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M_MECP2_20_KI_HT_T158A
Model Details
Change
No Change
Phenotypic Profile
Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Motor phenotype
General locomotor activity
1
Decreased
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Description:
Decreased locomotor activity
Exp Paradigm:
Open field test
Open field test
4.5 months
Description:
Decreased locomotor activity
Exp Paradigm:
Open field test
Developmental profile
Size/growth
1
Increased
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Description:
Increased body weight
Exp Paradigm:
Female mice: general observation
General observations
17 weeks
Description:
Increased body weight
Exp Paradigm:
Female mice: general observation
Molecular profile
Protein expression level evidence
1
Decreased
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Description:
Decreased mecp2 protein expression
Exp Paradigm:
Mecp2 protein expression
Western blot
3 months
Description:
Decreased mecp2 protein expression
Exp Paradigm:
Mecp2 protein expression
Molecular profile
Targeted expression
1
Abnormal
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Description:
Abnormally diffuse mecp2 immunoreactivity throughout nucleus with clear absence of co-localization with dna
Exp Paradigm:
Mecp2 immunoreactivity
Confocal microscopy
1 month, 3 months
Description:
Abnormally diffuse mecp2 immunoreactivity throughout nucleus with clear absence of co-localization with dna
Exp Paradigm:
Mecp2 immunoreactivity
Developmental profile
Developmental trajectory
1
No change
General observations
4 months
Motor phenotype
General locomotor activity
1
No change
Open field test
12 weeks
Not Reported:
Circadian sleep/wake cycle
,
Communications
,
Emotion
,
Immune response
,
Learning & memory
,
Maternal behavior
,
Neuroanatomy / ultrastructure / cytoarchitecture
,
Neurophysiology
,
Physiological parameters
,
Repetitive behavior
,
Seizure
,
Sensory
,
Social behavior
,
References:
1:
Goffin D , et al. 2011
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