| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
General locomotor activity1 |
No adverse effect
Description: Genetic reduction of crhr1 in mecp2-tg mice has no effect on distance traveled in open field test
Exp Paradigm: NA
|
Open field test |
4-5 months |
| |
|
Description: Genetic reduction of crhr1 in mecp2-tg mice has no effect on distance traveled in open field test
Exp Paradigm: NA |
|
|
| Social behavior |
Social interaction1 |
Refractory
Description: Genetic reduction of crhr1 in mecp2-tg mice has no effect of social behavior deficits
Exp Paradigm: NA
|
Partition test |
4-5 months |
| |
|
Description: Genetic reduction of crhr1 in mecp2-tg mice has no effect of social behavior deficits
Exp Paradigm: NA |
|
|
| Social behavior |
Social memory1 |
Refractory
Description: Genetic reduction of crhr1 in mecp2-tg mice has no effect of social behavior and memory deficits
Exp Paradigm: NA
|
Partition test |
2-3 month |
| |
|
Description: Genetic reduction of crhr1 in mecp2-tg mice has no effect of social behavior and memory deficits
Exp Paradigm: NA |
|
|
| Emotion |
Anxiety1 |
Ameliorated
Description: Genetic reduction of crhr1 in mecp2-tg mice reduces anxiety levels with amelioration seen in elevated plus maze and light-dark box test
Exp Paradigm: Light-dark exploration test
|
Light-dark exploration test |
4-5 months |
| |
|
Description: Genetic reduction of crhr1 in mecp2-tg mice reduces anxiety levels with amelioration seen in elevated plus maze and light-dark box test
Exp Paradigm: Light-dark exploration test |
|
|
| Emotion |
Anxiety1 |
Ameliorated
Description: Genetic reduction of crhr1 in mecp2-tg mice reduces anxiety levels with amelioration seen in elevated plus maze and light-dark box test
Exp Paradigm: Elevated plus maze test
|
Elevated plus maze test |
4-5 months |
| |
|
Description: Genetic reduction of crhr1 in mecp2-tg mice reduces anxiety levels with amelioration seen in elevated plus maze and light-dark box test
Exp Paradigm: Elevated plus maze test |
|
|
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Immune response, Learning & memory, Maternal behavior, Molecular profile, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, |
