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construct
M_MECP2_1.4_CKO_HE
Model Details
Change
No Change
     
Phenotypic Profile
Category Entity Quantity Experimental Paradigm Age at Testing
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain anatomy1
Abnormal
Description: Reduced neuronal size; increased density
Exp Paradigm: Histological analysis of sections utilizing thionine (neuronal) and dapi (nuclear) stain

Histology Unreported
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain anatomy1
Decreased
Description: Cell bodies and nuclei of hippocampus, cerebral cortex,but not cerebellum were of smaller size and more densely packed
Exp Paradigm: Histological analysis of sections utilizing thionine (neuronal) and dapi (nuclear) stain

Histology Unreported
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size1
Decreased
Description: Reduced brain size and weight.
Exp Paradigm: Autopsy analysis

Pathology Unreported
Neuroanatomy / Ultrastructure / Cytoarchitecture Brain size1
Decreased
Description: Reduced brain size and weight
Exp Paradigm: Autopsy analysis

Pathology Unreported
Developmental profile Developmental trajectory1
Abnormal
Description: Emergence of abnormal behavior such as nervousness, body trembling, pila erection, hard respiration around 3 months
Exp Paradigm: General observations

General observations >3 months
Developmental profile Developmental trajectory1
Abnormal
Description: Abnormal developmental trajectory; nervousness, body trembling, pila erection, hard respiration
Exp Paradigm: General observations

General observations >3 months
Developmental profile Size/growth1
Increased
Description: Overweight/physical deterioration
Exp Paradigm: General observations

General observations 3-6 months
Developmental profile Size/growth1
Increased
Description: Increased size/growth; overweight/physical deterioration
Exp Paradigm: General observations

General observations 3-6 months
Developmental profile General characteristics1 No change General observations 0-3 months
Developmental profile General characteristics1 No change General observations 0-3 months
Not Reported: Circadian sleep/wake cycle,  Communications,  Emotion,  Immune response,  Learning & memory,  Maternal behavior,  Molecular profile,  Motor phenotype,  Neurophysiology,  Physiological parameters,  Repetitive behavior,  Seizure,  Sensory,  Social behavior,  
 
References: 1:  Chen RZ , et al. 2001
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