| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
General locomotor activity1 |
No adverse effect
Description: Genetic reduction of crh in mecp2-tg mice has no affect on distance traveled in open field
Exp Paradigm: NA
|
Open field test |
4-5 months |
| |
|
Description: Genetic reduction of crh in mecp2-tg mice has no affect on distance traveled in open field
Exp Paradigm: NA |
|
|
| Social behavior |
Social interaction1 |
Refractory
Description: Genetic reduction of crh in mecp2-tg mice has no effect of social behavior deficits
Exp Paradigm: NA
|
Partition test |
4-5 months |
| |
|
Description: Genetic reduction of crh in mecp2-tg mice has no effect of social behavior deficits
Exp Paradigm: NA |
|
|
| Social behavior |
Social memory1 |
Refractory
Description: Genetic reduction of crh in mecp2-tg mice has no effect of social behavior and memory deficits
Exp Paradigm: NA
|
Partition test |
4-5 months |
| |
|
Description: Genetic reduction of crh in mecp2-tg mice has no effect of social behavior and memory deficits
Exp Paradigm: NA |
|
|
| Physiological parameters |
Hormone levels1 |
Restored
Description: Genetic reduction of crh in mecp2-tg mice reduces stress induced spike in corticosterone levels
Exp Paradigm: NA
|
Restraint-stress induced corticosterone levels |
4-5 months |
| |
|
Description: Genetic reduction of crh in mecp2-tg mice reduces stress induced spike in corticosterone levels
Exp Paradigm: NA |
|
|
| Emotion |
Anxiety1 |
Restored
Description: Genetic reduction of crh in mecp2-tg mice reduces anxiety and increases time spent in open arms or lit chamber in elevated plus maze and ligh-dark exploration test respectively
Exp Paradigm: Light-dark exploration test
|
Light-dark exploration test |
4-5 months |
| |
|
Description: Genetic reduction of crh in mecp2-tg mice reduces anxiety and increases time spent in open arms or lit chamber in elevated plus maze and ligh-dark exploration test respectively
Exp Paradigm: Light-dark exploration test |
|
|
| Emotion |
Anxiety1 |
Restored
Description: Genetic reduction of crh in mecp2-tg mice reduces anxiety and increases time spent in open arms or lit chamber in elevated plus maze and ligh-dark exploration test respectively
Exp Paradigm: Elevated plus maze test
|
Elevated plus maze test |
4-5 months |
| |
|
Description: Genetic reduction of crh in mecp2-tg mice reduces anxiety and increases time spent in open arms or lit chamber in elevated plus maze and ligh-dark exploration test respectively
Exp Paradigm: Elevated plus maze test |
|
|
| Molecular profile |
Gene expression1 |
No adverse effect
Description: Genetic reduction of crh in mecp2-tg mice does not alter the levels of avp (checked because avp levels can modulate anxiety)
Exp Paradigm: NA
|
Quantitative pcr (qrt-pcr) |
4-5 months |
| |
|
Description: Genetic reduction of crh in mecp2-tg mice does not alter the levels of avp (checked because avp levels can modulate anxiety)
Exp Paradigm: NA |
|
|
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Immune response, Learning & memory, Maternal behavior, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, |
