| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Social behavior |
Social approach1 |
Decreased
Description: Mecp2-tg animals are less interested in their familiar or novel partner mice in the partition test for social interaction and recognition; in the three-chamber test for social approach, mecp2-tg mice compared to wild-type littermates spend the same amount of time investigating a novel object but are less interested in a novel mouse;
Exp Paradigm: Partition test
|
Three-chamber social approach test |
7 weeks |
| |
|
Description: Mecp2-tg animals are less interested in their familiar or novel partner mice in the partition test for social interaction and recognition; in the three-chamber test for social approach, mecp2-tg mice compared to wild-type littermates spend the same amount of time investigating a novel object but are less interested in a novel mouse;
Exp Paradigm: Partition test |
|
|
| Social behavior |
Social memory1 |
Decreased
Description: Mecp2-tg mice (f1 fvb/n * 129s6/svev) spend similar amount of time with novel and familiar mouse indicating impaired memory
Exp Paradigm: NA
|
Partition test |
12-13 weeks |
| |
|
Description: Mecp2-tg mice (f1 fvb/n * 129s6/svev) spend similar amount of time with novel and familiar mouse indicating impaired memory
Exp Paradigm: NA |
|
|
| Social behavior |
Social interaction1 |
Decreased
Description: Mecp2-tg mice (f1 fvb/n * 129s6/svev) spend less time at the partitition with a stimulus mouse compared to controls
Exp Paradigm: NA
|
Partition test |
12-13 weeks |
| |
|
Description: Mecp2-tg mice (f1 fvb/n * 129s6/svev) spend less time at the partitition with a stimulus mouse compared to controls
Exp Paradigm: NA |
|
|
| Social behavior |
Social approach1 |
Decreased
Description: Mecp2-tg mice (f1 fvb/n * 129s6/svev) spend less time investigating stimulus mouse compared to controls
Exp Paradigm: NA
|
Three-chamber social approach test |
12 weeks |
| |
|
Description: Mecp2-tg mice (f1 fvb/n * 129s6/svev) spend less time investigating stimulus mouse compared to controls
Exp Paradigm: NA |
|
|
| Emotion |
Anxiety1 |
Increased
Description: Mecp2-tg mice compared to respective wild-type littermate animals spend less time in the open arms of an elevated plus maze and spend less time in the lit compartment of the light-dark box;
Exp Paradigm: Light-dark exploration test; males only tested;-light-dark exploration test
|
Light-dark exploration test |
7 weeks |
| |
|
Description: Mecp2-tg mice compared to respective wild-type littermate animals spend less time in the open arms of an elevated plus maze and spend less time in the lit compartment of the light-dark box;
Exp Paradigm: Light-dark exploration test; males only tested;-light-dark exploration test |
|
|
| Emotion |
Anxiety1 |
Increased
Description: Mecp2-tg mice compared to respective wild-type littermate animals spend less time in the open arms of an elevated plus maze and spend less time in the lit compartment of the light-dark box;
Exp Paradigm: Light-dark exploration test; males only tested;- elevated plus maze test
|
Elevated plus maze test |
7 weeks |
| |
|
Description: Mecp2-tg mice compared to respective wild-type littermate animals spend less time in the open arms of an elevated plus maze and spend less time in the lit compartment of the light-dark box;
Exp Paradigm: Light-dark exploration test; males only tested;- elevated plus maze test |
|
|
| Emotion |
Anxiety1 |
Increased
Description: Mecp2-tg, f1 hybrid background (fvb/n * 129+h1575:h1608s6/svev) mice display increased anxiety and spend less time in the open arms of elevated plus maze and in the lit compartment of the light-dark box compared to respective wild-type littermate animals
Exp Paradigm: Light-dark exploration test
|
Light-dark exploration test |
9-10 weeks |
| |
|
Description: Mecp2-tg, f1 hybrid background (fvb/n * 129+h1575:h1608s6/svev) mice display increased anxiety and spend less time in the open arms of elevated plus maze and in the lit compartment of the light-dark box compared to respective wild-type littermate animals
Exp Paradigm: Light-dark exploration test |
|
|
| Emotion |
Anxiety1 |
Increased
Description: Mecp2-tg, f1 hybrid background (fvb/n * 129+h1575:h1608s6/svev) mice display increased anxiety and spend less time in the open arms of elevated plus maze and in the lit compartment of the light-dark box compared to respective wild-type littermate animals
Exp Paradigm: Elevated plus maze test
|
Elevated plus maze test |
9-10 weeks |
| |
|
Description: Mecp2-tg, f1 hybrid background (fvb/n * 129+h1575:h1608s6/svev) mice display increased anxiety and spend less time in the open arms of elevated plus maze and in the lit compartment of the light-dark box compared to respective wild-type littermate animals
Exp Paradigm: Elevated plus maze test |
|
|
| Molecular profile |
Gene expression1 |
Abnormal
Description: Gene expression analysis of the amygdala identifies a subset of altered genes implicated in anxiety and/or social behavior in mecp2-tg mice compared to wildtype control littermates
Exp Paradigm: Quantitative pcr (qrt-pcr);
|
Quantitative pcr (qrt-pcr) |
6 weeks |
| |
|
Description: Gene expression analysis of the amygdala identifies a subset of altered genes implicated in anxiety and/or social behavior in mecp2-tg mice compared to wildtype control littermates
Exp Paradigm: Quantitative pcr (qrt-pcr); |
|
|
| Emotion |
Exploratory activity: habituation1 |
No change |
Three-chamber social approach test |
12 weeks |
| Motor phenotype |
General locomotor activity1 |
No change |
Open field test |
8-9 weeks |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Immune response, Learning & memory, Maternal behavior, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, |
