| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
General locomotor activity1 |
Decreased
Description: Decrease locomotor activity demonstrated by decreased total distance and vertical activity
Exp Paradigm: Open field test
|
Open field test |
15 weeks |
| |
|
Description: Decrease locomotor activity demonstrated by decreased total distance and vertical activity
Exp Paradigm: Open field test |
|
|
| Motor phenotype |
Motor coordination and balance1 |
Decreased
Description: Decreased muscle coordination
Exp Paradigm: Dowel walking test
|
Dowel walk test |
16 weeks |
| |
|
Description: Decreased muscle coordination
Exp Paradigm: Dowel walking test |
|
|
| Neurophysiology |
Neurotransmitter release1 |
Decreased
Description: Decreased levels of dopamine and norepinephrine neurotransmitters; no change in serotonin levels
Exp Paradigm: Whole-brain hplc
|
High-performance liquid chromatography (hplc) |
5 months |
| |
|
Description: Decreased levels of dopamine and norepinephrine neurotransmitters; no change in serotonin levels
Exp Paradigm: Whole-brain hplc |
|
|
| Physiological parameters |
Respiratory function1 |
Abnormal
Description: Abnormal breathing phenotype demonstrated by increased number of apnea episodes
Exp Paradigm: Whole-body plesmythographic measurements
|
Whole body plethysmography |
16 weeks |
| |
|
Description: Abnormal breathing phenotype demonstrated by increased number of apnea episodes
Exp Paradigm: Whole-body plesmythographic measurements |
|
|
| Molecular profile |
Gene expression1 |
Decreased
Description: Decreased expression level of tyrosine hydroxylase (th)
Exp Paradigm: Th/tph2 rna expression
|
In situ hybridization (ish) |
16-20 weeks |
| |
|
Description: Decreased expression level of tyrosine hydroxylase (th)
Exp Paradigm: Th/tph2 rna expression |
|
|
| Emotion |
Anxiety1 |
No change |
Light-dark exploration test |
12-14 weeks |
| Learning & memory |
Cued or contextual fear conditioning1 |
No change |
Fear conditioning test |
4.5 months |
| Motor phenotype |
Motor coordination and balance1 |
No change |
Accelerating rotarod test |
13 weeks |
| Social behavior |
Social interaction1 |
No change |
Partition test |
5 months |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Immune response, Maternal behavior, Neuroanatomy / ultrastructure / cytoarchitecture, Physiological parameters, Repetitive behavior, Seizure, Sensory, |
