| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Brain anatomy1 |
Decreased
Description: Cell bodies and nuclei of hippocampus, cerebral cortex, and cerebellum were of smaller size and more densely packed
Exp Paradigm: Histological analysis of sections utilizing thionine (neuronal) and dapi (nuclear) stain
|
Histology |
Unreported |
| |
|
Description: Cell bodies and nuclei of hippocampus, cerebral cortex, and cerebellum were of smaller size and more densely packed
Exp Paradigm: Histological analysis of sections utilizing thionine (neuronal) and dapi (nuclear) stain |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Brain cytoarchitecture1 |
Decreased
Description: Reduced neuronal cell size in ca2 region
Exp Paradigm: Tracing cell contours on brain section
|
Histology |
Unreported |
| |
|
Description: Reduced neuronal cell size in ca2 region
Exp Paradigm: Tracing cell contours on brain section |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Brain cytoarchitecture1 |
Decreased
Description: 15-25% smaller neurons in ca2 region
Exp Paradigm: Tracing cell contours on brain section
|
Histology |
Unreported |
| |
|
Description: 15-25% smaller neurons in ca2 region
Exp Paradigm: Tracing cell contours on brain section |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Brain size1 |
Decreased
Description: Reduced brain size and weight.
Exp Paradigm: Autopsy analysis
|
Measurement of tissue weight |
Unreported |
| |
|
Description: Reduced brain size and weight.
Exp Paradigm: Autopsy analysis |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Brain anatomy1 |
Decreased
Description: Reduced neuronal size; increased density
Exp Paradigm: Histological analysis of sections utilizing thionine (neuronal) and dapi (nuclear) stain
|
Histology |
Unreported |
| |
|
Description: Reduced neuronal size; increased density
Exp Paradigm: Histological analysis of sections utilizing thionine (neuronal) and dapi (nuclear) stain |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Brain size1 |
Decreased
Description: Reduced brain size and weight
Exp Paradigm: Autopsy analysis
|
Measurement of tissue weight |
Unreported |
| |
|
Description: Reduced brain size and weight
Exp Paradigm: Autopsy analysis |
|
|
| Developmental profile |
Developmental trajectory1 |
Abnormal
Description: Emergence of abnormal behavior such as nervousness, body trembling, pila erection, hard respiration around 5 weeks
Exp Paradigm: General observations
|
General observations |
5 weeks |
| |
|
Description: Emergence of abnormal behavior such as nervousness, body trembling, pila erection, hard respiration around 5 weeks
Exp Paradigm: General observations |
|
|
| Developmental profile |
Developmental trajectory1 |
Abnormal
Description: Abnormal developmental trajectory; nervousness, body trembling, pila erection, hard respiration
Exp Paradigm: General observations
|
General observations |
5 weeks |
| |
|
Description: Abnormal developmental trajectory; nervousness, body trembling, pila erection, hard respiration
Exp Paradigm: General observations |
|
|
| Developmental profile |
Size/growth1 |
Increased
Description: Overweight/physical deterioration
Exp Paradigm: General observations
|
General observations |
8 weeks |
| |
|
Description: Overweight/physical deterioration
Exp Paradigm: General observations |
|
|
| Developmental profile |
Size/growth1 |
Increased
Description: Increased size/growth
Exp Paradigm: General observations
|
General observations |
8 weeks |
| |
|
Description: Increased size/growth
Exp Paradigm: General observations |
|
|
| Molecular profile |
Gene expression1 |
Decreased
Description: Slightly smaller mecp2 transcript at a reduced level
Exp Paradigm: Rna expression
|
Northern blot |
Unreported |
| |
|
Description: Slightly smaller mecp2 transcript at a reduced level
Exp Paradigm: Rna expression |
|
|
| Molecular profile |
Protein expression level evidence1 |
Decreased
Description: Reduced mecp2 protein expression
Exp Paradigm: Protein expression
|
Immunohistochemistry |
Unreported |
| |
|
Description: Reduced mecp2 protein expression
Exp Paradigm: Protein expression |
|
|
| Molecular profile |
Gene expression1 |
Decreased
Description: Reduced mecp2 rna transcript expression
Exp Paradigm: Rna expression
|
Northern blot |
Unreported |
| |
|
Description: Reduced mecp2 rna transcript expression
Exp Paradigm: Rna expression |
|
|
| Molecular profile |
Protein expression level evidence1 |
Decreased
Description: No mecp2 immunoreactivity in brain.
Exp Paradigm: Protein expression
|
Immunohistochemistry |
Unreported |
| |
|
Description: No mecp2 immunoreactivity in brain.
Exp Paradigm: Protein expression |
|
|
| Molecular profile |
Protein expression level evidence1 |
Decreased
Description: No detection of mecp2 protein but peptides of smaller sizes
Exp Paradigm: Protein expression
|
Western blot |
Unreported |
| |
|
Description: No detection of mecp2 protein but peptides of smaller sizes
Exp Paradigm: Protein expression |
|
|
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Emotion, Immune response, Learning & memory, Maternal behavior, Motor phenotype, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior, |
