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M_MECP2_1.3_KO_HT_ALC
Model Details
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Phenotypic Profile
Category Entity Quantity Experimental Paradigm Age at Testing
Motor phenotype Motor coordination and balance1
Restored
Description: Motor coordination is restored to the same level as wild type
Exp Paradigm: Female mice: rotorod test

Accelerating rotarod test 6 weeks
Motor phenotype Grip strength1
No adverse effect
Description: No adverse effectin forepaw grip strength
Exp Paradigm: Grip strength assay

Grip strength test 3,4,6 weeks
Motor phenotype General locomotor activity1
No adverse effect
Description: No adverse effectin general locomotor activity
Exp Paradigm: Female mice: general motor activity levels during dark cycle

Light-dark exploration test 3,4,6 weeks
Developmental profile Size/growth1
No adverse effect
Description: No adverse effectin weight gain
Exp Paradigm: General observations

General observations Pn 0-47
Learning & memory Cued or contextual fear conditioning1
No adverse effect
Description: No adverse effectin contextual or cued fear conditioning
Exp Paradigm: Female mice: associative fear conditioning task

Fear conditioning test 0-6.5 weeks
Not Reported: Circadian sleep/wake cycle,  Communications,  Emotion,  Immune response,  Maternal behavior,  Molecular profile,  Neuroanatomy / ultrastructure / cytoarchitecture,  Neurophysiology,  Physiological parameters,  Repetitive behavior,  Seizure,  Sensory,  Social behavior,  
 
References: 1:  Schaevitz LR , et al. 2012
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