| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
Motor coordination and balance1 |
Decreased
Description: Decreased muscle coordination
Exp Paradigm: Rota-rod test for motor performance and coordination (male)
|
Accelerating rotarod test |
Unreported |
| |
|
Description: Decreased muscle coordination
Exp Paradigm: Rota-rod test for motor performance and coordination (male) |
|
|
| Motor phenotype |
Motor coordination and balance1 |
Decreased
Description: Decreased cerebellar learning ability
Exp Paradigm: Rota-rod test performance over successive trials test for cerebellar learning (male)
|
Accelerating rotarod test |
Unreported |
| |
|
Description: Decreased cerebellar learning ability
Exp Paradigm: Rota-rod test performance over successive trials test for cerebellar learning (male) |
|
|
| Motor phenotype |
General locomotor activity1 |
Decreased
Description: Decreased locomotor activity
Exp Paradigm: Activity on freewheel test (male)
|
Running wheel test |
Unreported |
| |
|
Description: Decreased locomotor activity
Exp Paradigm: Activity on freewheel test (male) |
|
|
| Emotion |
Anxiety1 |
Decreased
Description: Decreased levels of anxiety demonstrated by increased time spent in open arms and center region
Exp Paradigm: Elevated plus maze test (male)
|
Elevated plus maze test |
Unreported |
| |
|
Description: Decreased levels of anxiety demonstrated by increased time spent in open arms and center region
Exp Paradigm: Elevated plus maze test (male) |
|
|
| Learning & memory |
Cued or contextual fear conditioning1 |
Decreased
Description: Decreased fear conditioning and contextual association
Exp Paradigm: Cued and contextual fear task: freezing response to previously cued audible tone associated with foot shock (male)
|
Fear conditioning test |
Unreported |
| |
|
Description: Decreased fear conditioning and contextual association
Exp Paradigm: Cued and contextual fear task: freezing response to previously cued audible tone associated with foot shock (male) |
|
|
| Molecular profile |
Transcriptome diversity1 |
Abnormal
Description: Abnormal gene expression profile: increase expression: sgk, sap30, pdk4. decreased expression: fabp7, his2b, nrarp, gap43, kif1b, lin7b, zfp40
Exp Paradigm: Gene expression profile
|
Quantitative pcr (qrt-pcr) |
Unreported |
| |
|
Description: Abnormal gene expression profile: increase expression: sgk, sap30, pdk4. decreased expression: fabp7, his2b, nrarp, gap43, kif1b, lin7b, zfp40
Exp Paradigm: Gene expression profile |
|
|
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Immune response, Maternal behavior, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior, |
