| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Social behavior |
Social approach1 |
Decreased
Description: Mecp2-tg mice, (f1 fvb/n * c57bl/6) spend less time investigating stimulus mouse compared to controls
Exp Paradigm: NA
|
Three-chamber social approach test |
12 weeks |
| |
|
Description: Mecp2-tg mice, (f1 fvb/n * c57bl/6) spend less time investigating stimulus mouse compared to controls
Exp Paradigm: NA |
|
|
| Social behavior |
Social memory1 |
Decreased
Description: Mecp2-tg mice, (f1 fvb/n * c57bl/6) spend similar amount of time with novel and familiar mouse indicating impaired memory
Exp Paradigm: NA
|
Partition test |
12-13 weeks |
| |
|
Description: Mecp2-tg mice, (f1 fvb/n * c57bl/6) spend similar amount of time with novel and familiar mouse indicating impaired memory
Exp Paradigm: NA |
|
|
| Social behavior |
Social interaction1 |
Decreased
Description: Mecp2-tg mice, (f1 fvb/n * c57bl/6) spend less time at the partitition with a stimulus mouse spend less time at the partitition compared to controls
Exp Paradigm: NA
|
Partition test |
12-13 weeks |
| |
|
Description: Mecp2-tg mice, (f1 fvb/n * c57bl/6) spend less time at the partitition with a stimulus mouse spend less time at the partitition compared to controls
Exp Paradigm: NA |
|
|
| Physiological parameters |
Hormone levels1 |
Increased
Description: Mecp2-tg mice show increased serum levels of corticosterone after exposure to stress, compared to wild type littermates
Exp Paradigm: NA
|
Restraint-stress induced corticosterone levels |
4-5 months |
| |
|
Description: Mecp2-tg mice show increased serum levels of corticosterone after exposure to stress, compared to wild type littermates
Exp Paradigm: NA |
|
|
| Emotion |
Anxiety1 |
Increased
Description: Mecp2-tg mice, (f1 fvb/n * c57bl/6), display increased anxiety and spend less time in the open arms of elevated plus maze and in the lit compartment of the light-dark box compared to respective wild-type littermate animals
Exp Paradigm: Light-dark exploration test
|
Light-dark exploration test |
9-10 weeks |
| |
|
Description: Mecp2-tg mice, (f1 fvb/n * c57bl/6), display increased anxiety and spend less time in the open arms of elevated plus maze and in the lit compartment of the light-dark box compared to respective wild-type littermate animals
Exp Paradigm: Light-dark exploration test |
|
|
| Emotion |
Anxiety1 |
Increased
Description: Mecp2-tg mice, (f1 fvb/n * c57bl/6), display increased anxiety and spend less time in the open arms of elevated plus maze and in the lit compartment of the light-dark box compared to respective wild-type littermate animals
Exp Paradigm: Elevated plus maze test
|
Elevated plus maze test |
9-10 weeks |
| |
|
Description: Mecp2-tg mice, (f1 fvb/n * c57bl/6), display increased anxiety and spend less time in the open arms of elevated plus maze and in the lit compartment of the light-dark box compared to respective wild-type littermate animals
Exp Paradigm: Elevated plus maze test |
|
|
| Emotion |
Exploratory activity: habituation1 |
No change |
Three-chamber social approach test |
12 weeks |
| Motor phenotype |
General locomotor activity1 |
No change |
Open field test |
8-9 weeks |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Learning & memory, Maternal behavior, Molecular profile, Motor phenotype, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior, |
