| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Neurophysiology |
Neurotransmitter release: serotonin1 |
Decreased
Description: Decreased levels of serotonergic neurotransmitters; no change in dopamine and norepinephrine levels
Exp Paradigm: Whole-brain hplc
|
High-performance liquid chromatography (hplc) |
5 months |
| |
|
Description: Decreased levels of serotonergic neurotransmitters; no change in dopamine and norepinephrine levels
Exp Paradigm: Whole-brain hplc |
|
|
| Social behavior |
Aggression1 |
Increased
Description: Increased aggression levels
Exp Paradigm: Resident-intruder test
|
Resident-intruder test |
5 months |
| |
|
Description: Increased aggression levels
Exp Paradigm: Resident-intruder test |
|
|
| Physiological parameters |
Respiratory function1 |
Abnormal
Description: Abnormal breathing phenotype demonstrated by increased number of apnea episodes
Exp Paradigm: Whole-body plesmythographic measurements
|
Whole body plethysmography |
6.5 months |
| |
|
Description: Abnormal breathing phenotype demonstrated by increased number of apnea episodes
Exp Paradigm: Whole-body plesmythographic measurements |
|
|
| Molecular profile |
Gene expression1 |
Decreased
Description: Decreased expression level of tryptophan hydroxylase 2 (tph2)
Exp Paradigm: Th/tph2 rna expression
|
In situ hybridization (ish) |
3.5-4.5 months |
| |
|
Description: Decreased expression level of tryptophan hydroxylase 2 (tph2)
Exp Paradigm: Th/tph2 rna expression |
|
|
| Emotion |
Anxiety1 |
No change |
Light-dark exploration test |
12-14 weeks |
| Motor phenotype |
General locomotor activity1 |
No change |
Open field test |
Unreported |
| Motor phenotype |
Motor coordination and balance1 |
No change |
Accelerating rotarod test |
13 weeks |
| Motor phenotype |
Motor coordination and balance1 |
No change |
Dowel walk test |
16 weeks |
| Motor phenotype |
Self grooming: artificial stress evoked1 |
No change |
Splash test to evoke grooming behavior |
7 months |
| Repetitive behavior |
Repetitive digging1 |
No change |
Marble-burying test |
8 weeks |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Immune response, Learning & memory, Maternal behavior, Neuroanatomy / ultrastructure / cytoarchitecture, Physiological parameters, Seizure, Sensory, |
