| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
General locomotor activity1 |
Ameliorated
Description: Decreased voluntary locomotor activity is partailly restored to the level of wild type although wild type with treatment also has increased voluntary locomotor activity
Exp Paradigm: Voluntary wheel-running activity
|
Running wheel test |
8 weeks |
| |
|
Description: Decreased voluntary locomotor activity is partailly restored to the level of wild type although wild type with treatment also has increased voluntary locomotor activity
Exp Paradigm: Voluntary wheel-running activity |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Brain cytoarchitecture1 |
Restored
Description: Neuronal nuclei size is restored to the same level as wild type
Exp Paradigm: Ca1 neuronal nuclei size measurement
|
Nuclear size measurement |
8-10 weeks |
| |
|
Description: Neuronal nuclei size is restored to the same level as wild type
Exp Paradigm: Ca1 neuronal nuclei size measurement |
|
|
| Physiological parameters |
Respiratory function1 |
Restored
Description: Ventilatory capacity as measured by tidal volume and minute pulmonary ventilation is restored to the same level as wild type
Exp Paradigm: Whole-body plesmythographic measurements
|
Whole body plethysmography |
6 weeks |
| |
|
Description: Ventilatory capacity as measured by tidal volume and minute pulmonary ventilation is restored to the same level as wild type
Exp Paradigm: Whole-body plesmythographic measurements |
|
|
| Physiological parameters |
Respiratory function1 |
Ameliorated
Description: Abnormal in breathing pattern is partially restored to the level of wild type as indicated by no significant difference in 95% confidential interval of total duration of each breath (ci) but significantly higher coefficient of variation (cv) compared to wild type
Exp Paradigm: Whole-body plesmythographic measurements
|
Whole body plethysmography |
6 weeks |
| |
|
Description: Abnormal in breathing pattern is partially restored to the level of wild type as indicated by no significant difference in 95% confidential interval of total duration of each breath (ci) but significantly higher coefficient of variation (cv) compared to wild type
Exp Paradigm: Whole-body plesmythographic measurements |
|
|
| Developmental profile |
Size/growth1 |
Ameliorated
Description: Decreased body weight is partailly restored to the level of wild type although wild type with treatment also gains body weight
Exp Paradigm: General observations
|
General observations |
4-8 weeks |
| |
|
Description: Decreased body weight is partailly restored to the level of wild type although wild type with treatment also gains body weight
Exp Paradigm: General observations |
|
|
| Developmental profile |
Mortality/lethality1 |
Ameliorated
Description: Decreased in life span is improved by the treatment
Exp Paradigm: General observations
|
General observations |
0-5 months |
| |
|
Description: Decreased in life span is improved by the treatment
Exp Paradigm: General observations |
|
|
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Emotion, Immune response, Learning & memory, Maternal behavior, Molecular profile, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior, |
