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M_MECP2_14_KI_HE_A140V
Model Details
Change
No Change
     
Phenotypic Profile
Category Entity Quantity Experimental Paradigm Age at Testing
Neuroanatomy / Ultrastructure / Cytoarchitecture Dendritic architecture: spine density1
Decreased
Description: Decreased dendritic complexity of layer ii/iii pyramidal neurons of the somatosensory cortex
Exp Paradigm: Sholl analysis on z-stack images of golgi-cox stained layer ii-iii pyramidal neurons from the somatosensory cortex

Sholl analysis 2-3 months
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain cytoarchitecture1
Increased
Description: Increased packing density in the frontal cortex, olfactory bulbs, dentate gyrus and regions ca1, ca2, ca3 of hippocampus; increased density of cell nuclei in a140v cerebellar granule layer
Exp Paradigm: Histological analysis using cresyl violet staining

Histology 5 months
Developmental profile General characteristics1 No change General observations 14 months
Developmental profile Mortality/lethality1 No change General observations 14 months
Developmental profile Size/growth1 No change General observations 6-18 weeks
Molecular profile Gene expression1 No change Quantitative pcr (qrt-pcr) 6 months
Not Reported: Circadian sleep/wake cycle,  Communications,  Emotion,  Immune response,  Learning & memory,  Maternal behavior,  Motor phenotype,  Neurophysiology,  Physiological parameters,  Repetitive behavior,  Seizure,  Sensory,  Social behavior,  
 
References: 1:  Jentarra GM , et al. 2010
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