|
|
| Emotion |
Anxiety1 |
Refractory
Description: Genetic reduction of oprm1 has no effect on anxiety in mecp2-tg mice
Exp Paradigm: Light-dark exploration test
|
Light-dark exploration test |
2-3 month |
| |
|
Description: Genetic reduction of oprm1 has no effect on anxiety in mecp2-tg mice
Exp Paradigm: Light-dark exploration test |
|
|
| Emotion |
Anxiety1 |
Refractory
Description: Genetic reduction of oprm1 has no effect on anxiety in mecp2-tg mice
Exp Paradigm: Elevated plus maze test
|
Elevated plus maze test |
2-3 month |
| |
|
Description: Genetic reduction of oprm1 has no effect on anxiety in mecp2-tg mice
Exp Paradigm: Elevated plus maze test |
|
|
| Emotion |
Exploratory activity: habituation1 |
No adverse effect
Description: Genetic reduction of oprm1 has no effect onhabituation in three chamber test
Exp Paradigm: NA
|
Three-chamber social approach test |
2-3 month |
| |
|
Description: Genetic reduction of oprm1 has no effect onhabituation in three chamber test
Exp Paradigm: NA |
|
|
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Immune response, Learning & memory, Maternal behavior, Molecular profile, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, |
